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Journal of Cancer Research and Clinical Oncology

Erschienen in:

18.02.2020 | Review – Clinical Oncology

Volume de-escalation in radiation therapy: state of the art and new perspectives

verfasst von: Bruno Meduri, Fabiana Gregucci, Elisa D’Angelo, Anna Rita Alitto, Elisa Ciurlia, Isacco Desideri, Lorenza Marino, Paolo Borghetti, Michele Fiore, Alba Fiorentino, AIRO Giovani -Italian Association of Radiation Oncology-Young Members

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 4/2020

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Abstract

Purpose

New RT techniques and data emerging from follow-up for several tumor sites suggest that treatment volume de-escalation may permit to minimize therapy-related side effects and/or obtain better clinical outcomes. Here, we summarize the main evidence about volume de-escalation in RT.

Method

The relevant literature from PubMed was reviewed in this article. The ClinicalTrials.gov database was searched for clinical trials related to the specific topic.

Results

In Lymphoma, large-volume techniques (extended- and involved-field RT) are being successfully replaced by involved-site RT and involved-node RT. In head and neck carcinoma, spare a part of elective neck is controversial. In early breast cancer, partial breast irradiation has been established as a treatment option in low-risk patients. In pancreatic cancer stereotactic body radiotherapy may be used to dose escalation. Stereotactic radiosurgery should be the treatment choice for patients with oligometastatic brain disease and a life expectancy of more than 3 months, and it should be considered an alternative to WBRT for patients with multiple brain metastases.

Conclusion

Further clinical trials are necessary to improve the identification of suitable patient cohorts and the extent of possible volume de-escalation that does not compromise tumor control.

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Titel: Volume de-escalation in radiation therapy: state of the art and new perspectives
verfasst von: Bruno Meduri
Fabiana Gregucci
Elisa D’Angelo
Anna Rita Alitto
Elisa Ciurlia
Isacco Desideri
Lorenza Marino
Paolo Borghetti
Michele Fiore
Alba Fiorentino
AIRO Giovani -Italian Association of Radiation Oncology-Young Members
Publikationsdatum: 18.02.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 4/2020
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-020-03152-7

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24.04.2024 | DGIM 2024 | Nachrichten

Springer Medizin

Volume de-escalation in radiation therapy: state of the art and new perspectives

Abstract

Purpose

Method

Results

Conclusion

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Springer Medizin

Abstract

Purpose

Method

Results

Conclusion

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