Background
Methods
Study population
CMR scanning
Imaging analysis
Statistical analysis
Results
Study population
Normal (n = 18) | CAD without diabetes (n = 33) | CAD with diabetes (n = 28) |
p
| |
---|---|---|---|---|
Age, years | 49.78 ± 8.44 | 59.21 ± 12.60 | 58.12 ± 12.53 | 0.070 |
Male (n, %) | 12 (66.66%) | 21 (63.63%) | 18 (64.28%) | 0.976 |
HR, beats/min | 82.06 ± 22.05 | 77.03 ± 12.43 | 81.19 ± 16.14 | 0.515 |
Systolic BP, mmHg | 123.32 ± 22.13 | 127.81 ± 22.34 | 127.19 ± 23.40 | 0.800 |
Diastolic BP, mmHg | 74.32 ± 12.10 | 74.24 ± 18.45 | 76.13 ± 18.41 | 0.449 |
Duration of diabetes | 2 days to 14 years | N/A | ||
Angina (n, %) | - | 31 (93.94%) | 16 (57.14%) | 0.001 |
Cigarette Smoking (n, %) | - | 21 (63.63%) | 18 (64.29%) | 0.958 |
Drinking (n, %) | - | 16 (48.48%) | 14 (50.00%) | 0.906 |
Family history of cardiac disease (n, %) | - | 4 (12.12%) | 9 (32.14%) | 0.057 |
Killips classification (I, II, III, IV) | - | 27/4/2/0 | 23/3/2/0 | 0.991 |
Plasma Glucose (mmol/L) | - | 5.34 ± 1.65 | 13.90 ± 6.38 | <0.001 |
HBA1c,% | - | 9.38 ± 2.38 | N/A | |
Electrocardiogram changes (Pathologic Q waves) (n, %) | - | 9 (27.27%) | 6 (21.43%) | 0.597 |
Electrocardiogram changes (ST changes) (n, %) | - | 32 (96.97%) | 20 (71.43%) | 0.005 |
CMR LGE | - | 33 (100%) | 28 (100%) | N/A |
Coronary artery stenosis (One/Two /Three-vessel) | - | 13/4/16 | 8/6/14 | 0.635 |
Location of coronary artery occlusion (LAD/ LCX/ RCA) | - | 33/17/18 | 28/10/17 | 0.641 |
CAD treatment (Drugs/ PCI/CABG) | - | 5/28/0 | 7/21/0 | 0.335 |
Left ventricular function and size parameters
Normal (n = 20) | CAD without diabetes (n = 33) | CAD with diabetes (n = 28) |
p
| |
---|---|---|---|---|
LVEF,% | 61.34 ± 4.48 | 45.29 ± 12.83* | 41.9 ± 15.37*#
| <0.001 |
LVEDV, ml | 118.70 ± 23.69 | 147.14 ± 38.42* | 163.22 ± 38.64*#
| 0.002 |
LVESV, ml | 52.37 ± 23.72 | 83.15 ± 34.81* | 98.26 ± 43.54* | 0.001 |
LVSV, ml | 75.11 ± 9.93 | 63.99 ± 16.63 | 64.96 ± 20.18 | 0.067 |
LVMASS, g | 90.96 ± 22.57 | 130.17 ± 38.29* | 139.99 ± 33.72*#
| <0.001 |
LVEDD, cm | 4.85 ± 0.34 | 5.13 ± 0.55* | 5.44 ± 0.51*#
| 0.005 |
LVESD, cm | 3.38 ± 0.36 | 3.79 ± 0.67* | 3.98 ± 0.68* | 0.017 |
LV volume-time curve parameters
Normal (n = 20) | CAD without diabetes (n = 33) | CAD with diabetes (n = 28) |
p
| |
---|---|---|---|---|
PER (ml/s) | 138.26 ± 25.04 | 118.59 ± 34.32* | 90.35 ± 28.09*#
| <0.001 |
PET (msec)& | 113.52 ± 37.62 | 232.00 ± 215.10 | 336.74 ± 216.44 | 0.0008 |
PFR (ml/s) | 169.55 ± 50.85 | 128.04 ± 37.35* | 102.07 ± 36.11*#
| <0.001 |
PFT (msec) | 122.82 ± 37.64 | 147.92 ± 131.99 | 312.00 ± 143.25*#
| 0.004 |
PER/EDV (EDV/s) | 5.44 ± 0.92 | 4.620 ± 1.21* | 3.24 ± 1.12*#
| <0.001 |
PFR/EDV (EDV/s) | 6.48 ± 1.96 | 4.84 ± 0.99* | 3.36 ± 1.06*#
| <0.001 |
Logistic regression analysis for independent predictors
OR | 95% CI |
p
| |
---|---|---|---|
LVEF | 0.8494 | 0.6844 to 1.0541 | 0.1383 |
LVEDV | 0.9355 | 0.8449 to 1.0358 | 0.1996 |
LVEDD | 2.3366 | 0.0555 to 98.4616 | 0.6566 |
LVMASS | 0.9991 | 0.9443 to 1.0572 | 0.9757 |
PER (ml/s) | 0.9334 | 0.8014 to 1.0871 | 0.3756 |
PET (msec) | 1.1208 | 1.0023 to 1.2532 | 0.0454* |
PFR (ml/s) | 0.9967 | 0.9894 to 1.0040 | 0.3736 |
PFT (msec) | 1.0161 | 1.0001 to 1.0326 | 0.0412* |
PER/EDV (EDV/s) | 0.0917 | 0.0002 to 45.4775 | 0.4506 |
PFR/EDV (EDV/s) | 0.0139 | 0.0005 to 0.3955 | 0.0123* |