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Erschienen in: Pneumo News 8/2018

17.12.2018 | Idiopathische Lungenfibrose | fortbildung

Zwischen Physiologie und Pathologie

Was mit der Lunge im Alter passiert

verfasst von: Dr. med. Sven Stieglitz

Erschienen in: Pneumo News | Ausgabe 8/2018

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Zusammenfassung

Wir werden immer älter. Und das Alter wirkt sich auf die Lunge aus. Die zugrundeliegenden Mechanismen sollten wir kennen, um der Entstehung von Erkrankungen wie der idiopathischen Lungenfibrose, aber auch von Asthma bronchiale entgegenwirken zu können. Was ist noch physiologisch und wann wird es pathologisch?
Literatur
2.
Zurück zum Zitat Thannickal VJ, Murthy M, Balch WE, Chandel NS, Meiners S, Eickelberg O, Selman M, Pardo A, White ES, Levy BD, Busse PJ, Tuder RM, Antony VB, Sznajder JI, Budinger GR (2015) Blue journal conference. Aging and susceptibility to lung disease. Am J Respir Crit Care Med 191(3):261–269. https://doi.org/10.1164/rccm.201410-1876PP CrossRefPubMedPubMedCentralCrossRef Thannickal VJ, Murthy M, Balch WE, Chandel NS, Meiners S, Eickelberg O, Selman M, Pardo A, White ES, Levy BD, Busse PJ, Tuder RM, Antony VB, Sznajder JI, Budinger GR (2015) Blue journal conference. Aging and susceptibility to lung disease. Am J Respir Crit Care Med 191(3):261–269. https://​doi.​org/​10.​1164/​rccm.​201410-1876PP CrossRefPubMedPubMedCentralCrossRef
3.
Zurück zum Zitat Bui DS, Burgess JA, Lowe AJ, Perret JL, Lodge CJ, Bui M, Morrison S, Thompson BR, Thomas PS, Giles GG, Garcia-Aymerich J, Jarvis D, Abramson MJ, Walters EH, Matheson MC, Dharmage SC (2017) Childhood lung function predicts adult chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease overlap syndrome. Am J Respir Crit Care Med 196(1):39–46. https://doi.org/10.1164/rccm.201606-1272OC CrossRefPubMedCrossRef Bui DS, Burgess JA, Lowe AJ, Perret JL, Lodge CJ, Bui M, Morrison S, Thompson BR, Thomas PS, Giles GG, Garcia-Aymerich J, Jarvis D, Abramson MJ, Walters EH, Matheson MC, Dharmage SC (2017) Childhood lung function predicts adult chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease overlap syndrome. Am J Respir Crit Care Med 196(1):39–46. https://​doi.​org/​10.​1164/​rccm.​201606-1272OC CrossRefPubMedCrossRef
4.
Zurück zum Zitat Xu X, Laird N, Dockery DW, Schouten JP, Rijcken B, Weiss ST (1995) Age, period, and cohort effects on pulmonary function in a 24-year longitudinal study. Am J Epidemiol 141(6):554–566 CrossRefPubMedCrossRef Xu X, Laird N, Dockery DW, Schouten JP, Rijcken B, Weiss ST (1995) Age, period, and cohort effects on pulmonary function in a 24-year longitudinal study. Am J Epidemiol 141(6):554–566 CrossRefPubMedCrossRef
5.
Zurück zum Zitat Gillooly M, Lamb D (1993) Airspace size in lungs of lifelong non-smokers: effect of age and sex. Thorax 48(1):39–43 CrossRefPubMedPubMedCentralCrossRef Gillooly M, Lamb D (1993) Airspace size in lungs of lifelong non-smokers: effect of age and sex. Thorax 48(1):39–43 CrossRefPubMedPubMedCentralCrossRef
6.
Zurück zum Zitat Numa AH, Newth CJ (1996) Anatomic dead space in infants and children. J Appl Physiol 80(5):1485–1489 CrossRefPubMedCrossRef Numa AH, Newth CJ (1996) Anatomic dead space in infants and children. J Appl Physiol 80(5):1485–1489 CrossRefPubMedCrossRef
7.
Zurück zum Zitat Ware JH, Dockery DW, Louis TA, Xu XP, Ferris BG Jr., Speizer FE (1990) Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults. Am J Epidemiol 132(4):685–700 CrossRefPubMedCrossRef Ware JH, Dockery DW, Louis TA, Xu XP, Ferris BG Jr., Speizer FE (1990) Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults. Am J Epidemiol 132(4):685–700 CrossRefPubMedCrossRef
8.
Zurück zum Zitat Lumb AB (2000) Nunn’s applied respiratory physiology, 5. Aufl. Butterworth-Heinemann, Oxford Lumb AB (2000) Nunn’s applied respiratory physiology, 5. Aufl. Butterworth-Heinemann, Oxford
9.
Zurück zum Zitat Lombardi I Jr., Oliveira LM, Mayer AF, Jardim JR, Natour J (2005) Evaluation of pulmonary function and quality of life in women with osteoporosis. Osteoporos Int 16(10):1247–1253. https://doi.org/10.1007/s00198-005-1834-3 CrossRefPubMedCrossRef Lombardi I Jr., Oliveira LM, Mayer AF, Jardim JR, Natour J (2005) Evaluation of pulmonary function and quality of life in women with osteoporosis. Osteoporos Int 16(10):1247–1253. https://​doi.​org/​10.​1007/​s00198-005-1834-3 CrossRefPubMedCrossRef
10.
Zurück zum Zitat Enright PL, Kronmal RA, Manolio TA, Schenker MB, Hyatt RE (1994) Respiratory muscle strength in the elderly. Correlates and reference values. Cardiovascular Health Study Research Group. Am J Respir Crit Care Med 149(2 Pt 1):430–438. https://doi.org/10.1164/ajrccm.149.2.8306041 CrossRefPubMedCrossRef Enright PL, Kronmal RA, Manolio TA, Schenker MB, Hyatt RE (1994) Respiratory muscle strength in the elderly. Correlates and reference values. Cardiovascular Health Study Research Group. Am J Respir Crit Care Med 149(2 Pt 1):430–438. https://​doi.​org/​10.​1164/​ajrccm.​149.​2.​8306041 CrossRefPubMedCrossRef
11.
Zurück zum Zitat Polkey MI, Harris ML, Hughes PD, Hamnegard CH, Lyons D, Green M, Moxham J (1997) The contractile properties of the elderly human diaphragm. Am J Respir Crit Care Med 155(5):1560–1564. https://doi.org/10.1164/ajrccm.155.5.9154857 CrossRefPubMedCrossRef Polkey MI, Harris ML, Hughes PD, Hamnegard CH, Lyons D, Green M, Moxham J (1997) The contractile properties of the elderly human diaphragm. Am J Respir Crit Care Med 155(5):1560–1564. https://​doi.​org/​10.​1164/​ajrccm.​155.​5.​9154857 CrossRefPubMedCrossRef
12.
Zurück zum Zitat Tolep K, Higgins N, Muza S, Criner G, Kelsen SG (1995) Comparison of diaphragm strength between healthy adult elderly and young men. Am J Respir Crit Care Med 152(2):677–682. https://doi.org/10.1164/ajrccm.152.2.7633725 CrossRefPubMedCrossRef Tolep K, Higgins N, Muza S, Criner G, Kelsen SG (1995) Comparison of diaphragm strength between healthy adult elderly and young men. Am J Respir Crit Care Med 152(2):677–682. https://​doi.​org/​10.​1164/​ajrccm.​152.​2.​7633725 CrossRefPubMedCrossRef
13.
Zurück zum Zitat Sharma G, Goodwin J (2006) Effect of aging on respiratory system physiology and immunology. Clin Interv Aging 1(3):253–260 CrossRefPubMedPubMedCentralCrossRef Sharma G, Goodwin J (2006) Effect of aging on respiratory system physiology and immunology. Clin Interv Aging 1(3):253–260 CrossRefPubMedPubMedCentralCrossRef
14.
Zurück zum Zitat St-Jean-Pelletier F, Pion CH, Leduc-Gaudet JP, Sgarioto N, Zovile I, Barbat-Artigas S, Reynaud O, Alkaterji F, Lemieux FC, Grenon A, Gaudreau P, Hepple RT, Chevalier S, Belanger M, Morais JA, Aubertin-Leheudre M, Gouspillou G (2017) The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men. J Cachexia Sarcopenia Muscle 8(2):213–228. https://doi.org/10.1002/jcsm.12139 CrossRefPubMedCrossRef St-Jean-Pelletier F, Pion CH, Leduc-Gaudet JP, Sgarioto N, Zovile I, Barbat-Artigas S, Reynaud O, Alkaterji F, Lemieux FC, Grenon A, Gaudreau P, Hepple RT, Chevalier S, Belanger M, Morais JA, Aubertin-Leheudre M, Gouspillou G (2017) The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men. J Cachexia Sarcopenia Muscle 8(2):213–228. https://​doi.​org/​10.​1002/​jcsm.​12139 CrossRefPubMedCrossRef
15.
Zurück zum Zitat Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153(6):1194–1217. https://doi.org/10.1016/j.cell.2013.05.039 CrossRefPubMedPubMedCentralCrossRef Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153(6):1194–1217. https://​doi.​org/​10.​1016/​j.​cell.​2013.​05.​039 CrossRefPubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Fontana L, Partridge L, Longo VD (2010) Extending healthy life span-from yeast to humans. Science 328(5976):321–326. https://doi.org/10.1126/science.1172539 CrossRefPubMedPubMedCentralCrossRef Fontana L, Partridge L, Longo VD (2010) Extending healthy life span-from yeast to humans. Science 328(5976):321–326. https://​doi.​org/​10.​1126/​science.​1172539 CrossRefPubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Lehmann M, Korfei M, Mutze K, Klee S, Skronska-Wasek W, Alsafadi HN, Ota C, Costa R, Schiller HB, Lindner M, Wagner DE, Gunther A, Konigshoff M (2017) Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo. Eur Respir J. https://doi.org/10.1183/13993003.02367-2016 PubMedCentral Lehmann M, Korfei M, Mutze K, Klee S, Skronska-Wasek W, Alsafadi HN, Ota C, Costa R, Schiller HB, Lindner M, Wagner DE, Gunther A, Konigshoff M (2017) Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo. Eur Respir J. https://​doi.​org/​10.​1183/​13993003.​02367-2016 PubMedCentral
18.
Zurück zum Zitat American Thoracic S, European Respiratory S (2002) American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 165(2):277–304. https://doi.org/10.1164/ajrccm.165.2.ats01 CrossRefCrossRef American Thoracic S, European Respiratory S (2002) American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 165(2):277–304. https://​doi.​org/​10.​1164/​ajrccm.​165.​2.​ats01 CrossRefCrossRef
19.
Zurück zum Zitat Birch J, Barnes PJ, Passos JF (2017) Mitochondria, telomeres and cell senescence: implications for lung ageing and disease. Pharmacol Ther. https://doi.org/10.1016/j.pharmthera.2017.10.005 PubMed Birch J, Barnes PJ, Passos JF (2017) Mitochondria, telomeres and cell senescence: implications for lung ageing and disease. Pharmacol Ther. https://​doi.​org/​10.​1016/​j.​pharmthera.​2017.​10.​005 PubMed
20.
Zurück zum Zitat Bauer BA, Reed CE, Yunginger JW, Wollan PC, Silverstein MD (1997) Incidence and outcomes of asthma in the elderly. A population-based study in Rochester, Minnesota. Chest 111(2):303–310 CrossRefPubMedCrossRef Bauer BA, Reed CE, Yunginger JW, Wollan PC, Silverstein MD (1997) Incidence and outcomes of asthma in the elderly. A population-based study in Rochester, Minnesota. Chest 111(2):303–310 CrossRefPubMedCrossRef
21.
Zurück zum Zitat Inoue H, Niimi A, Takeda T, Matsumoto H, Ito I, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Kanemitsu Y, Chin K, Mishima M (2014) Pathophysiological characteristics of asthma in the elderly: a comprehensive study. Ann Allergy Asthma Immunol 113(5):527–533. https://doi.org/10.1016/j.anai.2014.08.002 CrossRefPubMedCrossRef Inoue H, Niimi A, Takeda T, Matsumoto H, Ito I, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Kanemitsu Y, Chin K, Mishima M (2014) Pathophysiological characteristics of asthma in the elderly: a comprehensive study. Ann Allergy Asthma Immunol 113(5):527–533. https://​doi.​org/​10.​1016/​j.​anai.​2014.​08.​002 CrossRefPubMedCrossRef
22.
Zurück zum Zitat Stein PD, Hull RD, Kayali F, Ghali WA, Alshab AK, Olson RE (2004) Venous thromboembolism according to age: the impact of an aging population. Arch Intern Med 164(20):2260–2265. https://doi.org/10.1001/archinte.164.20.2260 CrossRefPubMedCrossRef Stein PD, Hull RD, Kayali F, Ghali WA, Alshab AK, Olson RE (2004) Venous thromboembolism according to age: the impact of an aging population. Arch Intern Med 164(20):2260–2265. https://​doi.​org/​10.​1001/​archinte.​164.​20.​2260 CrossRefPubMedCrossRef
23.
Zurück zum Zitat Ewig S, Birkner N, Strauss R, Schaefer E, Pauletzki J, Bischoff H, Schraeder P, Welte T, Hoeffken G (2009) New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality. Thorax 64(12):1062–1069. https://doi.org/10.1136/thx.2008.109785 CrossRefPubMedPubMedCentralCrossRef Ewig S, Birkner N, Strauss R, Schaefer E, Pauletzki J, Bischoff H, Schraeder P, Welte T, Hoeffken G (2009) New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality. Thorax 64(12):1062–1069. https://​doi.​org/​10.​1136/​thx.​2008.​109785 CrossRefPubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Afonso AS, Verhamme KM, Sturkenboom MC, Brusselle GG (2011) COPD in the general population: prevalence, incidence and survival. Respir Med 105(12):1872–1884. https://doi.org/10.1016/j.rmed.2011.06.012 CrossRefPubMedCrossRef Afonso AS, Verhamme KM, Sturkenboom MC, Brusselle GG (2011) COPD in the general population: prevalence, incidence and survival. Respir Med 105(12):1872–1884. https://​doi.​org/​10.​1016/​j.​rmed.​2011.​06.​012 CrossRefPubMedCrossRef
25.
Zurück zum Zitat Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, Walsleben JA, Finn L, Enright P, Samet JM, Sleep Heart Health Study Research (2002) Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med 162(8):893–900 CrossRefPubMed Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, Walsleben JA, Finn L, Enright P, Samet JM, Sleep Heart Health Study Research (2002) Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med 162(8):893–900 CrossRefPubMed
Metadaten
Titel
Zwischen Physiologie und Pathologie
Was mit der Lunge im Alter passiert
verfasst von
Dr. med. Sven Stieglitz
Publikationsdatum
17.12.2018
Verlag
Springer Medizin
Erschienen in
Pneumo News / Ausgabe 8/2018
Print ISSN: 1865-5467
Elektronische ISSN: 2199-3866
DOI
https://doi.org/10.1007/s15033-018-1099-0

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