Skip to main content
Erschienen in: best practice onkologie 1-2/2023

30.01.2023 | Weichteilsarkome | CME-Topic

Lokalisierte Weichgewebesarkome

verfasst von: PD Dr. med. Lars Erik Podleska, Sebastian Bauer, Christoph Pöttgen, Arne Streitbürger, Jendrik Hardes, Georg Täger

Erschienen in: best practice onkologie | Ausgabe 1-2/2023

Einloggen, um Zugang zu erhalten

Zusammenfassung

Weichgewebesarkome sind selten. Die Symptome sind unspezifisch, die Tumoren treten an unterschiedlichsten Lokalisationen auf. Wegen des hohen Verteilungsgrads dieser Tumoren auf unterschiedliche Akteure des Gesundheitswesens ist das klinische Management von Weichgewebesarkomen problembehaftet. Die kontrastmittelverstärkte Magnetresonanztomographie (MRT) ist unverzichtbar zur Diagnostik. Die Weichenstellung der Therapie erfolgt durch eine korrekt durchgeführte und im Referenzzentren analysierte Biopsie. Grundpfeiler der lokalen Tumorbehandlung ist die Abwägung im prätherapeutischen Tumorboard. Grundzüge von Epidemiologie, Diagnostik, Verlaufskontrolle und v. a. der Entscheidungsfindung, basierend auf der Biopsie, werden dargestellt. Der multimodale Behandlungsansatz wird unter Hinweis auf die einschlägige und aktuelle Literatur skizziert. Die fachübergreifende S3-Leitlinie Weichgewebesarkome ist dabei ein wichtiges Instrument zur Steigerung von Behandlungsqualität und Patientensicherheit.
Literatur
1.
Zurück zum Zitat Montgomery C, Park KJ, Gardner JM et al (2019) Post-traumatic sarcomas: do they exist? Int J Surg Pathol 27:722–728CrossRef Montgomery C, Park KJ, Gardner JM et al (2019) Post-traumatic sarcomas: do they exist? Int J Surg Pathol 27:722–728CrossRef
2.
Zurück zum Zitat Davidson T, Westbury G, Harmer CL (1986) Radiation-induced soft-tissue sarcoma. Br J Surg 73:308–309CrossRef Davidson T, Westbury G, Harmer CL (1986) Radiation-induced soft-tissue sarcoma. Br J Surg 73:308–309CrossRef
3.
Zurück zum Zitat Virtanen A, Pukkala E, Auvinen A (2006) Incidence of bone and soft tissue sarcoma after radiotherapy: a cohort study of 295,712 Finnish cancer patients. Int J Cancer 118:1017–1021CrossRef Virtanen A, Pukkala E, Auvinen A (2006) Incidence of bone and soft tissue sarcoma after radiotherapy: a cohort study of 295,712 Finnish cancer patients. Int J Cancer 118:1017–1021CrossRef
4.
Zurück zum Zitat AACR Project GENIE Consortium (2017) AACR project GENIE: powering precision medicine through an international consortium. Cancer Discov 7:818–831CrossRef AACR Project GENIE Consortium (2017) AACR project GENIE: powering precision medicine through an international consortium. Cancer Discov 7:818–831CrossRef
5.
Zurück zum Zitat Maccarthy A, Bayne AM, Brownbill PA et al (2013) Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain 1951–2004. Br J Cancer 108:2455–2463CrossRef Maccarthy A, Bayne AM, Brownbill PA et al (2013) Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain 1951–2004. Br J Cancer 108:2455–2463CrossRef
6.
Zurück zum Zitat Jouenne F, Chauvot De Beauchene I, Bollaert E et al (2017) Germline CDKN2A/P16INK4A mutations contribute to genetic determinism of sarcoma. J Med Genet 54:607–612CrossRef Jouenne F, Chauvot De Beauchene I, Bollaert E et al (2017) Germline CDKN2A/P16INK4A mutations contribute to genetic determinism of sarcoma. J Med Genet 54:607–612CrossRef
7.
Zurück zum Zitat Nandra R et al (2015) If your lump is bigger than a golf ball and growing, think Sarcoma. Eur J Surg Oncol 41(10):1400–1405CrossRef Nandra R et al (2015) If your lump is bigger than a golf ball and growing, think Sarcoma. Eur J Surg Oncol 41(10):1400–1405CrossRef
9.
Zurück zum Zitat Cairncross L, Snow HA, Strauss DC et al (2019) Diagnostic performance of MRI and histology in assessment of deep lipomatous tumours. Br J Surg 106:1794–1799CrossRef Cairncross L, Snow HA, Strauss DC et al (2019) Diagnostic performance of MRI and histology in assessment of deep lipomatous tumours. Br J Surg 106:1794–1799CrossRef
10.
Zurück zum Zitat Subhawong TK, Wilky BA (2015) Value added: functional MR imaging in management of bone and soft tissue sarcomas. Curr Opin Oncol 27:323–331CrossRef Subhawong TK, Wilky BA (2015) Value added: functional MR imaging in management of bone and soft tissue sarcomas. Curr Opin Oncol 27:323–331CrossRef
11.
Zurück zum Zitat Crombe A, Alberti N, Stoeckle E et al (2016) Soft tissue masses with myxoid stroma: can conventional magnetic resonance imaging differentiate benign from malignant tumors? Eur J Radiol 85:1875–1882CrossRef Crombe A, Alberti N, Stoeckle E et al (2016) Soft tissue masses with myxoid stroma: can conventional magnetic resonance imaging differentiate benign from malignant tumors? Eur J Radiol 85:1875–1882CrossRef
12.
Zurück zum Zitat Erfanian Y, Grueneisen J, Kirchner J et al (2017) Integrated 18F-FDG PET/MRI compared to MRI alone for identification of local recurrences of soft tissue sarcomas: a comparison trial. Eur J Nucl Med Mol Imaging 44(11):1823–1831CrossRef Erfanian Y, Grueneisen J, Kirchner J et al (2017) Integrated 18F-FDG PET/MRI compared to MRI alone for identification of local recurrences of soft tissue sarcomas: a comparison trial. Eur J Nucl Med Mol Imaging 44(11):1823–1831CrossRef
13.
Zurück zum Zitat Fuglo HM, Jorgensen SM, Loft A et al (2012) The diagnostic and prognostic value of (1)(8)F-FDG PET/CT in the initial assessment of high-grade bone and soft tissue sarcoma. A retrospective study of 89 patients. Eur J Nucl Med Mol Imaging 39:1416–1424CrossRef Fuglo HM, Jorgensen SM, Loft A et al (2012) The diagnostic and prognostic value of (1)(8)F-FDG PET/CT in the initial assessment of high-grade bone and soft tissue sarcoma. A retrospective study of 89 patients. Eur J Nucl Med Mol Imaging 39:1416–1424CrossRef
14.
Zurück zum Zitat Sambri A, Bianchi G, Longhi A et al (2019) The role of 18F-FDG PET/CT in soft tissue sarcoma. Nucl Med Commun 40:626–631CrossRef Sambri A, Bianchi G, Longhi A et al (2019) The role of 18F-FDG PET/CT in soft tissue sarcoma. Nucl Med Commun 40:626–631CrossRef
15.
Zurück zum Zitat Casali PG, Abecassis N, Aro HT et al (2018) Soft tissue and visceral sarcomas: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 29:iv51–iv67CrossRef Casali PG, Abecassis N, Aro HT et al (2018) Soft tissue and visceral sarcomas: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 29:iv51–iv67CrossRef
16.
Zurück zum Zitat Umer HM, Umer M, Qadir I et al (2013) Impact of unplanned excision on prognosis of patients with extremity soft tissue sarcoma. Sarcoma 2013:498604CrossRef Umer HM, Umer M, Qadir I et al (2013) Impact of unplanned excision on prognosis of patients with extremity soft tissue sarcoma. Sarcoma 2013:498604CrossRef
17.
Zurück zum Zitat Grabellus F, Podleska LE, Sheu SY et al (2012) Neoadjuvant treatment improves capsular integrity and the width of the fibrous capsule of high-grade soft-tissue sarcomas. Eur J Surg Oncol 39:61–67CrossRef Grabellus F, Podleska LE, Sheu SY et al (2012) Neoadjuvant treatment improves capsular integrity and the width of the fibrous capsule of high-grade soft-tissue sarcomas. Eur J Surg Oncol 39:61–67CrossRef
18.
Zurück zum Zitat Gronchi A, Miah AB, Dei Tos AP et al (2021) Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS clinical practice guidelines for diagnosis, treatment and follow-up(). Ann Oncol 32:1348–1365CrossRef Gronchi A, Miah AB, Dei Tos AP et al (2021) Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS clinical practice guidelines for diagnosis, treatment and follow-up(). Ann Oncol 32:1348–1365CrossRef
19.
Zurück zum Zitat Fleshman R, Mayerson J, Wakely PE Jr. (2007) Fine-needle aspiration biopsy of high-grade sarcoma: a report of 107 cases. Cancer 111:491–498CrossRef Fleshman R, Mayerson J, Wakely PE Jr. (2007) Fine-needle aspiration biopsy of high-grade sarcoma: a report of 107 cases. Cancer 111:491–498CrossRef
20.
Zurück zum Zitat Agaimy A (2014) Value of core needle biopsy in preoperative diagnostics of soft tissue tumors: possibilities and limitations. Pathologe 35(2):189–197CrossRef Agaimy A (2014) Value of core needle biopsy in preoperative diagnostics of soft tissue tumors: possibilities and limitations. Pathologe 35(2):189–197CrossRef
21.
Zurück zum Zitat Traina F, Errani C, Toscano A et al (2015) Current concepts in the biopsy of musculoskeletal tumors. J Bone Joint Surg Am 97:e7CrossRef Traina F, Errani C, Toscano A et al (2015) Current concepts in the biopsy of musculoskeletal tumors. J Bone Joint Surg Am 97:e7CrossRef
22.
Zurück zum Zitat Young R, Snow H, Hendry S et al (2020) Correlation between percutaneous biopsy and final histopathology for retroperitoneal sarcoma: a single-centre study. ANZ J Surg 90:497–502CrossRef Young R, Snow H, Hendry S et al (2020) Correlation between percutaneous biopsy and final histopathology for retroperitoneal sarcoma: a single-centre study. ANZ J Surg 90:497–502CrossRef
23.
Zurück zum Zitat Al-Ibraheemi A, Folpe AL (2016) Voluntary second opinions in pediatric bone and soft tissue pathology: a retrospective review of 1601 cases from a single mesenchymal tumor consultation service. Int J Surg Pathol 24:685–691CrossRef Al-Ibraheemi A, Folpe AL (2016) Voluntary second opinions in pediatric bone and soft tissue pathology: a retrospective review of 1601 cases from a single mesenchymal tumor consultation service. Int J Surg Pathol 24:685–691CrossRef
24.
Zurück zum Zitat Pisters PW, Leung DH, Woodruff J et al (1996) Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 14:1679–1689CrossRef Pisters PW, Leung DH, Woodruff J et al (1996) Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 14:1679–1689CrossRef
25.
Zurück zum Zitat Callegaro D, Miceli R, Bonvalot S et al (2016) Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis. Lancet Oncol 17:671–680CrossRef Callegaro D, Miceli R, Bonvalot S et al (2016) Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis. Lancet Oncol 17:671–680CrossRef
26.
Zurück zum Zitat Gronchi A, Miceli R, Shurell E et al (2013) Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets. J Clin Oncol 31:1649–1655CrossRef Gronchi A, Miceli R, Shurell E et al (2013) Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets. J Clin Oncol 31:1649–1655CrossRef
27.
Zurück zum Zitat Berardi R, Morgese F, Rinaldi S et al (2020) Benefits and limitations of a multidisciplinary approach in cancer patient management. Cancer Manag Res 12:9363–9374CrossRef Berardi R, Morgese F, Rinaldi S et al (2020) Benefits and limitations of a multidisciplinary approach in cancer patient management. Cancer Manag Res 12:9363–9374CrossRef
28.
Zurück zum Zitat Blay JY, Soibinet P, Penel N et al (2017) Improved survival using specialized multidisciplinary board in sarcoma patients. Ann Oncol 28:2852–2859CrossRef Blay JY, Soibinet P, Penel N et al (2017) Improved survival using specialized multidisciplinary board in sarcoma patients. Ann Oncol 28:2852–2859CrossRef
29.
Zurück zum Zitat Eichler M, Andreou D, Golcher H et al (2021) Utilization of interdisciplinary tumor boards for sarcoma care in Germany: results from the PROsa study. Oncol Res Treat 44:301–312CrossRef Eichler M, Andreou D, Golcher H et al (2021) Utilization of interdisciplinary tumor boards for sarcoma care in Germany: results from the PROsa study. Oncol Res Treat 44:301–312CrossRef
30.
Zurück zum Zitat Lohsträter A, Germann S, Kohlmann T (2010) Möglichkeiten der Heilverfahrenssteuerung. Trauma Berufskrankh 12:199–207CrossRef Lohsträter A, Germann S, Kohlmann T (2010) Möglichkeiten der Heilverfahrenssteuerung. Trauma Berufskrankh 12:199–207CrossRef
31.
Zurück zum Zitat Grunewald TG, Alonso M, Avnet S et al (2020) Sarcoma treatment in the era of molecular medicine. EMBO Mol Med 12:e11131CrossRef Grunewald TG, Alonso M, Avnet S et al (2020) Sarcoma treatment in the era of molecular medicine. EMBO Mol Med 12:e11131CrossRef
32.
Zurück zum Zitat Abendroth A, Bauer S (2013) Adjuvant chemotherapy for soft tissue sarcoma? a clear no–well–yes–ish. Dtsch Med Wochenschr 138:2107–2110 Abendroth A, Bauer S (2013) Adjuvant chemotherapy for soft tissue sarcoma? a clear no–well–yes–ish. Dtsch Med Wochenschr 138:2107–2110
33.
Zurück zum Zitat Collin C, Godbold J, Hajdu S et al (1987) Localized extremity soft tissue sarcoma: an analysis of factors affecting survival. J Clin Oncol 5:601–612CrossRef Collin C, Godbold J, Hajdu S et al (1987) Localized extremity soft tissue sarcoma: an analysis of factors affecting survival. J Clin Oncol 5:601–612CrossRef
34.
Zurück zum Zitat Stojadinovic A, Leung DH, Hoos A et al (2002) Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomas. Ann Surg 235:424–434CrossRef Stojadinovic A, Leung DH, Hoos A et al (2002) Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomas. Ann Surg 235:424–434CrossRef
35.
Zurück zum Zitat Willeumier JJ, Rueten-Budde AJ, Jeys LM et al (2017) Individualised risk assessment for local recurrence and distant metastases in a retrospective transatlantic cohort of 687 patients with high-grade soft tissue sarcomas of the extremities: a multistate model. BMJ Open 7:e12930CrossRef Willeumier JJ, Rueten-Budde AJ, Jeys LM et al (2017) Individualised risk assessment for local recurrence and distant metastases in a retrospective transatlantic cohort of 687 patients with high-grade soft tissue sarcomas of the extremities: a multistate model. BMJ Open 7:e12930CrossRef
36.
Zurück zum Zitat Lahat G, Tuvin D, Wei C et al (2008) New perspectives for staging and prognosis in soft tissue sarcoma. Ann Surg Oncol 15:2739–2748CrossRef Lahat G, Tuvin D, Wei C et al (2008) New perspectives for staging and prognosis in soft tissue sarcoma. Ann Surg Oncol 15:2739–2748CrossRef
37.
Zurück zum Zitat Hagenmaier HSF, van Beeck AGK, Haas RL et al (2021) The influence of personalised sarcoma care (PERSARC) prediction modelling on clinical decision making in a multidisciplinary setting. Sarcoma 2021:8851354CrossRef Hagenmaier HSF, van Beeck AGK, Haas RL et al (2021) The influence of personalised sarcoma care (PERSARC) prediction modelling on clinical decision making in a multidisciplinary setting. Sarcoma 2021:8851354CrossRef
38.
Zurück zum Zitat Rueten-Budde AJ, van Praag VM, Studygroup P et al (2018) Dynamic prediction of overall survival for patients with high-grade extremity soft tissue sarcoma. Surg Oncol 27:695–701CrossRef Rueten-Budde AJ, van Praag VM, Studygroup P et al (2018) Dynamic prediction of overall survival for patients with high-grade extremity soft tissue sarcoma. Surg Oncol 27:695–701CrossRef
39.
Zurück zum Zitat Trovik CS, Bauer HC, Alvegard TA et al (2000) Surgical margins, local recurrence and metastasis in soft tissue sarcomas: 559 surgically-treated patients from the Scandinavian sarcoma group register. Eur J Cancer 36:710–716CrossRef Trovik CS, Bauer HC, Alvegard TA et al (2000) Surgical margins, local recurrence and metastasis in soft tissue sarcomas: 559 surgically-treated patients from the Scandinavian sarcoma group register. Eur J Cancer 36:710–716CrossRef
40.
Zurück zum Zitat Enneking WF, Kagan A (1975) “Skip” metastases in osteosarcoma. Cancer 36:2192–2205CrossRef Enneking WF, Kagan A (1975) “Skip” metastases in osteosarcoma. Cancer 36:2192–2205CrossRef
41.
Zurück zum Zitat Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res 1980(153):106–120 Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res 1980(153):106–120
42.
Zurück zum Zitat Grabellus F, Kraft C, Sheu SY et al (2009) Evaluation of 47 soft tissue sarcoma resection specimens after isolated limb perfusion with TNF-alpha and melphalan: histologically characterized improved margins correlate with absence of recurrences. Ann Surg Oncol 16:676–686CrossRef Grabellus F, Kraft C, Sheu SY et al (2009) Evaluation of 47 soft tissue sarcoma resection specimens after isolated limb perfusion with TNF-alpha and melphalan: histologically characterized improved margins correlate with absence of recurrences. Ann Surg Oncol 16:676–686CrossRef
43.
Zurück zum Zitat Jebsen NL, Engellau J, Engstrom K et al (2013) Patterns of local recurrence and dose fractionation of adjuvant radiation therapy in 462 patients with soft tissue sarcoma of extremity and trunk wall. Int J Radiat Oncol Biol Phys 86:949–955CrossRef Jebsen NL, Engellau J, Engstrom K et al (2013) Patterns of local recurrence and dose fractionation of adjuvant radiation therapy in 462 patients with soft tissue sarcoma of extremity and trunk wall. Int J Radiat Oncol Biol Phys 86:949–955CrossRef
44.
Zurück zum Zitat Harati K, Goertz O, Pieper A et al (2017) Soft tissue sarcomas of the extremities: surgical margins can be close as long as the resected tumor has no ink on it. Oncologist 22:1400–1410CrossRef Harati K, Goertz O, Pieper A et al (2017) Soft tissue sarcomas of the extremities: surgical margins can be close as long as the resected tumor has no ink on it. Oncologist 22:1400–1410CrossRef
45.
Zurück zum Zitat Lin PP, Pino ED, Normand AN et al (2007) Periosteal margin in soft-tissue sarcoma. Cancer 109:598–602CrossRef Lin PP, Pino ED, Normand AN et al (2007) Periosteal margin in soft-tissue sarcoma. Cancer 109:598–602CrossRef
46.
Zurück zum Zitat Chang HR, Gaynor J, Tan C et al (1990) Multifactorial analysis of survival in primary extremity liposarcoma. World J Surg 14:610–618CrossRef Chang HR, Gaynor J, Tan C et al (1990) Multifactorial analysis of survival in primary extremity liposarcoma. World J Surg 14:610–618CrossRef
47.
Zurück zum Zitat Chandrasekar CR, Wafa H, Grimer RJ et al (2008) The effect of an unplanned excision of a soft-tissue sarcoma on prognosis. J Bone Joint Surg Br 90:203–208CrossRef Chandrasekar CR, Wafa H, Grimer RJ et al (2008) The effect of an unplanned excision of a soft-tissue sarcoma on prognosis. J Bone Joint Surg Br 90:203–208CrossRef
48.
Zurück zum Zitat Alektiar KM, Velasco J, Zelefsky MJ et al (2000) Adjuvant radiotherapy for margin-positive high-grade soft tissue sarcoma of the extremity. Int J Radiat Oncol Biol Phys 48:1051–1058CrossRef Alektiar KM, Velasco J, Zelefsky MJ et al (2000) Adjuvant radiotherapy for margin-positive high-grade soft tissue sarcoma of the extremity. Int J Radiat Oncol Biol Phys 48:1051–1058CrossRef
49.
Zurück zum Zitat Alamanda VK, Delisca GO, Mathis SL et al (2013) The financial burden of reexcising incompletely excised soft tissue sarcomas: a cost analysis. Ann Surg Oncol 20:2808–2814CrossRef Alamanda VK, Delisca GO, Mathis SL et al (2013) The financial burden of reexcising incompletely excised soft tissue sarcomas: a cost analysis. Ann Surg Oncol 20:2808–2814CrossRef
50.
Zurück zum Zitat Stotter A, Fallowfield M, Mott A et al (1990) Role of compartmental resection for soft tissue sarcoma of the limb and limb girdle. Br J Surg 77:88–92CrossRef Stotter A, Fallowfield M, Mott A et al (1990) Role of compartmental resection for soft tissue sarcoma of the limb and limb girdle. Br J Surg 77:88–92CrossRef
51.
Zurück zum Zitat Pollock RE (1994) Limb-sparing therapy for soft tissue sarcomas. Curr Opin Gen Surg: 224–229 Pollock RE (1994) Limb-sparing therapy for soft tissue sarcomas. Curr Opin Gen Surg: 224–229
53.
Zurück zum Zitat Rosenberg SA, Tepper J, Glatstein E et al (1982) The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg 196:305–315CrossRef Rosenberg SA, Tepper J, Glatstein E et al (1982) The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg 196:305–315CrossRef
54.
Zurück zum Zitat Eggermont AM, Schraffordt Koops H, Klausner JM et al (1996) Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience. Ann Surg 224:756–764 (discussion 764–755)CrossRef Eggermont AM, Schraffordt Koops H, Klausner JM et al (1996) Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience. Ann Surg 224:756–764 (discussion 764–755)CrossRef
55.
Zurück zum Zitat Albertsmeier M, Rauch A, Roeder F et al (2018) External beam radiation therapy for resectable soft tissue sarcoma: a systematic review and meta-analysis. Ann Surg Oncol 25:754–767CrossRef Albertsmeier M, Rauch A, Roeder F et al (2018) External beam radiation therapy for resectable soft tissue sarcoma: a systematic review and meta-analysis. Ann Surg Oncol 25:754–767CrossRef
56.
Zurück zum Zitat Gingrich AA, Bateni SB, Monjazeb AM et al (2017) Neoadjuvant radiotherapy is associated with R0 resection and improved survival for patients with extremity soft tissue sarcoma undergoing surgery: a national cancer database analysis. Ann Surg Oncol 24:3252–3263CrossRef Gingrich AA, Bateni SB, Monjazeb AM et al (2017) Neoadjuvant radiotherapy is associated with R0 resection and improved survival for patients with extremity soft tissue sarcoma undergoing surgery: a national cancer database analysis. Ann Surg Oncol 24:3252–3263CrossRef
57.
Zurück zum Zitat O’sullivan B, Davis AM, Turcotte R et al (2002) Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet 359:2235–2241CrossRef O’sullivan B, Davis AM, Turcotte R et al (2002) Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet 359:2235–2241CrossRef
58.
Zurück zum Zitat Dickson MA, Schwartz GK, Keohan ML et al (2016) Progression-free survival among patients with well-differentiated or dedifferentiated liposarcoma treated with CDK4 inhibitor palbociclib: a phase 2 clinical trial. JAMA Oncol 2:937–940CrossRef Dickson MA, Schwartz GK, Keohan ML et al (2016) Progression-free survival among patients with well-differentiated or dedifferentiated liposarcoma treated with CDK4 inhibitor palbociclib: a phase 2 clinical trial. JAMA Oncol 2:937–940CrossRef
59.
Zurück zum Zitat Martin-Tellez KS, van Houdt WJ, van Coevorden F et al (2020) Isolated limb perfusion for soft tissue sarcoma: current practices and future directions. A survey of experts and a review of literature. Cancer Treat Rev 88:102058CrossRef Martin-Tellez KS, van Houdt WJ, van Coevorden F et al (2020) Isolated limb perfusion for soft tissue sarcoma: current practices and future directions. A survey of experts and a review of literature. Cancer Treat Rev 88:102058CrossRef
60.
Zurück zum Zitat Keung EZ, Tsai JW, Ali AM et al (2018) Analysis of the immune infiltrate in undifferentiated pleomorphic sarcoma of the extremity and trunk in response to radiotherapy: rationale for combination neoadjuvant immune checkpoint inhibition and radiotherapy. OncoImmunology 7:e1385689CrossRef Keung EZ, Tsai JW, Ali AM et al (2018) Analysis of the immune infiltrate in undifferentiated pleomorphic sarcoma of the extremity and trunk in response to radiotherapy: rationale for combination neoadjuvant immune checkpoint inhibition and radiotherapy. OncoImmunology 7:e1385689CrossRef
61.
Zurück zum Zitat Orth M, Lauber K, Niyazi M et al (2014) Current concepts in clinical radiation oncology. Radiat Environ Biophys 53:1–29CrossRef Orth M, Lauber K, Niyazi M et al (2014) Current concepts in clinical radiation oncology. Radiat Environ Biophys 53:1–29CrossRef
62.
Zurück zum Zitat Taeger G, Grabellus F, Podleska LE et al (2008) Effectiveness of regional chemotherapy with TNF-alpha/melphalan in advanced soft tissue sarcoma of the extremities. Int J Hyperthermia 24:193–203CrossRef Taeger G, Grabellus F, Podleska LE et al (2008) Effectiveness of regional chemotherapy with TNF-alpha/melphalan in advanced soft tissue sarcoma of the extremities. Int J Hyperthermia 24:193–203CrossRef
63.
Zurück zum Zitat Beane JD, Yang JC, White D et al (2014) Efficacy of adjuvant radiation therapy in the treatment of soft tissue sarcoma of the extremity: 20-year follow-up of a randomized prospective trial. Ann Surg Oncol 21:2484–2489CrossRef Beane JD, Yang JC, White D et al (2014) Efficacy of adjuvant radiation therapy in the treatment of soft tissue sarcoma of the extremity: 20-year follow-up of a randomized prospective trial. Ann Surg Oncol 21:2484–2489CrossRef
64.
Zurück zum Zitat Eilber FC, Brennan MF, Riedel E et al (2005) Prognostic factors for survival in patients with locally recurrent extremity soft tissue sarcomas. Ann Surg Oncol 12:228–236CrossRef Eilber FC, Brennan MF, Riedel E et al (2005) Prognostic factors for survival in patients with locally recurrent extremity soft tissue sarcomas. Ann Surg Oncol 12:228–236CrossRef
65.
Zurück zum Zitat Gronchi A, Casali PG, Mariani L et al (2005) Status of surgical margins and prognosis in adult soft tissue sarcomas of the extremities: a series of patients treated at a single institution. J Clin Oncol 23:96–104CrossRef Gronchi A, Casali PG, Mariani L et al (2005) Status of surgical margins and prognosis in adult soft tissue sarcomas of the extremities: a series of patients treated at a single institution. J Clin Oncol 23:96–104CrossRef
66.
Zurück zum Zitat O’donnell PW, Griffin AM, Eward WC et al (2014) The effect of the setting of a positive surgical margin in soft tissue sarcoma. Cancer 120:2866–2875CrossRef O’donnell PW, Griffin AM, Eward WC et al (2014) The effect of the setting of a positive surgical margin in soft tissue sarcoma. Cancer 120:2866–2875CrossRef
67.
Zurück zum Zitat Arndt CA, Crist WM (1999) Common musculoskeletal tumors of childhood and adolescence. N Engl J Med 341:342–352CrossRef Arndt CA, Crist WM (1999) Common musculoskeletal tumors of childhood and adolescence. N Engl J Med 341:342–352CrossRef
68.
Zurück zum Zitat Pasquali S, Pizzamiglio S, Touati N et al (2019) The impact of chemotherapy on survival of patients with extremity and trunk wall soft tissue sarcoma: revisiting the results of the EORTC-STBSG 62931 randomised trial. Eur J Cancer 109:51–60CrossRef Pasquali S, Pizzamiglio S, Touati N et al (2019) The impact of chemotherapy on survival of patients with extremity and trunk wall soft tissue sarcoma: revisiting the results of the EORTC-STBSG 62931 randomised trial. Eur J Cancer 109:51–60CrossRef
69.
Zurück zum Zitat Pasquali S, Colombo C, Pizzamiglio S et al (2018) High-risk soft tissue sarcomas treated with perioperative chemotherapy: Improving prognostic classification in a randomised clinical trial. Eur J Cancer 93:28–36CrossRef Pasquali S, Colombo C, Pizzamiglio S et al (2018) High-risk soft tissue sarcomas treated with perioperative chemotherapy: Improving prognostic classification in a randomised clinical trial. Eur J Cancer 93:28–36CrossRef
70.
Zurück zum Zitat Cocco E, Scaltriti M, Drilon A (2018) NTRK fusion-positive cancers and TRK inhibitor therapy. Nat Rev Clin Oncol 15:731–747CrossRef Cocco E, Scaltriti M, Drilon A (2018) NTRK fusion-positive cancers and TRK inhibitor therapy. Nat Rev Clin Oncol 15:731–747CrossRef
71.
Zurück zum Zitat Dieckmann N, Schildhaus HU, Bauer S (2021) Tropomyosin receptor kinases in sarcomas—of joy and despair. Curr Opin Oncol 33:336–344CrossRef Dieckmann N, Schildhaus HU, Bauer S (2021) Tropomyosin receptor kinases in sarcomas—of joy and despair. Curr Opin Oncol 33:336–344CrossRef
72.
Zurück zum Zitat Bissler JJ, Kingswood JC, Radzikowska E et al (2013) Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 381:817–824CrossRef Bissler JJ, Kingswood JC, Radzikowska E et al (2013) Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 381:817–824CrossRef
73.
Zurück zum Zitat Bauer S, Demetri GD, Halilovic E et al (2021) Pharmacokinetic-pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies. Br J Cancer 125:687–698CrossRef Bauer S, Demetri GD, Halilovic E et al (2021) Pharmacokinetic-pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies. Br J Cancer 125:687–698CrossRef
74.
Zurück zum Zitat Paoluzzi L, Cacavio A, Ghesani M et al (2016) Response to anti-PD1 therapy with nivolumab in metastatic sarcomas. Clin Sarcoma Res 6:24CrossRef Paoluzzi L, Cacavio A, Ghesani M et al (2016) Response to anti-PD1 therapy with nivolumab in metastatic sarcomas. Clin Sarcoma Res 6:24CrossRef
75.
Zurück zum Zitat Tawbi HA, Burgess M, Bolejack V et al (2017) Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial. Lancet Oncol 18:1493–1501CrossRef Tawbi HA, Burgess M, Bolejack V et al (2017) Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial. Lancet Oncol 18:1493–1501CrossRef
76.
Zurück zum Zitat Hamacher R, Kampfe D, Reuter-Jessen K et al (2018) Dramatic response of a PD-L1-positive advanced angiosarcoma of the scalp to pembrolizumab. JCO Precis Oncol 2:1–7 Hamacher R, Kampfe D, Reuter-Jessen K et al (2018) Dramatic response of a PD-L1-positive advanced angiosarcoma of the scalp to pembrolizumab. JCO Precis Oncol 2:1–7
77.
Zurück zum Zitat Vanhersecke L, Brunet M, Guegan JP et al (2021) Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression. Nat Cancer 2:794–802CrossRef Vanhersecke L, Brunet M, Guegan JP et al (2021) Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression. Nat Cancer 2:794–802CrossRef
Metadaten
Titel
Lokalisierte Weichgewebesarkome
verfasst von
PD Dr. med. Lars Erik Podleska
Sebastian Bauer
Christoph Pöttgen
Arne Streitbürger
Jendrik Hardes
Georg Täger
Publikationsdatum
30.01.2023
Verlag
Springer Medizin
Erschienen in
best practice onkologie / Ausgabe 1-2/2023
Print ISSN: 0946-4565
Elektronische ISSN: 1862-8559
DOI
https://doi.org/10.1007/s11654-022-00458-5

Weitere Artikel der Ausgabe 1-2/2023

best practice onkologie 1-2/2023 Zur Ausgabe

Kongresse – wichtig zu wissen

Wichtige Studien vom ASH 2022

onko-aktuell

onko-aktuell