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Erschienen in: Obesity Surgery 11/2020

18.06.2020 | Original Contributions

Weight Loss After RYGB Is Associated with an Increase in Serum Vitamin D in a Population with Low Prevalence of Hypovitaminosis D at Low Latitude

verfasst von: Sônia Lopes Pinto, Leidjaira Lopes Juvanhol, Josefina Bressan

Erschienen in: Obesity Surgery | Ausgabe 11/2020

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Abstract

Purpose

In Brazil and worldwide, few studies have investigated vitamin D deficiency in patients with severe obesity who underwent bariatric surgery associated with latitude and level of solar radiation. The objective of this study was to investigate the prevalence of vitamin D deficiency and the predictive factors of serum level changes after 12 months of RYGB in a low latitude region.

Materials and Methods

This study included 50 patients from a low-latitude city (10° 10′ 8″ S) in the north of Brazil. We collected data before surgery and after 3 and 12 months of surgery. The level of vitamin D was classified as deficiency (< 20 ng/ml), insufficiency (20–30 ng/ml), and sufficiency (≥ 30 ng/ml).

Results

The mean age of the patients was 38.7 ± 8.9 years, 69% were women, and percent excess weight loss (% EWL) was 83% after 1 year of surgery. The prevalence of vitamin D deficiency in the preoperative period was 14%, and after 3 and 12 months of surgery, it decreased to 4% and 6%, respectively. The variation in vitamin D after 12 months of surgery was positively associated with changes in BMI, body fat, and % EWL.

Conclusions

The prevalence of vitamin D deficiency is low in patients undergoing bariatric surgery in the northern region of Brazil, which is possibly related to low latitude. Weight loss was positively associated with an increase in serum vitamin D after surgery.
Literatur
1.
Zurück zum Zitat World Health Organization. World Health Statistics 2010. World Health. 2010;177. World Health Organization. World Health Statistics 2010. World Health. 2010;177.
2.
Zurück zum Zitat Mechanick JI, Kushner RF, Sugerman HJ, et al. Guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient. Endocr Pract. 2008;14:1–83.CrossRef Mechanick JI, Kushner RF, Sugerman HJ, et al. Guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient. Endocr Pract. 2008;14:1–83.CrossRef
3.
Zurück zum Zitat Carvalho A da S, Rosa RDS. Bariatric surgeries performed by the Brazilian National Health System in the period 2010–2016: a descriptive study of hospitalizations. Epidemiol e Serv saude Rev do Sist Unico Saude do Bras. 2019;28:e2018260. Carvalho A da S, Rosa RDS. Bariatric surgeries performed by the Brazilian National Health System in the period 2010–2016: a descriptive study of hospitalizations. Epidemiol e Serv saude Rev do Sist Unico Saude do Bras. 2019;28:e2018260.
4.
Zurück zum Zitat Concors SJ, Ecker BL, Maduka R, et al. Complications and surveillance after bariatric surgery. Curr Treat Options Neurol. 2016;18:1–12.CrossRef Concors SJ, Ecker BL, Maduka R, et al. Complications and surveillance after bariatric surgery. Curr Treat Options Neurol. 2016;18:1–12.CrossRef
5.
Zurück zum Zitat Vinolas H, Barnetche T, Ferrandi G, et al. Oral hydration, food intake, and nutritional status before and after bariatric surgery. Obes Surg. 2019;29:2896–903.CrossRef Vinolas H, Barnetche T, Ferrandi G, et al. Oral hydration, food intake, and nutritional status before and after bariatric surgery. Obes Surg. 2019;29:2896–903.CrossRef
6.
Zurück zum Zitat Pereira-Santos M, Costa PRF, Assis AMO, et al. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev. 2015;16:341–9.CrossRef Pereira-Santos M, Costa PRF, Assis AMO, et al. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev. 2015;16:341–9.CrossRef
7.
Zurück zum Zitat Malek M, Yousefi R, Safari S, et al. Dietary intakes and biochemical parameters of morbidly obese patients prior to bariatric surgery. Obes Surg. 2019;29:1816–22.CrossRef Malek M, Yousefi R, Safari S, et al. Dietary intakes and biochemical parameters of morbidly obese patients prior to bariatric surgery. Obes Surg. 2019;29:1816–22.CrossRef
8.
Zurück zum Zitat Aridi HD, Alami RS, Fouani T, et al. Prevalence of vitamin D deficiency in adults presenting for bariatric surgery in Lebanon. Surg Obes Relat Dis. 2016;12:405–11.CrossRef Aridi HD, Alami RS, Fouani T, et al. Prevalence of vitamin D deficiency in adults presenting for bariatric surgery in Lebanon. Surg Obes Relat Dis. 2016;12:405–11.CrossRef
9.
Zurück zum Zitat Vivan MA, Kops NL, Fülber ER, et al. Prevalence of vitamin D depletion, and associated factors, among patients undergoing bariatric surgery in southern Brazil. Obes Surg. 2019;29:3179–87.CrossRef Vivan MA, Kops NL, Fülber ER, et al. Prevalence of vitamin D depletion, and associated factors, among patients undergoing bariatric surgery in southern Brazil. Obes Surg. 2019;29:3179–87.CrossRef
10.
Zurück zum Zitat Santos MTA, Suano-Souza FI, Affonso Fonseca FL, et al. Is there association between vitamin D concentrations and body mass index variation in women submitted to Y-roux surgery? J Obes. 2018;2018:1–5.CrossRef Santos MTA, Suano-Souza FI, Affonso Fonseca FL, et al. Is there association between vitamin D concentrations and body mass index variation in women submitted to Y-roux surgery? J Obes. 2018;2018:1–5.CrossRef
11.
Zurück zum Zitat Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.CrossRef Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.CrossRef
12.
Zurück zum Zitat Krzizek EC, Brix JM, Herz CT, et al. Prevalence of micronutrient deficiency in patients with morbid obesity before bariatric surgery. Obes Surg. 2018;28:643–8.CrossRef Krzizek EC, Brix JM, Herz CT, et al. Prevalence of micronutrient deficiency in patients with morbid obesity before bariatric surgery. Obes Surg. 2018;28:643–8.CrossRef
13.
Zurück zum Zitat Ducloux R, Nobécourt E, Chevallier JM, et al. Vitamin D deficiency before bariatric surgery: should supplement intake be routinely prescribed? Obes Surg. 2011;21:556–60.CrossRef Ducloux R, Nobécourt E, Chevallier JM, et al. Vitamin D deficiency before bariatric surgery: should supplement intake be routinely prescribed? Obes Surg. 2011;21:556–60.CrossRef
15.
Zurück zum Zitat Nelson ML, Bolduc LM, Toder ME, et al. Correction of preoperative vitamin D deficiency after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2007;3:434–7.CrossRef Nelson ML, Bolduc LM, Toder ME, et al. Correction of preoperative vitamin D deficiency after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2007;3:434–7.CrossRef
16.
Zurück zum Zitat Beckman LM, Earthman CP, Thomas W, et al. Serum 25(OH) vitamin D concentration changes after roux-en-Y gastric bypass surgery. Obesity. 2013;21:E599–606.CrossRef Beckman LM, Earthman CP, Thomas W, et al. Serum 25(OH) vitamin D concentration changes after roux-en-Y gastric bypass surgery. Obesity. 2013;21:E599–606.CrossRef
17.
Zurück zum Zitat Gangloff A, Bergeron J, Pelletier-Beaumont E, et al. Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men. Int J Obes. 2015;39:1638–43.CrossRef Gangloff A, Bergeron J, Pelletier-Beaumont E, et al. Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men. Int J Obes. 2015;39:1638–43.CrossRef
18.
Zurück zum Zitat Cândido FG, Bressan J. Vitamin D: Link between osteoporosis, obesity, and diabetes? Int J Mol Sci. 2014;15:6569–91.CrossRef Cândido FG, Bressan J. Vitamin D: Link between osteoporosis, obesity, and diabetes? Int J Mol Sci. 2014;15:6569–91.CrossRef
19.
Zurück zum Zitat Bell NH, Shaw S, Turner RT. Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man. J Clin Invest. 1984;74:1540–4.CrossRef Bell NH, Shaw S, Turner RT. Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man. J Clin Invest. 1984;74:1540–4.CrossRef
20.
Zurück zum Zitat Beckman LM, Earthman CP, Thomas W, et al. Vitamin D in obesity. Curr Opin Endocrinol Diabetes Obes. 2013;24:389–94. Beckman LM, Earthman CP, Thomas W, et al. Vitamin D in obesity. Curr Opin Endocrinol Diabetes Obes. 2013;24:389–94.
21.
22.
Zurück zum Zitat Drincic AT, Armas LAG, Van Diest EE, et al. Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity. 2012;20:1444–8.CrossRef Drincic AT, Armas LAG, Van Diest EE, et al. Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity. 2012;20:1444–8.CrossRef
23.
Zurück zum Zitat Himbert C, Ose J, Delphan M, et al. A systematic review of the interrelation between diet- and surgery-induced weight loss and vitamin D status. Nutr Res. 2017;38:13–26.CrossRef Himbert C, Ose J, Delphan M, et al. A systematic review of the interrelation between diet- and surgery-induced weight loss and vitamin D status. Nutr Res. 2017;38:13–26.CrossRef
24.
Zurück zum Zitat Pannu PK, Zhao Y, Soares MJ. Reductions in body weight and percent fat mass increase the vitamin D status of obese subjects: a systematic review and metaregression analysis. Nutr Res. 2016;36:201–13.CrossRef Pannu PK, Zhao Y, Soares MJ. Reductions in body weight and percent fat mass increase the vitamin D status of obese subjects: a systematic review and metaregression analysis. Nutr Res. 2016;36:201–13.CrossRef
25.
Zurück zum Zitat Jablonski KL, Chonchol M, Pierce GL, et al. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2011;57:63–9.CrossRef Jablonski KL, Chonchol M, Pierce GL, et al. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2011;57:63–9.CrossRef
26.
Zurück zum Zitat Autier P, Boniol M, Pizot C, et al. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014;2:76–89.CrossRef Autier P, Boniol M, Pizot C, et al. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014;2:76–89.CrossRef
27.
Zurück zum Zitat O’Kane M, Pinkney J, Aasheim E, et al. BOMSS guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery. Br Obes Metab Surg Soc. 2014;2014:1–29. O’Kane M, Pinkney J, Aasheim E, et al. BOMSS guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery. Br Obes Metab Surg Soc. 2014;2014:1–29.
28.
Zurück zum Zitat Flores L, Martínez Osaba MJ, Andreu A, et al. Calcium and vitamin D supplementation after gastric bypass should be individualized to improve or avoid hyperparathyroidism. Obes Surg. 2010;20:738–43.CrossRef Flores L, Martínez Osaba MJ, Andreu A, et al. Calcium and vitamin D supplementation after gastric bypass should be individualized to improve or avoid hyperparathyroidism. Obes Surg. 2010;20:738–43.CrossRef
29.
Zurück zum Zitat Aasheim ET, Björkman S, Søvik TT, et al. Vitamin status after bariatric surgery: a randomized study of gastric bypass and duodenal switch. Am J Clin Nutr. 2009;90:15–22.CrossRef Aasheim ET, Björkman S, Søvik TT, et al. Vitamin status after bariatric surgery: a randomized study of gastric bypass and duodenal switch. Am J Clin Nutr. 2009;90:15–22.CrossRef
30.
Zurück zum Zitat Li Z, Zhou X, Fu W. Vitamin D supplementation for the prevention of vitamin D deficiency after bariatric surgery: a systematic review and meta-analysis. Eur J Clin Nutr. 2018;72:1061–70.CrossRef Li Z, Zhou X, Fu W. Vitamin D supplementation for the prevention of vitamin D deficiency after bariatric surgery: a systematic review and meta-analysis. Eur J Clin Nutr. 2018;72:1061–70.CrossRef
Metadaten
Titel
Weight Loss After RYGB Is Associated with an Increase in Serum Vitamin D in a Population with Low Prevalence of Hypovitaminosis D at Low Latitude
verfasst von
Sônia Lopes Pinto
Leidjaira Lopes Juvanhol
Josefina Bressan
Publikationsdatum
18.06.2020
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 11/2020
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-020-04780-1

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