Skip to main content
Erschienen in: Journal of Bioethical Inquiry 4/2018

05.12.2018 | Original Research

What Is the Good of It—Ethical Controls of Human Subject Health Research?

Curtin University Annual Ethics Lecture

verfasst von: Robert French

Erschienen in: Journal of Bioethical Inquiry | Ausgabe 4/2018

Einloggen, um Zugang zu erhalten

Abstract

The term “ethics” covers a multitude of virtues and possibly some sins where ethical perspectives differ. Given the diversity of ethical philosophies there is a question about what common ground can, or should, inform health research ethics. At a minimum it must be consistent with the law. Beyond that, ethics embraces a variety of possible approaches. This raises the question—what criteria are applied in determining the appropriate approach and what standards by way of quality control are applied to its decisional application by ethics committees or other authorities exercising responsibility in this difficult area. The particular issue of ethical perspectives on the use of “big data” in medical research also raises complex issues for consideration.
Fußnoten
1
London Research Ethics Committee (Reference 13/LO/1340).
 
2
Health Research Council Act 1990 (NZ) s 5, s 125, s26(2)
 
3
NHMRC Council Act 1992 s 7(1)(a)(v)
 
4
Gene Technology Act 2000 (Cth) s 108(3)(m)
 
Literatur
Zurück zum Zitat Al-Lamee, R. 2017. Patient information leaflet, version 1.6, 15 April 2014, provided 7 November. Al-Lamee, R. 2017. Patient information leaflet, version 1.6, 15 April 2014, provided 7 November.
Zurück zum Zitat Al-Lamee, R., D. Thompson, H.M. Dehbi, et al. 2017. Percutaneous coronary intervention in stable angina (ORBITA): A double-blind, randomised controlled trial. Lancet Nov 1: pii: S0140-6736(0117)32714-32719 [Epub ahead of print]. Al-Lamee, R., D. Thompson, H.M. Dehbi, et al. 2017. Percutaneous coronary intervention in stable angina (ORBITA): A double-blind, randomised controlled trial. Lancet Nov 1: pii: S0140-6736(0117)32714-32719 [Epub ahead of print].
Zurück zum Zitat Alving, A.S., B. Craige, T.N. Pullman, C.M. Whorton, R. Jones, and L. Eichelberger. 1948. Procedures used at Stateville Penitentiary for the testing of potential antimalarial agents. Journal of Clinical Investigation 27(3 Pt 2): 2–5. Alving, A.S., B. Craige, T.N. Pullman, C.M. Whorton, R. Jones, and L. Eichelberger. 1948. Procedures used at Stateville Penitentiary for the testing of potential antimalarial agents. Journal of Clinical Investigation 27(3 Pt 2): 2–5.
Zurück zum Zitat Beecher, H. 1961. Surgery as placebo. A quantitative study of bias. JAMA 176(13): 1102–1107. Beecher, H. 1961. Surgery as placebo. A quantitative study of bias. JAMA 176(13): 1102–1107.
Zurück zum Zitat Brim, R.L., and F.G. Miller. 2013. The potential benefit of the placebo effect in sham-controlled trials: Implications for risk-benefit assessments and informed consent. Journal Medical Ethics 39(11): 703–707. Brim, R.L., and F.G. Miller. 2013. The potential benefit of the placebo effect in sham-controlled trials: Implications for risk-benefit assessments and informed consent. Journal Medical Ethics 39(11): 703–707.
Zurück zum Zitat Brody, H., S.E. Leonard, J.B. Nie, and P. Weindling. 2014. United States responses to Japanese wartime inhuman experimentation after World War II: National security and wartime exigency. Cambridge Quarterly Heath Ethics 23(2): 220–230. Brody, H., S.E. Leonard, J.B. Nie, and P. Weindling. 2014. United States responses to Japanese wartime inhuman experimentation after World War II: National security and wartime exigency. Cambridge Quarterly Heath Ethics 23(2): 220–230.
Zurück zum Zitat Care Act 2014 (UK) Ch 2 “Health Research Authority”; Medicine for Human Use (Clinical Trials) Regulations 2004 (UK). Care Act 2014 (UK) Ch 2 “Health Research Authority”; Medicine for Human Use (Clinical Trials) Regulations 2004 (UK).
Zurück zum Zitat Chattopadyay, S., and R. De Vries. 2013. Respect for cultural diversity in bioethics is an ethical imperative. Journal of Medicine, Health Care and Philosophy 16(4): 639–645. Chattopadyay, S., and R. De Vries. 2013. Respect for cultural diversity in bioethics is an ethical imperative. Journal of Medicine, Health Care and Philosophy 16(4): 639–645.
Zurück zum Zitat Cobb, L.A., G.I. Thomas, D.H. Dillard, K.A. Merendino, R.A. Bruce. 1959. An evaluation of internal-mammary-artery ligation by a double-blind technic. New England Journal Medicine 260(22): 1115–1118. Cobb, L.A., G.I. Thomas, D.H. Dillard, K.A. Merendino, R.A. Bruce. 1959. An evaluation of internal-mammary-artery ligation by a double-blind technic. New England Journal Medicine 260(22): 1115–1118.
Zurück zum Zitat Comfort, N. 2009. The prisoner as model organism: Malaria research at Stateville Penitentiary. Studies in History and Philosophy of Science 40(3): 190–203. Comfort, N. 2009. The prisoner as model organism: Malaria research at Stateville Penitentiary. Studies in History and Philosophy of Science 40(3): 190–203.
Zurück zum Zitat Craik, E.M. 2015. The Hippocratic corpus: Content and context. Routledge. Craik, E.M. 2015. The Hippocratic corpus: Content and context. Routledge.
Zurück zum Zitat Guraya, S.Y., N.J.M. London, and S.S. Guraya. 2014. Ethics in medical research. Journal of Microscopy and Ultrastructure 2(3): 121–126. Guraya, S.Y., N.J.M. London, and S.S. Guraya. 2014. Ethics in medical research. Journal of Microscopy and Ultrastructure 2(3): 121–126.
Zurück zum Zitat Johns, C.H.W. 1904. Babylonian and Assyrian laws, contracts and letters, 64 [218]. Law Book Exchange Ltd. Johns, C.H.W. 1904. Babylonian and Assyrian laws, contracts and letters, 64 [218]. Law Book Exchange Ltd.
Zurück zum Zitat London, A.J., and J.B. Kadane. 2002. Placebos that harm: Sham surgery controls in clinical trials. Statistical Methods in Medical Research 11(5): 413–427. London, A.J., and J.B. Kadane. 2002. Placebos that harm: Sham surgery controls in clinical trials. Statistical Methods in Medical Research 11(5): 413–427.
Zurück zum Zitat Macklin, R. 2014. Respect for cultural diversity and pluralism. In Handbook of global bioethics, edited by H. ten Have, and B. Gordijn, 153–168. Dordrecht: Springer.CrossRef Macklin, R. 2014. Respect for cultural diversity and pluralism. In Handbook of global bioethics, edited by H. ten Have, and B. Gordijn, 153–168. Dordrecht: Springer.CrossRef
Zurück zum Zitat Maclean, C. 1818. Results of an investigation respecting epidemic and pestilential diseases. London: Thomas and George Underwood. Maclean, C. 1818. Results of an investigation respecting epidemic and pestilential diseases. London: Thomas and George Underwood.
Zurück zum Zitat Maehle, A. 1999. Drugs on trial: Experimental pharmacology and therapeutic innovation in the eighteenth century. Clio Medica 53: 194–195. Wellcome Institute Series in the History of Medicine. Maehle, A. 1999. Drugs on trial: Experimental pharmacology and therapeutic innovation in the eighteenth century. Clio Medica 53: 194–195. Wellcome Institute Series in the History of Medicine.
Zurück zum Zitat Millum, J. 2012. Canada’s new ethical guidelines for humans: A critique and comparison with the United States. Canadian Medical Journal 184(6): 657–661. Millum, J. 2012. Canada’s new ethical guidelines for humans: A critique and comparison with the United States. Canadian Medical Journal 184(6): 657–661.
Zurück zum Zitat Mittelstadt, B.D., and L. Floridi. 2016. The ethics of big data: Current and foreseeable issues in biomedical contexts. Cham, Switzerland: Springer Netherlands . Mittelstadt, B.D., and L. Floridi. 2016. The ethics of big data: Current and foreseeable issues in biomedical contexts. Cham, Switzerland: Springer Netherlands .
Zurück zum Zitat Moreno, J.D. 2005. Is there an ethicist in the house? On the cutting edge of bioethics. USA: Indiana University Press. Moreno, J.D. 2005. Is there an ethicist in the house? On the cutting edge of bioethics. USA: Indiana University Press.
Zurück zum Zitat Swiss Academy of Medical Sciences. 2015. Research with human subjects: A manual for practitioners, 2nd ed. Swiss Academy of Medical Sciences. 2015. Research with human subjects: A manual for practitioners, 2nd ed.
Zurück zum Zitat Semeniuk I., and S. Reverby. 2010. A shocking discovery. Nature 7467(7316): 645. Semeniuk I., and S. Reverby. 2010. A shocking discovery. Nature 7467(7316): 645.
Zurück zum Zitat Singer, P. 2000. Writings on an ethical life. New York: Harper Collins Books. Singer, P. 2000. Writings on an ethical life. New York: Harper Collins Books.
Zurück zum Zitat Somerville, M. 2000. The ethical canary—Science, society and the human spirit. Toronto: Penguin Books. Somerville, M. 2000. The ethical canary—Science, society and the human spirit. Toronto: Penguin Books.
Zurück zum Zitat Swift, T., and R. Huxtable. 2013. The ethics of sham surgery in Parkinson’s disease: Back to the future? Bioethics 27(4): 175–185. Swift, T., and R. Huxtable. 2013. The ethics of sham surgery in Parkinson’s disease: Back to the future? Bioethics 27(4): 175–185.
Zurück zum Zitat Tenery, R., H. Rakatansky, F.A. Riddick, M.S. Goldrich, L.J. Morse, J.M. O’Bannon, et al. 2002. Surgical “placebo” trials. Annals of Surgery 235(2): 303–307. Tenery, R., H. Rakatansky, F.A. Riddick, M.S. Goldrich, L.J. Morse, J.M. O’Bannon, et al. 2002. Surgical “placebo” trials. Annals of Surgery 235(2): 303–307.
Zurück zum Zitat Trials of War Criminals Before the Nuremberg Military Tribunals under Control Council Law No 10, US Government Printing Office 1949. 2: 181–182. Trials of War Criminals Before the Nuremberg Military Tribunals under Control Council Law No 10, US Government Printing Office 1949. 2: 181–182.
Metadaten
Titel
What Is the Good of It—Ethical Controls of Human Subject Health Research?
Curtin University Annual Ethics Lecture
verfasst von
Robert French
Publikationsdatum
05.12.2018
Verlag
Springer Singapore
Erschienen in
Journal of Bioethical Inquiry / Ausgabe 4/2018
Print ISSN: 1176-7529
Elektronische ISSN: 1872-4353
DOI
https://doi.org/10.1007/s11673-018-9883-4

Weitere Artikel der Ausgabe 4/2018

Journal of Bioethical Inquiry 4/2018 Zur Ausgabe