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Current Treatment Options in Gastroenterology

15.11.2019 | Stomach (P Malfertheiner, Section Editor)

What is the Relevance of Gastric Microbiota Beyond H. pylori?

verfasst von: Kerstin Schütte, MD, Peter Malfertheiner, MD, Christian Schulz, MD

Erschienen in: Current Treatment Options in Gastroenterology

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Abstract

Purpose

The role of Helicobacter pylori as key factor in gastric inflammation and the development of (pre-)cancerous lesions is undisputable. As an open system, the human upper gastrointestinal tract harbors a complex bacterial community which is highly impacted by the absence or presence of H. pylori. The interaction between other bacteria and H. pylori might impact on gastric carcinogenesis.

Recent findings

Several studies demonstrated differences in the composition of the gastric bacterial community in different stages of gastritis and between samples from tumor and adjacent tissue. In addition, animal studies demonstrated an increased and accelerated development of precancerous lesions in mice colonized with intestinal flora and H. pylori compared with mice mono-infected with H. pylori.

Conclusion

Other bacteria beyond H. pylori enter the focus in research on gastric carcinogenesis. However, we are still far from a thorough understanding of the pathophysiology of host-microbiota interaction and its impact on the development of malignant and precancerous changes.

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Titel: What is the Relevance of Gastric Microbiota Beyond H. pylori?
verfasst von: Kerstin Schütte, MD
Peter Malfertheiner, MD
Christian Schulz, MD
Publikationsdatum: 15.11.2019
Verlag: Springer US
Erschienen in: Current Treatment Options in Gastroenterology
Print ISSN: 1092-8472
Elektronische ISSN: 1534-309X
DOI: https://doi.org/10.1007/s11938-019-00245-2

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What is the Relevance of Gastric Microbiota Beyond H. pylori?

Abstract

Purpose

Recent findings

Conclusion

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Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Recent findings

Conclusion

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Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin