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Erschienen in: Intensive Care Medicine 2/2017

30.09.2016 | What's New in Intensive Care

What’s new in cognitive function in ICU survivors

verfasst von: Ramona O. Hopkins, Dorothy Wade, James C. Jackson

Erschienen in: Intensive Care Medicine | Ausgabe 2/2017

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Excerpt

Increasing numbers of patients survive a critical care admission, but many of them develop morbidities, including cognitive impairments, that have devastating consequences. Cognitive impairment affects 10–62 % of ICU survivors, with most studies reporting deficits in a third to half of patients [1]. Variability in the prevalence of cognitive impairments across studies is explained by heterogeneity in assessments (questionnaires, cognitive screening tests, or neuropsychological test batteries) and variable follow-up intervals [1]. While some patients have prior cognitive impairment, critical illness results in de novo cognitive deficits in previously healthy individuals. New or worsening cognitive impairment appears more prevalent in the critically ill than in other hospitalized patients. For example, one study found significantly higher odds of cognitive impairment after severe sepsis, compared to hospitalized patients without sepsis [2]. It is unclear if a “dose response” exists pertaining to the relationship between severity of illness and severity of cognitive impairment, although numerous studies have found that traditional markers of illness severity are not predictive of cognitive deficits or cognitive decline. …
Literatur
1.
Zurück zum Zitat Wolters AE, Slooter AJ, van der Kooi AW, van Dijk D (2013) Cognitive impairment after intensive care unit admission: a systematic review. Intensive Care Med 39:376–386CrossRefPubMed Wolters AE, Slooter AJ, van der Kooi AW, van Dijk D (2013) Cognitive impairment after intensive care unit admission: a systematic review. Intensive Care Med 39:376–386CrossRefPubMed
2.
Zurück zum Zitat Iwashyna TJ, Ely EW, Smith DM, Langa KM (2010) Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 304:1787–1794CrossRefPubMedPubMedCentral Iwashyna TJ, Ely EW, Smith DM, Langa KM (2010) Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 304:1787–1794CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Herridge MS, Moss M, Hough CL, Hopkins RO, Rice TW, Bienvenu OJ, Azoulay E (2016) Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. Intensive Care Med 42:725–738CrossRefPubMed Herridge MS, Moss M, Hough CL, Hopkins RO, Rice TW, Bienvenu OJ, Azoulay E (2016) Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. Intensive Care Med 42:725–738CrossRefPubMed
4.
Zurück zum Zitat Maley JH, Mikkelsen ME (2016) Short-term gains with long-term consequences: the evolving story of sepsis survivorship. Clin Chest Med 37:367–380CrossRefPubMed Maley JH, Mikkelsen ME (2016) Short-term gains with long-term consequences: the evolving story of sepsis survivorship. Clin Chest Med 37:367–380CrossRefPubMed
5.
Zurück zum Zitat Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW, BRAIN-ICU Study Investigators (2013) Long-term cognitive impairment after critical illness. N Engl J Med 369:1306–1316CrossRefPubMedPubMedCentral Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW, BRAIN-ICU Study Investigators (2013) Long-term cognitive impairment after critical illness. N Engl J Med 369:1306–1316CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Hopkins RO, Suchyta MR, Beene K, Jackson JC (2016) Critical illness acquired brain injury: neuroimaging and implications for rehabilitation. Rehabil Psychol 61:151–164CrossRefPubMed Hopkins RO, Suchyta MR, Beene K, Jackson JC (2016) Critical illness acquired brain injury: neuroimaging and implications for rehabilitation. Rehabil Psychol 61:151–164CrossRefPubMed
7.
Zurück zum Zitat Singer BH, Newstead MW, Zeng X, Cooke CL, Thompson RC, Singer K, Ghantasala R, Parent JM, Murphy GG, Iwashyna TJ, Standiford TJ (2016) Cecal ligation and puncture results in long-term central nervous system myeloid inflammation. PLoS One 11:e0149136CrossRefPubMedPubMedCentral Singer BH, Newstead MW, Zeng X, Cooke CL, Thompson RC, Singer K, Ghantasala R, Parent JM, Murphy GG, Iwashyna TJ, Standiford TJ (2016) Cecal ligation and puncture results in long-term central nervous system myeloid inflammation. PLoS One 11:e0149136CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Hopkins RO, Choong K, Zebuhr CA, Kudchadkar SR (2015) Transforming PICU culture to facilitate early rehabilitation. J Pediatr Intensive Care 4:204–211CrossRefPubMedPubMedCentral Hopkins RO, Choong K, Zebuhr CA, Kudchadkar SR (2015) Transforming PICU culture to facilitate early rehabilitation. J Pediatr Intensive Care 4:204–211CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Needham DM, Dinglas VD, Morris PE, Jackson JC, Hough CL, Mendez-Tellez PA, Wozniak AW, Colantuoni E, Ely EW, Rice TW, Hopkins RO, NIH NHLBI ARDS Network (2013) Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med 188:567–576CrossRefPubMedPubMedCentral Needham DM, Dinglas VD, Morris PE, Jackson JC, Hough CL, Mendez-Tellez PA, Wozniak AW, Colantuoni E, Ely EW, Rice TW, Hopkins RO, NIH NHLBI ARDS Network (2013) Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med 188:567–576CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Shah FA, Pike F, Alvarez K, Angus D, Newman AB, Lopez O, Tate J, Kapur V, Wilsdon A, Krishnan JA, Hansel N, Au D, Avdalovic M, Fan VS, Barr RG, Yende S (2013) Bidirectional relationship between cognitive function and pneumonia. Am J Respir Crit Care Med 188:586–592CrossRefPubMedPubMedCentral Shah FA, Pike F, Alvarez K, Angus D, Newman AB, Lopez O, Tate J, Kapur V, Wilsdon A, Krishnan JA, Hansel N, Au D, Avdalovic M, Fan VS, Barr RG, Yende S (2013) Bidirectional relationship between cognitive function and pneumonia. Am J Respir Crit Care Med 188:586–592CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Jackson JC, Hart RP, Gordon SM, Shintani A, Truman B, May L, Ely EW (2003) Six-month neuropsychological outcome of medical intensive care unit patients. Crit Care Med 31:1226–1234CrossRefPubMed Jackson JC, Hart RP, Gordon SM, Shintani A, Truman B, May L, Ely EW (2003) Six-month neuropsychological outcome of medical intensive care unit patients. Crit Care Med 31:1226–1234CrossRefPubMed
12.
Zurück zum Zitat Hopkins RO, Collingridge D, Weaver LK, Chan K, Orme JF Jr (2003) Neuropsychological sequelae following acute respiratory distress syndrome: two year outcome. J Int Neuropsychol Soc 9:584 Hopkins RO, Collingridge D, Weaver LK, Chan K, Orme JF Jr (2003) Neuropsychological sequelae following acute respiratory distress syndrome: two year outcome. J Int Neuropsychol Soc 9:584
13.
Zurück zum Zitat Jackson JC, Pandharipande PP, Girard TD, Brummel NE, Thompson JL, Hughes CG, Pun BT, Vasilevskis EE, Morandi A, Shintani AK, Hopkins RO, Bernard GR, Dittus RS, Ely EW, Bringing to Light the Risk F, Incidence of Neuropsychological Dysfunction in ICUssi (2014) Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study. Lancet Respir Med 2:369–379CrossRefPubMedPubMedCentral Jackson JC, Pandharipande PP, Girard TD, Brummel NE, Thompson JL, Hughes CG, Pun BT, Vasilevskis EE, Morandi A, Shintani AK, Hopkins RO, Bernard GR, Dittus RS, Ely EW, Bringing to Light the Risk F, Incidence of Neuropsychological Dysfunction in ICUssi (2014) Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study. Lancet Respir Med 2:369–379CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Herridge MS, Tansey CM, Matte A, Tomlinson G, Diaz-Granados N, Cooper A, Guest CB, Mazer CD, Mehta S, Stewart TE, Kudlow P, Cook D, Slutsky AS, Cheung AM (2011) Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 364:1293–1304CrossRefPubMed Herridge MS, Tansey CM, Matte A, Tomlinson G, Diaz-Granados N, Cooper A, Guest CB, Mazer CD, Mehta S, Stewart TE, Kudlow P, Cook D, Slutsky AS, Cheung AM (2011) Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 364:1293–1304CrossRefPubMed
15.
Zurück zum Zitat Jackson JC, Ely EW, Morey MC, Anderson VM, Denne LB, Clune J, Siebert CS, Archer KR, Torres R, Janz D, Schiro E, Jones J, Shintani AK, Levine B, Pun BT, Thompson J, Brummel NE, Hoenig H (2012) Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation. Crit Care Med 40:1088–1097CrossRefPubMedPubMedCentral Jackson JC, Ely EW, Morey MC, Anderson VM, Denne LB, Clune J, Siebert CS, Archer KR, Torres R, Janz D, Schiro E, Jones J, Shintani AK, Levine B, Pun BT, Thompson J, Brummel NE, Hoenig H (2012) Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation. Crit Care Med 40:1088–1097CrossRefPubMedPubMedCentral
Metadaten
Titel
What’s new in cognitive function in ICU survivors
verfasst von
Ramona O. Hopkins
Dorothy Wade
James C. Jackson
Publikationsdatum
30.09.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Intensive Care Medicine / Ausgabe 2/2017
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-016-4550-x

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