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Erschienen in: Intensive Care Medicine 6/2018

20.11.2017 | What's New in Intensive Care

What’s new in prognostication after cardiac arrest: microRNAs?

Erschienen in: Intensive Care Medicine | Ausgabe 6/2018

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Excerpt

Predicting whether a patient in an intensive care unit after a cardiac arrest (CA) will recover in good condition or will suffer irreversible and severe neurologic damage is challenging. Such prognostication would allow adapting healthcare to each individual, reduce the economic burden on the society, and inform patient relatives about the most plausible outcome at an early stage. It may also eventually serve as a solid basis for withdrawal of life-supporting therapies in futile cases. Current guidelines recommend the use of multimodal strategies for prediction of outcome. Yet, the risk of inaccurate prediction still remains, and complementary modalities may help to improve prediction accuracy. …
Literatur
1.
Zurück zum Zitat Adielsson A, Hollenberg J, Karlsson T, Lindqvist J, Lundin S, Silfverstolpe J, Svensson L, Herlitz J (2011) Increase in survival and bystander CPR in out-of-hospital shockable arrhythmia: bystander CPR and female gender are predictors of improved outcome. Experiences from Sweden in an 18-year perspective. Heart 97:1391–1396CrossRefPubMed Adielsson A, Hollenberg J, Karlsson T, Lindqvist J, Lundin S, Silfverstolpe J, Svensson L, Herlitz J (2011) Increase in survival and bystander CPR in out-of-hospital shockable arrhythmia: bystander CPR and female gender are predictors of improved outcome. Experiences from Sweden in an 18-year perspective. Heart 97:1391–1396CrossRefPubMed
2.
Zurück zum Zitat Wissenberg M, Lippert FK, Folke F, Weeke P, Hansen CM, Christensen EF, Jans H, Hansen PA, Lang-Jensen T, Olesen JB, Lindhardsen J, Fosbol EL, Nielsen SL, Gislason GH, Kober L, Torp-Pedersen C (2013) Association of national initiatives to improve cardiac arrest management with rates of bystander intervention and patient survival after out-of-hospital cardiac arrest. JAMA 310:1377–1384CrossRefPubMed Wissenberg M, Lippert FK, Folke F, Weeke P, Hansen CM, Christensen EF, Jans H, Hansen PA, Lang-Jensen T, Olesen JB, Lindhardsen J, Fosbol EL, Nielsen SL, Gislason GH, Kober L, Torp-Pedersen C (2013) Association of national initiatives to improve cardiac arrest management with rates of bystander intervention and patient survival after out-of-hospital cardiac arrest. JAMA 310:1377–1384CrossRefPubMed
3.
Zurück zum Zitat Sunde K, Pytte M, Jacobsen D, Mangschau A, Jensen LP, Smedsrud C, Draegni T, Steen PA (2007) Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest. Resuscitation 73:29–39CrossRefPubMed Sunde K, Pytte M, Jacobsen D, Mangschau A, Jensen LP, Smedsrud C, Draegni T, Steen PA (2007) Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest. Resuscitation 73:29–39CrossRefPubMed
4.
Zurück zum Zitat Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Aneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Kober L, Langorgen J, Lilja G, Moller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H, Investigators TTMT (2013) Targeted temperature management at 33 °C versus 36 °C after cardiac arrest. N Engl J Med 369:2197–2206CrossRefPubMed Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Aneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Kober L, Langorgen J, Lilja G, Moller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H, Investigators TTMT (2013) Targeted temperature management at 33 °C versus 36 °C after cardiac arrest. N Engl J Med 369:2197–2206CrossRefPubMed
5.
Zurück zum Zitat Kirkegaard H, Soreide E, de Haas I, Pettila V, Taccone FS, Arus U, Storm C, Hassager C, Nielsen JF, Sorensen CA, Ilkjaer S, Jeppesen AN, Grejs AM, Duez CHV, Hjort J, Larsen AI, Toome V, Tiainen M, Hastbacka J, Laitio T, Skrifvars MB (2017) Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial. JAMA 318:341–350CrossRefPubMedPubMedCentral Kirkegaard H, Soreide E, de Haas I, Pettila V, Taccone FS, Arus U, Storm C, Hassager C, Nielsen JF, Sorensen CA, Ilkjaer S, Jeppesen AN, Grejs AM, Duez CHV, Hjort J, Larsen AI, Toome V, Tiainen M, Hastbacka J, Laitio T, Skrifvars MB (2017) Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial. JAMA 318:341–350CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Nolan JP, Soar J, Cariou A, Cronberg T, Moulaert VR, Deakin C, Bottiger B, Friberg H, Sunde K, Sandroni C (2015) European resuscitation council guidelines for resuscitation 2015 section 5. Post resuscitation care. Resuscitation 95:202–222 Nolan JP, Soar J, Cariou A, Cronberg T, Moulaert VR, Deakin C, Bottiger B, Friberg H, Sunde K, Sandroni C (2015) European resuscitation council guidelines for resuscitation 2015 section 5. Post resuscitation care. Resuscitation 95:202–222
7.
Zurück zum Zitat Stammet P, Collignon O, Hassager C, Wise MP, Hovdenes J, Åneman A, Horn J, Devaux Y, Erlinge D, Kjaergaard J, Gasche Y, Wanscher M, Cronberg T, Friberg H, Wetterslev J, Pellis T, Kuiper M, Gilson G, Nielsen N (2015) Neuron-specific enolase as a predictor of death or poor neurological outcome after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C. J Am Coll Cardiol 65:2104–2114CrossRefPubMed Stammet P, Collignon O, Hassager C, Wise MP, Hovdenes J, Åneman A, Horn J, Devaux Y, Erlinge D, Kjaergaard J, Gasche Y, Wanscher M, Cronberg T, Friberg H, Wetterslev J, Pellis T, Kuiper M, Gilson G, Nielsen N (2015) Neuron-specific enolase as a predictor of death or poor neurological outcome after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C. J Am Coll Cardiol 65:2104–2114CrossRefPubMed
8.
Zurück zum Zitat Stammet P, Dankiewicz J, Nielsen N, Fays F, Collignon O, Hassager C, Wanscher M, Unden J, Wetterslev J, Pellis T, Aneman A, Hovdenes J, Wise MP, Gilson G, Erlinge D, Horn J, Cronberg T, Kuiper M, Kjaergaard J, Gasche Y, Devaux Y, Friberg H, Target Temperature Management after Out-of-Hospital Cardiac Arrest trial i (2017) Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C. Crit Care 21:153CrossRefPubMedPubMedCentral Stammet P, Dankiewicz J, Nielsen N, Fays F, Collignon O, Hassager C, Wanscher M, Unden J, Wetterslev J, Pellis T, Aneman A, Hovdenes J, Wise MP, Gilson G, Erlinge D, Horn J, Cronberg T, Kuiper M, Kjaergaard J, Gasche Y, Devaux Y, Friberg H, Target Temperature Management after Out-of-Hospital Cardiac Arrest trial i (2017) Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C. Crit Care 21:153CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Rink C, Khanna S (2011) MicroRNA in ischemic stroke etiology and pathology. Physiol Genom 43:521–528CrossRef Rink C, Khanna S (2011) MicroRNA in ischemic stroke etiology and pathology. Physiol Genom 43:521–528CrossRef
10.
Zurück zum Zitat Stammet P, Goretti E, Vausort M, Zhang L, Wagner DR, Devaux Y (2012) Circulating microRNAs after cardiac arrest. Crit Care Med 40:3209–3214CrossRefPubMed Stammet P, Goretti E, Vausort M, Zhang L, Wagner DR, Devaux Y (2012) Circulating microRNAs after cardiac arrest. Crit Care Med 40:3209–3214CrossRefPubMed
11.
Zurück zum Zitat Gilje P, Gidlof O, Rundgren M, Cronberg T, Al-Mashat M, Olde B, Friberg H, Erlinge D (2014) The brain-enriched microRNA miR-124 in plasma predicts neurological outcome after cardiac arrest. Crit Care 18:R40CrossRefPubMedPubMedCentral Gilje P, Gidlof O, Rundgren M, Cronberg T, Al-Mashat M, Olde B, Friberg H, Erlinge D (2014) The brain-enriched microRNA miR-124 in plasma predicts neurological outcome after cardiac arrest. Crit Care 18:R40CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Devaux Y, Dankiewicz J, Salgado-Somoza A, Stammet P, Collignon O, Gilje P, Gidlof O, Zhang L, Vausort M, Hassager C, Wise MP, Kuiper M, Friberg H, Cronberg T, Erlinge D, Nielsen N, For Target Temperature Management After Cardiac Arrest Trial I (2016) Association of circulating microRNA-124-3p levels with outcomes after out-of-hospital cardiac arrest: a substudy of a randomized clinical trial. JAMA Cardiol 1:305–313CrossRefPubMed Devaux Y, Dankiewicz J, Salgado-Somoza A, Stammet P, Collignon O, Gilje P, Gidlof O, Zhang L, Vausort M, Hassager C, Wise MP, Kuiper M, Friberg H, Cronberg T, Erlinge D, Nielsen N, For Target Temperature Management After Cardiac Arrest Trial I (2016) Association of circulating microRNA-124-3p levels with outcomes after out-of-hospital cardiac arrest: a substudy of a randomized clinical trial. JAMA Cardiol 1:305–313CrossRefPubMed
13.
Zurück zum Zitat Devaux Y, Salgado-Somoza A, Dankiewicz J, Boileau A, Stammet P, Schritz A, Zhang L, Vausort M, Gilje P, Erlinge D, Hassager C, Wise MP, Kuiper M, Friberg H, Nielsen N, Investigators TT-t (2017) Incremental value of circulating MiR-122-5p to predict outcome after out of hospital cardiac arrest. Theranostics 7:2555–2564CrossRefPubMedPubMedCentral Devaux Y, Salgado-Somoza A, Dankiewicz J, Boileau A, Stammet P, Schritz A, Zhang L, Vausort M, Gilje P, Erlinge D, Hassager C, Wise MP, Kuiper M, Friberg H, Nielsen N, Investigators TT-t (2017) Incremental value of circulating MiR-122-5p to predict outcome after out of hospital cardiac arrest. Theranostics 7:2555–2564CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Lei P, Li Y, Chen X, Yang S, Zhang J (2009) Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury. Brain Res 1284:191–201CrossRefPubMed Lei P, Li Y, Chen X, Yang S, Zhang J (2009) Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury. Brain Res 1284:191–201CrossRefPubMed
15.
Zurück zum Zitat Andersson P, Gidlof O, Braun OO, Gotberg M, van der Pals J, Olde B, Erlinge D (2012) Plasma levels of liver-specific miR-122 is massively increased in a porcine cardiogenic shock model and attenuated by hypothermia. Shock 37:234–238CrossRefPubMed Andersson P, Gidlof O, Braun OO, Gotberg M, van der Pals J, Olde B, Erlinge D (2012) Plasma levels of liver-specific miR-122 is massively increased in a porcine cardiogenic shock model and attenuated by hypothermia. Shock 37:234–238CrossRefPubMed
16.
Zurück zum Zitat Laterza OF, Lim L, Garrett-Engele PW, Vlasakova K, Muniappa N, Tanaka WK, Johnson JM, Sina JF, Fare TL, Sistare FD, Glaab WE (2009) Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clin Chem 55:1977–1983CrossRefPubMed Laterza OF, Lim L, Garrett-Engele PW, Vlasakova K, Muniappa N, Tanaka WK, Johnson JM, Sina JF, Fare TL, Sistare FD, Glaab WE (2009) Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clin Chem 55:1977–1983CrossRefPubMed
Metadaten
Titel
What’s new in prognostication after cardiac arrest: microRNAs?
Publikationsdatum
20.11.2017
Erschienen in
Intensive Care Medicine / Ausgabe 6/2018
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-017-4995-6

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