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06.09.2018 | What's New in Intensive Care

What’s new on emerging resistant Candida species

verfasst von: Andrea Cortegiani, Giovanni Misseri, Anuradha Chowdhary

Erschienen in: Intensive Care Medicine | Ausgabe 4/2019

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Accounting for more than 400,000 annual cases worldwide, with an incidence from 0.24 to 34.3 patients/1000 ICU admissions and mortality that approaches 40%, Candida spp. constitute the third or fourth most common cause of healthcare-related infections worldwide [1]. Although C. albicans remains the main causative pathogen, the increasing isolations of non-albicans Candida spp. resistant to first- and second-line antifungals (namely, fluconazole and echinocandins) in nosocomial infections is concerning. Resistance to azoles remains uncommon in C. albicans (< 5%), but it is more prevalent in C. glabrata (4–16%), C. parapsilosis (4–10%), and C. tropicalis (4–9%) [2]. Acquired resistance following echinocandin exposure appears to be on the rise, and the emergence of multi-resistant species among Candida glabrata and the novel pathogen Candida auris poses a serious threat to critically ill patients. …

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Titel: What’s new on emerging resistant Candida species
verfasst von: Andrea Cortegiani
Giovanni Misseri
Anuradha Chowdhary
Publikationsdatum: 06.09.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 4/2019
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-018-5363-x

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What’s new on emerging resistant Candida species

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