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Intensive Care Medicine

Erschienen in:

19.11.2018 | Editorial

“What’s new?”

Immunostimulating strategies in the ICU

verfasst von: Peter Pickkers, Tom van der Poll

Erschienen in: Intensive Care Medicine | Ausgabe 1/2019

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Excerpt

Until now, treatment of sepsis has been characterized by two revolutionary steps that significantly improved survival: the introduction of antibiotics and the development of intensive care units (ICUs). Whereas antibiotics target the pathogen, all other treatments focus on support of the host. As sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection [1], a third revolution—immunotherapy targeting the patient’s immune reaction—might be at the break of dawn to further improve the outcome of sepsis patients. …

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315(8):801–810CrossRefPubMedPubMedCentral

van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG (2017) The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol 17(7):407–420CrossRefPubMed

Peters van Ton AM, Kox M, Abdo WF, Pickkers P (2018) Precision immunotherapy for sepsis. Front Immunol 9:1926CrossRefPubMedPubMedCentral

Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE, Burnham KL, Nurnberg P, Schultz MJ, Horn J, Cremer OL et al (2017) Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study. Lancet Respir Med 5(10):816–826CrossRefPubMed

Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P, Mills TC, Rautanen A, Gordon AC, Garrard C, Hill AV et al (2016) Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir Med 4(4):259–271CrossRefPubMedPubMedCentral

Conway Morris A, Datta D, Shankar-Hari M, Stephen J, Weir CJ, Rennie J, Antonelli J, Bateman A, Warner N, Judge K et al (2018) Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study. Intensive Care Med 44(5):627–635CrossRefPubMedPubMedCentral

Wong HR, Atkinson SJ, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA et al (2016) Combining prognostic and predictive enrichment strategies to identify children with septic shock responsive to corticosteroids. Crit Care Med 44(10):e1000–e1003CrossRefPubMedPubMedCentral

Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, Weber-Carstens S, Hasper D, Keh D, Zuckermann H et al (2009) Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 180(7):640–648CrossRefPubMed

Delsing CE, Gresnigt MS, Leentjens J, Preijers F, Frager FA, Kox M, Monneret G, Venet F, Bleeker-Rovers CP, van de Veerdonk FL et al (2014) Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series. BMC Infect Dis 14:166CrossRefPubMedPubMedCentral

10.

Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, Monneret G, Rimmele T, Blood T, Morre M et al (2018) Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial. JCI Insight 3(5). https://doi.org/10.1172/jci.insight.98960

11.

Timmermans K, Kox M, Vaneker M, van den Berg M, John A, van Laarhoven A, van der Hoeven H, Scheffer GJ, Pickkers P (2016) Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients. Intensive Care Med 42(4):551–561CrossRefPubMedPubMedCentral

12.

Venet F, Cour M, Demaret J, Monneret G, Argaud L (2016) Decreased monocyte HLA-DR expression in patients after non-shockable out-of-hospital cardiac arrest. Shock 46(1):33–36CrossRefPubMed

13.

van Vught LA, Klein Klouwenberg PC, Spitoni C et al (2016) Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis. JAMA 315(14):1469–1479CrossRefPubMed

14.

Opal SM, Fisher CJ, Dhainaut J-FA, Vincent J-L, Brase R, Lowry SF, Sadoff JC, Slotman GJ, Levy H, Balk RA et al (1997) Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, doubleblind, placebo-controlled, multicenter trial. Crit Care Med 25(7):1115–24

15.

Shakoory B, Carcillo JA, Chatham WW, Amdur RL, Zhao H, Dinarello CA, Cron RQ, Opal SM (2016) Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III trial. Crit Care Med 44(2):275–281CrossRefPubMedPubMedCentral

Titel: “What’s new?”
Immunostimulating strategies in the ICU
verfasst von: Peter Pickkers
Tom van der Poll
Publikationsdatum: 19.11.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 1/2019
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-018-5462-8

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