Background
Methods
Eligibility criteria
Types of participants
Types of intervention(s)
Types of outcomes
Types of studies
Search strategy
Study selection
Assessment of methodological quality
Data collection
Data analysis
Head-to-head direct evidence
Network meta-analyses to enable indirect comparisons
Risk of bias across studies
Results
Study selection
Study characteristics and risk of bias within studies
V vs F vs P(n = 4) | V vs F (n = 8) | V vs P(n = 10) | F vs P (n = 9) | Total (n = 31) | |
---|---|---|---|---|---|
Year
| (1999, 2003, 2004, 2009) | (1994, 1997, 1998, 2000, 2007) | (1993, 1996, 1997, 1998, 2004) | (1991, 1998, 2002, 2004, 2005) | (1991, 1997, 1999, 2003, 2009) |
Anxious depression (No)
| 3 (75%) | 7 (88%) | 10 (100%) | 8 (89%) | 28 (90%) |
Study duration (weeks)
| (6, 6, 8, 12) | (6, 8, 9, 12, 12) | (4, 6, 8, 11, 13) | (4, 6, 8, 12, 13) | (4, 6, 8, 12, 13) |
Number of follow-up visits
| (6, 7, 8, 8) | (6, 6, 7, 8, 9) (NA = 1) | (5, 6, 7, 8, 8) | (3, 8, 9, 9, 9) (NA = 1) | (3, 6, 7, 8, 9) (NA = 2) |
Industry sponsorship (yes)
| 4 (100%) | 8 (100%) | 10 (100%) | 8 (100%) (NA = 1) | 30 (100%) (NA = 1) |
Exclusion of placebo responders (yes)
| 4 (100%) | 5 (63%) | 10 (100%) | 6 (75%) (NA = 1) | 25 (83%) (NA = 1) |
Patient type
| (NA = 1) | (NA = 1) | (NA = 2) | ||
Inpatients | 1 (25%) | 2 (25%) | 1 (11%) | 1 (12.5%) | 5 (17%) |
Outpatients | 3 (75%) | 5 (63%) | 7 (78%) | 6 (75%) | 21 (73%) |
Outpatients in primary care | 0 (0%) | 1 (12%) | 1 (11%) | 1 (12.5%) | 3 (10%) |
Scale used
| |||||
HDRS | 4 (100%) | 5 (63%) | 4 (40%) | 8 (89%) | 23 (74%) |
MADRS | 0 (0%) | 3 (37%) | 6 (60%) | 1 (11%) | 8 (26%) |
Type of analysis
| |||||
ITT with LOCF | 4 (100%) | 8 (100%) | 10 (100%) | 8 (89%) | 30 (97%) |
Mixed model | 0 (0%) | 0 (0%) | 0 (0%) | 1 (11%) | 1 (3%) |
Initial severity (HDRS score ≥25)
| 3 (75%) | 5 (63%) | 6 (60%) | 3 (37.5%) (NA = 1) | 17 (57%) (NA = 1) |
Results from individual studies and synthesis of results
Head-to-head direct evidence
Network meta-analyses to enable indirect comparisons
FLUp
|
1.03
|
[0.75 to 1.41]
|
0.88
|
[0.63 to 1.25]
|
0.58
|
[0.46 to 0.74]
|
0.46
|
[0.35 to 0.60]
| |
0.94 | [0.61 to 1.43] |
VENLAFp
|
0.86
|
[0.64 to 1.16]
|
0.57
|
[0.46 to 0.70]
|
0.45
|
[0.37 to 0.52]
| |
0.91 | [0.59 to 1.39] | 0.97 | [0.66 to 1.42] |
FLU/VENLAFp
|
0.66
|
[0.51 to 0.84]
|
0.51
|
[0.40 to 0.66]
| |
0.51
|
[0.37 to 0.71]
|
0.55
|
[0.41 to 0.73]
|
0.57
|
[0.42 to 0.76]
|
FLU
|
0.79
|
[0.68 to 0.91]
| |
0.44
|
[0.31 to 0.63]
|
0.47
|
[0.37 to 0.61]
|
0.49
|
[0.36 to 0.65]
| 0.86 | [0.74 to 1.00] |
VENLAF
|