Introduction
Materials and methods
Subjects
Fetal scanning protocol
Neonatal scanning protocol and DTI fitting procedure
Calculation of the diffusion tensor in the fetal brain
Step 1 Data preparation, inspection, and rejection of damaged data, and distortion correction
Category | Code 1 | Code 2 | Code 3 | Code 4 |
---|---|---|---|---|
Number of successful reconstructions/number of scans acquired with this code | 18/18 | 5/6 | 3/7 | 0/5 |
Number of slices to be discarded due to severe artefact (%) | < 10 | 10–20 | > 20–35 | > 35 |
Step 2 Production of a b0 volume image as a registration target
Step 3 Initial motion correction for DW images
Step 4 Refinement of motion correction for DW images
Step 5 Calculation of a final DT map and derived quantities
Tractography and region of interest analysis
Results
FA mean (± sd) | ADC mean (± sd) (units: × 10−3 mm2/s) | |
---|---|---|
Forceps major | 0.34 (± 0.06) | 1.62 (± 0.10) |
Forceps minor | 0.27 (± 0.04) | 1.62 (± 0.15) |
CST | 0.27 (± 0.03) | 1.42 (± 0.11) |
ROIs (n fetal, n preterm) | Mean FA (± SD) | Mean ADC (± SD) (units: × 10−3 mm2/s) | ||
---|---|---|---|---|
Fetal | Preterm | Fetal | Preterm | |
PLIC (21, 32) | 0.37 (± 0.07) | 0.41 (± 0.01) | 1.31 (± 0.12) | 1.13 (± 0.06) |
Genu (25, 32) | 0.46 (± 0.08) | 0.54 (± 0.05) | 1.44 (± 0.14) | 1.23 (± 0.14) |
Splenium (21, 32) | 0.49 (± 0.09) | 0.56 (± 0.06) | 1.48 (± 0.16) | 1.28 (± 0.12) |
Frontal WM (23, 31) | 0.14 (± 0.04) | 0.10 (± 0.02) | 1.89 (± 0.20) | 1.78 (± 0.12) |
CSO (24, 32) | 0.14 (± 0.03) | 0.11 (± 0.02) | 1.86 (± 0.19) | 1.78 (± 0.09) |
Occipital WM (24, 27) | 0.20 (± 0.06) | 0.18 (± 0.05) | 1.62 (± 0.19) | 1.46 (± 0.11) |
Thalamus (24, 32) | 0.16 (± 0.03) | 0.13 (± 0.02) | 1.29 (± 0.15) | 1.16 (± 0.05) |
Cerebellum (23, 21) | 0.15 (± 0.04) | 0.13 (± 0.04) | 1.45 (± 0.13) | 1.26 (± 0.09) |
Pons (24, 30) | 0.18 (± 0.06) | 0.17 (± 0.04) | 1.28 (± 0.14) | 1.13 (± 0.07) |
% Visible ROIs | ||
---|---|---|
Fetus | Preterm | |
PLIC | 81 | 100 |
Genu | 96 | 100 |
Splenium | 81 | 100 |
Frontal WM | 88 | 97 |
Occipital WM | 92 | 84 |
CSO | 92 | 100 |
Thalamus | 92 | 100 |
Cerebellum | 88 | 66 |
Pons | 92 | 94 |