Skip to main content
Erschienen in: Brain Structure and Function 8/2018

10.07.2018 | Original Article

White matter correlates of temporal discounting in older adults

verfasst von: S. Duke Han, Konstantinos Arfanakis, Debra A. Fleischman, Lei Yu, David A. Bennett, Patricia A. Boyle

Erschienen in: Brain Structure and Function | Ausgabe 8/2018

Einloggen, um Zugang zu erhalten

Abstract

Temporal discounting, the tendency to select a smaller reward offered sooner over a larger reward offered at a later time, has been associated with a number of real-world decision-making outcomes important for health and wellbeing. Neurobiological mechanisms supporting temporal discounting have been explored among younger participants, and these have considered white matter integrity. However, the white matter correlates of temporal discounting in older adults are unclear. We hypothesized that greater temporal discounting would be associated with poorer white matter integrity measures, more specifically lower fractional anisotropy and higher trace, in older adults. Participants were 302 older persons without dementia (mean age = 81.38, mean years of education = 15.75, 75.5% female, mean MMSE = 28.29) from the Rush Memory and Aging Project, a community-based longitudinal study of aging. Temporal discounting was assessed using standard elicitation questions. White matter integrity was assessed with diffusion tensor imaging (DTI). Regression models were adjusted for the effects of age, sex, education, and white matter lesions. Secondary models further adjusted for global cognition. Results revealed significant associations between temporal discounting and white matter integrity measures (FA and trace) in bilateral frontal, frontostriatal, and temporal–parietal lobe white matter tracts, and results remained significant after further accounting for global cognition. These results suggest that temporal discounting is inversely associated with white matter integrity in old age and that this association is independent of global cognition.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
Zurück zum Zitat Bach M, Laun FB, Leemans A, Tax CMW, Biessels GJ, Stieltjes B et al (2014) Methodological considerations on tract-based spatial statistics (TBSS). NeuroImage 100:358–369CrossRefPubMed Bach M, Laun FB, Leemans A, Tax CMW, Biessels GJ, Stieltjes B et al (2014) Methodological considerations on tract-based spatial statistics (TBSS). NeuroImage 100:358–369CrossRefPubMed
Zurück zum Zitat Ballard K, Knutson B (2009) Dissociable neural representations of future reward magnitude and delay during temporal discounting. NeuroImage 45:143–150CrossRefPubMed Ballard K, Knutson B (2009) Dissociable neural representations of future reward magnitude and delay during temporal discounting. NeuroImage 45:143–150CrossRefPubMed
Zurück zum Zitat Basser PJ, Pierpaoli C (1996) Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111:209–219CrossRefPubMed Basser PJ, Pierpaoli C (1996) Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111:209–219CrossRefPubMed
Zurück zum Zitat Bennett DA, Wilson RS, Schneider JA, Evans DA, Beckett LA, Aggarwal NT, Barnes LL, Fox JH, Bach J (2002) Natural history of mild cognitive impairment in older persons. Neurology 59:198–205CrossRefPubMed Bennett DA, Wilson RS, Schneider JA, Evans DA, Beckett LA, Aggarwal NT, Barnes LL, Fox JH, Bach J (2002) Natural history of mild cognitive impairment in older persons. Neurology 59:198–205CrossRefPubMed
Zurück zum Zitat Bennett DA, Schneider JA, Aggarwal NT, Arvanitakis Z, Shah RC, Kelly JF, Fox JH, Cochran EJ, Arends D, Treinkman AD, Wilson RS (2006) Decision rules guiding the clinical diagnosis of Alzheimer’s disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. Neuroepidemiology 27:169–176CrossRefPubMed Bennett DA, Schneider JA, Aggarwal NT, Arvanitakis Z, Shah RC, Kelly JF, Fox JH, Cochran EJ, Arends D, Treinkman AD, Wilson RS (2006) Decision rules guiding the clinical diagnosis of Alzheimer’s disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. Neuroepidemiology 27:169–176CrossRefPubMed
Zurück zum Zitat Bennett DA, Schneider JA, Buchman AS, Barnes LL, Boyle PA, Wilson RS (2012) Overview and findings from the Rush Memory and Aging Project. Curr Alzheimer Res 9(6):646–663CrossRefPubMedCentralPubMed Bennett DA, Schneider JA, Buchman AS, Barnes LL, Boyle PA, Wilson RS (2012) Overview and findings from the Rush Memory and Aging Project. Curr Alzheimer Res 9(6):646–663CrossRefPubMedCentralPubMed
Zurück zum Zitat Boyle PA, Yu L, Segawa E, Wilson RS, Buchman AS, Laibson DI, Bennett DA (2012) Association of cognition with temporal discounting in community based older persons. BMC Geriatrics 12:48CrossRefPubMedCentralPubMed Boyle PA, Yu L, Segawa E, Wilson RS, Buchman AS, Laibson DI, Bennett DA (2012) Association of cognition with temporal discounting in community based older persons. BMC Geriatrics 12:48CrossRefPubMedCentralPubMed
Zurück zum Zitat Boyle PA, Yu L, Gamble KJ, Bennett DA (2013) Temporal discounting is associated with and increased risk of mortality among community-based older persons without dementia. PLoS One 8(6):e67376CrossRefPubMedCentralPubMed Boyle PA, Yu L, Gamble KJ, Bennett DA (2013) Temporal discounting is associated with and increased risk of mortality among community-based older persons without dementia. PLoS One 8(6):e67376CrossRefPubMedCentralPubMed
Zurück zum Zitat Frost R, McNaughton N (2017) The neural basis of delay discounting: a review and preliminary model. Neurosci Biobehav Rev 79:48–65CrossRefPubMed Frost R, McNaughton N (2017) The neural basis of delay discounting: a review and preliminary model. Neurosci Biobehav Rev 79:48–65CrossRefPubMed
Zurück zum Zitat Han SD, Boyle PA, Yu L, Fleischman DA, Arfanakis K, Bennett DA (2013) Ventromedial PFC, parahippocampal, and cerebellar connectivity are associated with temporal discounting in old age. Exp Gerontol 48:1489–1498CrossRefPubMed Han SD, Boyle PA, Yu L, Fleischman DA, Arfanakis K, Bennett DA (2013) Ventromedial PFC, parahippocampal, and cerebellar connectivity are associated with temporal discounting in old age. Exp Gerontol 48:1489–1498CrossRefPubMed
Zurück zum Zitat Han SD, Boyle PA, Yu L, Fleischman DA, Arfanakis K, Leurgans S, Bennett DA (2014) Financial literacy is associated with medial brain region functional connectivity in old age. Arch Gerontol Geriatr 59:429–438CrossRefPubMedCentralPubMed Han SD, Boyle PA, Yu L, Fleischman DA, Arfanakis K, Leurgans S, Bennett DA (2014) Financial literacy is associated with medial brain region functional connectivity in old age. Arch Gerontol Geriatr 59:429–438CrossRefPubMedCentralPubMed
Zurück zum Zitat Han SD, Boyle PA, Arfanakis K, Fleischman D, Yu L, James BD, Bennett DA (2016a) Financial literacy is associated with white matter integrity in old age. Neuroimage 130:223–229CrossRefPubMed Han SD, Boyle PA, Arfanakis K, Fleischman D, Yu L, James BD, Bennett DA (2016a) Financial literacy is associated with white matter integrity in old age. Neuroimage 130:223–229CrossRefPubMed
Zurück zum Zitat Han SD, Boyle PA, Yu L, Arfanakis K, James BD, Fleischman DA, Bennett DA (2016b) Grey matter correlates of susceptibility to scams in community-dwelling older adults. Brain Imaging Behavior 10:524–532CrossRef Han SD, Boyle PA, Yu L, Arfanakis K, James BD, Fleischman DA, Bennett DA (2016b) Grey matter correlates of susceptibility to scams in community-dwelling older adults. Brain Imaging Behavior 10:524–532CrossRef
Zurück zum Zitat Hanggi J, Lohrey C, Drobetz R, Baetschmann H, Forstmeier S, Maercker A, Jancke L (2016) Strength of structural and functional frontostriatal connectivity predicts self-control in the healthy elderly. Front Aging Neurosci 8:307CrossRefPubMedCentralPubMed Hanggi J, Lohrey C, Drobetz R, Baetschmann H, Forstmeier S, Maercker A, Jancke L (2016) Strength of structural and functional frontostriatal connectivity predicts self-control in the healthy elderly. Front Aging Neurosci 8:307CrossRefPubMedCentralPubMed
Zurück zum Zitat Herrmann ES, Johnson PS, Johnson MW (2015) Examining delay discounting of condom-protected sex among men who have sex with men using crowdsourcing technology. AIDS Behav 19:1655–1665CrossRefPubMedCentralPubMed Herrmann ES, Johnson PS, Johnson MW (2015) Examining delay discounting of condom-protected sex among men who have sex with men using crowdsourcing technology. AIDS Behav 19:1655–1665CrossRefPubMedCentralPubMed
Zurück zum Zitat James BD, Boyle PA, Yu L, Han SD, Bennett DA (2015) Cognitive decline is associated with risk aversion and temporal discounting in older adults without dementia. PLoS One 10:e0121900CrossRefPubMedCentralPubMed James BD, Boyle PA, Yu L, Han SD, Bennett DA (2015) Cognitive decline is associated with risk aversion and temporal discounting in older adults without dementia. PLoS One 10:e0121900CrossRefPubMedCentralPubMed
Zurück zum Zitat Laibson D (1997) Golden eggs and hyperbolic discounting. Q J Econ 112:443–478CrossRef Laibson D (1997) Golden eggs and hyperbolic discounting. Q J Econ 112:443–478CrossRef
Zurück zum Zitat LeBihan D, Mangin JF, Poupon C, Clark CA, Pappata S et al (2001) Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging 13:534–546CrossRef LeBihan D, Mangin JF, Poupon C, Clark CA, Pappata S et al (2001) Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging 13:534–546CrossRef
Zurück zum Zitat Marks BL, Madden DJ, Bucur B, Provenzale JM, White LE, Cabeza R, Huettel SA (2007) Role of aerobic fitness and aging on cerebral white matter integrity. Ann NY Acad Sci 1097:111–171CrossRef Marks BL, Madden DJ, Bucur B, Provenzale JM, White LE, Cabeza R, Huettel SA (2007) Role of aerobic fitness and aging on cerebral white matter integrity. Ann NY Acad Sci 1097:111–171CrossRef
Zurück zum Zitat Marks SM, Lockart SN, Baker SL, Jagust WJ (2017) Tau and beta-amyloid are associated with medial temporal lobe structure, function, and memory encoding in normal aging. J Neurosci 37:3192–3201CrossRefPubMedCentralPubMed Marks SM, Lockart SN, Baker SL, Jagust WJ (2017) Tau and beta-amyloid are associated with medial temporal lobe structure, function, and memory encoding in normal aging. J Neurosci 37:3192–3201CrossRefPubMedCentralPubMed
Zurück zum Zitat McClelland J, Dalton B, Kekic M, Bartholdy S, Campbell IC, Schmidt U (2016) A systematic review of temporal discounting in eating disorders and obesity: behavioral and neuroimaging findings. Neurosci Biobehav Rev 71:506–528CrossRefPubMed McClelland J, Dalton B, Kekic M, Bartholdy S, Campbell IC, Schmidt U (2016) A systematic review of temporal discounting in eating disorders and obesity: behavioral and neuroimaging findings. Neurosci Biobehav Rev 71:506–528CrossRefPubMed
Zurück zum Zitat McKhann G, Drachman D, Folstein M, Katzman R, Price D, Standlan E (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS/ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34:939–944CrossRefPubMed McKhann G, Drachman D, Folstein M, Katzman R, Price D, Standlan E (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS/ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34:939–944CrossRefPubMed
Zurück zum Zitat Moody L, Franck C, Hatz L, Bickel WK (2016) Impulsivity and polysubstance use: a systematic comparison of delay discounting in mon, dual, and tri-substance use. Exp Clin Psychopharmacol 24:30–37CrossRefPubMedCentralPubMed Moody L, Franck C, Hatz L, Bickel WK (2016) Impulsivity and polysubstance use: a systematic comparison of delay discounting in mon, dual, and tri-substance use. Exp Clin Psychopharmacol 24:30–37CrossRefPubMedCentralPubMed
Zurück zum Zitat Mukherjee P, Berman JI, Chung SW, Hess CP, Henry RG (2008) Diffusion tensor MR imaging and fiber tractography: theoretical underpinnings. AJNR 29:632–641CrossRefPubMedCentralPubMed Mukherjee P, Berman JI, Chung SW, Hess CP, Henry RG (2008) Diffusion tensor MR imaging and fiber tractography: theoretical underpinnings. AJNR 29:632–641CrossRefPubMedCentralPubMed
Zurück zum Zitat Odom AL (2011) Delay discounting: trait variable? Behav Proces 87:1–9CrossRef Odom AL (2011) Delay discounting: trait variable? Behav Proces 87:1–9CrossRef
Zurück zum Zitat Odom AL, Baumann AAL (2010) Delay discounting: state and trait variable. In: Madden GJ, Bickel WK (eds) Impulsivity: the behavioral and neurological science of discounting. APA Books, Washington, DC, pp 39–65CrossRef Odom AL, Baumann AAL (2010) Delay discounting: state and trait variable. In: Madden GJ, Bickel WK (eds) Impulsivity: the behavioral and neurological science of discounting. APA Books, Washington, DC, pp 39–65CrossRef
Zurück zum Zitat Olson EA, Collins PF, Hooper CJ, Muetzel R, Lim KO, Lucianna M (2008) White matter integrity predicts delay discounting behavior in 9- to 23-year-olds: a diffusion tensor imaging study. J Cogn Neurosci 21:1406–1421CrossRef Olson EA, Collins PF, Hooper CJ, Muetzel R, Lim KO, Lucianna M (2008) White matter integrity predicts delay discounting behavior in 9- to 23-year-olds: a diffusion tensor imaging study. J Cogn Neurosci 21:1406–1421CrossRef
Zurück zum Zitat Peper JS, Mandl RCW, Braams BR, Water ED, Heijboer AC, Koolschijn PCMP, Crone EA (2013) Delay discounting and frontostriatal fiber tracts: a combined DTI and MTR study on impulsive choices in healthy young adults. Cereb Cortex 23:1695–1702CrossRefPubMed Peper JS, Mandl RCW, Braams BR, Water ED, Heijboer AC, Koolschijn PCMP, Crone EA (2013) Delay discounting and frontostriatal fiber tracts: a combined DTI and MTR study on impulsive choices in healthy young adults. Cereb Cortex 23:1695–1702CrossRefPubMed
Zurück zum Zitat Peters J, Buchel C (2011) The neural mechanisms of inter-temporal decision-making: understanding variability. Trends Cognit Sci 15:207–239CrossRef Peters J, Buchel C (2011) The neural mechanisms of inter-temporal decision-making: understanding variability. Trends Cognit Sci 15:207–239CrossRef
Zurück zum Zitat Pierpaoli C, Walker L, Irfanoglu MO, Barnett A, Basser PJ et al (2010) TORTOISE: an integrated software package for processing of diffusion MRI data. In: Proceedings of the 18th Annual Meeting ISMRM, Stockholm, Sweden. 1597 Pierpaoli C, Walker L, Irfanoglu MO, Barnett A, Basser PJ et al (2010) TORTOISE: an integrated software package for processing of diffusion MRI data. In: Proceedings of the 18th Annual Meeting ISMRM, Stockholm, Sweden. 1597
Zurück zum Zitat Reimers S, Maylor EA, Stewart N, Chater N (2009) Associations between a one-shot delay discounting measure and age, income, education and real-world impulsive behavior. Personal Individ Differ 47:973–978CrossRef Reimers S, Maylor EA, Stewart N, Chater N (2009) Associations between a one-shot delay discounting measure and age, income, education and real-world impulsive behavior. Personal Individ Differ 47:973–978CrossRef
Zurück zum Zitat Reynolds B, Schiffbauer R (2005) Delay of gratification and delay discounting: a unifying feedback model of delay-related impulsive behavior. Psychol Record 55:439–460CrossRef Reynolds B, Schiffbauer R (2005) Delay of gratification and delay discounting: a unifying feedback model of delay-related impulsive behavior. Psychol Record 55:439–460CrossRef
Zurück zum Zitat Schwarz CG, Reid RI, Gunter JL, Senjem ML, Przybelski SA, Zuk SM et al (2014) Improved DTI registration allows voxel-based analysis that outperforms tract-based spatial statistics. NeuroImage 94:65–78CrossRefPubMed Schwarz CG, Reid RI, Gunter JL, Senjem ML, Przybelski SA, Zuk SM et al (2014) Improved DTI registration allows voxel-based analysis that outperforms tract-based spatial statistics. NeuroImage 94:65–78CrossRefPubMed
Zurück zum Zitat Smith SM, Nichols TE (2009) Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localization in cluster inference. Neuroimage 44:83–98CrossRefPubMed Smith SM, Nichols TE (2009) Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localization in cluster inference. Neuroimage 44:83–98CrossRefPubMed
Zurück zum Zitat Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE et al (2006) Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31:1487–1505CrossRefPubMed Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE et al (2006) Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31:1487–1505CrossRefPubMed
Zurück zum Zitat Van den Bos W, Rodriguez CA, Schweitzer JB, McClure SM (2014) Connectivity strength of dissociable striatal tracts predict individual differences in temporal discounting. J Neurosci 34:10298–10310CrossRefPubMedCentralPubMed Van den Bos W, Rodriguez CA, Schweitzer JB, McClure SM (2014) Connectivity strength of dissociable striatal tracts predict individual differences in temporal discounting. J Neurosci 34:10298–10310CrossRefPubMedCentralPubMed
Zurück zum Zitat Vanderveldt A, Oliveira L, Green L (2016) Delay discounting: pigeon, rat, human—does it matter? J Exp Psychol Anim Learn Cognit 42:141–162CrossRef Vanderveldt A, Oliveira L, Green L (2016) Delay discounting: pigeon, rat, human—does it matter? J Exp Psychol Anim Learn Cognit 42:141–162CrossRef
Zurück zum Zitat Varentsova A, Zhang S, Arfanakis K (2014) Development of a high angular resolution diffusion imaging human brain template. Neuroimage 91:177–186CrossRefPubMed Varentsova A, Zhang S, Arfanakis K (2014) Development of a high angular resolution diffusion imaging human brain template. Neuroimage 91:177–186CrossRefPubMed
Zurück zum Zitat Voss MW, Heo S, Prakash RS, Erickson KI, Alves H, Chaddock L, Szabo AN, Mailey EL, Wojcicki TR, White SM, Gothe N, McAuley E, Sutton BP, Kramer AF (2013) The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Map 34:2972–2985CrossRef Voss MW, Heo S, Prakash RS, Erickson KI, Alves H, Chaddock L, Szabo AN, Mailey EL, Wojcicki TR, White SM, Gothe N, McAuley E, Sutton BP, Kramer AF (2013) The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Map 34:2972–2985CrossRef
Zurück zum Zitat Wilson RS, Barnes LL, Bennett DA (2003) Assessment of lifetime participation in cognitively stimulating activities. J Clin Exp Psychol 25:634–642 Wilson RS, Barnes LL, Bennett DA (2003) Assessment of lifetime participation in cognitively stimulating activities. J Clin Exp Psychol 25:634–642
Zurück zum Zitat Zacharaki EI, Kanterakis S, Bryan RN, Davatzikos C (2008) Measuring brain lesion progression with a supervised tissue classification system. Med Image Comput Comput Assist Interv 11:620–627PubMed Zacharaki EI, Kanterakis S, Bryan RN, Davatzikos C (2008) Measuring brain lesion progression with a supervised tissue classification system. Med Image Comput Comput Assist Interv 11:620–627PubMed
Metadaten
Titel
White matter correlates of temporal discounting in older adults
verfasst von
S. Duke Han
Konstantinos Arfanakis
Debra A. Fleischman
Lei Yu
David A. Bennett
Patricia A. Boyle
Publikationsdatum
10.07.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 8/2018
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-018-1712-3

Weitere Artikel der Ausgabe 8/2018

Brain Structure and Function 8/2018 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Neu im Fachgebiet Neurologie

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.