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European Archives of Psychiatry and Clinical Neuroscience

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28.12.2016 | Short Communication

White matter correlates of the disorganized speech dimension in schizophrenia

verfasst von: Petra V. Viher, Katharina Stegmayer, Stéphanie Giezendanner, Andrea Federspiel, Stephan Bohlhalter, Roland Wiest, Werner Strik, Sebastian Walther

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 1/2018

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Abstract

Disorganized speech is related to functional abnormalities in schizophrenia. To test the association between formal thought disorders (FTDs) and white matter microstructure, we applied a behavioral rating and diffusion tensor imaging in 61 patients with schizophrenia spectrum disorders. The Bern Psychopathology Scale was used to rate the dimension of language abnormalities ranging from negative FTDs, basically unaltered speech, to positive FTDs. Tract-based spatial statistics indicated increased fractional anisotropy in left hemispheric pathways of the language system in patients with negative FTDs. Thus, altered white matter properties in relevant fiber tracts may represent vulnerability to specific formal thought disorders.

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Titel: White matter correlates of the disorganized speech dimension in schizophrenia
verfasst von: Petra V. Viher
Katharina Stegmayer
Stéphanie Giezendanner
Andrea Federspiel
Stephan Bohlhalter
Roland Wiest
Werner Strik
Sebastian Walther
Publikationsdatum: 28.12.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 1/2018
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-016-0753-y

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