nach oben

Breast Cancer Research

Erschienen in:

01.02.2000 | Commentary

Whither high-dose chemotherapy in breast cancer?

verfasst von: Astrid Mayer, Helena Earl

Erschienen in: Breast Cancer Research | Ausgabe 1/2000

Einloggen, um Zugang zu erhalten

Abstract

Four trials of high-dose chemotherapy with stem cell support in breast cancer in the adjuvant and metastatic settings have shown no long-term disease-free or overall survival gain. This relative failure of a single high-dose therapy we believe opens up the development of a dose-dense approach with block scheduling as the most promising way forward. This intensive chemotherapy can be more easily combined with the newer biological therapies and our prediction is that this will prove to be the most effective treatment in the future for women with poor risk breast cancer.

Norton L, Day R: Potential innovations in scheduling cancer chemotherapy. In: Important Advances in Oncology. Edited by deVita V, Hellman S, Rosenberg S. Philadelphia: JB Lippincott Company;. 1991, 57-72.

Barnes DM, Miles DW: Response of metastatic breast cancer to trastuzumab?. Lancet. 2000, 355: 160-161. 10.1016/S0140-6736(99)00430-4.CrossRefPubMed

Peters WP, Shpall EJ, Jones RB, Olsen GA, Bast RC, Gockerman JP, Moor JO: High-dose combination alkylating agents with bone marrow support as initial treatment for metastatic breast cancer. J Clin Oncol. 1988, 6: 1368-1376.PubMed

Peters WP, Ross M, Vredenburgh JJ, Meisenberg B, Marks LB, Winer E, Kurtzberg J, Bast RC, Jones R, Shpall E: High dose chemotherapy and autologous bone marrow support as consolidation after standard dose adjuvant chemotherapy for high-risk primary breast cancer. J Clin Oncol. 1993, 11: 1132-1143.PubMed

Rodenhuis S, Richel DJ, van der Wall E, Schornagel JH, Baars JW, Koning CCE, Peterse J, Borger JH, Nooijen WJ, Dalesio O, Rutgers E: Randomised trial of high-dose chemotherapy and haemopoietic progenitor-cell support in operable breast cancer with extensive axillary lymph node involvement. Lancet. 1998, 352: 515-572. 10.1016/S0140-6736(98)01350-6.CrossRefPubMed

Hortobagyi GN, Buzdar AU, Theriault RL, Valero V, Frye D, Booser DH, Holmes FA, Giralt S, Khouri I, Andersson B, Gajewski JL, Rondon G, Smith TL, Singletary SE, Ames FC, Sneige N, Strom EA, McNeese MD, Deisseroth AB, Champlin RE: Randomized trial of high-dose chemotherapy and blood cell autografts for high-risk primary breast carcinoma. J Natl Cancer Inst. 2000, 92: 225-233. 10.1093/jnci/92.3.225.CrossRefPubMed

Peters W, Rosner G, Vredenburgh J, Shpall E, Crump M, Richardson P, Marks L, Cirrincione C, Wood W, Henderson I, Hurd D, Norton L: A prospective, randomised comparison of two doses of combination alkylating agents as consolidation after CAF in high-risk primary breast cancer involving ten or more axillary lymph nodes (LN): Preliminary results of CALBG9082/SWOG 9114/NCIC MA-13 [abstract]. Proc Am Soc Clin Oncol. 1999, 18: 2-

The Scandinavian Breast Cancer Study 9401: Results from a randomised adjuvant breast cancer study with high dose chemotherapy with CTCb, supported by autologous bone marrow stem cells versus dose escalated and tailored FEC therapy [abstract]. Proc Am Soc Clin Oncol. 1999, 18: 2a-

Bezwoda WR, Seymour L, Dansey R: High-dose chemotherapy with haematopoietic rescue as primary treatment for metastatic breast cancer: a randomised trial. J Clin Oncol. 1995, 13: 2483-2489.PubMed

10.

Bezwoda WR: Primary and high dose chemotherapy for metastatic breast cancer: update and analysis of prognostic features [abstract]. Proc Am Soc Clin Oncol. 1998, 17: 115-

11.

Bezwoda WR: Randomised controlled trial of high-dose chemotherapy (HD-CNVp) versus standard dose (CAF) chemotherapy for high risk, surgically treated, primary breast cancer [abstract]. Eur J Cancer. 1999, 35(suppl 4): 230-10.1016/S0959-8049(99)81322-7.CrossRef

12.

Bezwoda WR: Randomised controlled trial of high-dose chemotherapy (HD-CNVp) versus standard (CAF) chemotherapy for high-risk, surgically treated, primary breast cancer [abstract]. Proc Am Soc Clin Oncol. 1999, 18: 2a-

13.

Weiss RB, Rifkin RM, Stewart FM, Theriault RL, Williams LA, Herman AA, Beveridge RA: High dose chemotherapy for high risk primary breast cancer: an on-site review of the Bezwoda study. Lancet. 2000, 355: 999-1003. 10.1016/S0140-6736(00)90024-2.CrossRefPubMed

14.

Bergh J: Where next with stem-cell-supported high-dose therapy for breast cancer?. Lancet. 2000, 355: 944-945. 10.1016/S0140-6736(00)90007-2.CrossRefPubMed

15.

Lippman ME: High-dose chemotherapy plus autologous bone marrow transplantation for metastatic breast cancer. N Engl J Med. 2000, 342: 1119-1120. 10.1056/NEJM200004133421508.CrossRefPubMed

16.

Bonadonna G, Valagussa P, Moliterni A, Zambetti M, Brambilla C: Adjuvant cyclophosphamide, methotrexate, and fluorouracil in node positive breast cancer: the results of 20 years of follow-up. N Engl J Med. 1995, 332: 901-906. 10.1056/NEJM199504063321401.CrossRefPubMed

17.

Hryniuk W, Bush H: The importance of high dose intensity in chemotherapy of metastatic breast cancer. J Clin Oncol. 1984, 2: 1281-1287.PubMed

18.

Hrynuik W, Levine MN: Analysis of dose intensity for adjuvant chemotherapy trials in stage II breast cancer. J Clin Oncol. 1986, 4: 1162-1170.

19.

Wood WC, Budman DR, Korzun H, Robert Cooper, Younger J, Hart RD, Moore A, Ellerton JA, Norton L, Ferree CR, Ballow AC, Frei E, Craig Henderson I: Dose and dose intensity of adjuvant chemotherapy for stage II, node positive breast carcinoma. N Engl J Med. 1994, 330: 1253-1259. 10.1056/NEJM199405053301801.CrossRefPubMed

20.

Fossati R, Confalonieri C, Torri V, Ghislandi E, Penna A, Pistotti V, Tinazzi A, Liberati A: Cytotoxic and hormonal treatment for metastatic breast cancer a systematic review of published randomised trials involving 31,510 women. J Clin Oncol. 1998, 16: 3439-3460.PubMed

21.

Stadtmauer EA, O'Neill A, Goldstein LJ, Crilley PA, Mangan KF, Ingle JN, Brodsky I, Martino S, Lazarus HM, Erban JK, Sickles C, Glick JH: Conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous haematopoietic stem cell transplant group. N Engl J Med. 2000, 342: 1069-1076. 10.1056/NEJM200004133421501.CrossRefPubMed

22.

Lotz JP, Cure H, Janvier M, Morvan F, Asselain B, Guillemot M, Laadem A, Maraninchi D, Gisselbrecht C, Roche H: High-dose chemotherapy (HD-CT) with haemopoietic stem cell transplantation (HSCT) for metastatic breast cancer (MBC): results of the French Protocol PEGASE 04 [abstract]. Proc Am Soc Clin Oncol. 1999, 18: 43a-

23.

Day R: Treatment sequencing, asymmetry, and uncertainty: protocol strategies for combination chemotherapy. Cancer Res. 1986, 46: 3876-3885.PubMed

24.

Goldie JH, Coldman AJ: A mathematical model for relating the drug sensitivity of tumours to their spontaneous mutation rate. Cancer Treatment Reports. 1979, 63: 1727-1733.PubMed

Titel: Whither high-dose chemotherapy in breast cancer?
verfasst von: Astrid Mayer
Helena Earl
Publikationsdatum: 01.02.2000
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 1/2000
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr262

Neu im Fachgebiet Onkologie

19.04.2024 | EAU 2024 | Kongressbericht | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Whither high-dose chemotherapy in breast cancer?

Abstract

Neu im Fachgebiet Onkologie

Prostatakarzinom: EU initiiert neues Screeningkonzept

Blasenkarzinom – Biomarker statt Zytologie?

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Adjuvante Brustkrebstherapie: Doppelt hält besser

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2000

Comparison of written reports of mammography, sonography and magnetic resonance mammography for preoperative evaluation of breast lesions, with special emphasis on magnetic resonance mammography

Nuclear-cytoplasmic shuttling of p21Cip1/WAF1is regulated by Akt

Breast imaging technology: Recent advances in imaging endogenous or transferred gene expression utilizing radionuclide technologies in living subjects: applications to breast cancer

An in vitrobreast cell immortalisation assay

Phase III trial of chemotherapy ? HerceptinR in metastatic breast cancer

c-erbB2 homodimerisation in mammary epithelial cells

Neu im Fachgebiet Onkologie

Prostatakarzinom: EU initiiert neues Screeningkonzept

Blasenkarzinom – Biomarker statt Zytologie?

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Adjuvante Brustkrebstherapie: Doppelt hält besser

Update Onkologie