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Erschienen in: Skeletal Radiology 8/2012

01.08.2012 | Scientific Article

Whole-body MRI in neurofibromatosis: incidental findings and prevalence of scoliosis

verfasst von: Jacob L. Jaremko, Peter J. MacMahon, Martin Torriani, Vanessa L. Merker, Victor F. Mautner, Scott R. Plotkin, Miriam A. Bredella

Erschienen in: Skeletal Radiology | Ausgabe 8/2012

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Abstract

Objective

To demonstrate incidental findings and scoliosis on whole-body MRI (WBMRI) in patients with neurofibromatosis type 1 and 2 (NF1 & NF2, respectively), and schwannomatosis.

Materials and methods

Institutional review board approval and written informed consent were obtained for this prospective HIPAA-compliant study. A total of 247 subjects (141 with NF1, 55 with NF2, 51 with schwannomatosis; 132 women (53.5%); mean age, 41 years, range, 18–97 years) underwent WBMRI using coronal STIR (TR/TE: 4190/111 ms, TI: 150 ms) and T1-weighted images (TR/TE: 454/10 ms), 10-mm slice thickness, imaging time ~40 min. Images were reviewed for the presence of incidental findings, outside of nerve sheath tumors. The presence of scoliosis was recorded and curve morphology was assessed and quantified.

Results

Incidental findings other than scoliosis were recorded in 104/247 (42%) patients, most often affecting the musculoskeletal system (65/247 patients, 26%). We found 16/247 (6.5%) significant incidental findings likely to affect clinical management, including avascular necrosis of bone in eight patients (five with NF2), eight insufficiency fractures, and four non-neurogenic neoplasms (Hodgkin's lymphoma, liposarcoma, dermoid cyst, large uterine myoma requiring excision). Scoliosis was seen in 50/247 patients (20%), including 8/55 with NF2 (15%) and 11/51 with schwannomatosis (22%).

Conclusions

Incidental findings in the neurofibromatoses frequently involve the skeleton. Given the relatively high incidence of unsuspected osteonecrosis and stress fractures, close attention to the skeleton on WBMRI is advised. In addition, knowledge of common incidental findings can help clinicians prepare patients who undergo WBMRI for potential unexpected findings.
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Metadaten
Titel
Whole-body MRI in neurofibromatosis: incidental findings and prevalence of scoliosis
verfasst von
Jacob L. Jaremko
Peter J. MacMahon
Martin Torriani
Vanessa L. Merker
Victor F. Mautner
Scott R. Plotkin
Miriam A. Bredella
Publikationsdatum
01.08.2012
Verlag
Springer-Verlag
Erschienen in
Skeletal Radiology / Ausgabe 8/2012
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-011-1333-x

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