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14.11.2023 | Retinal Disorders

Widefield swept-source optical coherence tomography angiography metrics associated with neovascular glaucoma in patients with proliferative diabetic retinopathy

verfasst von: Edward S. Lu, Ying Cui, Rongrong Le, Ying Zhu, Jay C. Wang, Inês Laíns, Raviv Katz, Yifan Lu, Rebecca Zeng, Itika Garg, David M. Wu, Deeba Husain, Leo A. Kim, John B. Miller

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology

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Abstract

Purpose

To explore the association between widefield swept-source optical coherence tomography angiography (WF SS-OCTA) metrics, including nonperfusion area (NPA) and neovascularization (NV), and presence of neovascular glaucoma (NVG) in patients with proliferative diabetic retinopathy (PDR).

Methods

A prospective, cross-sectional study was conducted from November 2018 to February 2020. A total of 85 eyes of 60 PDR patients without NVG and 9 eyes of 8 PDR patients with NVG were included. Retinal ischemic parameters (NPA; ischemia index [NPA/total retinal area]) and NV features (NV number; NV area; NV vessel density) were evaluated. Foveal avascular zone (FAZ), macular thickness/volume, and choroidal thickness/volume were obtained using the Zeiss ARI Network. WF SS-OCTA retinal and choroidal metrics, systemic, and ocular parameters were screened using Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression for variable selection. Firth’s bias-reduced logistic regression (outcome: presence of NVG) was subsequently used to identify parameters associated with NVG.

Results

After LASSO variable selection, 8 variables were significantly associated with the presence of NVG: DM duration (years), insulin (yes/no), best-corrected visual acuity (BCVA) (logMAR), IOP, ischemia index, skeletonized vessel density, macular thickness (inner inferior, outer temporal regions). Firth’s bias-reduced logistic regression showed ischemia index (odds ratio [OR]=13.2, 95% confidence interval [CI]:5.3–30.7, P<0.001) and BCVA (OR=5.8, 95%CI:1.2–28.8, P<0.05) were associated with the presence of NVG. NV metrics, FAZ, and choroidal parameters were not related to NVG.

Conclusions

Retinal ischemia but not NV was associated with the presence of NVG in patients with PDR using WF SS-OCTA. Larger, longitudinal studies are needed to validate imaging biomarkers associated with diabetic NVG.
Literatur
23.
Zurück zum Zitat Kim K, In You J, Park JR et al (2021) Quantification of retinal microvascular parameters by severity of diabetic retinopathy using wide-field swept-source optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Klin Exp Ophthalmol 259(8):2103–2111. https://​doi.​org/​10.​1007/​s00417-021-05099-y CrossRef Kim K, In You J, Park JR et al (2021) Quantification of retinal microvascular parameters by severity of diabetic retinopathy using wide-field swept-source optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Klin Exp Ophthalmol 259(8):2103–2111. https://​doi.​org/​10.​1007/​s00417-021-05099-y CrossRef
Metadaten
Titel
Widefield swept-source optical coherence tomography angiography metrics associated with neovascular glaucoma in patients with proliferative diabetic retinopathy
verfasst von
Edward S. Lu
Ying Cui
Rongrong Le
Ying Zhu
Jay C. Wang
Inês Laíns
Raviv Katz
Yifan Lu
Rebecca Zeng
Itika Garg
David M. Wu
Deeba Husain
Leo A. Kim
John B. Miller
Publikationsdatum
14.11.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-023-06290-z