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01.12.2012 | Case report | Ausgabe 1/2012 Open Access

Journal of Medical Case Reports 1/2012

Wilson disease in a Nigerian child: a case report

Zeitschrift:
Journal of Medical Case Reports > Ausgabe 1/2012
Autoren:
Christopher Imokhuede Esezobor, Nora Banjoko, Adekunle Rotimi-Samuel, Foluso Ebun Afolabi Lesi
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-6-200) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contribution

CIE was the primary physician of the child and initiated the writing of the case. NB extracted the clinical data from the medical record. ARS performed the slit-lamp examination while FEAL made the provisional diagnosis of WD and was a major contributor to writing the case. All authors read and approved the final manuscript.

Abstract

Introduction

Wilson disease is rarely reported among African children. This report describes the second case report of a Nigerian child with Wilson disease in three decades.

Case presentation

An eight-year-old African boy presented with generalized oedema and ascites and proteinuria. Over the next three weeks he developed conjugated hyperbilirubinaemia, severe coagulopathy and prominent extrapyramidal features consisting of rigidity, tremors at rest and in action, shuffling gait, slurred speech and emotional lability. Slit-lamp examination of his eyes revealed Kayser-Fleischer rings and sunflower cataracts. His serum caeruloplasmin level was 5mg/dL. Using the scoring system proposed by the 8th International Meeting of Wilson Disease and Menkes Disease, a diagnosis of Wilson disease was made.

Conclusions

Wilson disease does occur in African children, although the diagnosis is rarely made. A diagnosis of Wilson disease should be entertained in the evaluation of African children presenting with liver dysfunction and/or extrapyramidal neurological features.

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Zusatzmaterial
Authors’ original file for figure 1
13256_2012_2146_MOESM1_ESM.pdf
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