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Erschienen in: Der Schmerz 5/2016

28.09.2016 | Schwerpunkt

Wirkung von Oxytocin auf das menschliche Schmerzerleben

verfasst von: A.-C. Pfeifer, B. Ditzen, E. Neubauer, M. Schiltenwolf

Erschienen in: Der Schmerz | Ausgabe 5/2016

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Zusammenfassung

Hintergrund

Die Wirkung des körpereigenen Hormons Oxytocin und dessen Nützlichkeit für die Schmerztherapie werden in der Forschung über die letzten Jahre vermehrt untersucht und diskutiert. Erste Studienergebnisse konnten bereits die Effekte des Hormons in Bezug auf Geburtsvorgang und Stillen hervorheben. Diverse Tierstudien konnten zudem die Wirksamkeit auf Bindungsverhalten und Schmerzempfinden belegen. Unklar ist allerdings nach wie vor, wie Oxytocin auf das menschliche Schmerzerleben wirkt. Die potenzielle therapeutische Wirksamkeit von Oxytocin könnte für die Primär- und Sekundärversorgung von Schmerzpatienten besonders bedeutsam sein, da es in diesem Bereich verstärkt zu Schmerzchronifizierung kommen kann.

Methoden

Die Datenbanken PubMed, Medline und PsycINFO wurden auf die Begriffe Oxytocin, „pain“, „human“, „analgesic“ durchsucht. Die Suche nach Originalarbeiten ergab insgesamt 89 Artikel, nachdem Studien zu Schmerzen bei Geburt, Stillen und Tierstudien ausgeschlossen worden waren. Es wurden nur Studien eingeschlossen, welche zwischen 1994 und 2015 durchgeführt wurden. Es konnten insgesamt 17 Studien für dieses Review verwendet werden. Davon befassten sich 13 Studien mit der Applikation von Oxytocin und 4 weitere Studien mit der Messung von Oxytocin im Plasma.

Schlussfolgerung

Dieses Review soll einen Überblick über den aktuellen Forschungsstand von Oxytocin und dessen direkten und indirekten Zusammenhang mit dem menschlichen Schmerzerleben geben und die daraus resultierenden Konsequenzen für die multimodale Schmerztherapie hervorheben.
Literatur
1.
Zurück zum Zitat Alfvén G (2004) Plasma oxytocin in children with recurrent abdominal pain. J Pediatr Gastroenterol Nutr 38(5):513–517PubMedCrossRef Alfvén G (2004) Plasma oxytocin in children with recurrent abdominal pain. J Pediatr Gastroenterol Nutr 38(5):513–517PubMedCrossRef
2.
Zurück zum Zitat Alfvén G, de la Torre B, Uvnäs-Moberg K (1994) Depressed concentrations of oxytocin and cortisol in children with recurrent abdominal pain of non-organic origin. Acta Paediatr 83(10):1076–1080PubMedCrossRef Alfvén G, de la Torre B, Uvnäs-Moberg K (1994) Depressed concentrations of oxytocin and cortisol in children with recurrent abdominal pain of non-organic origin. Acta Paediatr 83(10):1076–1080PubMedCrossRef
3.
Zurück zum Zitat Anderberg UM, Uvnäs-Moberg K (2000) Plasma oxytocin levels in female fibromyalgia syndrome patients. Z Rheumatol 59(6):373–379PubMedCrossRef Anderberg UM, Uvnäs-Moberg K (2000) Plasma oxytocin levels in female fibromyalgia syndrome patients. Z Rheumatol 59(6):373–379PubMedCrossRef
4.
Zurück zum Zitat Arletti R, Benelli A, Bertolini A (1993) Influence of oxytocin on nociception and morphine antinociception. Neuropeptides 24(3):125–129PubMedCrossRef Arletti R, Benelli A, Bertolini A (1993) Influence of oxytocin on nociception and morphine antinociception. Neuropeptides 24(3):125–129PubMedCrossRef
5.
Zurück zum Zitat Arletti R, Bertolini A (1987) Oxytocin acts as an antidepressant in two animal models of depression. Life Sci 41(14):1725–1730PubMedCrossRef Arletti R, Bertolini A (1987) Oxytocin acts as an antidepressant in two animal models of depression. Life Sci 41(14):1725–1730PubMedCrossRef
6.
Zurück zum Zitat Beckmann H, Lang RE, Gattaz WF (1985) Vasopressin – oxytocin in cerebrospinal fluid of schizophrenic patients and normal controls. Psychoneuroendocrinology 10(2):187–191PubMedCrossRef Beckmann H, Lang RE, Gattaz WF (1985) Vasopressin – oxytocin in cerebrospinal fluid of schizophrenic patients and normal controls. Psychoneuroendocrinology 10(2):187–191PubMedCrossRef
7.
Zurück zum Zitat Bethlehem RA, van Honk J, Auyeung B, Baron-Cohen S (2013) Oxytocin, brain physiology, and functional connectivity: a review of intranasal oxytocin fMRI studies. Psychoneuroendocrinology 38(7):962–974PubMedCrossRef Bethlehem RA, van Honk J, Auyeung B, Baron-Cohen S (2013) Oxytocin, brain physiology, and functional connectivity: a review of intranasal oxytocin fMRI studies. Psychoneuroendocrinology 38(7):962–974PubMedCrossRef
8.
Zurück zum Zitat Bodnar RJ, Nilaver G, Wallace MM, Badillo-Martinez D, Zimmerman EA (1984) Pain threshold changes in rats following central injection of beta-endorphin, met-enkephalin, vasopressin or oxytocin antisera. Int J Neurosci 24(2):149–160PubMedCrossRef Bodnar RJ, Nilaver G, Wallace MM, Badillo-Martinez D, Zimmerman EA (1984) Pain threshold changes in rats following central injection of beta-endorphin, met-enkephalin, vasopressin or oxytocin antisera. Int J Neurosci 24(2):149–160PubMedCrossRef
9.
Zurück zum Zitat Bouchon M (2010) Low-dose oxytocin stops unexplained ‘burning’ pain in fibromyalgia: a case report Bouchon M (2010) Low-dose oxytocin stops unexplained ‘burning’ pain in fibromyalgia: a case report
10.
Zurück zum Zitat Breton JD, Veinante P, Uhl-Bronner S, Vergnano AM, Freund-Mercier MJ, Schlichter R, Poisbeau P (2008) Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I‑II which amplify GABAergic inhibition. Mol Pain 4:19PubMedPubMedCentralCrossRef Breton JD, Veinante P, Uhl-Bronner S, Vergnano AM, Freund-Mercier MJ, Schlichter R, Poisbeau P (2008) Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I‑II which amplify GABAergic inhibition. Mol Pain 4:19PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R (2013) Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study. Psychoneuroendocrinology 38(3):399–407PubMedCrossRef Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R (2013) Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study. Psychoneuroendocrinology 38(3):399–407PubMedCrossRef
12.
Zurück zum Zitat Carter CS, Grippo AJ, Pournajafi-Nazarloo H, Ruscio MG, Porges SW (2008) Oxytocin, vasopressin and sociality. Prog Brain Res 170:331–336PubMedCrossRef Carter CS, Grippo AJ, Pournajafi-Nazarloo H, Ruscio MG, Porges SW (2008) Oxytocin, vasopressin and sociality. Prog Brain Res 170:331–336PubMedCrossRef
13.
Zurück zum Zitat Crock LW, Kolber BJ, Morgan CD, Sadler KE, Vogt SK, Bruchas MR, Gereau RW (2012) Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain. J Neurosci 32(41):14217–14226PubMedPubMedCentralCrossRef Crock LW, Kolber BJ, Morgan CD, Sadler KE, Vogt SK, Bruchas MR, Gereau RW (2012) Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain. J Neurosci 32(41):14217–14226PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Ditzen B, Schaer M, Gabriel B, Bodenmann G, Ehlert U, Heinrichs M (2009) Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biol Psychiatry 65(9):728–731PubMedCrossRef Ditzen B, Schaer M, Gabriel B, Bodenmann G, Ehlert U, Heinrichs M (2009) Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biol Psychiatry 65(9):728–731PubMedCrossRef
15.
Zurück zum Zitat Eisenach JC, Tong C, Curry R (2015) Phase 1 safety assessment of intrathecal oxytocin. Anesthesiology 122(2):407–413PubMedCrossRef Eisenach JC, Tong C, Curry R (2015) Phase 1 safety assessment of intrathecal oxytocin. Anesthesiology 122(2):407–413PubMedCrossRef
16.
Zurück zum Zitat Eisenberger NI, Way BM, Taylor SE, Welch WT, Lieberman MD (2007) Understanding genetic risk for aggression: clues from the brain’s response to social exclusion. Biol Psychiatry 61(9):1100–1108PubMedCrossRef Eisenberger NI, Way BM, Taylor SE, Welch WT, Lieberman MD (2007) Understanding genetic risk for aggression: clues from the brain’s response to social exclusion. Biol Psychiatry 61(9):1100–1108PubMedCrossRef
17.
Zurück zum Zitat Eliava M, Melchior M, Knobloch-Bollmann S, Wahis J, Da Silva Gouveia M, Tang Y, Ciobano AC, Triana del Rio R et al (2016) A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing. Neuron Accept 89. doi:10.1016/j.neuron.2016.01.041 Eliava M, Melchior M, Knobloch-Bollmann S, Wahis J, Da Silva Gouveia M, Tang Y, Ciobano AC, Triana del Rio R et al (2016) A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing. Neuron Accept 89. doi:10.​1016/​j.​neuron.​2016.​01.​041
18.
Zurück zum Zitat Frasch A, Zetzsche T, Steiger A, Jirikowski GF (1995) Reduction of plasma oxytocin levels in patients suffering from major depression. Adv Exp Med Biol 395:257–258PubMed Frasch A, Zetzsche T, Steiger A, Jirikowski GF (1995) Reduction of plasma oxytocin levels in patients suffering from major depression. Adv Exp Med Biol 395:257–258PubMed
19.
Zurück zum Zitat Ge Y, Lundeberg T, Yu LC (2002) Blockade effect of mu and kappa opioid antagonists on the anti-nociception induced by intra-periaqueductal grey injection of oxytocin in rats. Brain Res 927(2):204–207PubMedCrossRef Ge Y, Lundeberg T, Yu LC (2002) Blockade effect of mu and kappa opioid antagonists on the anti-nociception induced by intra-periaqueductal grey injection of oxytocin in rats. Brain Res 927(2):204–207PubMedCrossRef
20.
21.
Zurück zum Zitat Grewen KM, Light KC, Mechlin B, Girdler SS (2008) Ethnicity is associated with alterations in oxytocin relationships to pain sensitivity in women. Ethn Health 13(3):219–241PubMedPubMedCentralCrossRef Grewen KM, Light KC, Mechlin B, Girdler SS (2008) Ethnicity is associated with alterations in oxytocin relationships to pain sensitivity in women. Ethn Health 13(3):219–241PubMedPubMedCentralCrossRef
22.
Zurück zum Zitat Holt-Lunstad J, Birmingham WC, Light KC (2014) Relationship quality and oxytocin Influence of stable and modifiable aspects of relationships. J Soc Pers Relat 5(23):0265407514536294 Holt-Lunstad J, Birmingham WC, Light KC (2014) Relationship quality and oxytocin Influence of stable and modifiable aspects of relationships. J Soc Pers Relat 5(23):0265407514536294
23.
Zurück zum Zitat Kessner S, Sprenger C, Wrobel N, Wiech K, Bingel U (2013) Effect of oxytocin on placebo analgesia: a randomized study. JAMA 310(16):1733–1735PubMedCrossRef Kessner S, Sprenger C, Wrobel N, Wiech K, Bingel U (2013) Effect of oxytocin on placebo analgesia: a randomized study. JAMA 310(16):1733–1735PubMedCrossRef
24.
Zurück zum Zitat Kirsch P, Esslinger C, Chen Q, Mier D, Lis S, Siddhanti S, Gruppe H, Mattay VS, Gallhofer B, Meyer-Lindenberg A (2005) Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci 25(49):11489–11493PubMedCrossRef Kirsch P, Esslinger C, Chen Q, Mier D, Lis S, Siddhanti S, Gruppe H, Mattay VS, Gallhofer B, Meyer-Lindenberg A (2005) Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci 25(49):11489–11493PubMedCrossRef
25.
Zurück zum Zitat Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E (2005) Oxytocin increases trust in humans. Nature 435(7042):673–676PubMedCrossRef Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E (2005) Oxytocin increases trust in humans. Nature 435(7042):673–676PubMedCrossRef
26.
Zurück zum Zitat Linkowski P, Geenen V, Kerkhofs M, Mendlewicz J, Legros JJ (1984) Cerebrospinal fluid neurophysins in affective illness and in schizophrenia. Eur Arch Psychiatry Neurol Sci 234(3):162–165PubMedCrossRef Linkowski P, Geenen V, Kerkhofs M, Mendlewicz J, Legros JJ (1984) Cerebrospinal fluid neurophysins in affective illness and in schizophrenia. Eur Arch Psychiatry Neurol Sci 234(3):162–165PubMedCrossRef
27.
Zurück zum Zitat Liu W, Song C, Yang J, Lin B, Wang C (1990) Involvement of oxytocin in spinal cord in acupuncture analgesia. Zhen Ci Yan Jiu 15(1):24–29PubMed Liu W, Song C, Yang J, Lin B, Wang C (1990) Involvement of oxytocin in spinal cord in acupuncture analgesia. Zhen Ci Yan Jiu 15(1):24–29PubMed
28.
Zurück zum Zitat Louvel D, Delvaux M, Felez A, Fioramonti J, Bueno L, Lazorthes Y, Frexinos J (1996) Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome. Gut 39(5):741–747PubMedPubMedCentralCrossRef Louvel D, Delvaux M, Felez A, Fioramonti J, Bueno L, Lazorthes Y, Frexinos J (1996) Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome. Gut 39(5):741–747PubMedPubMedCentralCrossRef
29.
Zurück zum Zitat Luppi P, Levi-Montalcini R, Bracci-Laudiero L, Bertolini A, Arletti R, Tavernari D, Vigneti E, Aloe L (1993) NGF is released into plasma during human pregnancy: an oxytocin-mediated response? Neuroreport 4(8):1063–1065PubMedCrossRef Luppi P, Levi-Montalcini R, Bracci-Laudiero L, Bertolini A, Arletti R, Tavernari D, Vigneti E, Aloe L (1993) NGF is released into plasma during human pregnancy: an oxytocin-mediated response? Neuroreport 4(8):1063–1065PubMedCrossRef
30.
Zurück zum Zitat Madrazo I, Franco-Bourland RE, León-Meza VM, Mena I (1987) Intraventricular somatostatin-14, arginine vasopressin, and oxytocin: analgesic effect in a patient with intractable cancer pain. Appl Neurophysiol 50(1–6):427–431PubMed Madrazo I, Franco-Bourland RE, León-Meza VM, Mena I (1987) Intraventricular somatostatin-14, arginine vasopressin, and oxytocin: analgesic effect in a patient with intractable cancer pain. Appl Neurophysiol 50(1–6):427–431PubMed
31.
Zurück zum Zitat Mameli S, Pisanu GM, Sardo S, Marchi A, Pili A, Carboni M, Minerba L, Trincas G, Carta MG, Melis MG, Melis MG (2014) Oxytocin nasal spray in fibromyalgic patients. Rheumatol Int 34(8):1047–1052PubMedCrossRef Mameli S, Pisanu GM, Sardo S, Marchi A, Pili A, Carboni M, Minerba L, Trincas G, Carta MG, Melis MG, Melis MG (2014) Oxytocin nasal spray in fibromyalgic patients. Rheumatol Int 34(8):1047–1052PubMedCrossRef
32.
Zurück zum Zitat Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M (2011) Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci 12(9):524–538PubMedCrossRef Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M (2011) Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci 12(9):524–538PubMedCrossRef
33.
Zurück zum Zitat Millan MJ, Schmauss C, Millan MH, Herz A (1984) Vasopressin and oxytocin in the rat spinal cord: analysis of their role in the control of nociception. Brain Res 309(2):384–388PubMedCrossRef Millan MJ, Schmauss C, Millan MH, Herz A (1984) Vasopressin and oxytocin in the rat spinal cord: analysis of their role in the control of nociception. Brain Res 309(2):384–388PubMedCrossRef
34.
Zurück zum Zitat Neumann ID, Krömer SA, Toschi N, Ebner K (2000) Brain oxytocin inhibits the (re)activity of the hypothalamo-pituitary-adrenal axis in male rats: involvement of hypothalamic and limbic brain regions. Regul Pept 96(1–2):31–38PubMedCrossRef Neumann ID, Krömer SA, Toschi N, Ebner K (2000) Brain oxytocin inhibits the (re)activity of the hypothalamo-pituitary-adrenal axis in male rats: involvement of hypothalamic and limbic brain regions. Regul Pept 96(1–2):31–38PubMedCrossRef
35.
Zurück zum Zitat Ohlsson B, Truedsson M, Bengtsson M, Torstenson R, Sjölund K, Björnsson ES, Simrèn M (2005) Effects of long-term treatment with oxytocin in chronic constipation; a double blind, placebo-controlled pilot trial. Neurogastroenterol Motil 17(5):697–704PubMedCrossRef Ohlsson B, Truedsson M, Bengtsson M, Torstenson R, Sjölund K, Björnsson ES, Simrèn M (2005) Effects of long-term treatment with oxytocin in chronic constipation; a double blind, placebo-controlled pilot trial. Neurogastroenterol Motil 17(5):697–704PubMedCrossRef
36.
Zurück zum Zitat Paloyelis Y, Krahé C, Maltezos S, Williams SC, Howard MA, Fotopoulou A (2016) The analgesic effect of oxytocin in humans: a double-blinded placebo controlled cross-over study using laser-evoked potentials. J Neuroendocrinol 28. doi:10.1111/jne.12347 PubMed Paloyelis Y, Krahé C, Maltezos S, Williams SC, Howard MA, Fotopoulou A (2016) The analgesic effect of oxytocin in humans: a double-blinded placebo controlled cross-over study using laser-evoked potentials. J Neuroendocrinol 28. doi:10.​1111/​jne.​12347 PubMed
37.
Zurück zum Zitat Parker KJ, Buckmaster CL, Schatzberg AF, Lyons DM (2005) Intranasal oxytocin administration attenuates the ACTH stress response in monkeys. Psychoneuroendocrinology 30(9):924–929PubMedCrossRef Parker KJ, Buckmaster CL, Schatzberg AF, Lyons DM (2005) Intranasal oxytocin administration attenuates the ACTH stress response in monkeys. Psychoneuroendocrinology 30(9):924–929PubMedCrossRef
38.
Zurück zum Zitat Petersson M, Alster P, Lundeberg T, Uvnäs-Moberg K (1996) Oxytocin increases nociceptive thresholds in a long-term perspective in female and male rats. Neurosci Lett 212(2):87–90PubMedCrossRef Petersson M, Alster P, Lundeberg T, Uvnäs-Moberg K (1996) Oxytocin increases nociceptive thresholds in a long-term perspective in female and male rats. Neurosci Lett 212(2):87–90PubMedCrossRef
39.
Zurück zum Zitat Petersson M, Hulting AL, Uvnäs-Moberg K (1999) Oxytocin causes a sustained decrease in plasma levels of corticosterone in rats. Neurosci Lett 264(1–3):41–44PubMedCrossRef Petersson M, Hulting AL, Uvnäs-Moberg K (1999) Oxytocin causes a sustained decrease in plasma levels of corticosterone in rats. Neurosci Lett 264(1–3):41–44PubMedCrossRef
40.
Zurück zum Zitat Phillips WJ, Ostrovsky O, Galli RL, Dickey S (2006) Relief of acute migraine headache with intravenous oxytocin: report of two cases. J Pain Palliat Care Pharmacother 20(3):25–28PubMed Phillips WJ, Ostrovsky O, Galli RL, Dickey S (2006) Relief of acute migraine headache with intravenous oxytocin: report of two cases. J Pain Palliat Care Pharmacother 20(3):25–28PubMed
41.
Zurück zum Zitat Quevedo AS, Coghill RC (2007) Attentional modulation of spatial integration of pain: evidence for dynamic spatial tuning. J Neurosci 27(43):11635–11640PubMedCrossRef Quevedo AS, Coghill RC (2007) Attentional modulation of spatial integration of pain: evidence for dynamic spatial tuning. J Neurosci 27(43):11635–11640PubMedCrossRef
42.
Zurück zum Zitat Rash JA, Aguirre-Camacho A, Campbell TS (2014) Oxytocin and pain: a systematic review and synthesis of findings. Clin J Pain 30(5):453–462PubMed Rash JA, Aguirre-Camacho A, Campbell TS (2014) Oxytocin and pain: a systematic review and synthesis of findings. Clin J Pain 30(5):453–462PubMed
43.
Zurück zum Zitat Rash JA, Campbell TS (2014) The effect of intranasal oxytocin administration on acute cold pressor pain: a placebo-controlled, double-blind, within-participants crossover investigation. Psychosom Med 76(6):422–429PubMedCrossRef Rash JA, Campbell TS (2014) The effect of intranasal oxytocin administration on acute cold pressor pain: a placebo-controlled, double-blind, within-participants crossover investigation. Psychosom Med 76(6):422–429PubMedCrossRef
44.
Zurück zum Zitat Reeta K, Mediratta PK, Rathi N, Jain H, Chugh C, Sharma KK (2006) Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice. Regul Pept 135(1–2):85–90PubMedCrossRef Reeta K, Mediratta PK, Rathi N, Jain H, Chugh C, Sharma KK (2006) Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice. Regul Pept 135(1–2):85–90PubMedCrossRef
45.
Zurück zum Zitat Russell JA, Leng G, Bicknell RJ (1995) Opioid tolerance and dependence in the magnocellular oxytocin system: a physiological mechanism? Exp Physiol 80(3):307–340PubMedCrossRef Russell JA, Leng G, Bicknell RJ (1995) Opioid tolerance and dependence in the magnocellular oxytocin system: a physiological mechanism? Exp Physiol 80(3):307–340PubMedCrossRef
46.
Zurück zum Zitat Schandry R (2006) Biologische Psychologie. Beltz, Weinheim Schandry R (2006) Biologische Psychologie. Beltz, Weinheim
47.
Zurück zum Zitat Schorscher-Petcu A, Sotocinal S, Ciura S, Dupré A, Ritchie J, Sorge RE, Crawley JN, Hu SB, Nishimori K, Young LJ et al (2010) Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1 A receptor in the mouse. J Neurosci 30(24):8274–8284PubMedPubMedCentralCrossRef Schorscher-Petcu A, Sotocinal S, Ciura S, Dupré A, Ritchie J, Sorge RE, Crawley JN, Hu SB, Nishimori K, Young LJ et al (2010) Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1 A receptor in the mouse. J Neurosci 30(24):8274–8284PubMedPubMedCentralCrossRef
48.
Zurück zum Zitat Singer T, Snozzi R, Bird G, Petrovic P, Silani G, Heinrichs M, Dolan RJ (2008) Effects of oxytocin and prosocial behavior on brain responses to direct and vicariously experienced pain. Emotion 8(6):781–791PubMedPubMedCentralCrossRef Singer T, Snozzi R, Bird G, Petrovic P, Silani G, Heinrichs M, Dolan RJ (2008) Effects of oxytocin and prosocial behavior on brain responses to direct and vicariously experienced pain. Emotion 8(6):781–791PubMedPubMedCentralCrossRef
49.
Zurück zum Zitat Tracy LM, Georgiou-Karistianis N, Gibson SJ, Giummarra MJ (2015) Oxytocin and the modulation of pain experience: implications for chronic pain management. Neurosci Biobehav Rev 55:53–67PubMedCrossRef Tracy LM, Georgiou-Karistianis N, Gibson SJ, Giummarra MJ (2015) Oxytocin and the modulation of pain experience: implications for chronic pain management. Neurosci Biobehav Rev 55:53–67PubMedCrossRef
50.
Zurück zum Zitat Uvnäs-Moberg K, Alster P, Petersson M, Sohlström A, Björkstrand E (1998) Postnatal oxytocin injections cause sustained weight gain and increased nociceptive thresholds in male and female rats. Pediatr Res 43(3):344–348PubMedCrossRef Uvnäs-Moberg K, Alster P, Petersson M, Sohlström A, Björkstrand E (1998) Postnatal oxytocin injections cause sustained weight gain and increased nociceptive thresholds in male and female rats. Pediatr Res 43(3):344–348PubMedCrossRef
51.
Zurück zum Zitat Uvnäs-Moberg K, Bruzelius G, Alster P, Lundeberg T (1993) The antinociceptive effect of non-noxious sensory stimulation is mediated partly through oxytocinergic mechanisms. Acta Physiol Scand 149(2):199–204PubMedCrossRef Uvnäs-Moberg K, Bruzelius G, Alster P, Lundeberg T (1993) The antinociceptive effect of non-noxious sensory stimulation is mediated partly through oxytocinergic mechanisms. Acta Physiol Scand 149(2):199–204PubMedCrossRef
52.
Zurück zum Zitat Uvnäs-Moberg K, Eklund M, Hillegaart V, Ahlenius S (2000) Improved conditioned avoidance learning by oxytocin administration in high-emotional male Sprague-Dawley rats. Regul Pept 88(1–3):27–32PubMedCrossRef Uvnäs-Moberg K, Eklund M, Hillegaart V, Ahlenius S (2000) Improved conditioned avoidance learning by oxytocin administration in high-emotional male Sprague-Dawley rats. Regul Pept 88(1–3):27–32PubMedCrossRef
53.
Zurück zum Zitat Uvnas-Moberg K, Petersson M (2005) Oxytocin, a mediator of anti-stress, well-being, social interaction, growth and healing. Z Psychosom Med Psychother 51(1):57–80PubMed Uvnas-Moberg K, Petersson M (2005) Oxytocin, a mediator of anti-stress, well-being, social interaction, growth and healing. Z Psychosom Med Psychother 51(1):57–80PubMed
54.
Zurück zum Zitat Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E et al (2010) REVIEW: Oxytocin: crossing the bridge between basic science and pharmacotherapy. CNS Neurosci Ther 16(5:e138–56CrossRef Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E et al (2010) REVIEW: Oxytocin: crossing the bridge between basic science and pharmacotherapy. CNS Neurosci Ther 16(5:e138–56CrossRef
55.
Zurück zum Zitat Wang YL, Yuan Y, Yang J, Wang CH, Pan YJ, Lu L, Wu YQ, Wang DX, Lv LX, Li RR et al (2013) The interaction between the oxytocin and pain modulation in headache patients. Neuropeptides 47(2):93–97PubMedCrossRef Wang YL, Yuan Y, Yang J, Wang CH, Pan YJ, Lu L, Wu YQ, Wang DX, Lv LX, Li RR et al (2013) The interaction between the oxytocin and pain modulation in headache patients. Neuropeptides 47(2):93–97PubMedCrossRef
56.
Zurück zum Zitat Windle RJ, Shanks N, Lightman SL, Ingram CD (1997) Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats. Endocrinology 138(7):2829–2834PubMed Windle RJ, Shanks N, Lightman SL, Ingram CD (1997) Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats. Endocrinology 138(7):2829–2834PubMed
57.
Zurück zum Zitat Yang J (1994) Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system. Spine 19(8):867–871PubMedCrossRef Yang J (1994) Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system. Spine 19(8):867–871PubMedCrossRef
58.
Zurück zum Zitat Yang J, Li P, Liang JY, Pan YJ, Yan XQ, Yan FL, Hao F, Zhang XY, Zhang J, Zhang J, Zhang J (2011) Oxytocin in the periaqueductal grey regulates nociception in the rat. Regul Pept 169(1–3):39–42PubMedCrossRef Yang J, Li P, Liang JY, Pan YJ, Yan XQ, Yan FL, Hao F, Zhang XY, Zhang J, Zhang J, Zhang J (2011) Oxytocin in the periaqueductal grey regulates nociception in the rat. Regul Pept 169(1–3):39–42PubMedCrossRef
59.
60.
Zurück zum Zitat Yunus MB, Ahles TA, Aldag JC, Masi AT (1991) Relationship of clinical features with psychological status in primary fibromyalgia. Arthritis Rheum 34(1):15–21PubMedCrossRef Yunus MB, Ahles TA, Aldag JC, Masi AT (1991) Relationship of clinical features with psychological status in primary fibromyalgia. Arthritis Rheum 34(1):15–21PubMedCrossRef
61.
Zurück zum Zitat Zunhammer M, Geis S, Busch V, Greenlee MW, Eichhammer P (2015) Effects of intranasal oxytocin on thermal pain in healthy men: a randomized functional magnetic resonance imaging study. Psychosom Med 77(2):156–166PubMedCrossRef Zunhammer M, Geis S, Busch V, Greenlee MW, Eichhammer P (2015) Effects of intranasal oxytocin on thermal pain in healthy men: a randomized functional magnetic resonance imaging study. Psychosom Med 77(2):156–166PubMedCrossRef
Metadaten
Titel
Wirkung von Oxytocin auf das menschliche Schmerzerleben
verfasst von
A.-C. Pfeifer
B. Ditzen
E. Neubauer
M. Schiltenwolf
Publikationsdatum
28.09.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Der Schmerz / Ausgabe 5/2016
Print ISSN: 0932-433X
Elektronische ISSN: 1432-2129
DOI
https://doi.org/10.1007/s00482-016-0164-z

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