Skip to main content

30.06.2017 | Original Research | Ausgabe 6/2017 Open Access

Journal of Genetic Counseling 6/2017

Women’s Experience with Non-Invasive Prenatal Testing and Emotional Well-being and Satisfaction after Test-Results

Journal of Genetic Counseling > Ausgabe 6/2017
Rachèl V. van Schendel, G. C. M. Lieve Page-Christiaens, Lean Beulen, Caterina M. Bilardo, Marjon A. de Boer, Audrey B. C. Coumans, Brigitte H. W. Faas, Irene M. van Langen, Klaske D. Lichtenbelt, Merel C. van Maarle, Merryn V. E. Macville, Dick Oepkes, Eva Pajkrt, Lidewij Henneman, for the Dutch NIPT Consortium
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s10897-017-0118-3) contains supplementary material, which is available to authorized users.


Increasingly, high-risk pregnant women opt for non-invasive prenatal testing (NIPT) instead of invasive diagnostic testing. Since NIPT is less accurate than invasive testing, a normal NIPT result might leave women less reassured. A questionnaire study was performed among pregnant women with elevated risk for fetal aneuploidy based on first-trimester combined test (risk ≥1:200) or medical history, who were offered NIPT in the nationwide Dutch TRIDENT study. Pre- and post-test questionnaires (n = 682) included measures on: experiences with NIPT procedure, feelings of reassurance, anxiety (State-Trait Anxiety Inventory, STAI), child-related anxiety (PRAQ-R), and satisfaction. The majority (96.1%) were glad to have been offered NIPT. Most (68.5%) perceived the waiting time for NIPT results (mean: 15 days, range 5–32) as (much) too long. Most women with a normal NIPT result felt reassured (80.9%) or somewhat reassured (15.7%). Levels of anxiety and child-related anxiety were significantly lower after receiving a normal NIPT result as compared to the moment of intake (p < 0.001). Women with inadequate health literacy or a medical history (e.g. previous child with trisomy) experienced significantly higher post-test-result anxiety (Mean (M) STAI = 31.6 and 30.0, respectively) compared to those with adequate health literacy (M = 28.6) and no medical history (M = 28.6), indicating these women might benefit from extra information and/or guidance when communicating NIPT test-results. Introducing NIPT as an alternative to invasive testing, led to an offer that satisfied and largely reassured high-risk pregnant women.

Unsere Produktempfehlungen

e.Med Interdisziplinär


Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Nicht verpassen: e.Med bis 13. März 2019 100€ günstiger im ersten Jahr!

ESM 1 (DOCX 21 kb)
Über diesen Artikel

Weitere Artikel der Ausgabe 6/2017

Journal of Genetic Counseling 6/2017 Zur Ausgabe