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Current Dermatology Reports

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25.10.2018 | Wound Care and Healing (H Lev-Tov, Section Editor)

Wound Healing with Botanicals: a Review and Future Perspectives

verfasst von: Cassandra L. Quave

Erschienen in: Current Dermatology Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

Botanicals have long played a crucial role in the management of chronic and infected wounds, yet the mechanistic basis of these therapies remains largely poorly understood by modern science.

Recent Findings

Studies have begun to unveil the mechanistic bases of botanical therapies for wound healing, but more work is necessary. Most notably, investigation into the growing conditions, post-harvest treatment, and pharmacological preparation of these botanicals has demonstrated their importance in terms of the chemical makeup and pharmacological activity of the final product used in pre-clinical and clinical studies.

Summary

This work evaluates the potential safety, efficacy, and mechanistic basis of some key botanical ingredients used in traditional medicine for wound care: aloe, marigold, and St. John’s Wort. Furthermore, perspectives on the future role that botanical natural products may play in anti-infective and wound care, innovations are explored.

Pazyar N, Yaghoobi R, Rafiee E, Mehrabian A, Feily A. Skin wound healing and phytomedicine: a review. Skin Pharmacol Physiol. 2014;27(6):303–10.CrossRef

Willis KJ. State of the World’s plants report. London, England: Royal Botanic Gardens, Kew; 2017.

The Plant List Version 1.1. Published on the Internet. 2013. http://www.theplantlist.org/. Accessed September 9 2018.

Stevens PF. Angiosperm Phylogeny Website, version 14. 2001 Onwards. http://www.mobot.org/MOBOT/research/APweb/. Accessed September 10 2018.

Carter S, Newton LE, Lavranos JJ, Walker CC. Aloes: the definitive guide. London: Royal Botanic Gardens, Kew; 2011.

Ross IA. Medicinal plants of the world: chemical constituents, traditional, and modern medicinal uses. Humana Press; 1999.

Femenia A, Sánchez ES, Simal S, Rosselló C. Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydr Polym. 1999;39(2):109–17. https://doi.org/10.1016/S0144-8617(98)00163-5.CrossRef

Tizard IR, Ni Y. Carbohydrates, immune stimulating. In: Delves PJ, editor. Encyclopedia of immunology. Second ed. Oxford: Elsevier; 1998. p. 427–31.CrossRef

Wamer WG, Vath P, Falvey DE. In vitro studies on the photobiological properties of aloe emodin and aloin a. Free Radic Biol Med. 2003;34(2):233–42.CrossRef

10.

•• Minjares-Fuentes R, Femenia A, Comas-Serra F, Rodríguez-González VM. Compositional and structural features of the main bioactive polysaccharides present in the Aloe vera plant. J AOAC Int. 2018;101. Doi:https://doi.org/10.5740/jaoacint.18-0119. This study examines the variability in compositional features of Aloe vera gel and provides a chemical explanation for differences in the pharmacology of aloe shown in the literature. CrossRef

11.

Teplicki E, Ma Q, Castillo DE, Zarei M, Hustad AP, Chen J, et al. The effects of Aloe vera on wound healing in cell proliferation, migration, and viability. Wounds. 2018;30(9):263–8.

12.

Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C. The efficacy of aloe vera used for burn wound healing: a systematic review. Burns: J Int Soc Burn Injuries. 2007;33(6):713–8. https://doi.org/10.1016/j.burns.2006.10.384.CrossRef

13.

Cuttle L, Kempf M, Kravchuk O, George N, Liu PY, Chang HE, et al. The efficacy of Aloe vera, tea tree oil and saliva as first aid treatment for partial thickness burn injuries. Burns: J Int Soc Burn Injuries. 2008;34(8):1176–82. https://doi.org/10.1016/j.burns.2008.03.012.CrossRef

14.

• Sari Y, Purnawan I, Kurniawan DW, Sutrisna E. A comparative study of the effects of Nigella sativa oil gel and Aloe vera gel on wound healing in diabetic rRats. J Evidence-based Integr Med. 2018;23:2515690X18772804. https://doi.org/10.1177/2515690X18772804 This study examines two popular traditional medicines for wound care and offers comparative insight into the efficacy of Aloe vera over that of another botanical. CrossRef

15.

Rodrigues LO, de Oliveira ACL, Tabrez S, Shakil S, Khan MI, Asghar MN, et al. Mutagenic, antioxidant and wound healing properties of Aloe vera. J Ethnopharmacol. 2018;227:191–7. https://doi.org/10.1016/j.jep.2018.08.034.CrossRefPubMed

16.

• Woeller Collynn F, Woodroof A, Cottler Patrick S, Pollock Stephen J, Haidaris Constantine G, Phipps RP. In vitro characterization of variable porosity wound dressing with anti-scar properties. Eplasty. 2018;18:e21 This study offers an interesting perspective on the incorporation of botanicals into medical devices for the promotion of wound healing. PubMedPubMedCentral

17.

Coelho FH, Salvadori G, Rados PV, Magnusson A, Danilevicz CK, Meurer L, et al. Topical Aloe vera (Aloe barbadensis Miller) extract does not accelerate the oral wound healing in rats. Phytother Res. 2015;29(7):1102–5. https://doi.org/10.1002/ptr.5352.CrossRefPubMed

18.

Dat AD, Poon F, Pham KBT, Doust J. Aloe vera for treating acute and chronic wounds. Cochrane Database Syst Rev 2012(2). doi:https://doi.org/10.1002/14651858.CD008762.pub2.

19.

Korac RR, Khambholja KM. Potential of herbs in skin protection from ultraviolet radiation. Pharm Rev. 2011;5(10):164–73. https://doi.org/10.4103/0973-7847.91114.CrossRef

20.

Lloyd EC, Rodgers BC, Michener M, Williams MS. Outpatient burns: prevention and care. Am Fam Physician. 2012;85(1):25–32.PubMed

21.

Burusapat C, Supawan M, Pruksapong C, Pitiseree A, Suwantemee C. Topical Aloe vera gel for accelerated wound healing of split-thickness skin graft donor sites: a double-blind, randomized, controlled trial and systematic review. Plast Reconstr Surg. 2018;142(1):217–26.CrossRef

22.

Basch E, Bent S, Foppa I, Haskmi S, Kroll D, Mele M, et al. Marigold (Calendula officinalis L.): an evidence-based systematic review by the natural standard research collaboration. J Herb Pharmacother. 2006;6(3/4):135–59. https://doi.org/10.1300/J157v06n03-08.

23.

Khalid KA, da Silva JAT. Biology of Calendula officinalis Linn.: focus on pharmacology, biological activities and agronomic practices. Medicinal and Aromatic Plant Sci Biotechnol. 2012;6(1):12–27.

24.

De Feo V, Aquino R, Menghini A, Ramundo E, Senatore F. Traditional phytotherapy in the Peninsula Sorrentina, Campania, southern Italy. J Ethnopharmacol. 1992;36(2):113–25. https://doi.org/10.1016/0378-8741(92)90010-O.CrossRefPubMed

25.

Neves JM, Matos C, Moutinho C, Queiroz G, Gomes LR. Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal). J Ethnopharmacol. 2009;124(2):270–83. https://doi.org/10.1016/j.jep.2009.04.041.CrossRefPubMed

26.

• Jarić S, Kostić O, Mataruga Z, Pavlović D, Pavlović M, Mitrović M, et al. Traditional wound-healing plants used in the Balkan region (Southeast Europe). J Ethnopharmacol. 2018;211:311–28. https://doi.org/10.1016/j.jep.2017.09.018 This is a literature review of 128 plant species used in traditional remedies for wound healing in the Balkans. It highlights the medicinal applications of Calendula officinalis and Hypericum perforatum for these purposes. CrossRefPubMed

27.

Mustafa B, Hajdari A, Krasniqi F, Hoxha E, Ademi H, Quave CL, et al. Medical ethnobotany of the Albanian Alps in Kosovo. J Ethnobiol Ethnomed. 2012;8:6. https://doi.org/10.1186/1746-4269-8-6.CrossRefPubMedPubMedCentral

28.

Mustafa B, Hajdari A, Pieroni A, Pulaj B, Koro X, Quave CL. A cross-cultural comparison of folk plant uses among Albanians, Bosniaks, Gorani and Turks living in south Kosovo. J Ethnobiol Ethnomed. 2015;11:39. https://doi.org/10.1186/s13002-015-0023-5.CrossRefPubMedPubMedCentral

29.

Jarić S, Popović Z, Mačukanović-Jocić M, Djurdjević L, Mijatović M, Karadžić B, et al. An ethnobotanical study on the usage of wild medicinal herbs from Kopaonik Mountain (Central Serbia). J Ethnopharmacol. 2007;111(1):160–75. https://doi.org/10.1016/j.jep.2006.11.007.CrossRefPubMed

30.

Lans C, Turner N, Khan T, Brauer G, Boepple W. Ethnoveterinary medicines used for ruminants in British Columbia. Can J Ethnobiol Ethnomed. 2007;3(1):11.CrossRef

31.

Muley B, Khadabadi S, Banarase N. Phytochemical constituents and pharmacological activities of Calendula officinalis Linn (Asteraceae): a review. Tropical J Pharmaceutical Res. 2009;8(5).

32.

Zitterl-Eglseer K, Sosa S, Jurenitsch J, Schubert-Zsilavecz M, Della Loggia R, Tubaro A, et al. Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.). J Ethnopharmacol. 1997;57(2):139–44. https://doi.org/10.1016/S0378-8741(97)00061-5.CrossRefPubMed

33.

Preethi KC, Kuttan G, Kuttan R. Anti-inflammatory activity of flower extract of Calendula officinalis Linn. And its possible mechanism of action. Indian J Exp Biol. 2009;47(2):113–20.PubMed

34.

Naeini A, Miri R, Shafiei N, Tabandeh M, Oryan A, Nazifi S. Effects of topical application of Calendula officinalis gel on collagen and hydroxyproline content of skin in rats. Comp Clin Pathol. 2012;21(3):253–7. https://doi.org/10.1007/s00580-010-1087-1.CrossRef

35.

Efstratiou E, Hussain AI, Nigam PS, Moore JE, Ayub MA, Rao JR. Antimicrobial activity of Calendula officinalis petal extracts against fungi, as well as Gram-negative and Gram-positive clinical pathogens. Complement Ther Clin Pract. 2012;18(3):173–6. https://doi.org/10.1016/j.ctcp.2012.02.003.CrossRefPubMed

36.

•• Nicolaus C, Junghanns S, Hartmann A, Murillo R, Ganzera M, Merfort I. In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts. J Ethnopharmacol. 2017;196:94–103. https://doi.org/10.1016/j.jep.2016.12.006 This study provides details on a useful model for in vitro evaluation of botanical extracts for potential mechanisms of wound healing. CrossRefPubMed

37.

•• Buzzi M, de Freitas F, Winter M. A prospective, descriptive study to assess the clinical benefits of using Calendula officinalis hydroglycolic extract for the topical treatment of diabetic foot ulcers. Ostomy Wound Manage. 2016;62(3):8–24 This study demonstrates promising data on the topical spray application of C. officinalis extracts in diabetic foot ulcers. In addition to observations of wound closure in many patients, there was also a reduction in odorous wounds. PubMed

38.

Panahi Y, Sharif MR, Sharif A, Beiraghdar F, Zahiri Z, Amirchoopani G, et al. A randomized comparative trial on the therapeutic efficacy of topical Aloe vera and Calendula officinalis on diaper dermatitis in children. Sci World J. 2012;2012:810234–5. https://doi.org/10.1100/2012/810234.

39.

Bolderston A, Lloyd NS, Wong RKS, Holden L, Robb-Blenderman L. Supportive Care Guidelines Group of Cancer Care Ontario Program in Evidence-based Care. The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline. Support Care Cancer. 2006;14(8):802. https://doi.org/10.1007/s00520-006-0063-4.CrossRefPubMed

40.

HMPC. Community Herbal Monograpg on Calendula officinalis L., flos. Committee on Herbal Medicinal Products (HMPC), European Medicines Agency. 2008.

41.

Reider N, Komericki P, Hausen BM, Fritsch P, Aberer W. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis. 2001;45(5):269–72. https://doi.org/10.1034/j.1600-0536.2001.450503.x.CrossRefPubMed

42.

Mattalia G, Quave CL, Pieroni A. Traditional uses of wild food and medicinal plants among Brigasc, Kyé, and Provençal communities on the Western Italian Alps. Genet Resour Crop Evol. 2013;60(2):587–603. https://doi.org/10.1007/s10722-012-9859-x.CrossRef

43.

Kültür S. Medicinal plants used in Kırklareli Province (Turkey). J Ethnopharmacol. 2007;111(2).CrossRef

44.

Savikin K, Zdunic G, Menkovic N, Zivkovic J, Cujic N, Terescenko M, et al. Ethnobotanical study on traditional use of medicinal plants in South-Western Serbia. Zlatibor District J Ethnopharmacol. 2013;146(3):803–10. https://doi.org/10.1016/j.jep.2013.02.006.CrossRefPubMed

45.

Redžić SS. The ecological aspect of ethnobotany and ethnopharmacology of population in Bosnia and Herzegovina. Collegium Antropologicum. 2007;3:869–90.

46.

Šarić-Kundalić B, Fritz E, Dobeš C, Saukel J. Traditional medicine in the pristine village of Prokoško Lake on Vranica Mountain, Bosnia and Herzegovina. Scientia Pharmaceutica. 2010;78(2):275–90. https://doi.org/10.3797/scipharm.1003-06.CrossRefPubMedCentral

47.

Mustafa B, Hajdari A, Pajazita Q, Syla B, Quave CL, Pieroni A. An ethnobotanical survey of the Gollak region. Kosovo Genet Resour Crop Evol. 2012;59(5):739–54. https://doi.org/10.1007/s10722-011-9715-4.CrossRef

48.

Yeşilada E, Honda G, Sezik E, Tabata M, Goto K, Ikeshiro Y. Traditional medicine in Turkey IV. Folk medicine in the Mediterranean subdivision. J Ethnopharmacol. 1993;39(1):31–8. https://doi.org/10.1016/0378-8741(93)90048-A.CrossRefPubMed

49.

Sezik E, Yeşilada E, Honda G, Takaishi Y, Takeda Y, Tanaka T. Traditional medicine in Turkey X. Folk medicine in Central Anatolia. J Ethnopharmacol. 2001;75(2):95–115. https://doi.org/10.1016/S0378-8741(00)00399-8.CrossRefPubMed

50.

Hölzl J, Petersen M. Chemical constituents of Hypericum species. In: Ernst E, editor. Hypericum: the genus Hypericum. New York: Taylor & Francis; 2003. p. 77–93.

51.

Crockett SL, Poller B, Tabanca N, Pferschy-Wenzig E-M, Kunert O, Wedge DE, et al. Bioactive xanthones from the roots of Hypericum perforatum (common St John’s wort). J Sci Food Agric. 2011;91(3):428–34. https://doi.org/10.1002/jsfa.4202.CrossRef

52.

Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE. Hyperforin as a possible antidepressant component of Hypericum extracts. Life Sci. 1998;63(6):499–510. https://doi.org/10.1016/S0024-3205(98)00299-9.CrossRefPubMed

53.

•• Lyles JT, Kim A, Nelson K, Bullard-Roberts AL, Hajdari A, Mustafa B, et al. The chemical and antibacterial evaluation of St. John’s Wort oil macerates used in Kosovar traditional medicine. Front Microbiol. 2017;8:1639. https://doi.org/10.3389/fmicb.2017.01639 This study provides a detailed look at the differences in the chemical makeup and biological activity of St. John’s Wort extracts, highlighting the important role that extraction methodologies can have on study outcomes. CrossRefPubMedPubMedCentral

54.

Gunpinar S, Kilic OA, Duran I, Tosun M, Firat T, Soyler G. Evaluation of the effect of topical Hypericum perforatum oil on excisional palatal wound healing in rabbits. J Investig Surg. 2018:1–10. https://doi.org/10.1080/08941939.2018.1474980.

55.

Altıparmak M, Eskitaşçıoğlu T. Comparison of systemic and topical Hypericum perforatum on diabetic surgical wounds. J Investig Surg. 2018;31(1):29–37. https://doi.org/10.1080/08941939.2016.1272654.CrossRef

56.

• Güneş S, Tıhmınlıoğlu F. Hypericum perforatum incorporated chitosan films as potential bioactive wound dressing material. Int J Biol Macromol. 2017;102:933–43. https://doi.org/10.1016/j.ijbiomac.2017.04.080 This study demonstrates how botanical ingredients can be incorporated into wound dressings and evaluated both for antimicrobial and human cytotoxicity in vitro. CrossRefPubMed

57.

Wölfle U, Seelinger G, Schempp CM. Topical application of St. John’s wort (Hypericum perforatum). Planta Med. 2014;80(02/03):109–20. https://doi.org/10.1055/s-0033-1351019.CrossRefPubMed

58.

Yücel A, Kan Y, Yesilada E, Akın O. Effect of St.John’s wort (Hypericum perforatum) oily extract for the care and treatment of pressure sores; a case report. J Ethnopharmacol. 2017;196:236–41. https://doi.org/10.1016/j.jep.2016.12.030.CrossRefPubMed

59.

Schempp CM, Winghofer B, Lüdtke R, Simon-Haarhaus B, Schöpf E, Simon JC. Topical application of St John’s wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells. Br J Dermatol. 2002;142(5):979–84. https://doi.org/10.1046/j.1365-2133.2000.03482.x.CrossRef

60.

Lavagna SM, Secci D, Chimenti P, Bonsignore L, Ottaviani A, Bizzarri B. Efficacy of Hypericum and Calendula oils in the epithelial reconstruction of surgical wounds in childbirth with caesarean section Il. Farmaco. 2001;56(5):451–3. https://doi.org/10.1016/S0014-827X(01)01060-6.CrossRefPubMed

61.

Kamuhabwa A, Roelandts R, Witte P. Skin photosensitization with topical hypericin in hairless mice. J Photochem Photobiol B. 1998;53:110–4.CrossRef

62.

Davids LM, Kleemann B, Kacerovska D, Pizinger K, Kidson SH. Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. J Photochem Photobiol B. 2008;91(2–3):67–76. https://doi.org/10.1016/j.jphotobiol.2008.01.011.CrossRefPubMed

Titel: Wound Healing with Botanicals: a Review and Future Perspectives
verfasst von: Cassandra L. Quave
Publikationsdatum: 25.10.2018
Verlag: Springer US
Erschienen in: Current Dermatology Reports / Ausgabe 4/2018
Elektronische ISSN: 2162-4933
DOI: https://doi.org/10.1007/s13671-018-0247-4

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Wound Healing with Botanicals: a Review and Future Perspectives

Abstract

Purpose of Review

Recent Findings

Summary

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