Erschienen in:
13.05.2019 | IM - COMMENTARY
Xanthine oxidase inhibitors in elderly patients with heart failure: useful or useless?
verfasst von:
Vivianne Presta, Barbara Citoni, Giuliano Tocci
Erschienen in:
Internal and Emergency Medicine
|
Ausgabe 6/2019
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Excerpt
Elevated serum uric acid levels have been progressively emerged as a powerful and independent risk factor for many cardiovascular diseases, including hypertension [
1,
2], coronary artery disease [
3,
4], stroke [
5,
6] and congestive heart failure [
7‐
9]. It has been also reported strong, positive and independent correlations between high-serum levels of uric acid and metabolic abnormalities, including hypercholesterolemia, atherogenic dyslipidaemia, obesity, metabolic syndrome, and diabetes [
10,
11]. Additionally, high serum uric acid levels are able to predict progression from end-stage renal and heart failure and they have been related to worsen prognosis and increased risk of cardiovascular death in many observational studies [
12]. On the other hand, several reports have demonstrated that reducing levels of serum uric acid levels with xanthine oxidase inhibitors was associated with better prognosis and improved event-free survival rate in different cardiovascular settings, including hypertension [
13,
14], coronary artery disease [
15,
16], and even congestive heart failure. On the basis of these consideration, high-serum levels of uric acid should never be neglected or ignored, independently by the clinical context or the clinical condition in which they are observed [
17]. …
