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01.12.2012 | Case report | Ausgabe 1/2012 Open Access

Journal of Medical Case Reports 1/2012

Xanthogranuloma of the intrasellar region presenting in pituitary dysfunction: a case report

Journal of Medical Case Reports > Ausgabe 1/2012
Takamasa Nishiuchi, Koji Murao, Hitomi Imachi, Yoshio Kushida, Reiji Haba, Nobuyuki Kawai, Takashi Tamiya, Toshihiko Ishida
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-6-119) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

TN and KM was major contributor to the writing of the manuscript. TN, KM, HI and TI analyzed and interpreted the patient data regarding endocrinological disease. YK and RH performed the histological examination of the xanthogranuloma. NK and TT performed neurosurgery on the patient. All authors read and approved the final manuscript.


Intracranial xanthogranulomas arise most commonly in the choroid plexus, almost uniformly in the trigone of the lateral ventricle, whereas xanthogranulomas of the sellar region are quite rare [1]. In some cases, a significant degree of overlap in these features occurs, and many xanthogranulomas of the sellar region may have been incorrectly identified as craniopharyngiomas. One study found that 37 craniopharyngiomas (33.6%) consisted predominantly of a xanthogranulomatous component [2]. Xanthogranulomas, also known as cholesterol granulomas, are granulomatous lesions characterized by cholesterol clefts, hemosiderin deposits, multi-nucleated foreign body giant cells, foamy macrophage accumulation and fibrous proliferation [26]. It is not clear, however, whether these additional characteristics represent a distinct entity, given the greater number of characteristics that xanthogranulomas share with craniopharyngiomas. Because the diagnosis depends on surgical intervention, the natural history of xanthogranulomas is unknown. Therefore, it is difficult to diagnose them preoperatively. Furthermore, when xanthogranuloma components predominate in the lesion, differential diagnosis of various lesions with xanthogranuloma is difficult [7, 8]. Additionally, no typical radiological signs exist for xanthogranulomas [9]. Differentiation of cystic mass lesions of the sellar and parasellar regions may pose a diagnostic dilemma for neurosurgeons, radiologists and pathologists involved in treating patients with these entities. Establishing an accurate working diagnosis for sellar region pathology or histology is critical in predicting the likelihood of lesion recurrence and guiding postoperative adjunctive management. Therefore, further reports are required so that clinicians can gain greater insight into the clinical course, management and associated outcome of xanthogranuloma. Herein we report the case of a patient with pituitary dysfunction caused by xanthogranuloma of the intrasellar region.

Case presentation

A 47-year-old man of Japanese origin presented with a history of headache, general fatigue and appetite loss of 3 months' duration. He was 178.2 cm in height and weighed 57 kg. His blood pressure was 90/50 mmHg, and his pulse was 64 beats/minute. His clinical examination showed the patient to be alert with initial signs of upper-visual-field defects. His physical examination revealed no absence of axillary or pubic hair and no neurological abnormalities. The results of the initial laboratory examinations conducted to determine hormone status are presented in Table 1. The anterior pituitary provocation test with corticotropin-releasing hormone, growth hormone-releasing hormone, gonadotropin-releasing hormone and thyrotropin-releasing hormone revealed impairment or low response of the secretory functions of cortisol, adrenocorticotropin, growth hormone, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone and prolactin (Table 2). These abnormal responses to hormone stimulation, along with the patient's hormonal status, were indicative of hypopituitarism, specifically, hypogonadotropic hypogonadism.
Table 1
Laboratory data of the patienta
Laboratory data
Normal range
ACTH (pg/ml)
4 to 48
Prolactin (ng/ml)
0 to 10
GH (ng/ml)
0 to 5
IGF-I (ng/ml)
264 to 542
TSH (μIU/ml)
0.3 to 5.0
ADH (pg/ml)
0.3 to 4.2
LH (mIU/ml)
> 0.5
FSH (mIU/ml)
> 1.0
Testosterone (ng/dl)
< 70
330 to 740
Cortisol (μg/dl)
5 to 17.9
F-T4 (ng/dl)
0.97 to 1.69
White blood cells (cells/μl)
4700 to 8700
Red blood cells (×104/μl)
400 to 540
Hemoglobin (g/dl)
13 to 17
LDH (U/l)
90 to 280
GOT (U/l)
8 to 40
4 to 40
Na+ (mEq/L)
135 to 145
K+ (mEq/L)
3.5 to 5.0
Cl (mEq/L)
98 to 108
Ca2+ (mg/dl)
8.5 to 10.0
Glucose (mg/dl)
65 to 110
Plasma osmolality (mOsm/kg H2O)
284 to 294
Urine osmolality (mOsm/kg H2O)
200 to 900
Urine 17-OHCS (mg/day)
3 to 9
Urine 17-KS (mg/day)
3 to 11
aLaboratory data are from initial evaluation. ACTH, adrenocorticotropin; GH, growth hormone; IGF-I, insulin-like growth factor I; TSH, thyroid-stimulating hormone; ADH,; LH, luteinizing hormone; FSH, follicle-stimulating hormone; F-T4, free thyroxine; LDH, lactate dehydrogenase; GOT, glutamic oxaloacetic transaminase; GPT, glutamic pyruvic transaminase; 17-OHCS, 17-hyroxycorticosteroid; 17-KS, 17-ketosteroid.
Table 2
Results of the anterior pituitary provocation test; adrenocorticotropic hormone and cortisol response for corticotropin-releasing hormone stimulation, growth hormone response for growth hormone-releasing hormone stimulation, luteinizing hormone and follicle-stimulating hormone response for gonadotropin-releasing hormone stimulationa
0 minutes
30 minutes
60 minutes
90 minutes
TSH (μIU/ml)
PRL (ng/ml)
ACTH (pg/ml)
Cortisol (μg/dl)
GH (ng/ml)
LH (mIU/L)
aTSH: thyroid-stimulating hormone, PRL: prolactin, ACTH: adrenocorticotropic hormone, GH: growth hormone, LH: luteinizing hormone, FSH: follicle-stimulating hormone.
MRI showed a clearly defined, intra- and suprasellar lesions with a diameter of 12 × 18 × 15 mm. The lesion appeared as mainly isointense to gray matter with some hyperintense areas and showed inhomogeneous contrast enhancement in the T1-weighted images (Figures 1A and 1B). The mass was also heterogeneously iso- or hypointense on T2-weighted images (Figure 1C).
On the basis of the above-mentioned examinations, our preoperative diagnosis was Rathke's cleft cyst (RCC) or non-functioning pituitary adenoma associated with hypophysitis. The lesion was completely removed by surgical exploration via transsphenoidal selective tumorectomy 5 months after clinical onset. Our pathological examination of the pituitary tumor revealed that the tumor was composed of abundant small epithelial cells with foamy macrophage or lymphoid infiltration, some of which were undergoing necrosis (Figure 2A). Hemosiderin deposits were also observed (Figure 2B). Atypically, there was no evidence of calcification or remarkable cholesterol clefts. On the basis of the histopathological examination, we confirmed the presence of an intrasellar xanthogranuloma and no observed cholesterol clefts.
Postoperatively, the patient's visual field defects and headache improved. However, he needed to continue endocrine replacement therapy (20 mg/day of hydrocortisone and 25 to 50 μg/day of thyroxine). MRI showed that the mass had been completely removed and revealed no evidence of tumor remnants.


The spectrum of cystic pathology occurring in the sellar region includes craniopharyngiomas, RCCs, colloid cysts, arachnoid cysts, cystic pituitary adenomas, epidermoid cysts, dermoid cysts and xanthogranulomas [10, 11]. Xanthogranulomas have been reported to occur at various sites inside and outside the cranial vault [2]. However, xanthogranuloma of the sellar region is very rare. Xanthogranuloma of the sellar region was first reported in 1988 [3], with only 4 of 211 sellar and juxtasellar tumors (1.9%) showing the features typical of cholesterol granulomas. Paulus et al. described and classified xanthogranuloma of the sellar region as a distinct entity, after which the World Health Organization accepted that xanthogranuloma of the sellar region differs from classical craniopharyngioma in several ways: age at onset, anatomical site and localization of the lesion, and symptoms and prognosis [2, 12].
The histogenesis and pathogenesis of xanthogranuloma remain unclear, and these details are controversial and probably heterogeneous. It is generally thought that the xanthogranulomatous reaction is induced mainly by chronic inflammatory processes in circumscribed areas of craniopharyngiomas or at the cyst wall and adjacent tissue of RCCs [2, 13]. Degenerative changes in pituitary adenomas also may act as triggers [3], and extreme adeno- or infundibuloneurohypophysitis may result in giant cell granuloma. Secondary hypophysitis can arise from bacterial, viral and fungal infections, often in an immunocompromised host, or from systemic disorders such as autoimmune diseases, Langerhans histiocytosis and Erdheim-Chester disease. On the other hand, Paulus et al.[2] proposed xanthogranuloma of the sellar region as a distinct entity and found hemosiderin deposits in almost all (97%) of their 37 cases as a result of obstruction of a cavity, hemorrhage or both. Compared to classical craniopharyngiomas, xanthogranulomas characteristically occur in adolescents and young adults, predominantly at an intrasellar location, and are smaller in size and concomitant with more severe endocrine deficiencies, but they are more easily resected and lead to good treatment outcomes. Craniopharyngiomas usually arise in the pituitary stalk and grow, at least during the initial stage, mainly in the suprasellar space. The tumor in our patient was found at a classical location for RCCs, pituitary adenomas or hypophysitis, that is, the intrasellar portion and the sella turcica [2, 5, 6, 9], although the adenomatous lesion was not included histologically.
Typical features of a xanthogranuloma of the sellar region include cholesterol clefts, lymphoplasmacellular infiltrates, marked hemosiderin deposits, multi-nucleated foreign body giant cells around the cholesterol clefts, accumulation of macrophages and only small epithelial cell clusters [2]. These features have been found in almost all cases of sellar xanthogranuloma. It is not clear, however, whether the additional characteristics represent a distinct entity, given the greater number of common characteristics. Indeed, in one study, 8% of xanthogranulomas of the sellar region had histological features consistent with adenomatous craniopharyngioma, whereas 35% (13 of 37) had squamous or columnar epithelium, but no other evidence of RCCs [2]. On the basis of these considerations and the histological findings in our patient, we speculate that our patient initially may have had RCCs or hypophysitis.
For xanthogranulomas, no typical radiological signs exist [9]. Although it is not always possible to identify the component of each signal intensity during surgery, researchers speculated in a previous report that cholesterol clefts show T1-weighted high- and T2-weighted low-signal intensities, that hemosiderin cysts containing xanthogranuloma-like fluid show T1-weighted high/iso- and T2-weighted high-signal intensities and that thick fibrosis (granulation) show both T1-weighted and T2-weighted low-signal intensities [14]. The mixed signal intensities on both T1- and T2-weighted images with heterogeneous enhancement reflect their complex histologic components. The cholesterol deposits of a xanthogranuloma appear hyperintense on T1-weighted images; however, calcifications, micro- or focal hemorrhages and hemosiderin deposits contained in tumors can frequently result in heterogeneous cystic lesions and may be essential in the formation of xanthogranulomas as the trigger for granulomatous changes or as a result of these changes.
A MEDLINE English-language literature search commencing from 2000 revealed eight separate reports of cases of sellar xanthogranuloma [47, 9, 15]. MRI was performed in all eight of the reviewed cases (Table 3). Eight previous cases of sellar xanthogranuloma with MRI findings manifested hypo- and heterogeneous intensity on T2-weighted imaging studies. For seven of nine reported cases (including the present case), mixed high-intensity lesions were seen on T1-weighted imaging and, generally, low or heterogeneous intensity on T2-weighted imaging.
Table 3
Reviewed cases of xanthogranulomaa
Clinical findings
Radiological findings (MRI)
Tumor size (cm)
Time to operation
Tumor region
Present case
Body weight loss
Visual disturbance
T1:H/I, T2:CE:heterogeneous
Mixed-intensity solid tumor
1.2 × 1.8 × 1.5
5 M
Required medical supplement
Reithmeier et al., 2002 [4]
Loss of libido
Hypophyseal insufficiency
Visual dysfunction
T1:H, CE:heterogeneous
Not described
Yonezawa et al., 2003 [5]
General fatigue
Appetite loss
T1:H, T2:L, heterogeneous:CE:
Mixed-intensity cystic tumor
Not described
3 M
Doing well 3 months later
Burt et al., 2003 [6]
Erectile dysfunction
Hypophyseal dysfunction
Visual defects
T1:H, T2:heterogeneous CE:heterogeneous
Mixed-intensity partially cystic tumor
1.8 × 1.5
3 W to 3 M
Doing well 18 months later
Body weight loss
T1:H, T2:L, CE:N
Mixed-intensity cystic tumor
Not described
12 M
Required medical supplement
Jung et al., 2005 [9]
Visual disturbance
T1:H, T2:L, CE:heterogeneous
Mixed-intensity solid tumor
2.0 × 2.0 × 2.5
12 M
Not described
Appetite loss
Secondary adrenal insufficiency
Diabetes insipidus
T1, T2:heterogeneous
Mixed-intensity cystic tumor
5 W
Not described
Liu et al., 2008 [22]
Consciousness disorder
Blurred vision
T1:H, T2:H and focal L
Mixed-intensity cystic tumor
3.4 × 3.8 × 4.2
2 D
Doing well 6 months later
Sugata et al., 2009 [7]
General fatigue
Visual disturbance
T1:I or L, T2:L, CE:heterogeneous
Mixed-intensity solid tumor
5 to 10 Y
Required medical supplement
aH, high intensity; L, low intensity; I, isointensity; heterogeneous, heterogeneous intensity; CE, gadolinium contrast enhancement; N, negative; Y, years; M, months; D, days; T1, T1-weighted; T2, T2-weighted.
A xanthogranuloma of the sellar region usually causes symptoms of an endocrine nature, despite favorable survival outcomes for patients with xanthogranulomas. In this case, a good outcome is defined as a socially independent life without impairment but no recovery of endocrine function. The appropriate therapeutic strategy for most cases of xanthogranuloma of the sellar region appears to be to correct the underlying endocrine problems first. Patients often need to receive long-term endocrine replacement therapy to improve their symptoms. In the eight cases of xanthogranuloma in the literature that we reviewed, no examples of recurring xanthogranuloma of the sellar region were noted, and the overall outcome for patients with this condition appeared to be favorable (Table 3). However, only three of eight patients whose intrasellar tumors were removed within 3 months of clinical onset recovered without requiring endocrine replacement therapy (Table 3). Another three patients, including the patient described in our present case report, required medical support because of mild hypopituitarism after the operation. The outcomes of the other three patients were not described (Table 3). Even if the tumor size is small, an intrasellar tumor or delayed surgical intervention probably results in unfavorable endocrine outcomes. On the contrary, despite the presence of tumors 3 cm or larger in diameter, suprasellar lesions appear to carry a better endocrinological prognosis if appropriate treatment is initiated as soon as possible. The increased risk of permanent pituitary dysfunction in various sellar lesions undergoing xanthogranulomatous reaction is probably related to their cause: hemorrhage, inflammation or degeneration. Therefore, surgical intervention early in the development of these changes may improve pituitary function [5, 6, 15]. This seems to suggest that surgical intervention within 3 months of clinical onset and the tumor's being in a non-intrasellar location are important factors that result in favorable postoperative pituitary function. It is possible that early surgical decompression resulted in recovery of pituitary function in cases 3, 4 and 8, but that chronic inflammation in cases 1, 5 and 9 resulted in destruction and fibrosis of the pituitary as well as irreversible hormonal deficits (Table 3).


Because xanthogranulomas of the sellar region are rare, their nature and clinical course remain somewhat unclear. The seriousness of the hypopituitarism, the hyperintensity of T1-weighted MRI or hypointensity of T2-weighted MRI, and the absence of calcification should alert clinicians to the possibility that the tumor may be a xanthogranuloma. Therefore, xanthogranulomas should be included in the preoperative differential diagnosis of intrasellar tumors. Moreover, we suggest that such tumors should be treated as soon as possible, within a minimum of 3 to 4 months, especially in the case of tumors occupying the intrasellar region, to improve endocrinological outcomes, even if the tumors seem small.


Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

TN and KM was major contributor to the writing of the manuscript. TN, KM, HI and TI analyzed and interpreted the patient data regarding endocrinological disease. YK and RH performed the histological examination of the xanthogranuloma. NK and TT performed neurosurgery on the patient. All authors read and approved the final manuscript.

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