nach oben

Critical Care

Erschienen in:

01.06.2006 | Review

Year in review 2005: Critical Care – resource management

verfasst von: André Carlos Kajdacsy-Balla Amaral, Gordon D Rubenfeld

Erschienen in: Critical Care | Ausgabe 3/2006

Einloggen, um Zugang zu erhalten

Abstract

During 2005 Critical Care published several original papers dealing with resource management. Emphasis was placed on sepsis, especially the coagulation cascade, prognosis and resuscitation. The papers highlighted important aspects of the pathophysiology of coagulation and inflammation in sepsis, as well as dealing with the proper use of newly developed compounds. Several aspects of prognosis in critically ill patients were investigated, focusing on biological markers and clinical indexes. Resuscitation received great attention, dealing with the effects of fluid infusion in hemodynamics and the lung. The information obtained can be used to address unknown effects of established therapies, to enlighten current clinical discussion on controversial topics, and to introduce novel medical resources and strategies. Future clinical work will rely heavily on these preclinical and laboratory data.

Amaral A, Opal SM, Vincent JL: Coagulation in sepsis. Intensive Care Med 2004, 30: 1032-1040. 10.1007/s00134-004-2291-8CrossRefPubMed

Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344: 699-709. 10.1056/NEJM200103083441001CrossRefPubMed

Warren BL, Eid A, Singer P, Pillay SS, Carl P, Novak I, Chalupa P, Atherstone A, Penzes I, Kubler A, et al.: Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA 2001, 286: 1869-1878. 10.1001/jama.286.15.1869CrossRefPubMed

Abraham E, Reinhart K, Opal S, Demeyer I, Doig C, Rodriguez AL, Beale R, Svoboda P, Laterre PF, Simon S, et al.: Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA 2003, 290: 238-247. 10.1001/jama.290.2.238CrossRefPubMed

de Pont AC, Bakhtiari K, Hutten BA, de Jonge E, Vroom MB, Meijers JC, Buller HR, Levi M: Recombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case control study. Crit Care 2005, 9: R490-R497. 10.1186/cc3774PubMedCentralCrossRefPubMed

van 't Veer C, Mann KG: Regulation of tissue factor initiated thrombin generation by the stoichiometric inhibitors tissue factor pathway inhibitor, antithrombin-III, and heparin cofactor-II. J Biol Chem 1997, 272: 4367-4377. 10.1074/jbc.272.7.4367CrossRefPubMed

Blajchman MA, Austin RC, Fernandez-Rachubinski F, Sheffield WP: Molecular basis of inherited human antithrombin deficiency. Blood 1992, 80: 2159-2171.PubMed

Klein NJ, Shennan GI, Heyderman RS, Levin M: Alteration in glycosaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils. J Cell Sci 1992, 102: 821-832.PubMed

Kountchev J, Bijuklic K, Bellmann R, Wiedermann CJ, Joannidis M: Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis. Crit Care 2005, 9: R596-R600. 10.1186/cc3808PubMedCentralCrossRefPubMed

10.

Levy H, Laterre PF, Bates B, Qualy RL: Steroid use in PROWESS severe sepsis patients treated with drotrecogin alfa (activated). Crit Care 2005, 9: R502-R507. 10.1186/cc3778PubMedCentralCrossRefPubMed

11.

Keh D, Boehnke T, Weber-Cartens S, Schulz C, Ahlers O, Bercker S, Volk HD, Doecke WD, Falke KJ, Gerlach H: Immunologic and hemodynamic effects of 'low-dose' hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 2003, 167: 512-520. 10.1164/rccm.200205-446OCCrossRefPubMed

12.

Oppert MF, Schindler RF, Husung CF, Offermann KF, Graf KJ, Boenisch O, Boenisch OF, Barckow DF, Frei UF, Eckardt KU: Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 2005, 33: 2457-2464. 10.1097/01.CCM.0000186370.78639.23CrossRefPubMed

13.

Prigent H, Maxime V, Annane D: Clinical review: corticotherapy in sepsis. Crit Care 2004, 8: 122-129. 10.1186/cc2374PubMedCentralCrossRefPubMed

14.

Hoen S, Mazoit JX, Asehnoune K, Brailly-Tabard S, Benhamou D, Moine P, Edouard AR: Hydrocortisone increases the sensitivity to alpha1-adrenoceptor stimulation in humans following hemorrhagic shock. Crit Care Med 2005, 33: 2737-2743. 10.1097/01.CCM.0000189743.55352.0ECrossRefPubMed

15.

Vincent JL, Nadel S, Kutsogiannis DJ, Gibney RT, Yan SB, Wyss VL, Bailey JE, Mitchell CL, Sarwat S, Shinall SM, et al.: Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies. Crit Care 2005, 9: R331-R343. 10.1186/cc3538PubMedCentralCrossRefPubMed

16.

Afifi AA, Sacks ST, Liu VY, Weil MH, Shubin H: Accumulative prognostic index for patients with barbiturate, glutethimide and meprobamate intoxication. N Engl J Med 1971, 285: 1497-1502.CrossRefPubMed

17.

Jaimes F, Farbiarz J, Alvarez D, Martinez C: Comparison between logistic regression and neural networks to predict death in patients with suspected sepsis in the emergency room. Crit Care 2005, 9: R150-R156. 10.1186/cc3054PubMedCentralCrossRefPubMed

18.

von Dossow V, Rotard K, Redlich U, Hein OV, Spies CD: Circulating immune parameters predicting the progression from hospital-acquired pneumonia to septic shock in surgical patients. Crit Care 2005, 9: R662-R669. 10.1186/cc3826PubMedCentralCrossRefPubMed

19.

Christ-Crain M, Morgenthaler NG, Struck J, Harbarth S, Bergmann A, Muller B: Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study. Crit Care 2005, 9: R816-R824. 10.1186/cc3885PubMedCentralCrossRefPubMed

20.

Hein OV, Misterek K, Tessmann JP, van Dossow V, Krimphove M, Spies C: Time course of endothelial damage in septic shock: prediction of outcome. Crit Care 2005, 9: R323-R330. 10.1186/cc3532PubMedCentralCrossRefPubMed

21.

Mrus JM, Braun L, Yi MS, Linde-Zwirble WT, Johnston JA: Impact of HIV/AIDS on care and outcomes of severe sepsis. Crit Care 2005, 9: R623-R630. 10.1186/cc3811PubMedCentralCrossRefPubMed

22.

Fodor L, Fodor A, Ramon Y, Shoshani O, Rissin Y, Ullmann Y: Controversies in fluid resuscitation for burn management: literature review and our experience. Injury 2006, 37: 374-379. 10.1016/j.injury.2005.06.037CrossRefPubMed

23.

Martin GS, Eaton S, Mealer M, Moss M: Extravascular lung water in patients with severe sepsis: a prospective cohort study. Crit Care 2005, 9: R74-R82. 10.1186/cc3025PubMedCentralCrossRefPubMed

24.

Dubin A, Murias G, Maskin B, Pozo MO, Sottile JP, Baran M, Edul VS, Canales HS, Badie JC, Etcheverry G, et al.: Increased blood flow prevents intramucosal acidosis in sheep endotoxemia: a controlled study. Crit Care 2005, 9: R66-R73. 10.1186/cc3021PubMedCentralCrossRefPubMed

25.

Kellum JA, Song M, Venkataraman R: Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis. Chest 2004, 125: 243-248. 10.1378/chest.125.1.243CrossRefPubMed

26.

Qian T, Nieminen AL, Herman B, Lemasters JJ: Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes. Am J Physiol Cell Physiol 1997, 273: C1783-C1792.

27.

Vincent JL, Sakr Y, Reinhart K, Sprung CL, Gerlach H, Ranieri VM: Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study. Crit Care 2005, 9: R745-R754. 10.1186/cc3895PubMedCentralCrossRefPubMed

28.

Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R, SAFE Study Investigators: A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004, 350: 2247-2256. 10.1056/NEJMoa040232CrossRefPubMed

29.

van Eijk LT, Pickkers P, Smits P, van den BW, Bouw MP, van der Hoeven JG: Microvascular permeability during experimental human endotoxemia: an open intervention study. Crit Care 2005, 9: R157-R164. 10.1186/cc3050PubMedCentralCrossRefPubMed

30.

Fleck A, Raines G, Hawker F, Trotter J, Wallace PI, Ledingham IM, Calman KC: Increased vascular permeability: a major cause of hypoalbuminaemia in disease and injury. Lancet 1985, 1: 781-784. 10.1016/S0140-6736(85)91447-3CrossRefPubMed

31.

Margarson MP, Soni NC: Effects of albumin supplementation on microvascular permeability in septic patients. J Appl Physiol 2002, 92: 2139-2145. 10.1063/1.1495889CrossRefPubMed

32.

Ernest D, Belzberg AS, Dodek PM: Distribution of normal saline and 5% albumin infusions in septic patients. Crit Care Med 1999, 27: 46-50. 10.1097/00003246-199901000-00025CrossRefPubMed

33.

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED: Changes in central venous saturation after major surgery, and association with outcome. Crit Care 2005, 9: R694-R699. 10.1186/cc3888PubMedCentralCrossRefPubMed

34.

Page B, Vieillard-Baron A, Chergui K, Peyrouset O, Rabiller A, Beauchet A, Aegerter P, Jardin F: Early veno-venous haemodiafiltration for sepsis-related multiple organ failure. Crit Care 2005, 9: R755-R763. 10.1186/cc3886PubMedCentralCrossRefPubMed

35.

Ratanarat R, Brendolan A, Piccinni P, Dan M, Salvatori G, Ricci Z, Ronco C: Pulse high-volume haemofiltration for treatment of severe sepsis: effects on hemodynamics and survival. Crit Care 2005, 9: R294-R302. 10.1186/cc3529PubMedCentralCrossRefPubMed

36.

De Waele JJ, Hoste E, Blot SI, Decruyenaere J, Colardyn F: Intra-abdominal hypertension in patients with severe acute pancreatitis. Crit Care 2005, 9: R452-R457. 10.1186/cc3754PubMedCentralCrossRefPubMed

37.

Gao F, Melody T, Daniels DF, Giles S, Fox S: The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study. Crit Care 2005, 9: R764-R770. 10.1186/cc3909PubMedCentralCrossRefPubMed

38.

Macias WL, Nelson DR, Williams M, Garg R, Janes J, Sashegyi A: Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis. Crit Care 2005, 9: R607-R622. 10.1186/cc3795PubMedCentralCrossRefPubMed

39.

Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL: Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004, 32: 1825-1831. 10.1097/01.CCM.0000138558.16257.3FCrossRefPubMed

40.

Boerma EC, Mathura KR, van der Voort PH, Spronk PE, Ince C: Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. Crit Care 2005, 9: R601-R606. 10.1186/cc3809PubMedCentralCrossRefPubMed

41.

Stewart PA: Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 1983, 61: 1444-1461.CrossRefPubMed

42.

O'Dell E, Tibby SM, Durward A, Aspell J, Murdoch IA: Validation of a method to partition the base deficit in meningococcal sepsis: a retrospective study. Crit Care 2005, 9: R464-R470. 10.1186/cc3760PubMedCentralCrossRefPubMed

43.

Broessner G, Beer R, Franz G, Lackner P, Engelhardt K, Brenneis C, Pfausler B, Schmutzhard E: Case report: severe heat stroke with multiple organ dysfunction – a novel intravascular treatment approach. Crit Care 2005, 9: R498-R501. 10.1186/cc3771PubMedCentralCrossRefPubMed

44.

Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346: 557-563. 10.1056/NEJMoa003289CrossRefPubMed

45.

Gentilello LM, Jurkovich GJ, Stark MS, Hassantash SA, O'Keefe GE: Is hypothermia in the victim of major trauma protective or harmful? A randomized, prospective study. Ann Surg 1997, 226: 439-447. 10.1097/00000658-199710000-00005PubMedCentralCrossRefPubMed

46.

Ryan M, Levy MM: Clinical review: fever in intensive care unit patients. Crit Care 2003, 7: 221-225. 10.1186/cc1879PubMedCentralCrossRefPubMed

47.

Su F, Nguyen ND, Wang Z, Cai Y, Rogiers P, Vincent JL: Fever control in septic shock: beneficial or harmful? Shock 2005, 23: 516-520.PubMed

48.

Redl HR, Martin U, Khadem A, Pelinka LE, van Griensven M: Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model. Crit Care 2005, 9: R735-R744. 10.1186/cc3825PubMedCentralCrossRefPubMed

Titel: Year in review 2005: Critical Care – resource management
verfasst von: André Carlos Kajdacsy-Balla Amaral
Gordon D Rubenfeld
Publikationsdatum: 01.06.2006
Verlag: BioMed Central
Erschienen in: Critical Care / Ausgabe 3/2006
Elektronische ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc4953

Neu im Fachgebiet AINS

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

hier abonnieren

Springer Medizin

Year in review 2005: Critical Care – resource management

Abstract

Neu im Fachgebiet AINS

Magen-Darm-Blutungen werden präklinisch oft falsch eingeschätzt

Sepsis-Verdacht: Eine Stunde, fünf essenzielle Maßnahmen

Hinter dieser Appendizitis steckte ein Erreger

Ärztliche Empathie hilft gegen Rückenschmerzen

Update AINS

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2006

Hyperglycaemia in critically ill patients: marker or mediator of mortality?

Anti-Xa activity after subcutaneous administration of dalteparin in ICU patients with and without subcutaneous oedema: a pilot study

Sedation in the intensive care unit with remifentanil/propofol versus midazolam/fentanyl: a randomised, open-label, pharmacoeconomic trial

Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumonia

Recently published papers: Pandemic flu, the latest ARDS trials, raising legs and other stories

The incidence and outcome of septic shock patients in the absence of early-goal directed therapy

Neu im Fachgebiet AINS

Magen-Darm-Blutungen werden präklinisch oft falsch eingeschätzt

Sepsis-Verdacht: Eine Stunde, fünf essenzielle Maßnahmen

Hinter dieser Appendizitis steckte ein Erreger

Ärztliche Empathie hilft gegen Rückenschmerzen

Update AINS