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Molecular Imaging and Biology

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08.05.2018 | Research Article

Zero-Extra-Dose PET Delayed Imaging with Data-Driven Attenuation Correction Estimation

verfasst von: Lifang Pang, Wentao Zhu, Yun Dong, Yang Lv, Hongcheng Shi

Erschienen in: Molecular Imaging and Biology | Ausgabe 1/2019

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Abstract

Purpose

Delayed positron emission tomography (PET) imaging may improve sensitivity and specificity in lesion detection. We proposed a PET data-driven method to estimate the attenuation map (AM) for the delayed scan without an additional x-ray computed tomography (CT).

Procedures

An emission-attenuation-scatter joint estimation framework was developed. Several practical issues for clinical datasets were addressed. Particularly, the unknown scatter correction was incorporated in the joint estimation algorithm. The scaling problem was solved using prior information from the early CT scan. Fourteen patient datasets were added to evaluate the method. These patients went through two separate PET/CT scans. The delayed CT-based AM served as ground truth for the delayed scan. Standard uptake values (SUVmean and SUVmax) of lesion and normal tissue regions of interests (ROIs) in the early and delayed phase and the respective %DSUV (percentage change of SUVmean at two different time points) were analyzed, all with estimated and the true AM. Three radiologists participated in lesion detection tasks with images reconstructed with both AMs and rated scores for detectability.

Results

The mean relative difference of SUVmean in lesion and normal liver tissue were 3.30 and 6.69 %. The average lesion-to-background contrast (detectability) with delayed PET images using CT AM was 60 % higher than that of the earlier PET image, and was 64 % higher when using the data-based AM. %DSUV for lesions and liver backgrounds with CT-based AM were − 0.058 ± 0.25 and − 0.33 ± 0.08 while with data-based AM were − 0.00 ± 0.26 and − 0.28 ± 0.08. Only slight significance difference was found between using CT-based AM and using the data-based AM reconstruction delay phase on %DSUV of lesion. The scores associated with the two AMs matched well consistently.

Conclusions

Our method may be used in delayed PET imaging, which allows no secondary CT radiation in delayed phase. The quantitative analysis for lesion detection purpose could be ensured.

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Titel: Zero-Extra-Dose PET Delayed Imaging with Data-Driven Attenuation Correction Estimation
verfasst von: Lifang Pang
Wentao Zhu
Yun Dong
Yang Lv
Hongcheng Shi
Publikationsdatum: 08.05.2018
Verlag: Springer International Publishing
Erschienen in: Molecular Imaging and Biology / Ausgabe 1/2019
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-018-1205-z

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Zero-Extra-Dose PET Delayed Imaging with Data-Driven Attenuation Correction Estimation

Abstract

Purpose

Procedures

Results

Conclusions

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