Zevorcabtagene Autoleucel: First Approval
- 18.06.2024
- AdisInsight Report
Erschienen in:
- Verfasst von
- Sohita Dhillon
- Erschienen in
- Molecular Diagnosis & Therapy | Ausgabe 4/2024
Abstract
Zevorcabtagene autoleucel (泽沃基奥仑赛注射液) is a fully humanised B cell maturation antigen (BCMA)-targeting specific chimeric antigen receptor (CAR) T-cell therapy being developed by CARsgen for the treatment of multiple myeloma. Zevorcabtagene autoleucel is an autologous CAR T cell comprising a fully human BCMA-specific scFv (25C2), a CD8α hinge region and transmembrane domain, a 4-1BB costimulatory domain and a CD3-ζ T cell activation domain. Zevorcabtagene autoleucel recognizes and induces selective toxicity against BCMA-expressing tumour cells leading to their elimination. In February 2024, zevorcabtagene autoleucel received its first approval in China for the treatment of adults with relapsed or refractory multiple myeloma who have progressed after ≥ 3 prior lines of therapy (including ≥ 1 proteasome inhibitor and an immunomodulatory agent). Clinical studies of zevorcabtagene autoleucel are underway in Canada and the US. This article summarizes the milestones in the development of zevorcabtagene autoleucel leading to this first approval for relapsed or refractory multiple myeloma.
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- Titel
- Zevorcabtagene Autoleucel: First Approval
- Verfasst von
-
Sohita Dhillon
- Publikationsdatum
- 18.06.2024
- Verlag
- Springer International Publishing
- Erschienen in
-
Molecular Diagnosis & Therapy / Ausgabe 4/2024
Print ISSN: 1177-1062
Elektronische ISSN: 1179-2000 - DOI
- https://doi.org/10.1007/s40291-024-00723-z
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