Background
Tumor type | Expression | Functional role | Related gene | Role | References |
---|---|---|---|---|---|
Breast cancer | Downregulation | – | – | Tumor suppressor | |
Glioma | Upregulation | Proliferation, migration invasion, cell cycle, EMT process | E-Cadherin, N-cadherin, Snail, MMP2, MMP9, Integrin β1, ZEB1, Twist, HES-1, NICD | Oncogene | |
Colorectal cancer | Upregulation | Proliferation, cell cycle, invasion, apoptosis, EMT process | miR-484, p53, cyclin B1, PARP, ZEB1, E-cadherin, ZO-1, Vimentin, N-cadherin | Oncogene | |
Gastric cancer | Upregulation | Proliferation, cell cycle, migration, apoptosis, EMT process | N-Cadherin, Vimentin, ZEB1, Snail, MMP14, Twist, E-cadherin, EpCAM, Cyclin D1, Bcl2, Bax, Slug, | Oncogene | |
Hepatocellular carcinoma | Upregulation/downregulation | Proliferation, apoptosis, invasion, metastasis | ZEB1, MMP-14, MMP16, miR-9, miR-150 | Oncogene/tumor suppressor | |
Ovarian cancer | Upregulation | Proliferation, migration, chemoresistance | miR-150, Sp1 | Oncogene | |
Melanoma | Upregulation | Proliferation | Ki67, PCNA, CyclinD1 | Oncogene | [47] |
Non-small cell lung cancer | Upregulation | – | – | Oncogene | [48] |
Osteosarcoma | Upregulation | Proliferation, invasion | miR-200b, miR-200c, BMI1, Sp1, ZEB2 | Oncogene | [49] |
Esophageal squamous cell carcinoma | Upregulation | – | – | Oncogene | [50] |
Acute myeloid leukemia | Upregulation | Proliferation, apoptosis | – | Oncogene | [51] |
Natural killer/T-cell lymphoma | Upregulation | Proliferation apoptosis, cell cycle | NF-kB, P53 | Oncogene | [52] |
Cancer type | Clinicopathological features | References |
---|---|---|
Glioma | Advanced tumor stage and poor prognosis | |
Colorectal cancer | Lymphatic invasion, advanced TNM stage, vascular invasion, poor prognosis | |
Gastric cancer | Lymphatic invasion, advanced TNM stage, vascular invasion, poor prognosis | |
Hepatocellular carcinoma | Intrahepatic invasion, extrahepatic invasion, poor prognosis | [41] |
Ovarian cancer | Insensitivity of platinum-based chemotherapy | [45] |
Melanoma | Tumor thickness, lymph node metastasis, advanced tumor stages, poor prognosis | [47] |
Non-small cell lung cancer | Advanced tumor differentiation grade, lymph node metastasis, advanced TMN stage, poorer prognosis | [48] |
Osteosarcoma | Poor prognosis | [49] |
Esophageal squamous cell carcinoma | Advanced histological grade, advanced T stage, poor prognosis | [50] |