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Archives of Virology
Erschienen in: Archives of Virology 10/2018

06.06.2018 | Original Article

Zika-virus-infected human full-term placental explants display pro-inflammatory responses and undergo apoptosis

verfasst von: Milene Rocha Ribeiro, Jusciele Brogin Moreli, Rafael Elias Marques, Michelle Premazzi Papa, Lana Monteiro Meuren, Paula Rahal, Luciana Barros de Arruda, Antonio Helio Oliani, Denise Cristina Mós Vaz Oliani, Sonia Maria Oliani, Aarthi Narayanan, Maurício Lacerda Nogueira

Erschienen in: Archives of Virology | Ausgabe 10/2018

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Abstract

Zika virus (ZIKV) is a flavivirus that has been highly correlated with the development of neurological disorders and other malformations in newborns and stillborn fetuses after congenital infection. This association is supported by the presence of ZIKV in the fetal brain and amniotic fluid, and findings suggest that infection of the placental barrier is a critical step for fetal ZIKV infection in utero. Therefore, relevant models to investigate the interaction between ZIKV and placental tissues are essential for understanding the pathogenesis of Zika syndrome. In this report, we demonstrate that explant tissue from full-term human placentas sustains a productive ZIKV infection, though the results depend on the strain. Viral infection was found to be associated with pro-inflammatory cytokine expression and apoptosis of the infected tissue, and these findings confirm that placental explants are targets of ZIKV replication. We propose that human placental explants are useful as a model for studying ZIKV infection ex vivo.
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Metadaten
Titel
Zika-virus-infected human full-term placental explants display pro-inflammatory responses and undergo apoptosis
verfasst von
Milene Rocha Ribeiro
Jusciele Brogin Moreli
Rafael Elias Marques
Michelle Premazzi Papa
Lana Monteiro Meuren
Paula Rahal
Luciana Barros de Arruda
Antonio Helio Oliani
Denise Cristina Mós Vaz Oliani
Sonia Maria Oliani
Aarthi Narayanan
Maurício Lacerda Nogueira
Publikationsdatum
06.06.2018
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 10/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-018-3911-x

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