Skip to main content
Erschienen in: Obesity Surgery 2/2017

24.11.2016 | Review Article

Zinc Deficiency after Gastric Bypass for Morbid Obesity: a Systematic Review

verfasst von: Kamal K. Mahawar, Aparna Govil Bhasker, Vivek Bindal, Yitka Graham, Usha Dudeja, Muffazal Lakdawala, Peter K. Small

Erschienen in: Obesity Surgery | Ausgabe 2/2017

Einloggen, um Zugang zu erhalten

Abstract

Up to 50% of patients have zinc deficiency before bariatric surgery. Roux-en-Y gastric bypass (RYGB) is the commonest bariatric procedure worldwide. It can further exacerbate zinc deficiency by reducing intake as well as absorption. The British Obesity and Metabolic Surgery Society, therefore, recommends that zinc level should be monitored routinely following gastric bypass. However, the American guidance does not recommend such monitoring for all RYGB patients and reserves it for patients with ‘specific findings’. This review concludes that clinically relevant Zn deficiency is rare after RYGB. Routine monitoring of zinc levels is hence unnecessary for asymptomatic patients after RYGB and should be reserved for patients with skin lesions, hair loss, pica, dysgeusia, hypogonadism or erectile dysfunction in male patients, and unexplained iron deficiency anaemia.
Literatur
3.
Zurück zum Zitat Livingstone C. Zinc: physiology, deficiency, and parenteral nutrition. Nutr Clin Pract. 2015;30(3):371–82.CrossRefPubMed Livingstone C. Zinc: physiology, deficiency, and parenteral nutrition. Nutr Clin Pract. 2015;30(3):371–82.CrossRefPubMed
4.
Zurück zum Zitat Stein J, Stier C, Raab H, et al. Review article: the nutritional and pharmacological consequences of obesity surgery. Aliment Pharmacol Ther. 2014;40(6):582–609.CrossRefPubMed Stein J, Stier C, Raab H, et al. Review article: the nutritional and pharmacological consequences of obesity surgery. Aliment Pharmacol Ther. 2014;40(6):582–609.CrossRefPubMed
6.
Zurück zum Zitat Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & bariatric surgery. Obesity (Silver Spring). 2013;21(Suppl 1):S1–27.CrossRef Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & bariatric surgery. Obesity (Silver Spring). 2013;21(Suppl 1):S1–27.CrossRef
7.
Zurück zum Zitat Angrisani L, Santonicola A, Iovino P, et al. Bariatric surgery worldwide 2013. Obes Surg. 2015;25(10):1822–32.CrossRefPubMed Angrisani L, Santonicola A, Iovino P, et al. Bariatric surgery worldwide 2013. Obes Surg. 2015;25(10):1822–32.CrossRefPubMed
9.
Zurück zum Zitat Billeter AT, Probst P, Fischer L, et al. Risk of malnutrition, trace metal, and vitamin deficiency post Roux-en-Y gastric bypass—a prospective study of 20 patients with BMI <35 kg/m2. Obes Surg. 2015;25(11):2125–34.CrossRefPubMed Billeter AT, Probst P, Fischer L, et al. Risk of malnutrition, trace metal, and vitamin deficiency post Roux-en-Y gastric bypass—a prospective study of 20 patients with BMI <35 kg/m2. Obes Surg. 2015;25(11):2125–34.CrossRefPubMed
10.
Zurück zum Zitat Papamargaritis D, Aasheim ET, Sampson B, et al. Copper, selenium and zinc levels after bariatric surgery in patients recommended to take multivitamin-mineral supplementation. J Trace Elem Med Biol. 2015;31:167–72.CrossRefPubMed Papamargaritis D, Aasheim ET, Sampson B, et al. Copper, selenium and zinc levels after bariatric surgery in patients recommended to take multivitamin-mineral supplementation. J Trace Elem Med Biol. 2015;31:167–72.CrossRefPubMed
11.
Zurück zum Zitat Ernst B, Thurnheer M, Schmid SM, et al. Evidence for the necessity to systematically assess micronutrient status prior to bariatric surgery. Obes Surg. 2009;19(1):66–73.CrossRefPubMed Ernst B, Thurnheer M, Schmid SM, et al. Evidence for the necessity to systematically assess micronutrient status prior to bariatric surgery. Obes Surg. 2009;19(1):66–73.CrossRefPubMed
12.
Zurück zum Zitat Gobato RC, Seixas Chaves DF, Chaim EA. Micronutrient and physiologic parameters before and 6 months after RYRYGB. Surg Obes Relat Dis. 2014;10(5):944–51.CrossRefPubMed Gobato RC, Seixas Chaves DF, Chaim EA. Micronutrient and physiologic parameters before and 6 months after RYRYGB. Surg Obes Relat Dis. 2014;10(5):944–51.CrossRefPubMed
13.
Zurück zum Zitat Remedios C, Bhasker AG, Dhulla N, et al. Bariatric nutrition guidelines for the Indian population. Obes Surg. 2016;26(5):1057–68.CrossRefPubMed Remedios C, Bhasker AG, Dhulla N, et al. Bariatric nutrition guidelines for the Indian population. Obes Surg. 2016;26(5):1057–68.CrossRefPubMed
14.
Zurück zum Zitat Ruz M, Carrasco F, Rojas P, et al. Zinc absorption and zinc status are reduced after Roux-en-Y gastric bypass: a randomized study using 2 supplements. Am J Clin Nutr. 2011;94(4):1004–11.CrossRefPubMed Ruz M, Carrasco F, Rojas P, et al. Zinc absorption and zinc status are reduced after Roux-en-Y gastric bypass: a randomized study using 2 supplements. Am J Clin Nutr. 2011;94(4):1004–11.CrossRefPubMed
15.
Zurück zum Zitat Pires LV, Martins LM, Geloneze B, et al. Hadad do Monte SJ, do Nascimento Nagueira N, et al. the effect of Roux-en-Y gastric bypass on zinc nutritional status. Obes Surg. 2007;17(5):617–21.CrossRefPubMed Pires LV, Martins LM, Geloneze B, et al. Hadad do Monte SJ, do Nascimento Nagueira N, et al. the effect of Roux-en-Y gastric bypass on zinc nutritional status. Obes Surg. 2007;17(5):617–21.CrossRefPubMed
16.
Zurück zum Zitat de Torres Rossi RG, Dos Santos MT, de Souza FI, et al. Nutrient intake of women 3 years after Roux-en-Y gastric bypass surgery. Obes Surg. 2012;22(10):1548–53.CrossRefPubMed de Torres Rossi RG, Dos Santos MT, de Souza FI, et al. Nutrient intake of women 3 years after Roux-en-Y gastric bypass surgery. Obes Surg. 2012;22(10):1548–53.CrossRefPubMed
17.
Zurück zum Zitat Cominetti C, Garrido Jr AB, Cozzolino SM. Zinc nutritional status of morbidly obese patients before and after Roux-en-Y gastric bypass: a preliminary report. Obes Surg. 2006;16(4):448–53.CrossRefPubMed Cominetti C, Garrido Jr AB, Cozzolino SM. Zinc nutritional status of morbidly obese patients before and after Roux-en-Y gastric bypass: a preliminary report. Obes Surg. 2006;16(4):448–53.CrossRefPubMed
18.
Zurück zum Zitat Rosa FT, de Oliveira-Penaforte FR, de Arruda LI, et al. Altered plasma response to zinc and iron tolerance test after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2011;7(3):309–14.CrossRefPubMed Rosa FT, de Oliveira-Penaforte FR, de Arruda LI, et al. Altered plasma response to zinc and iron tolerance test after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2011;7(3):309–14.CrossRefPubMed
19.
Zurück zum Zitat Freeland-Graves JH, Lee JJ, Mousa TY, et al. Patients at risk for trace element deficiencies: bariatric surgery. J Trace Elem Med Biol. 2014;28(4):495–503.CrossRefPubMed Freeland-Graves JH, Lee JJ, Mousa TY, et al. Patients at risk for trace element deficiencies: bariatric surgery. J Trace Elem Med Biol. 2014;28(4):495–503.CrossRefPubMed
20.
Zurück zum Zitat Lewandowski H, Breen TL, Huang EY. Kwashiorkor and an acrodermatitis enteropathica-like eruption after a distal gastric bypass surgical procedure. Endocr Pract. 2007;13(3):277–82.CrossRefPubMed Lewandowski H, Breen TL, Huang EY. Kwashiorkor and an acrodermatitis enteropathica-like eruption after a distal gastric bypass surgical procedure. Endocr Pract. 2007;13(3):277–82.CrossRefPubMed
21.
Zurück zum Zitat Basfi-Fer K, Rojas P, Carrasco F, et al. Evolution of the intake and nutritional status of zinc, iron and copper in women undergoing bariatric surgery until the second year after surgery. [article in Spanish]. Nutr Hosp. 2012;27(5):1527–35.PubMed Basfi-Fer K, Rojas P, Carrasco F, et al. Evolution of the intake and nutritional status of zinc, iron and copper in women undergoing bariatric surgery until the second year after surgery. [article in Spanish]. Nutr Hosp. 2012;27(5):1527–35.PubMed
22.
Zurück zum Zitat Monshi B, Stockinger T, Vigl K, et al. Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. J Dtsch Dermatol Ges. 2015;13(11):1147–54.PubMed Monshi B, Stockinger T, Vigl K, et al. Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. J Dtsch Dermatol Ges. 2015;13(11):1147–54.PubMed
23.
Zurück zum Zitat Mankaney GN, Vipperla K. Images in clinical medicine. Acquired acrodermatitis enteropathica. N Engl J Med. 2014;371(1):67.CrossRefPubMed Mankaney GN, Vipperla K. Images in clinical medicine. Acquired acrodermatitis enteropathica. N Engl J Med. 2014;371(1):67.CrossRefPubMed
24.
Zurück zum Zitat Vick G, Mahmoudizad R, Fiala K. Intravenous zinc therapy for acquired zinc deficiency secondary to gastric bypass surgery: a case report. Dermatol Ther. 2015;28(4):222–5.CrossRefPubMed Vick G, Mahmoudizad R, Fiala K. Intravenous zinc therapy for acquired zinc deficiency secondary to gastric bypass surgery: a case report. Dermatol Ther. 2015;28(4):222–5.CrossRefPubMed
25.
Zurück zum Zitat Shahsavari D, Ahmed Z, Karikkineth A, Williams R, Zigel C. Zinc-deficiency acrodermatitis in a patient with chronic alcoholism and gastric bypass: a case report. J Commun Hosp Intern Med Perspect. 2014; 4. eCollection 2014. Shahsavari D, Ahmed Z, Karikkineth A, Williams R, Zigel C. Zinc-deficiency acrodermatitis in a patient with chronic alcoholism and gastric bypass: a case report. J Commun Hosp Intern Med Perspect. 2014; 4. eCollection 2014.
26.
Zurück zum Zitat Zouridaki E, Papafragkaki DK, Papafragkakis H, et al. Dermatological complications after bariatric surgery: report of two cases and review of the literature. Dermatology. 2014;228(1):5–9.CrossRefPubMed Zouridaki E, Papafragkaki DK, Papafragkakis H, et al. Dermatological complications after bariatric surgery: report of two cases and review of the literature. Dermatology. 2014;228(1):5–9.CrossRefPubMed
28.
Zurück zum Zitat Balsa JA, Botella-Carretero JI, Gómez-Martín JM, et al. Copper and zinc serum levels after derivative bariatric surgery: differences between Roux-en-Y gastric bypass and biliopancreatic diversion. Obes Surg. 2011;21(6):744–50.CrossRefPubMed Balsa JA, Botella-Carretero JI, Gómez-Martín JM, et al. Copper and zinc serum levels after derivative bariatric surgery: differences between Roux-en-Y gastric bypass and biliopancreatic diversion. Obes Surg. 2011;21(6):744–50.CrossRefPubMed
29.
Zurück zum Zitat Rojas P, Carrasco F, Codoceo J, et al. Trace element status and inflammation parameters after 6 months of Roux-en-Y gastric bypass. Obes Surg. 2011;21(5):561–8.CrossRefPubMed Rojas P, Carrasco F, Codoceo J, et al. Trace element status and inflammation parameters after 6 months of Roux-en-Y gastric bypass. Obes Surg. 2011;21(5):561–8.CrossRefPubMed
30.
Zurück zum Zitat Gasteyger C, Suter M, Gaillard RC, et al. Nutritional deficiencies after Roux-en-Y gastric bypass for morbid obesity often cannot be prevented by standard multivitamin supplementation. Am J Clin Nutr. 2008;87(5):1128–33.PubMed Gasteyger C, Suter M, Gaillard RC, et al. Nutritional deficiencies after Roux-en-Y gastric bypass for morbid obesity often cannot be prevented by standard multivitamin supplementation. Am J Clin Nutr. 2008;87(5):1128–33.PubMed
31.
Zurück zum Zitat Gong K, Gagner M, Pomp A, et al. Micronutrient deficiencies after laparoscopic gastric bypass: recommendations. Obes Surg. 2008;18(9):1062–6.CrossRefPubMed Gong K, Gagner M, Pomp A, et al. Micronutrient deficiencies after laparoscopic gastric bypass: recommendations. Obes Surg. 2008;18(9):1062–6.CrossRefPubMed
32.
Zurück zum Zitat Sallé A, Demarsy D, Poirier AL, et al. Zinc deficiency: a frequent and underestimated complication after bariatric surgery. Obes Surg. 2010;20(12):1660–70.CrossRefPubMed Sallé A, Demarsy D, Poirier AL, et al. Zinc deficiency: a frequent and underestimated complication after bariatric surgery. Obes Surg. 2010;20(12):1660–70.CrossRefPubMed
33.
Zurück zum Zitat Gehrer S, Kern B, Peters T, et al. Fewer nutrient deficiencies after laparoscopic sleeve gastrectomy (LSG) than after laparoscopic Roux-Y-gastric bypass (LRYGB)—a prospective study. Obes Surg. 2010;20(4):447–53.CrossRefPubMed Gehrer S, Kern B, Peters T, et al. Fewer nutrient deficiencies after laparoscopic sleeve gastrectomy (LSG) than after laparoscopic Roux-Y-gastric bypass (LRYGB)—a prospective study. Obes Surg. 2010;20(4):447–53.CrossRefPubMed
34.
Zurück zum Zitat Dalcanale L, Oliveira CP, Faintuch J, et al. Long-term nutritional outcome after gastric bypass. Obes Surg. 2010;20(2):181–7.CrossRefPubMed Dalcanale L, Oliveira CP, Faintuch J, et al. Long-term nutritional outcome after gastric bypass. Obes Surg. 2010;20(2):181–7.CrossRefPubMed
35.
Zurück zum Zitat Madan AK, Orth WS, Tichansky DS, et al. Vitamin and trace mineral levels after laparoscopic gastric bypass. Obes Surg. 2006;16(5):603–6.CrossRefPubMed Madan AK, Orth WS, Tichansky DS, et al. Vitamin and trace mineral levels after laparoscopic gastric bypass. Obes Surg. 2006;16(5):603–6.CrossRefPubMed
36.
Zurück zum Zitat Moizé V, Andreu A, Flores L, et al. Long-term dietary intake and nutritional deficiencies following sleeve gastrectomy or Roux-En-Y gastric bypass in a mediterranean population. J Acad Nutr Diet. 2013;113(3):400–10.CrossRefPubMed Moizé V, Andreu A, Flores L, et al. Long-term dietary intake and nutritional deficiencies following sleeve gastrectomy or Roux-En-Y gastric bypass in a mediterranean population. J Acad Nutr Diet. 2013;113(3):400–10.CrossRefPubMed
37.
Zurück zum Zitat Homan J, Schijns W, Aarts EO, et al. An optimized multivitamin supplement lowers the number of vitamin and mineral deficiencies three years after Roux-en-Y gastric bypass: a cohort study. Surg Obes Relat Dis. 2016;12(3):659–67.CrossRefPubMed Homan J, Schijns W, Aarts EO, et al. An optimized multivitamin supplement lowers the number of vitamin and mineral deficiencies three years after Roux-en-Y gastric bypass: a cohort study. Surg Obes Relat Dis. 2016;12(3):659–67.CrossRefPubMed
38.
Zurück zum Zitat Roohani N, Hurrell R, Kelishadi R, et al. Zinc and its importance for human health: an integrative review. J Res Med Sci. 2013;18(2):144–57.PubMedPubMedCentral Roohani N, Hurrell R, Kelishadi R, et al. Zinc and its importance for human health: an integrative review. J Res Med Sci. 2013;18(2):144–57.PubMedPubMedCentral
39.
Zurück zum Zitat No Authors Listed. Food and Nutrition Board, Institute of Medicine. Zinc. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, D.C.: National Academy Press; 2001. p. 442–501. No Authors Listed. Food and Nutrition Board, Institute of Medicine. Zinc. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, D.C.: National Academy Press; 2001. p. 442–501.
40.
Zurück zum Zitat Klevay LM. Bariatric surgery and the assessment of copper and zinc nutriture. Obes Surg. 2010;20(5):672–3.CrossRefPubMed Klevay LM. Bariatric surgery and the assessment of copper and zinc nutriture. Obes Surg. 2010;20(5):672–3.CrossRefPubMed
41.
Zurück zum Zitat Lowe NM, Fekete K, Decsi T. Methods of assessment of zinc status in humans: a systematic review. Am J Clin Nutr. 2009;89(6):2040S–51S.CrossRefPubMed Lowe NM, Fekete K, Decsi T. Methods of assessment of zinc status in humans: a systematic review. Am J Clin Nutr. 2009;89(6):2040S–51S.CrossRefPubMed
Metadaten
Titel
Zinc Deficiency after Gastric Bypass for Morbid Obesity: a Systematic Review
verfasst von
Kamal K. Mahawar
Aparna Govil Bhasker
Vivek Bindal
Yitka Graham
Usha Dudeja
Muffazal Lakdawala
Peter K. Small
Publikationsdatum
24.11.2016
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 2/2017
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-016-2474-8

Weitere Artikel der Ausgabe 2/2017

Obesity Surgery 2/2017 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

CME: 2 Punkte

Prof. Dr. med. Gregor Antoniadis Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

CME: 2 Punkte

Dr. med. Benjamin Meyknecht, PD Dr. med. Oliver Pieske Das Webinar S2e-Leitlinie „Distale Radiusfraktur“ beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

CME: 2 Punkte

Dr. med. Mihailo Andric
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.