Skip to main content
Erschienen in: Gastro-News 5/2018

16.10.2018 | Zöliakie | fortbildung

Nahrungsmittelinduzierte Erkrankungen

NZGS klar abgrenzen von Zöliakie und Weizen- oder Getreidesensitivität

verfasst von: Prof. Dr. med. Martin Raithel, Dr. med. Volker Rödl, Jaqueline Ehrle, Elisabeth Oswald, Dr. med. Katharina Hotfiel

Erschienen in: Gastro-News | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Zusammenfassung

Das Bild der Zöliakie hat sich deutlich vom malabsorptiven Verlauf, hin zu einem chamäleonartigen Verlauf mit wenigen oder nur oligosymptomatischen gastrointestinalen Beschwerden, aber zunehmend extraintestinalen und neuropsychiatrischen Symptomen geändert. Letzteres betrifft auch die Nicht-Zöliakie-Glutensensitivität (NZGS). Mit steigender Zahl allergischer Erkrankungen muss die NZGS von der Zöliakie und der Weizen- oder Getreidemehlallergie streng abgegrenzt werden.
Literatur
1.
Zurück zum Zitat Arranz-Otaegui A, Gonzalez Carretero L, Ramsey MN, Fuller DQ, Richter T. Archaeobotanical evidence reveals the origins of bread 14,400 years ago in northeastern Jordan. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(31):7925–30.CrossRef Arranz-Otaegui A, Gonzalez Carretero L, Ramsey MN, Fuller DQ, Richter T. Archaeobotanical evidence reveals the origins of bread 14,400 years ago in northeastern Jordan. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(31):7925–30.CrossRef
2.
Zurück zum Zitat Reilly NR. The Gluten-Free Diet: Recognizing Fact, Fiction, and Fad. The Journal of pediatrics. 2016;175:206–10CrossRef Reilly NR. The Gluten-Free Diet: Recognizing Fact, Fiction, and Fad. The Journal of pediatrics. 2016;175:206–10CrossRef
3.
Zurück zum Zitat Pietzak M. Celiac disease, wheat allergy, and gluten sensitivity: when gluten free is not a fad. JPEN Journal of parenteral and enteral nutrition. 2012;36(1 Suppl):68s–75sCrossRef Pietzak M. Celiac disease, wheat allergy, and gluten sensitivity: when gluten free is not a fad. JPEN Journal of parenteral and enteral nutrition. 2012;36(1 Suppl):68s–75sCrossRef
4.
Zurück zum Zitat Stein J, Kist M, Raithel M. Erkrankungen durch Nahrungsmittel. Wissenschaftliche Verlagsgesellschaft Stuttgart. 2011 Stein J, Kist M, Raithel M. Erkrankungen durch Nahrungsmittel. Wissenschaftliche Verlagsgesellschaft Stuttgart. 2011
5.
Zurück zum Zitat Paajanen L, Vaarala O, Karttunen R, Tuure T, Korpela R, Kokkonen J. Increased IFN-gamma secretion from duodenal biopsy samples in delayed- type cow‘s milk allergy. Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology. 2005;16(5):439–44CrossRef Paajanen L, Vaarala O, Karttunen R, Tuure T, Korpela R, Kokkonen J. Increased IFN-gamma secretion from duodenal biopsy samples in delayed- type cow‘s milk allergy. Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology. 2005;16(5):439–44CrossRef
6.
Zurück zum Zitat Biesiekierski JR, Iven J. Non-coeliac gluten sensitivity: piecing the puzzle together. United European gastroenterology journal. 2015;3(2):160–5CrossRef Biesiekierski JR, Iven J. Non-coeliac gluten sensitivity: piecing the puzzle together. United European gastroenterology journal. 2015;3(2):160–5CrossRef
7.
Zurück zum Zitat Biesiekierski JR, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. The American journal of gastroenterology. 2011;106(3):508–14; quiz 15CrossRef Biesiekierski JR, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. The American journal of gastroenterology. 2011;106(3):508–14; quiz 15CrossRef
8.
Zurück zum Zitat Hahn M, Hagel AF, Hirschmann S, Bechthold C, Konturek P, Neurath M, et al. Modern diagnosis of celiac disease and relevant differential diagnoses in the case of cereal intolerance. Allergo journal international. 2014;23(2):67–77CrossRef Hahn M, Hagel AF, Hirschmann S, Bechthold C, Konturek P, Neurath M, et al. Modern diagnosis of celiac disease and relevant differential diagnoses in the case of cereal intolerance. Allergo journal international. 2014;23(2):67–77CrossRef
9.
Zurück zum Zitat Husby S, Koletzko S, Korponay-Szabo IR, Mearin ML, Phillips A, Shamir R, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. Journal of pediatric gastroenterology and nutrition. 2012;54(1):136–60CrossRef Husby S, Koletzko S, Korponay-Szabo IR, Mearin ML, Phillips A, Shamir R, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. Journal of pediatric gastroenterology and nutrition. 2012;54(1):136–60CrossRef
10.
Zurück zum Zitat Werkstetter KJ, Korponay-Szabo IR, Popp A, Villanacci V, Salemme M, Heilig G, et al. Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice. Gastroenterology. 2017;153(4):924–35CrossRef Werkstetter KJ, Korponay-Szabo IR, Popp A, Villanacci V, Salemme M, Heilig G, et al. Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice. Gastroenterology. 2017;153(4):924–35CrossRef
11.
Zurück zum Zitat Kaukinen K, Turjanmaa K, Maki M, Partanen J, Venalainen R, Reunala T, et al. Intolerance to cereals is not specific for coeliac disease. Scandinavian journal of gastroenterology. 2000;35(9):942–6CrossRef Kaukinen K, Turjanmaa K, Maki M, Partanen J, Venalainen R, Reunala T, et al. Intolerance to cereals is not specific for coeliac disease. Scandinavian journal of gastroenterology. 2000;35(9):942–6CrossRef
12.
Zurück zum Zitat Raithel M, Weidenhiller M, Abel R, Baenkler HW, Hahn EG. Colorectal mucosal histamine release by mucosa oxygenation in comparison with other established clinical tests in patients with gastrointestinally mediated allergy. World journal of gastroenterology. 2006;12(29):4699–705CrossRef Raithel M, Weidenhiller M, Abel R, Baenkler HW, Hahn EG. Colorectal mucosal histamine release by mucosa oxygenation in comparison with other established clinical tests in patients with gastrointestinally mediated allergy. World journal of gastroenterology. 2006;12(29):4699–705CrossRef
13.
Zurück zum Zitat Burkhardt JG, Chapa-Rodriguez A, Bahna SL. Gluten sensitivities and the allergist: Threshing the grain from the husks. Allergy. 2018;73(7):1359–68CrossRef Burkhardt JG, Chapa-Rodriguez A, Bahna SL. Gluten sensitivities and the allergist: Threshing the grain from the husks. Allergy. 2018;73(7):1359–68CrossRef
14.
Zurück zum Zitat Raithel M, Hagel A, Albrecht H, Zopf Y, Naegel A, Baenkler HW, et al. Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet. BMC gastroenterology. 2015;15:41CrossRef Raithel M, Hagel A, Albrecht H, Zopf Y, Naegel A, Baenkler HW, et al. Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet. BMC gastroenterology. 2015;15:41CrossRef
15.
Zurück zum Zitat Hoffmann HJ, Skjold T, Raithel M, Adolf K, Hilberg O, Dahl R. Response of respiratory flour allergics in an ingested flour challenge may involve plasmacytoid dendritic cells, CD25+ and CD152+ T cells. International archives of allergy and immunology. 2006;140(3):252–60CrossRef Hoffmann HJ, Skjold T, Raithel M, Adolf K, Hilberg O, Dahl R. Response of respiratory flour allergics in an ingested flour challenge may involve plasmacytoid dendritic cells, CD25+ and CD152+ T cells. International archives of allergy and immunology. 2006;140(3):252–60CrossRef
16.
Zurück zum Zitat Schwab D, Raithel M, Klein P, Winterkamp S, Weidenhiller M, Radespiel-Troeger M, et al. Immunoglobulin E and eosinophilic cationic protein in segmental lavage fluid of the small and large bowel identify patients with food allergy. The American journal of gastroenterology. 2001;96(2):508–14CrossRef Schwab D, Raithel M, Klein P, Winterkamp S, Weidenhiller M, Radespiel-Troeger M, et al. Immunoglobulin E and eosinophilic cationic protein in segmental lavage fluid of the small and large bowel identify patients with food allergy. The American journal of gastroenterology. 2001;96(2):508–14CrossRef
17.
Zurück zum Zitat Schuppan D, Zimmer KP. The diagnosis and treatment of celiac disease. Deutsches Arzteblatt international. 2013;110(49):835–46PubMedPubMedCentral Schuppan D, Zimmer KP. The diagnosis and treatment of celiac disease. Deutsches Arzteblatt international. 2013;110(49):835–46PubMedPubMedCentral
18.
Zurück zum Zitat Massari S, Liso M, De Santis L, Mazzei F, Carlone A, Mauro S, et al. Occurrence of nonceliac gluten sensitivity in patients with allergic disease. International archives of allergy and immunology. 2011;155(4):389–94CrossRef Massari S, Liso M, De Santis L, Mazzei F, Carlone A, Mauro S, et al. Occurrence of nonceliac gluten sensitivity in patients with allergic disease. International archives of allergy and immunology. 2011;155(4):389–94CrossRef
19.
Zurück zum Zitat Weidenhiller M, Muller S, Schwab D, Hahn EG, Raithel M, Winterkamp S. Microscopic (collagenous and lymphocytic) colitis triggered by food allergy. Gut. 2005;54(2):312–3CrossRef Weidenhiller M, Muller S, Schwab D, Hahn EG, Raithel M, Winterkamp S. Microscopic (collagenous and lymphocytic) colitis triggered by food allergy. Gut. 2005;54(2):312–3CrossRef
20.
Zurück zum Zitat Blanco C, Quiralte J, Castillo R, Delgado J, Arteaga C, Barber D, et al. Anaphylaxis after ingestion of wheat flour contaminated with mites. The Journal of allergy and clinical immunology. 1997;99(3):308–13.CrossRef Blanco C, Quiralte J, Castillo R, Delgado J, Arteaga C, Barber D, et al. Anaphylaxis after ingestion of wheat flour contaminated with mites. The Journal of allergy and clinical immunology. 1997;99(3):308–13.CrossRef
21.
Zurück zum Zitat Ellis A, Linaker BD. Non-coeliac gluten sensitivity? Lancet (London, England). 1978;1(8078):1358–9CrossRef Ellis A, Linaker BD. Non-coeliac gluten sensitivity? Lancet (London, England). 1978;1(8078):1358–9CrossRef
22.
Zurück zum Zitat Jonas A. Wheat-sensitive-but not coeliac. Lancet (London, England). 1978;2(8098):1047CrossRef Jonas A. Wheat-sensitive-but not coeliac. Lancet (London, England). 1978;2(8098):1047CrossRef
23.
Zurück zum Zitat Catassi C, Elli L, Bonaz B, Bouma G, Carroccio A, Castillejo G, et al. Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts‘ Criteria. Nutrients. 2015;7(6):4966–77CrossRef Catassi C, Elli L, Bonaz B, Bouma G, Carroccio A, Castillejo G, et al. Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts‘ Criteria. Nutrients. 2015;7(6):4966–77CrossRef
24.
Zurück zum Zitat Elli L, Tomba C, Branchi F, Fini L, Valiante F, Teresa Bardella M, et al. 107 Results From the “GLUTOX” Trial: A Randomised, Double Blind, Placebo Controlled Crossover Study on “Non Celiac Gluten Sensitivity” 2015. e87 p Elli L, Tomba C, Branchi F, Fini L, Valiante F, Teresa Bardella M, et al. 107 Results From the “GLUTOX” Trial: A Randomised, Double Blind, Placebo Controlled Crossover Study on “Non Celiac Gluten Sensitivity” 2015. e87 p
25.
Zurück zum Zitat Dale HF, Hatlebakk JG, Hovdenak N, Ystad SO, Lied GA. The effect of a controlled gluten challenge in a group of patients with suspected noncoeliac gluten sensitivity: A randomized, double-blind placebo-controlled challenge. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society. 2018 Dale HF, Hatlebakk JG, Hovdenak N, Ystad SO, Lied GA. The effect of a controlled gluten challenge in a group of patients with suspected noncoeliac gluten sensitivity: A randomized, double-blind placebo-controlled challenge. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society. 2018
26.
Zurück zum Zitat Raithel M, Kluger AK, Dietz B, Hetterich U. [Non-allergic gluten sensitivity. A controversial disease - or not yet sufficiently explored?]. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 2016;59(7):821–6CrossRef Raithel M, Kluger AK, Dietz B, Hetterich U. [Non-allergic gluten sensitivity. A controversial disease - or not yet sufficiently explored?]. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 2016;59(7):821–6CrossRef
27.
Zurück zum Zitat Vazquez-Roque MI, Camilleri M, Smyrk T, Murray JA, Marietta E, O‘Neill J, et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology. 2013;144(5):903–11.e3CrossRef Vazquez-Roque MI, Camilleri M, Smyrk T, Murray JA, Marietta E, O‘Neill J, et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology. 2013;144(5):903–11.e3CrossRef
28.
Zurück zum Zitat Catassi C, Bai JC, Bonaz B, Bouma G, Calabro A, Carroccio A, et al. Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients. 2013;5(10):3839–53CrossRef Catassi C, Bai JC, Bonaz B, Bouma G, Calabro A, Carroccio A, et al. Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients. 2013;5(10):3839–53CrossRef
29.
Zurück zum Zitat Raithel M. Fruktane - Bestandteil der FODMAP-Diät: Ein weiterer Baustein als Trigger bei weizensensitiven Patienten. Gastro News. 2018;5(1):12–3CrossRef Raithel M. Fruktane - Bestandteil der FODMAP-Diät: Ein weiterer Baustein als Trigger bei weizensensitiven Patienten. Gastro News. 2018;5(1):12–3CrossRef
30.
Zurück zum Zitat Ziegler JU, Steiner D, Longin CFH, Würschum T, Schweiggert RM, Carle R. Wheat and the irritable bowel syndrome — FODMAP levels of modern and ancient species and their retention during bread making. Journal of Functional Foods. 2016;25:257–66CrossRef Ziegler JU, Steiner D, Longin CFH, Würschum T, Schweiggert RM, Carle R. Wheat and the irritable bowel syndrome — FODMAP levels of modern and ancient species and their retention during bread making. Journal of Functional Foods. 2016;25:257–66CrossRef
Metadaten
Titel
Nahrungsmittelinduzierte Erkrankungen
NZGS klar abgrenzen von Zöliakie und Weizen- oder Getreidesensitivität
verfasst von
Prof. Dr. med. Martin Raithel
Dr. med. Volker Rödl
Jaqueline Ehrle
Elisabeth Oswald
Dr. med. Katharina Hotfiel
Publikationsdatum
16.10.2018
Verlag
Springer Medizin
Erschienen in
Gastro-News / Ausgabe 5/2018
Print ISSN: 1869-1005
Elektronische ISSN: 2520-8667
DOI
https://doi.org/10.1007/s15036-018-0451-x

Weitere Artikel der Ausgabe 5/2018

Gastro-News 5/2018 Zur Ausgabe

der besondere fall

Ein Infekt unklarer Genese

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.