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24.06.2023 | Protocols

A randomized controlled trial of an intervention promoting physical activity and healthy eating recommendations in systemic lupus erythematosus: the protocol study “Living Well with Lupus”

verfasst von: Sofia Mendes Sieczkowska, Fabiana Infante Smaira, Bruna Caruso Mazzolani, Marina Romero, Sandra Gofinet Pasoto, Ana Lúcia de Sá Pinto, Fernanda Rodrigues Lima, Victor Rodrigues De Oliveira, Serli Ueda, Fabiana Braga Benatti, Hamilton Roschel, Bruno Gualano

Erschienen in: Rheumatology International | Ausgabe 10/2023

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Abstract

There is a paucity of studies assessing multidisciplinary interventions focused on tackling physical inactivity/sedentary behavior and poor dietary habits in SLE. The Living well with Lupus (LWWL) is a randomized controlled trial to investigate whether a six-month lifestyle change intervention will improve cardiometabolic risk factors (primary outcome) among systemic lupus erythematosus (SLE) patients with low disease activity (SLEDAI score ≤ 4) and with high cardiovascular risk. As secondary goals, we will evaluate: (1) the intervention’s safety, efficacy, and feasibility in promoting lifestyle changes, and (2) the effects of the intervention on secondary outcomes (i.e., clinical parameters, functional capacity, fatigue, psychological aspects, sleep quality and health-related quality of life). Patients will be randomly allocated to either a control (i.e., standard care) or a lifestyle intervention group using a simple randomization (1:1 ratio, blocks of 20). Mixed Model analyses will be conducted for comparing groups following an intention-to-treat approach. A per protocol analysis will also be conducted. This study has the potential to generate new, clinically relevant data able to refine the multidisciplinary management of SLE patients. Protocol version number: NCT04431167 (first version).

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Titel: A randomized controlled trial of an intervention promoting physical activity and healthy eating recommendations in systemic lupus erythematosus: the protocol study “Living Well with Lupus”
verfasst von: Sofia Mendes Sieczkowska
Fabiana Infante Smaira
Bruna Caruso Mazzolani
Marina Romero
Sandra Gofinet Pasoto
Ana Lúcia de Sá Pinto
Fernanda Rodrigues Lima
Victor Rodrigues De Oliveira
Serli Ueda
Fabiana Braga Benatti
Hamilton Roschel
Bruno Gualano
Publikationsdatum: 24.06.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Rheumatology International / Ausgabe 10/2023
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-023-05370-x

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A randomized controlled trial of an intervention promoting physical activity and healthy eating recommendations in systemic lupus erythematosus: the protocol study “Living Well with Lupus”

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