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Erschienen in: European Archives of Oto-Rhino-Laryngology 7/2011

01.07.2011 | Otology

Acoustic overstimulation-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice

verfasst von: Yong Cui, Guang-wei Sun, Daisuke Yamashita, Sho Kanzaki, Tatsuo Matsunaga, Masato Fujii, Kimitaka Kaga, Kaoru Ogawa

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 7/2011

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Abstract

Fibrocytes of the spiral limbus are thought to play a significant role in maintaining ion homeostasis in the cochlea. The present study measured physiological and morphological changes in spiral limbus of mice in response to noise exposure. 6-week-old male C3H/HeJJcl mice were exposed to octave-band noise (120 dB SPL) for 2 h and evaluated at a series of times thereafter, up to 8 weeks. Permanent hearing loss resulted in the mice, as assessed by auditory brainstem response (ABR) recordings. The fibrocytes loss was found in the spiral limbus of the apical turn, which has been proved to be induced by apoptosis. These results suggest that noise exposure might result in apoptosis of fibrocytes in spiral limbus, which suggest a mechanism for noise-induced hearing loss.
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Metadaten
Titel
Acoustic overstimulation-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice
verfasst von
Yong Cui
Guang-wei Sun
Daisuke Yamashita
Sho Kanzaki
Tatsuo Matsunaga
Masato Fujii
Kimitaka Kaga
Kaoru Ogawa
Publikationsdatum
01.07.2011
Verlag
Springer-Verlag
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 7/2011
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-011-1484-3

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