nach oben

European Journal of Nutrition

Erschienen in:

01.12.2015 | Review

Advanced physiological roles of guanidinoacetic acid

verfasst von: Sergej M. Ostojic

Erschienen in: European Journal of Nutrition | Ausgabe 8/2015

Einloggen, um Zugang zu erhalten

Abstract

Dietary guanidinoacetic acid (GAA) seems to improve cellular bioenergetics by stimulating creatine biosynthesis. However, GAA could have other biological functions that might affect its possible use as a food ingredient in human nutrition. In this paper, we identified several alternative physiological roles of supplemental GAA, including the stimulation of hormonal release and neuromodulation, an alteration of metabolic utilization of arginine, and an adjustment of oxidant–antioxidant status. A better knowledge of how GAA affects human physiology may facilitate its use as an experimental nutritional intervention for novel purposes and conditions.

Weber CJ (1934) Isolation of glycocyamine from urine. Exp Biol Med 32:172–174CrossRef

Davenport HW, Fisher RB, Wilhelmi AE (1938) The metabolism of creatine: the role of glycocyamine in creatine synthesis. Biochem J 32(2):262–270CrossRef

Edison EE, Brosnan ME, Meyer C, Brosnan JT (2007) Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo. Am J Physiol Renal Physiol 293(6):F1799–F1804CrossRef

Tsubakihara Y, Suzuki A, Hayashi T, Shoji T, Togawa M, Okada N (1999) The effect of guanidinoacetic acid supplementation in patients with chronic renal failure. In: Mori A, Ishida M, Clark JF (eds) Guanidino compounds in biology and medicine, vol 5. Blackwell Science Asia, Tokyo, pp 139–144

Ostojic SM, Stojanovic MD, Hoffman JR (2015) Six-week oral guanidinoacetic acid administration improves muscular performance in healthy volunteers. J Investig Med. doi:10.1097/JIM.0000000000000212

Ostojic SM, Hoffman JR, Stojanovic M, Drid P (2015) 28-day GAA supplementation improves clinical outcomes in patients with chronic fatigue syndrome. Med Sci Sport Exerc 48(5):S47

McBreairty LE, Robinson JL, Furlong KR, Brunton JA, Bertolo RF (2015) Guanidinoacetate is more effective than creatine at enhancing tissue creatine stores while consequently limiting methionine availability in Yucatan miniature pigs. PLoS One 10(6):e0131563CrossRef

Van Zandt V, Borsook H (1951) New biological approach to the treatment of congestive heart failure. Ann West Med Surg 5(10):856–862

Borsook ME, Billig HK, Golseth JG (1952) Betaine and glycocyamine in the treatment of disability resulting from acute anterior poliomyelitis. Ann West Med Surg 6(7):423–427

10.

Aynsley-Green A, Alberti KG (1974) In vivo stimulation of insulin secretion by guanidine derivatives in the rat. Horm Metab Res 6(2):115–120CrossRef

11.

Alsever RN, Georg RH, Sussman KE (1970) Stimulation of insulin secretion by guanidinoacetic acid and other guanidine derivatives. Endocrinology 86(2):332–336CrossRef

12.

Marco J, Calle C, Hedo JA, Villanueva ML (1976) Glucagon-releasing activity of guanidine compounds in mouse pancreatic islets. FEBS Lett 64(1):52–54CrossRef

13.

Charles S, Tamagawa T, Henquin JC (1982) A single mechanism for the stimulation of insulin release and 86Rb+ efflux from rat islets by cationic amino acids. Biochem J 208(2):301–308CrossRef

14.

Meglasson MD, Wilson JM, Yu JH, Robinson DD, Wyse BM, de Souza CJ (1993) Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL6Job/ob mice and increases glucose disappearance in rhesus monkeys. J Pharmacol Exp Ther 266(3):1454–1462

15.

Baker DH (2009) Advances in protein-amino acid nutrition of poultry. Amino Acids 37(1):29–41CrossRef

16.

Ringel J, Lemme A, Redshaw MS, Damme K (2008) The effects of supplemental guanidino acetic acid as a precursor of creatine in vegetable broiler diets on performance and carcass parameters. Poult Sci 87(Suppl 1):72

17.

Michiels J, Maertens L, Buyse J, Lemme A, Rademacher M, Dierick NA, De Smet S (2012) Supplementation of guanidinoacetic acid to broiler diets: effects on performance, carcass characteristics, meat quality, and energy metabolism. Poult Sci 91(2):402–412CrossRef

18.

Dilger RN, Bryant-Angeloni K, Payne RL, Lemme A, Parsons CM (2013) Dietary guanidino acetic acid is an efficacious replacement for arginine for young chicks. Poult Sci 92(1):171–177CrossRef

19.

Tong BC, Barbul A (2004) Cellular and physiological effects of arginine. Mini Rev Med Chem 4(8):823–832CrossRef

20.

De Deyn PP, Macdonald RL (1990) Guanidino compounds that are increased in cerebrospinal fluid and brain of uremic patients inhibit GABA and glycine responses on mouse neurons in cell culture. Ann Neurol 28(5):627–633CrossRef

21.

Neu A, Neuhoff H, Trube G, Fehr S, Ullrich K, Roeper J, Isbrandt D (2002) Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism. Neurobiol Dis 11(2):298–307CrossRef

22.

Ostojic SM, Stojanovic MD (2015) Guanidinoacetic acid loading affects plasma & #x03B3;-aminobutyric acid in healthy men. Eur J Nutr 54(5):855–858CrossRef

23.

James E, Morrison JF (1966) The reaction of phosphagens with ATP: creatine phosphotransferase. Biochim Biophys Acta 128(2):327–336CrossRef

24.

Rowley GL, Greenleaf AL, Kenyon GL (1971) On the specificity of creatine kinase. New glycocyamines and glycocyamine analogs related to creatine. J Am Chem Soc 93(12):5542–5551CrossRef

25.

Lygate CA, Aksentijevic D, Dawson D, ten Hove M, Phillips D, de Bono JP, Medway DJ, Sebag-Montefiore L, Hunyor I, Channon KM, Clarke K, Zervou S, Watkins H, Balaban RS, Neubauer S (2013) Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice. Circ Res 112(6):945–955CrossRef

26.

Boehm EA, Radda GK, Tomlin H, Clark JF (1996) The utilisation of creatine and its analogues by cytosolic and mitochondrial creatine kinase. Biochim Biophys Acta 1274(3):119–128CrossRef

27.

Kan HE, Renema WK, Isbrandt D, Heerschap A (2004) Phosphorylated guanidinoacetate partly compensates for the lack of phosphocreatine in skeletal muscle of mice lacking guanidinoacetate methyltransferase. J Physiol 560(1):219–229CrossRef

28.

Zugno AI, Stefanello FM, Scherer EB, Mattos C, Pederzolli CD, Andrade VM, Wannmacher CM, Wajner M, Dutra-Filho CS, Wyse AT (2008) Guanidinoacetate decreases antioxidant defenses and total protein sulfhydryl content in striatum of rats. Neurochem Res 33(9):1804–1810CrossRef

29.

Mori A, Kohno M, Masumizu T, Nosa Y, Packer I (1996) Guanidino compounds generate reactive oxygen species. Biochem Mol Biol Int 40(1):135–143

30.

Wang LS, Shi BM, Shan AS, Zhang YY (2012) Effects of guanidinoacetic acid on growth performance, meat quality and antioxidation in growing-finishing pigs. J Anim Vet Adv 11(5):631–636CrossRef

31.

Hiramatsu M (2003) A role of guanidino compounds in the brain. Mol Cell Biochem 244(1–2):57–62CrossRef

32.

Major RH, Weber CJ (1928) The effects of glycocyamine and glyocyamidine on the blood pressure. Johns Hopkins Med J 42:207

33.

Major RH (1929) Observations on the effects of certain guanidine compounds upon the blood pressure. Tr A Am Physician 44:332

34.

Major RH (1930) Some observations upon the physiologic and therapeutic action of glycocyamine. J Clin Investig 9(1):24

35.

Ginsberg AM, Stoland OO (1931) The effect of glycocyamine on the coronary circulation. Pharmacol Exp Ther 41(2):195–208

36.

Udenfriend S, Creveling CR, Ozaki M, Daly JW, Witkop B (1959) Inhibitors of norepinephrine metabolism in vivo. Arch Biochem Biophys 84:249–251CrossRef

37.

Charlier R (1961) Coronary vasodilators: international series of monographs on pure and applied biology division: modern trends in physiological sciences, vol 10. Pergamon Press, Oxford

38.

Tousoulis D, Kampoli AM, Tentolouris C, Papageorgiou N, Stefanadis C (2012) The role of nitric oxide on endothelial function. Curr Vasc Pharmacol 10(1):4–18CrossRef

39.

Stockler S, Schutz PW, Salomons GS (2007) Cerebral creatine deficiency syndromes: clinical aspects, treatment and pathophysiology. Subcell Biochem 46:149–166CrossRef

40.

Schulze A (2003) Creatine deficiency syndromes. Mol Cell Biochem 244(1–2):143–150CrossRef

41.

Braisant O (2012) Creatine and guanidionoacetate transport at blood-brain and blood-cerebrospinal fluid barriers. J Inherit Metab Dis 35(4):655–664CrossRef

Titel: Advanced physiological roles of guanidinoacetic acid
verfasst von: Sergej M. Ostojic
Publikationsdatum: 01.12.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 8/2015
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-015-1050-7

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2015

A novel Mediterranean diet index from Lebanon: comparison with Europe

Angiotensin-converting enzyme gene insertion/deletion polymorphism in nutritional disorders in children

Higher plasma lipopolysaccharide concentrations are associated with less favorable phenotype in overweight/obese men

The influence of the menstrual cycle on energy balance and taste preference in Asian Chinese women

Iron bioavailability from commercially available iron supplements