nach oben

European Journal of Pediatrics

Erschienen in:

01.03.2012 | Original Paper

Agreement of specific IgE and skin prick test in an unselected cohort of two-year-old children

verfasst von: Anne D. Rø, Marit Saunes, Ingeborg Smidesang, Ola Storrø, Torbjørn Øien, Torolf Moen, Roar Johnsen

Erschienen in: European Journal of Pediatrics | Ausgabe 3/2012

Einloggen, um Zugang zu erhalten

Abstract

The objective of this study was to evaluate the agreement between specific IgE (sIgE) and skin prick test (SPT), and the possible association between total IgE concentration and allergy-related disorders, when performed in an unselected cohort of 353 two-year olds. Median total IgE was within the reference value for two-year-old children regardless of the presence or absence of allergy-related disorders. 18.7% of the children had one or more positive reactions to SPT and/or sIgE in a panel of 12 allergens. Agreement between SPT and sIgE was variable, being best for peanut and poorest for milk. Conclusion: In young children total IgE is of limited value when evaluating allergy-related disorder. The lack of agreement among the positive tests of the sIgE and SPT for some allergens imply that these tests should not be used interchangeably, and both tests should probably be used complementarily when diagnosing atopic sensitization in small children.

Ahlstedt S, Murray CS (2006) In vitro diagnosis of allergy: how to interpret IgE antibody results in clinical practice. Prim Care Respir J 15:228–236PubMedCrossRef

Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M et al (2010) Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 126:S1–S58PubMedCrossRef

Calabria CW, Dietrich J, Hagan L (2009) Comparison of serum-specific IgE (ImmunoCAP) and skin-prick test results for 53 inhalant allergens in patients with chronic rhinitis. Allergy Asthma Proc 30:386–396PubMedCrossRef

Carosso A, Bugiani M, Migliore E, Anto JM, DeMarco R (2007) Reference values of total serum IgE and their significance in the diagnosis of allergy in young European adults. Int Arch Allergy Immunol 142:230–238PubMedCrossRef

Cobbaert CM, Jonker GJ (2005) Allergy testing on the IMMULITE 2000 random-access immunoanalyzer—a clinical evaluation study. Clin Chem Lab Med 43:772–781PubMedCrossRef

Cox L, Williams B, Sicherer S, Oppenheimer J, Sher L, Hamilton R, Golden D (2008) Pearls and pitfalls of allergy diagnostic testing: report from the American College of Allergy, Asthma and Immunology/American Academy of Allergy, Asthma and Immunology Specific IgE Test Task Force. Ann Allergy Asthma Immunol 101:580–592PubMedCrossRef

Dieguez MC, Cerecedo I, Muriel A, Zamora J, Abraira V, Camacho E, Anton M, de la Hoz B (2009) Utility of diagnostic tests in the follow-up of egg-allergic children. Clin Exp Allergy 39:1575–1584PubMedCrossRef

Dotterud CK, Storro O, Johnsen R, Oien T (2010) Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial. Br J Dermatol 163:616–623PubMedCrossRef

Du Toit G, Santos A, Roberts G, Fox AT, Smith P, Lack G (2009) The diagnosis of IgE-mediated food allergy in childhood. Pediatr Allergy Immunol 20:309–319PubMedCrossRef

10.

Emerson RM, Charman CR, Williams HC (2000) The Nottingham Eczema Severity Score: preliminary refinement of the Rajka and Langeland grading. Br J Dermatol 142:288–297PubMedCrossRef

11.

Erwin EA, Ronmark E, Wickens K, Perzanowski MS, Barry D, Lundback B, Crane J, Platts-Mills TA (2007) Contribution of dust mite and cat specific IgE to total IgE: relevance to asthma prevalence. J Allergy Clin Immunol 119:359–365PubMedCrossRef

12.

Frith J, Fleming L, Bossley C, Ullmann N, Bush A (2011) The complexities of defining atopy in severe childhood asthma. Clin Exp Allergy

13.

Host A, Andrae S, Charkin S, Diaz-Vazquez C, Dreborg S, Eigenmann PA, Friedrichs F, Grinsted P, Lack G, Meylan G, Miglioranzi P, Muraro A, Nieto A, Niggemann B, Pascual C, Pouech MG, Rance F, Rietschel E, Wickman M (2003) Allergy testing in children: why, who, when and how? Allergy 58:559–569PubMedCrossRef

14.

Kjaer HF, Eller E, Andersen KE, Host A, Bindslev-Jensen C (2009) The association between early sensitization patterns and subsequent allergic disease. The DARC birth cohort study. Pediatr Allergy Immunol 20:726–734PubMedCrossRef

15.

Kovac K, Dodig S, Tjesic-Drinkovic D, Raos M (2007) Correlation between asthma severity and serum IgE in asthmatic children sensitized to Dermatophagoides pteronyssinus. Arch Med Res 38:99–105PubMedCrossRef

16.

Nickel R, Illi S, Lau S, Sommerfeld C, Bergmann R, Kamin W, Forster J, Schuster A, Niggemann B, Wahn U (2005) Variability of total serum immunoglobulin E levels from birth to the age of 10 years. A prospective evaluation in a large birth cohort (German Multicenter Allergy Study). Clin Exp Allergy 35:619–623PubMedCrossRef

17.

Ollert M, Weissenbacher S, Rakoski J, Ring J (2005) Allergen-specific IgE measured by a continuous random-access immunoanalyzer: interassay comparison and agreement with skin testing. Clin Chem 51:1241–1249PubMedCrossRef

18.

Ostblom E, Lilja G, Ahlstedt S, van Hage M, Wickman M (2008) Patterns of quantitative food-specific IgE-antibodies and reported food hypersensitivity in 4-year-old children. Allergy 63:418–424PubMedCrossRef

19.

Rance F, Juchet A, Bremont F, Dutau G (1997) Correlations between skin prick tests using commercial extracts and fresh foods, specific IgE, and food challenges. Allergy 52:1031–1035PubMedCrossRef

20.

Silvestri M, Pistorio A, Battistini E, Rossi GA (2010) IgE in childhood asthma: relevance of demographic characteristics and polysensitisation. Arch Dis Child 95:979–984PubMedCrossRef

21.

Sinclair D, Peters SA (2004) The predictive value of total serum IgE for a positive allergen specific IgE result. J Clin Pathol 57:956–959PubMedCrossRef

22.

Smidesang I, Saunes M, Storro O, Oien T, Holmen TL, Johnsen R, Henriksen AH (2008) Atopic dermatitis among 2-year olds; high prevalence, but predominantly mild disease—the PACT study, Norway. Pediatr Dermatol 25:13–18PubMedCrossRef

23.

Smidesang I, Saunes M, Storro O, Oien T, Holmen TL, Johnsen R, Henriksen AH (2009) Allergy related disorders among 2-yrs olds in a general population. The PACT Study. Pediatr Allergy Immunol 21:315–320PubMedCrossRef

24.

Storro O, Oien T, Dotterud CK, Jenssen JA, Johnsen R (2010) A primary health-care intervention on pre- and postnatal risk factor behavior to prevent childhood allergy. The Prevention of Allergy among Children in Trondheim (PACT) study. BMC Public Health 10:443PubMedCrossRef

25.

Sturgill S, Bernard LA (2004) Atopic dermatitis update. Curr Opin Pediatr 16:396–401PubMedCrossRef

26.

Wang J, Godbold JH, Sampson HA (2008) Correlation of serum allergy (IgE) tests performed by different assay systems. J Allergy Clin Immunol 121:1219–1224PubMedCrossRef

27.

Williams HC, Burney PG, Hay RJ, Archer CB, Shipley MJ, Hunter JJ, Bingham EA, Finlay AY, Pembroke AC, Graham-Brown RA et al (1994) The U.K. Working Party’s Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatol 131:383–396PubMedCrossRef

28.

Wood RA, Segall N, Ahlstedt S, Williams PB (2007) Accuracy of IgE antibody laboratory results. Ann Allergy Asthma Immunol 99:34–41PubMedCrossRef

Titel: Agreement of specific IgE and skin prick test in an unselected cohort of two-year-old children
verfasst von: Anne D. Rø
Marit Saunes
Ingeborg Smidesang
Ola Storrø
Torbjørn Øien
Torolf Moen
Roar Johnsen
Publikationsdatum: 01.03.2012
Verlag: Springer-Verlag
Erschienen in: European Journal of Pediatrics / Ausgabe 3/2012
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-011-1580-9

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Agreement of specific IgE and skin prick test in an unselected cohort of two-year-old children

Abstract

Neu im Fachgebiet Pädiatrie

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

Häufigste Gründe für Brustschmerzen bei Kindern

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

Durch übermäßige Internetnutzung wird oft die Schule verpasst

Update Pädiatrie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2012

Description of children with 45,X/46,XY karyotype

Erratum to: Chest physiotherapy using passive expiratory techniques does not reduce bronchiolitis severity: a randomised controlled trial

Tracheal agenesis: approach towards this severe diagnosis. Case report and review of the literature

Real-time registration of adverse events in Dutch hospitalized children in general pediatric units: first experiences

The prevalence and etiology of anemia among HIV-infected children in India

Two cases of type A infant botulism in Grenoble, France: no honey for infants

Neu im Fachgebiet Pädiatrie

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

Häufigste Gründe für Brustschmerzen bei Kindern

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

Durch übermäßige Internetnutzung wird oft die Schule verpasst

Update Pädiatrie