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01.04.2004 | Leitthema

„Alternative“ Effekte von Lokalanästhetika

verfasst von: S. Pecher, B. W. Böttiger, B. Graf, Dr. Dr. M. W. Hollmann

Erschienen in: Die Anaesthesiologie | Ausgabe 4/2004

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Zusammenfassung

In dem folgenden Artikel werden verschiedene Effekte von Lokalanästhetika beschrieben, die nicht allein durch deren bekannte natriumkanalblockierende Wirkung zu erklären sind. Besonders hervorzuheben ist ihre antiinflammatorische Aktivität, v. a. die Fähigkeit, pathologische Veränderungen, wie exzessive Stimulation des inflammatorischen Systems, zu inhibieren ohne jedoch das körpereigene Abwehrsystem zu schwächen. Im Vergleich zu anderen immunsupprimierenden Medikamenten könnten auch Lokalanästhetika für die Zukunft eine viel versprechende Therapieoption sein. Neben ihrer allgemeinanästhetischen Wirkung scheinen Lokalanästhetika zerebroprotektive Effekte zu haben. Somit könnte ihr Einsatz bei neurochirurgischen Eingriffen von Interesse sein, insbesondere im Hinblick auf ihre kardiovaskuläre Stabilität. Zudem haben Lokalanästhetika die Fähigkeit, die brochiale Hyperreaktivität zu senken, auch wenn die Mechanismen hierzu letztendlich noch nicht im Detail geklärt sind. Die „alternativen“ Effekte der Lokalanästhetika stellen insgesamt eine interessante Perspektive dar, deren Relevanz derzeit jedoch nicht absehbar ist.

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Titel: „Alternative“ Effekte von Lokalanästhetika
verfasst von: S. Pecher
B. W. Böttiger
B. Graf
Dr. Dr. M. W. Hollmann
Publikationsdatum: 01.04.2004
Verlag: Springer-Verlag
Erschienen in: Die Anaesthesiologie / Ausgabe 4/2004
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI: https://doi.org/10.1007/s00101-003-0629-1

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