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13.03.2024 | Original Paper

Aortic regurgitation is associated with African American and Asian race, smoking, renal disease, and numerous autoimmune diseases in addition to traditional cardiovascular risk factors but has lower risk with alcohol intake

verfasst von: Brandon Timmerman, Mehrtash Hashemzadeh, Mohammad Reza Movahed

Erschienen in: Clinical Research in Cardiology

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Abstract

Background

Aortic regurgitation (AR) is associated with increasing age, rheumatic heart disease, and a bicuspid aortic valve, but its association with other comorbidities and race is less known. The purpose of this study was to investigate any association between AR and comorbid conditions in older adults above 40.

Method

The large Nationwide Inpatient Sample database was utilized for our study using uni- and multivariate analysis. Data were extracted from available ICD-10 codes for the years of 2016–2020.

Results

The NIS data included 112,982,565 patients. A total of 660,730 were found to have AR. AR was found to be associated with male gender (OR 1.15, CI 1.14–1.16, P < 0.001), smoking (OR 1.04, CI 1.02–1.05, P < 0.001), hypertension (OR 1.65, CI 1.62–1.68, P < 0.001), hyperlipidemia (OR 1.36, CI 1.34–1.37, P < 0.001), chronic kidney disease (OR 1.22, CI 1.21–1.24, P < 0.001), antiphospholipid antibody syndrome (OR 1.56, CI 1.33–1.83, P < 0.001), rheumatoid arthritis (OR 1.1, CI 1.06–1.14, P < 0.001), scleroderma (OR 1.49, CI 1.31–1.7, P < 0.001), systemic connective tissue disorders (OR 1.32, CI 1.25–1.4, P < 0.001), Raynaud’s syndrome (OR 1.62, CI 1.47–1.77, P < 0.001), and systemic lupus erythematosus (OR 1.44, CI 1.34–1.54, P < 0.001) in add to known bicuspid aortic valve.

Conclusion

Using a very large database, we found new associations between AR and many comorbid conditions, including many inflammatory and chronic degenerative diseases in addition to the known risk factors.

Graphical Abstract

Aortic regurgitation is associated with cardiovascular risk factors, race, and numerous autoimmune diseases.

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Weber MA, Schmieder RE, Kandzari DE, Townsend RR, Mahfoud F, Tsioufis K, Kario K, Pocock S, Tatakis F, Ewen S, Choi JW, East C, Lee DP, Ma A, Cohen DL, Wilensky R, Devireddy CM, Lea JP, Schmid A, Fahy M, Böhm M (2022) Hypertension urgencies in the SPYRAL HTN-OFF MED Pivotal trial. Clin Res Cardiol 111(11):1269–1275. https://doi.org/10.1007/s00392-022-02064-5CrossRefPubMedPubMedCentral

Titel: Aortic regurgitation is associated with African American and Asian race, smoking, renal disease, and numerous autoimmune diseases in addition to traditional cardiovascular risk factors but has lower risk with alcohol intake
verfasst von: Brandon Timmerman
Mehrtash Hashemzadeh
Mohammad Reza Movahed
Publikationsdatum: 13.03.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Research in Cardiology
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-024-02424-3

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