nach oben

Erschienen in:

01.12.2024 | Original Paper

Applications of topical immunomodulators enhance clinical signs of vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC): a meta-analysis

verfasst von: Nir Erdinest, Dror Ben Ephraim Noyman, Naomi London, Itay Lavy, Nadav Levinger, David Landau, Abraham Solomon, Yair Morad, Shehzad A. Naroo

Erschienen in: International Ophthalmology | Ausgabe 1/2024

Einloggen, um Zugang zu erhalten

Abstract

Purpose

This meta-analysis aimed to review the safety and efficacy of topical cyclosporine A (CsA) and topical tacrolimus in allergic eye disease.

Methods

A systematic search identified thirteen studies and a total of 445 patients for inclusion, making this the largest meta-analysis published on the subject. The current review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

Results

Thirteen randomized control trials were included in the meta-analysis. Eleven studies used CsA as the treatment, and two used Tacrolimus. In total, 445 participants were included, of whom 76.6% were male. The mean age of participants across the included studies was 14 years. All studies reported clinical signs as evaluated by an examining clinician. Signs were usually assessed by anatomical region, with the most common regions being the conjunctiva and the cornea, and the most common signs assessed were hyperemia and papillae. Three studies accounted for more than 50% of the meta-analysis's weight. Effect size (d) ranged from − 2.37 to − 0.03, negative values favoring immunomodulators. Fixed Effect Meta-Analysis returned an SMD of − 0.81 (95% CI [− 0.98, − 0.65]). However, there was significant heterogeneity (I² = 61%, Q_w = 30.76) in the outcome measure (P = 0.0021); therefore, a random-effect meta-analysis was also completed in which the pooled SMD was − 0.98 (95% CI [− 1.26, − 0.69], τ² = 0.16).

Conclusions

This study affirms the current scientific community's stance that immunomodulators effectively treat clinical signs, including blepharitis, conjunctival hyperemia, edema, papillae, and corneal damage in severe ocular allergic disease.

Csorba A, Soproni A, Maneschg O, Nagy Z, Szamosi A (2019) Application of corticosteroid eye drops for allergic eye diseases in children. Orv Hetil 160(9):329–337CrossRefPubMed

Baranwal V, Mishra A, Sharma V, Gupta S, Sunder S, Verma S (2019) The prevalence of various eye diseases among patients of different nationalities attending the ophthalmology clinic at a tertiary care united nations hospital: a 5 year retrospective analysis. J Contemp Med Res 6(9):I7–I10

Graif Y, Garty B-Z, Livne I, Green MS, Shohat T (2004) Prevalence and risk factors for allergic rhinitis and atopic eczema among schoolchildren in Israel: results from a national study. Ann Allergy Asthma Immunol 92(2):245–249CrossRefPubMed

Zhong J-Y, Lee Y-C, Hsieh C-J, Tseng C-C, Yiin L-M (2018) Association between dry eye disease, air pollution and weather changes in Taiwan. Int J Environ Res Public Health 15(10):2269CrossRefPubMedPubMedCentral

Shaker M, Salcone E (2016) An update on ocular allergy. Curr Opin Allergy Clin Immunol 16(5):505–510. https://doi.org/10.1097/ACI.0000000000000299CrossRefPubMed

Patel DS, Arunakirinathan M, Stuart A, Angunawela R (2017) Allergic eye disease. BMJ 359:j4706. https://doi.org/10.1136/bmj.j4706CrossRefPubMed

Bielory L (2011) Ocular allergy. Mt Sinai J Med 78(5):740–758. https://doi.org/10.1002/msj.20291CrossRefPubMed

Bielory L (2008) Ocular allergy treatment. Immunol Allergy Clin North Am 28(1):189–224. https://doi.org/10.1016/j.iac.2007.12.001.

Das AV, Donthineni PR, Prashanthi GS, Basu S (2019) Allergic eye disease in children and adolescents seeking eye care in India: electronic medical records driven big data analytics report II. Ocul Surf 17(4):683–689CrossRefPubMed

10.

Akpek EK, Dart JK, Watson S, Christen W, Dursun D, Yoo S, et al (2004) A randomized trial of topical cyclosporin 0.05% in topical steroid–resistant atopic keratoconjunctivitis. Ophthalmology 111(3):476–482.

11.

Keklikci U, Dursun B, Cingu AK (2014) Topical cyclosporine a 0.05% eyedrops in the treatment of vernal keratoconjunctivitis-randomized placebo-controlled trial. Adv Clin Exp Med Official Organ Wroclaw Med Univ 23(3):455–461.

12.

Kiliç A, Gürler B (2006) Topical 2% cyclosporine A in preservative-free artificial tears for the treatment of vernal keratoconjunctivitis. Can J Ophthalmol 41(6):693–698CrossRefPubMed

13.

Ricciardi L, Furci F, Stefania I (2019) H1-antihistamines for allergic diseases: old aged but not old-fashioned drugs. Int J Aller Medications 5:037

14.

Leonardi A, Capobianco D, Benedetti N, Capobianco A, Cavarzeran F, Scalora T et al (2019) Efficacy and tolerability of ketotifen in the treatment of seasonal allergic conjunctivitis: comparison between ketotifen 0.025% and 0.05% eye drops. Ocular immunol Inflammation 27(8):1352–1356.

15.

Mounsey AL, Gray RE (2016) Topical antihistamines and mast cell stabilizers for treating allergic conjunctivitis. Am Fam Physician 93(11):915–916PubMed

16.

Church MK (2016) Allergy, histamine and antihistamines. Histamine and histamine receptors in health and disease. Springer, Cham, pp 321–331.

17.

Butrus S, Portela R (2005) Ocular allergy: diagnosis and treatment. Ophthalmol Clin North Am 18(4):485–492. https://doi.org/10.1016/j.ohc.2005.07.007.

18.

Leonardi A, Silva D, Perez FD, Bozkurt B, Sharma V, Allegri P et al (2019) Management of ocular allergy. Allergy. https://doi.org/10.1111/all.13786CrossRefPubMed

19.

Wu B, Tong J, Ran Z (2019) Tacrolimus therapy in steroid-refractory ulcerative colitis: a review. Inflamm Bowel Dis. https://doi.org/10.1093/ibd/izz068CrossRefPubMedPubMedCentral

20.

Schneeweiss S, Doherty M, Zhu S, Funch D, Schlienger RG, Fernandez-Vidaurre C et al (2009) Topical treatments with pimecrolimus, tacrolimus and medium- to high-potency corticosteroids, and risk of lymphoma. Dermatology 219(1):7–21. https://doi.org/10.1159/000209289CrossRefPubMed

21.

Daniell M, Constantinou M, Vu HT, Taylor HR (2006) Randomised controlled trial of topical ciclosporin A in steroid dependent** allergic conjunctivitis. Br J Ophthalmol 90(4):461–464. https://doi.org/10.1136/bjo.2005.082461CrossRefPubMedPubMedCentral

22.

Urban RC Jr, Cotlier E (1986) Corticosteroid-induced cataracts. Surv Ophthalmol 31(2):102–110CrossRefPubMed

23.

Bonini S, Bonini S, Lambiase A, Marchi S, Pasqualetti P, Zuccaro O et al (2000) Vernal keratoconjunctivitis revisited: a case series of 195 patients with long-term followup. Ophthalmology 107(6):1157–1163CrossRefPubMed

24.

Chan HH, Salmon JF (2019) Glaucoma caused by topical corticosteroid application to the eyelids. Med J Aust 210(4):142–153CrossRef

25.

Raj A, Salvador-Culla B, Anwar H, Sykakis E, Figueiredo MS, Figueiredo FC (2020) Long-term outcomes on de novo ocular hypertensive response to topical corticosteroids after corneal transplantation. Cornea 39(1):45–51CrossRefPubMed

26.

Wu YT, Truong TN, Tam C, Mendoza MN, Zhu L, Evans DJ et al (2019) Impact of topical corticosteroid pretreatment on susceptibility of the injured murine cornea to Pseudomonas aeruginosa colonization and infection. Exp Eye Res 179:1–7CrossRefPubMed

27.

Jinagal J, Gupta PC, Pilania RK, Ram J (2019) Systemic toxicity of topical corticosteroids. Indian J Ophthalmol 67(4):559CrossRefPubMedPubMedCentral

28.

Cutolo CA, Barabino S, Bonzano C, Traverso CE (2019) The use of topical corticosteroids for treatment of dry eye syndrome. Ocul Immunol Inflamm 27(2):266–275CrossRefPubMed

29.

Bilgin AB, Dogan ME, Ayaz Y, Apaydin KC (2019) Comparison of efficacy and safety of loteprednol etabonate 0.5% and topical dexamethasone 1% in post-vitrectomy inflammation. Ocular Immunol Inflammation 27(2):312–318.

30.

Ilyas H, Slonim CB, Braswell GR, Favetta JR, Schulman M (2004) Long-term safety of loteprednol etabonate 0.2% in the treatment of seasonal and perennial allergic conjunctivitis. Eye Contact Lens 30(1):10–13.

31.

Öner V, Türkcü FM, Taş M, Alakuş MF, İşcan Y (2012) Topical loteprednol etabonate 0.5% for treatment of vernal keratoconjunctivitis: efficacy and safety. Japan J Ophthalmol 56(4):312–318.

32.

Kraft M, Soost S, Worm M (2020) Topical and systemic corticosteroids. Kanerva’s Occup Dermatol, pp 1433–1444.

33.

Simpson EL, Flohr C, Eichenfield LF, Bieber T, Sofen H, Taïeb A et al (2018) Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: a randomized, placebo-controlled phase II trial (TREBLE). J Am Acad Dermatol 78(5):863–871.e11.

34.

Armstrong S, Green P (2018) “Apply sparingly”? A review of topical corticosteroids. Dalhousie Med J 45(1).

35.

Corpuz M, Johnstone T, Kazarian A, Ostrom R (2018) Inhaled corticosteroids stimulate cAMP production and enhance βAR signaling in a non-genomic fashion in human airway smooth muscle cells. FASEB J 32(1_supplement):686.

36.

Chalmers JR, Axon E, Harvey J, Santer M, Ridd MJ, Lawton S et al (2019) Different strategies for using topical corticosteroids in people with eczema. Cochrane Database Syst Rev 2019(6).

37.

Yang Q, Oranje AP, Panda S, van der Wouden JC, Moed H (2018) Different strategies for using topical corticosteroids for established eczema. Cochrane Database System Rev 2018(1).

38.

Zhang Y, Xu J, Fang F (2019) Future directions for corticosteroids in treatment of sepsis—reply. JAMA Internal Med 179(6):845.

39.

Lim SY, Bolster MB (2019) Corticosteroids 28. Neurorheumatology: A Comprehenisve Guide to Immune Mediated Disorders of the Nervous System, 261.

40.

Erdinest N, Ben-Eli H, Solomon A (2019) Topical tacrolimus for allergic eye diseases. Curr Opin Allergy Clin Immunol 19(5):535–543CrossRefPubMed

41.

Erdinest N, Solomon A (2014) Topical immunomodulators in the management of allergic eye diseases. Curr Opin Allergy Clin Immunol 14(5):457–463. https://doi.org/10.1097/ACI.0000000000000089CrossRefPubMed

42.

Singalavanija S, Noppakun N, Limpongsanuruk W, Wisuthsarewong W, Aunhachoke K, Chunharas A et al (2006) Efficacy and safety of tacrolimus ointment in pediatric Patients with moderate to severe atopic dermatitis. J Med Assoc Thai 89(11):1915–1922PubMed

43.

Shoughy SS, Jaroudi MO, Tabbara KF (2016) Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis. Clin Ophthalmol 10:643–647. https://doi.org/10.2147/OPTH.S99157CrossRefPubMedPubMedCentral

44.

Miyazaki D, Fukushima A, Ohashi Y, Ebihara N, Uchio E, Okamoto S et al (2017) Steroid-sparing effect of 0.1% Tacrolimus eye drop for treatment of shield ulcer and corneal epitheliopathy in refractory allergic ocular diseases. Ophthalmology 124(3):287–294. https://doi.org/10.1016/j.ophtha.2016.11.002.

45.

Liendo VL, Vola ME, Barreiro TP, Wakamatsu TH, Gomes JP, Santos MSod (2017). Topical tacrolimus for the treatment of severe allergic keratoconjunctivitis in children. Arquivos Brasileiros de Oftalmologia 80(4):211–214.

46.

Kheirkhah A, Zavareh MK, Farzbod F, Mahbod M, Behrouz MJ (2011) Topical 0.005% tacrolimus eye drop for refractory vernal keratoconjunctivitis. Eye (Lond) 25(7):872–880. https://doi.org/10.1038/eye.2011.75.

47.

Chatterjee S, Agrawal D (2016) Tacrolimus in corticosteroid-refractory vernal keratoconjunctivitis. Cornea 35(11):1444–1448. https://doi.org/10.1097/ICO.0000000000000918CrossRefPubMed

48.

Benaim D, Ttart F, Bauvin O, Delcampe A, Joly P, Muraine M et al (2019) Tacrolimus ointment in the management of atopic keratoconjunctivitis. J Francais d'Ophtalmologie 42(4):e147–e151CrossRef

49.

Barot RK, Shitole SC, Bhagat N, Patil D, Sawant P, Patil K (2016) Therapeutic effect of 0.1% tacrolimus eye ointment in allergic ocular diseases. J Clin Diagn Res JCDR 10(6):NC05.

50.

BenEzra D, Pe’er J, Brodsky M, Cohen E (1986) Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis. Am J Ophthalmol 101(3):278–282CrossRefPubMed

51.

Secchi AG, Tognon MS, Leonardi A (1990) Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am J Ophthalmol 110(6):641–645CrossRefPubMed

52.

Bleik JH, Tabbara KF (1991) Topical cyclosporine in vernal keratoconjunctivitis. Ophthalmology 98(11):1679–1684CrossRefPubMed

53.

Matsuda S, Koyasu S (2000) Mechanisms of action of cyclosporine. Immunopharmacology 47(2–3):119–125. https://doi.org/10.1016/s0162-3109(00)00192-2CrossRefPubMed

54.

Kosrirukvongs P, Luengchaichawange C (2004) Topical cyclosporine 0.5 per cent and preservative-free ketorolac tromethamine 0.5 per cent in vernal keratoconjunctivitis. J Med Assoc Thai 87(2):190–197.

55.

Spadavecchia L, Fanelli P, Tesse R, Brunetti L, Cardinale F, Bellizzi M et al (2006) Efficacy of 1.25% and 1% topical cyclosporine in the treatment of severe vernal keratoconjunctivitis in childhood. Pediatr Allergy Immunol 17(7):527–532. https://doi.org/10.1111/j.1399-3038.2006.00427.x

56.

Peters DH, Fitton A, Plosker GL, Faulds DT (1993) A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation. Drugs 46(4):746–794.

57.

Hooks MA (1994) Tacrolimus, a new immunosuppressant—a review of the literature. Ann Pharmacother 28(4):501–511CrossRefPubMed

58.

Laskow DA, Neylan JF III, Shapiro RS, Pirsch JD, Vergne-Marini PJ, Tomlanovich SJ (1998) The role of tacrolimus in adult kidney transplantation: a review. Clin Transplant 12(6):489–503PubMed

59.

Shapiro R (1998) Tacrolimus in pediatric renal transplantation: a review. Pediatr Transplant 2(4):270–276PubMed

60.

Sengoku T, Morita K, Sakuma S, Motoyama Y, Goto T (1999) Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models. Eur J Pharmacol 379(2–3):183–189. https://doi.org/10.1016/s0014-2999(99)00500-2CrossRefPubMed

61.

Sakuma S, Higashi Y, Sato N, Sasakawa T, Sengoku T, Ohkubo Y et al (2001) Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system.(Comparison with steroids). Int Immunopharmacol 1(6):1219–1226.

62.

Soter NA, Fleischer AB Jr, Webster GF, Monroe E, Lawrence I (2001) Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part II, safety. J Am Acad Dermatol 44(1 Suppl):S39–S46. https://doi.org/10.1067/mjd.2001.109817CrossRefPubMed

63.

Kang S, Paller A, Soter N, Satoi Y, Rico MJ, Hanifin JM (2003) Safe treatment of head/neck AD with tacrolimus ointment. J Dermatol Treat 14(2):86–94CrossRef

64.

Lan CC, Lin CT, Chen GS, Huang CC, Chen YT, Wang LF (2003) Tacrolimus ointment for the treatment of atopic dermatitis: report of first clinical experience in Taiwan. Kaohsiung J Med Sci 19(6):296–303CrossRefPubMed

65.

Rikkers SM, Holland GN, Drayton GE, Michel FK, Torres MF, Takahashi S (2003) Topical tacrolimus treatment of atopic eyelid disease. Am J Ophthalmol 135(3):297–302. https://doi.org/10.1016/s0002-9394(02)01982-7CrossRefPubMed

66.

Fung JJ (2004) Tacrolimus and transplantation: a decade in review. Transplantation 77(9 Suppl):S41–S43. https://doi.org/10.1097/01.tp.000126926.61434.a5CrossRefPubMed

67.

Moher D, Liberati A, Tetzlaff J, Altman DG (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8(5):336–341CrossRefPubMed

68.

Higgins JP, Green S (2008) Cochrane handbook for systematic reviews of interventions. The Cochrane Collaboration. http://www.cochrane-handbook.org

69.

Cumpston MS, McKenzie JE, Welch VA, Brennan SE (2022) Strengthening systematic reviews in public health: guidance in the Cochrane Handbook for Systematic Reviews of Interventions. J Public Health 44(4):e588–e592CrossRef

70.

Gupta V, Sahu PK (2001) Topical cyclosporin A in the management of vernal keratoconjunctivitis. Eye (Lond) 15(Pt 1):39–41. https://doi.org/10.1038/eye.2001.10CrossRefPubMed

71.

Hingorani M, Moodaley L, Calder VL, Buckley RJ, Lightman S (1998) A randomized, placebo-controlled trial of topical cyclosporin A in steroid-dependent atopic keratoconjunctivitis. Ophthalmology 105(9):1715–1720CrossRefPubMed

72.

Pucci N, Novembre E, Cianferoni A, Lombardi E, Bernardini R, Caputo R et al (2002) Efficacy and safety of cyclosporine eyedrops in vernal keratoconjunctivitis. Ann Allergy Asthma Immunol 89(3):298–303. https://doi.org/10.1016/S1081-1206(10)61958-8CrossRefPubMed

73.

Zhang X, Tang J, Wang Q (2014) Analysis on tacrolimus efficacy in the treatment of vernal keratoconjunctivitis. Int Eye Sci 14:666–669

74.

Leonardi A, Doan S, Amrane M, Ismail D, Montero J, Németh J et al (2019) A randomized, controlled trial of cyclosporine a cationic emulsion in pediatric vernal keratoconjunctivitis: the VEKTIS study. Ophthalmology 126(5):671–681CrossRefPubMed

75.

Ohashi Y, Ebihara N, Fujishima H, Fukushima A, Kumagai N, Nakagawa Y et al (2010) A randomized, placebo-controlled clinical trial of tacrolimus ophthalmic suspension 0.1% in severe allergic conjunctivitis. J Ocul Pharmacol Ther 26(2):165–174. https://doi.org/10.1089/jop.2009.0087.

76.

Deeks JJ, Higgins JP, Altman DG, Group CSM (2019) Analysing data and undertaking meta‐analyses. Cochrane handbook for systematic reviews of interventions, pp 241–284.

77.

Ebihara N, Ohashi Y, Uchio E, Okamoto S, Kumagai N, Shoji J et al (2009) A large prospective observational study of novel cyclosporine 0.1% aqueous ophthalmic solution in the treatment of severe allergic conjunctivitis. J Ocul Pharmacol Ther 25(4):365–372. https://doi.org/10.1089/jop.2008.0103.

78.

Pucci N, Caputo R, Mori F, De LC, Di GL, Massai C et al (2010) Long-term safety and efficacy of topical cyclosporine in 156 children with vernal keratoconjunctivitis. Int J Immunopathol Pharmacol 23(3):865–871CrossRefPubMed

79.

Labcharoenwongs P, Jirapongsananuruk O, Visitsunthorn N, Kosrirukvongs P, Saengin P, Vichyanond P (2012) A double-masked comparison of 0.1% tacrolimus ointment and 2% cyclosporine eye drops in the treatment of vernal keratoconjunctivitis in children. Asian Pac J Allergy Immunol 30(3):177–184.

80.

Vichyanond P, Kosrirukvongs P (2013) Use of cyclosporine A and tacrolimus in treatment of vernal keratoconjunctivitis. Curr Allergy Asthma Rep 13(3):308–314. https://doi.org/10.1007/s11882-013-0345-0CrossRefPubMed

81.

Utine CA, Stern M, Akpek EK (2010) Clinical review: topical ophthalmic use of cyclosporin A. Ocul Immunol Inflamm 18(5):352–361. https://doi.org/10.3109/09273948.2010.498657CrossRefPubMed

82.

Survase SA, Kagliwal LD, Annapure US, Singhal RS (2011) Cyclosporin A—a review on fermentative production, downstream processing and pharmacological applications. Biotechnol Adv 29(4):418–435. https://doi.org/10.1016/j.biotechadv.2011.03.004CrossRefPubMed

83.

Keklikci U, Soker SI, Sakalar YB, Unlu K, Ozekinci S, Tunik S (2008) Efficacy of topical cyclosporin A 0.05% in conjunctival impression cytology specimens and clinical findings of severe vernal keratoconjunctivitis in children. Jpn J Ophthalmol 52(5):357–562. https://doi.org/10.1007/s10384-008-0577-z.

84.

Yamanaka M, Yokota S, Iwao Y, Noguchi S, Itai S (2014) Development and evaluation of a tacrolimus cream formulation using a binary solvent system. Int J Pharm 464(1–2):19–26. https://doi.org/10.1016/j.ijpharm.2014.01.017CrossRefPubMed

85.

Ebihara N, Ohashi Y, Fujishima H, Fukushima A, Nakagawa Y, Namba K et al (2012) Blood level of tacrolimus in patients with severe allergic conjunctivitis treated by 0.1% tacrolimus ophthalmic suspension. Allergol Int 61(2):275–282. https://doi.org/10.2332/allergolint.11-OA-0349

86.

Harada N, Inada N, Ishimori A, Shoji J, Sawa M (2014) Follow-up study on patients with vernal keratoconjunctivitis undergoing topical 0.1% tacrolimus treatment. Nihon Ganka Gakkai Zasshi 118(4):378–384.

87.

Yazu H, Shimizu E, Aketa N, Dogru M, Okada N, Fukagawa K et al (2019) The efficacy of 0.1% tacrolimus ophthalmic suspension in the treatment of severe atopic keratoconjunctivitis. Ann Allergy Asthma Immunol 122(4):387–392CrossRefPubMed

88.

Won CH, Seo PG, Park YM, Yang JM, Lee KH, Sung KJ et al (2004) A multicenter trial of the efficacy and safety of 0.03% tacrolimus ointment for atopic dermatitis in Korea. J Dermatolo Treatment 15(1):30–34.

89.

Schachner LA, Lamerson C, Sheehan MP, Boguniewicz M, Mosser J, Raimer S et al (2005) Tacrolimus ointment 0.03% is safe and effective for the treatment of mild to moderate atopic dermatitis in pediatric patients: results from a randomized, double-blind, vehicle-controlled study. Pediatrics 116(3):e334–e42.

90.

Virtanen HM, Reitamo S, Kari M, Kari O (2006) Effect of 0.03% tacrolimus ointment on conjunctival cytology in patients with severe atopic blepharoconjunctivitis: a retrospective study. Acta Ophthalmol Scand 84(5):693–695. https://doi.org/10.1111/j.1600-0420.2006.00699.x.

91.

Attas-Fox L, Barkana Y, Iskhakov V, Rayvich S, Gerber Y, Morad Y et al (2008) Topical tacrolimus 0.03% ointment for intractable allergic conjunctivitis: an open-label pilot study. Curr Eye Res 33(7):545–549. https://doi.org/10.1080/02713680802149115.

92.

Kymionis GD, Goldman D, Ide T, Yoo SH. Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. Cornea. 2008;27(2):228–9. doi: https://doi.org/10.1097/ICO.0b013e318159afbb [doi];00003226–200802000–00020 [pii].

93.

Tam PM, Young AL, Cheng LL, Lam PT (2010) Topical tacrolimus 0.03% monotherapy for vernal keratoconjunctivitis--case series. Br J Ophthalmol 94(10):1405–1406. https://doi.org/10.1136/bjo.2009.172387

94.

Al-Amri AM, Fiorentini SF, Albarry MA, Bamahfouz AY (2017) Long-term use of 0.003% tacrolimus suspension for treatment of vernal keratoconjunctivitis. Oman J Ophthalmol 10(3):145.

95.

Samyukta SK, Pawar N, Ravindran M, Allapitchai F, Rengappa R (2019) Monotherapy of topical tacrolimus 0.03% in the treatment of vernal keratoconjunctivitis in the pediatric population. J Am Assoc Pediatric Ophthalmol Strabismus 23(1):36-e1CrossRef

96.

Ueda Y, Tomoe H, Takahashi H, Takahashi Y, Yamashita H, Kaneko H et al (2014) Interstitial cystitis associated with primary Sjogren’s syndrome successfully treated with a combination of tacrolimus and corticosteroid: a case report and literature review. Mod Rheumatol. https://doi.org/10.3109/14397595.2014.895283CrossRefPubMed

97.

Vichyanond P, Tantimongkolsuk C, Dumrongkigchaiporn P, Jirapongsananuruk O, Visitsunthorn N, Kosrirukvongs P (2004) Vernal keratoconjunctivitis: result of a novel therapy with 0.1% topical ophthalmic FK-506 ointment. J Allergy Clin Immunol 113(2):355–358.

98.

Zhao M, He F, Yang Y, Lin W, Qiu W, Meng Q et al (2022) Therapeutic efficacy of tacrolimus in vernal keratoconjunctivitis: a meta-analysis of randomised controlled trials. Eur J Hosp Pharm 29(3):129–133CrossRefPubMed

99.

Wan KH-N, Chen LJ, Rong SS, Pang CP, Young AL (2013) Topical cyclosporine in the treatment of allergic conjunctivitis: a meta-analysis. Ophthalmology 120(11):2197–203.

Titel: Applications of topical immunomodulators enhance clinical signs of vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC): a meta-analysis
verfasst von: Nir Erdinest
Dror Ben Ephraim Noyman
Naomi London
Itay Lavy
Nadav Levinger
David Landau
Abraham Solomon
Yair Morad
Shehzad A. Naroo
Publikationsdatum: 01.12.2024
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 1/2024
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-03097-7

Neu im Fachgebiet Augenheilkunde

Metastase in der periokulären Region

Metastasen Leitthema

Orbitale und periokuläre metastatische Tumoren galten früher als sehr selten. Aber mit der ständigen Aktualisierung von Medikamenten und Nachweismethoden für die Krebsbehandlung werden neue Chemotherapien und Strahlenbehandlungen eingesetzt. Die …

Staging und Systemtherapie bei okulären und periokulären Metastasen

Metastasen Leitthema

Metastasen bösartiger Erkrankungen sind die häufigsten Tumoren, die im Auge diagnostiziert werden. Sie treten bei ungefähr 5–10 % der Patienten mit soliden Tumoren im Verlauf der Erkrankung auf. Besonders häufig sind diese beim Mammakarzinom und …

Wundheilung nach Trabekulektomie

Trabekulektomie CME-Artikel

Die überschießende Wundheilung in der filtrierenden Glaukomchirurgie ist ein zentraler Faktor für ein operatives Versagen. Nach der Einführung der Trabekulektomie in den 1960er-Jahren wurden viele Faktoren erkannt, die mit einer vermehrten …

„standard operating procedures“ (SOP) – Vorschlag zum therapeutischen Management bei periokulären sowie intraokulären Metastasen

Metastasen Leitthema

Peri- sowie intraokuläre Metastasen sind insgesamt gesehen selten und meist Zeichen einer fortgeschrittenen primären Tumorerkrankung. Die Therapie ist daher zumeist palliativ und selten kurativ. Zudem ist die Therapiefindung sehr individuell. Die …

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Applications of topical immunomodulators enhance clinical signs of vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC): a meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Augenheilkunde

Metastase in der periokulären Region

Staging und Systemtherapie bei okulären und periokulären Metastasen

Wundheilung nach Trabekulektomie

„standard operating procedures“ (SOP) – Vorschlag zum therapeutischen Management bei periokulären sowie intraokulären Metastasen

Update Augenheilkunde

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2024

A comparative study of cystoid macula edema following glaucoma drainage device surgery versus trabeculectomy

Determination of progressive endothelial cell loss after posterior chamber phakic intraocular lens implantation

Efficacy of tocilizumab in patients with moderate-to-severe corticosteroid-resistant thyroid eye disease: a prospective study

Pediatric keratoconus epidemiology: a systematic scoping review

Visual outcomes after cataract surgery in monocular compared to binocular patients: a case–control study

Impact of duration of silicone oil tamponade on foveal and parafoveal thickness in rhegmatogenous retinal detachment: a retrospective cohort study

Neu im Fachgebiet Augenheilkunde

Metastase in der periokulären Region

Staging und Systemtherapie bei okulären und periokulären Metastasen

Wundheilung nach Trabekulektomie

„standard operating procedures“ (SOP) – Vorschlag zum therapeutischen Management bei periokulären sowie intraokulären Metastasen

Update Augenheilkunde