Erschienen in:
30.10.2022 | ASO Author Reflections
ASO Author Reflections: Assessing the Diagnostic Accuracy of Circulating Tumor DNA, Imaging, and Carcinoembryonic Antigen to Detect Recurrent Colon Cancer
verfasst von:
Zaiba Shafik Dawood, MBBS, Zorays Moazzam, MD, Timothy M. Pawlik, MD, PhD, MPH, MTS, MBA, FACS, FRACS (Hon.)
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 1/2023
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Excerpt
Colorectal cancer (CRC) is the third most common malignancy and the second most common cause of cancer-related mortality.
1 Following primary resection of CRC, 20–40% of patients will experience recurrence in the form of liver, lung, peritoneal, or lymph node metastasis.
2 Owing to this increased risk of recurrence, surveillance strategies such as measurement of carcinoembryonic antigen (CEA) and imaging (computed tomography [CT] scan, positron emission tomography [PET] scan, chest x-ray, and abdominal ultrasound) have been recommended by many societies.
3 Additionally, newer non-invasive strategies to detect recurrence, such as circulating tumor DNA (CtDNA) have demonstrable efficacy in the detection of recurrence.
1 Adherence to such strategies is presumed to confer a survival benefit to CRC patients.
4 Although ‘optimal’ surveillance strategies for CRC remain a subject of debate, to date no meta-analysis has comprehensively compared the sensitivity, specificity, and accuracy of these surveillance strategies. Moreover, the diagnostic accuracy of CtDNA has not been assessed in any review. …
