Introduction
Materials and methods
Study design and population
Definitions
Statistical analysis
Results
Study participants
Baseline characteristics
Complete ANS | Partial ANS | Repeat ANS | No ANS | P | |
---|---|---|---|---|---|
N = 987 | N = 560 | N = 100 | N = 270 | ||
Maternal age, year | 33(30,37) | 33(29,37) | 33(29,37) | 33(30,37) | 0.713 |
Assisted reproductive technology | 102(10.3) | 47(8.4) | 7(7.0) | 14(5.2) | 0.052 |
Cesarean section | 955(96.8) | 522(93.2) | 93(93.0) | 235(87.0) | <0.001 |
Classification of hypertension | 0.006 | ||||
Chronic hypertension | 90(9.1) | 61(10.9) | 10(10.0) | 24(8.9) | |
Gestational hypertension | 166(16.8) | 136(24.3) | 28(28.0) | 66(24.4) | |
Preeclampsia | 665(67.4) | 315(56.3) | 54(54.0) | 160(59.3) | |
Eclampsia | 31(3.1) | 21(3.8) | 3(3.0) | 10(3.7) | |
HELLP syndrome | 35(3.5) | 27(4.8) | 5(5.0) | 10(3.7) | |
PPROM | 88(8.9) | 71(12.7) | 9(9.0) | 2(8.1) | 0.074 |
Chorioamnionitis | 24(2.4) | 15(2.7) | 3(3.0) | 1(0.4) | 0.156 |
Gestational Age, wk | 30(29,31) | 30(29,31) | 30(29,31) | 30(29,31) | 0.463 |
Birth weight (g), mean (SD) | 1190(1000,1370) | 1200(1000,1423) | 1245(1100,1450) | 1250(1050,1430) | 0.007 |
Birth weight z-scores | −0.105(−0.549,0.404) | −0.004(−0.546,0.537) | 0.144(−0.421,0.539) | 0.005(−0.9,0.677) | 0.026 |
Birth head circumference, cm | 27(25.5,28) | 27(25,28.5) | 27(26,29) | 27(26,29) | 0.434 |
Male gender | 496(50.3) | 30(53.8) | 43(43.0) | 141(52.2) | 0.202 |
Multiples | 145(14.7) | 74(13.2) | 15(15.0) | 23(8.5) | 0.066 |
Inborn | 974(98.7) | 548(97.9) | 100(100.0) | 243(90.0) | <0.001 |
Apgar <7 at 5 min | 98(9.9) | 81(14.5) | 10(10.0) | 51(18.9) | <0.001 |
SNAPPE-II | 13(5,27) | 14(5,30) | 13(0,27.8) | 14(5,28) | 0.167 |
Adverse neonatal outcomes
Complete ANS | Partial ANS | Repeat ANS | No ANS | P | |
---|---|---|---|---|---|
N = 987 | N = 560 | N = 100 | N = 270 | ||
Resuscitation | 602(61.0) | 350(62.5) | 58(58) | 167(61.9) | 0.834 |
Intubation in DR | 248(25.1) | 164(29.3) | 26(26.0) | 87(32.2) | 0.078 |
PS | 398(40.3) | 245(43.8) | 31(31) | 107(39.6) | 0.101 |
PS ≥ 2 times | 106(10.7) | 71(12.7) | 10(10.0) | 27(10) | 0.577 |
Hyperglycemia | 77(7.8) | 49(8.8) | 5(5.0) | 15(5.6) | 0.299 |
Hypoglycemia | 151(15.3) | 67(12.0) | 15(15.0) | 45(16.7) | 0.216 |
Ventilation days/length of stay | 0(0,115) | 0(0,128) | 0(0,82) | 19(0,125) | 0.274 |
Oxygen therapy days/length of stay | 347(126,706) | 386(139,717) | 263(29,540) | 304(104,639) | 0.043 |
Pneumothorax | 8(1.1) | 4(1.0) | 2(3.3) | 5(2.6) | 0.231 |
Pulmonary hemorrhage | 46(14.7) | 35(6.3) | 8(8.0) | 15(5.6) | 0.366 |
NRDS (3–4) | 206(20.9) | 103(18.4) | 18(18) | 45(18.0) | 0.370 |
BPDa | 95/827(11.5) | 47/455(10.3) | 14/85(16.5) | 21/202(10.4) | 0.409 |
Death or BPD | 75(14.7) | 75(13.4) | 16(16.0) | 44(16.3) | 0.694 |
SNI | 15(1.5) | 13(2.3) | 0(0) | 5(1.9) | 0.361 |
Death or SNI | 64(6.5) | 39(7.0) | 2(2.0) | 27(10.0) | 0.045 |
NEC | 21(2.1) | 12(2.1) | 2(2.0) | 9(3.3) | 0.678 |
Death or NEC | 73(7.4) | 38(6.8) | 3(3.0) | 30(11.1) | 0.038 |
ROPb | 42(6.1) | 14(3.4) | 5(6.5) | 7(3.9) | 0.178 |
Death or ROP | 95(9.6) | 43(7.7) | 7(7.0) | 31(11.5) | 0.258 |
EUGR | 424(46.2) | 266(51.8) | 48(49.5) | 99(41.8) | 0.054 |
Head circumference at discharge | 31(30,32) | 31(30,32) | 31(30,32) | 31(30,32.5) | 0.103 |
Length at discharge | 44(43,46) | 44(42.5,46) | 44(43,45) | 44.5(42,46) | 0.461 |
Weight at discharge | 2100(1970,2780) | 2077(1930,2257.5) | 2100(1960,2300) | 2100(1955,2340) | 0.174 |
Death | 53(5.4) | 29(5.2) | 2(2.0) | 24(8.9) | 0.042 |
Complete ANS | Partial ANS | Repeat ANS | No ANS | |
---|---|---|---|---|
N = 987 | N = 560 | N = 100 | N = 270 | |
AORc(95%CI) | AOR (95%CI) | AOR (95%CI) | ||
Resuscitation | 1 | 1.31(0.90,1.41) | 0.91(0.58,1.40) | 1.19(0.76,1.78) |
Intubation in DR | 1 | 1.35(0.92,1.86) | 1.35(0.82,2.25) | 1.38(0.90,1.82) |
PS | 1 | 1.09(0.87,1.36) | 0.80(0.50,1.27) | 1.25(0.93,1.42) |
PS ≥ 2 times | 1 | 1.26(0.91,1.76) | 1.05(0.52,2.12) | 1.01(0.63,1.61) |
Pneumothorax | 1 | 0.97(0.59,4.23) | 3.86(0.92,19.4) | 2.79(0.80,9.74) |
Pulmonary hemorrhage | 1 | 1.58(0.94,2.83) | 2.76(0.98,5.59) | 1.53(0.76,2.82) |
3–4 NRDS | 1 | 0.78(0.55,1.32) | 0.78(0.62,1,1.83) | 0.85(0.63,1.62) |
BPDa | 1 | 0.88(0.69,1.38) | 1.85(0.99,3.77) | 0.92(0.83,1.79) |
Death or BPD | 1 | 0.97(0.03,1.29) | 1.46(0.79,2.94) | 1.38(0.89,186) |
SNI | 1 | 1.70(0.79,3.68) | - | 1.56(0.54,3.72) |
Death or SNI | 1 | 1.33(0.89,1.82) | 0.48(0.18,1.35) | 1.68(1.29,3.80) |
NEC | 1 | 1.45(0.63,3.26) | 0.97(0.43,2.00) | 1.31(0.45,4.65) |
Death or NEC | 1 | 0.89(0.62,1.46) | 0.56(0.29,1.75) | 1.78(1.55,2.89) |
ROPb | 1 | 0.58(0.31,1.08) | 1.07(0.42,2.87) | 0.68(0.43,1.79) |
Death or ROP | 1 | 0.90(0.68,1.14) | 0.78(0.36,1.82) | 1.51(0.80,1.92) |
EUGR | 1 | 1.56(0.99,2.02) | 1.46(0.65,2.82) | 0.92(0.67,1.25) |
Death | 1 | 0.93(0.57,1.50) | 0.39(0.1,1.68) | 1.85(1.10,3.14) |
Complete ANS N = 987 | Partial ANS N = 560 | Repeat ANS N = 100 | No ANS N = 270 | |
---|---|---|---|---|
estimated changes (95% CI)a | estimated changes (95% CI)a | estimated changes (95% CI)a | ||
Oxygen therapy days/ length of stay | 1 | 9.1(-12.1, 32.5) | -18.3(-39.2, -2.1) | -8.8(-37.0,22.1) |
Ventilation days/ length of stay | 1 | 9.3(-9.3, 29.2) | -63.5(-129.2,,9.3) | -39.0(-88.6, 8.9) |
Head circumference at discharge | 1 | -0.52(-0.81, 0.44) | -0.23(-0.76, 0.51) | -0.33(-0.48, 0.30) |
Length at discharge | 1 | -0.35(-0.75, 0.08) | -0.38(-1.6, 0.52) | -0.33(-0.89, 0.45) |
Weight at discharge | 1 | -45.9(-83.9, 7.4) | 8.77(-69.5, 88.0) | 8.72(-43.0, 67.1) |