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01.12.2024 | Original Paper

Automated analysis of choroidal thickness in patients with systemic lupus erithematosus treated with hydroxychloroquine

verfasst von: Borja Arias-Peso, María Chacón González, Damián García-Navarro, María Pilar Ruiz del Tiempo , Nieves Pardiñas Barón, Luis Sáez-Comet, Oscar Ruiz-Moreno, Francisco Bartol-Puyal, Silvia Méndez-Martínez, Luis Pablo Júlvez

Erschienen in: International Ophthalmology | Ausgabe 1/2024

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Abstract

Purpose

To evaluate the influence of hydroxychloroquine (HCQ) in choroidal thickness (CT) in patients with systemic lupus erythematous (SLE), considering the possible impact of disease activity on the choroid.

Methods

Cross-sectional study comparing three groups: two groups of SLE patients treated with HCQ without HCQ-retinopathy (32 eyes/32 patients with < 5 years of HCQ (group 1) and 44 eyes/44 patients with > 5 years of HCQ (group 2)), and an age-matched healthy control group of 46 eyes/46 patients (group 3). A complete ophthalmic examination was performed, including swept-source optical coherence tomography (SS-OCT) Triton (Topcon). Data were correlated to systemic disease activity parameters.

Results

CT was thicker in group 1 compared to group 3 in central, nasal, and superior sectors, and to group 2 in inner superior and outer inferior sectors (p < 0.05). In the correlation analysis, disease activity and CT were inversely correlated in most sectors (p < 0.05). In the regression analysis, HCQ was related to thinner CT in temporal and inferior sectors and disease activity with variations in nasal sectors (p < 0.05).

Conclusions

In SLE patients, HCQ is correlated to decreased CT, especially in the inferior and temporal areas. The choroid shows different responses to SLE activity and HCQ, and some sectors may be more sensitive than others.

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Titel: Automated analysis of choroidal thickness in patients with systemic lupus erithematosus treated with hydroxychloroquine
verfasst von: Borja Arias-Peso
María Chacón González
Damián García-Navarro
María Pilar Ruiz del Tiempo
Nieves Pardiñas Barón
Luis Sáez-Comet
Oscar Ruiz-Moreno
Francisco Bartol-Puyal
Silvia Méndez-Martínez
Luis Pablo Júlvez
Publikationsdatum: 01.12.2024
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 1/2024
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-03016-w

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Automated analysis of choroidal thickness in patients with systemic lupus erithematosus treated with hydroxychloroquine

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

Purpose

Methods

Results

Conclusions

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