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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 3/2010

01.06.2010 | Review

Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis?

verfasst von: Pamela Mangat, Natalia Wegner, Patrick J Venables, Jan Potempa

Erschienen in: Arthritis Research & Therapy | Ausgabe 3/2010

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Abstract

Peptidylarginine deiminases (PADs) convert arginine within a peptide (peptidylarginine) into peptidylcitrulline. Citrullination by human PADs is important in normal physiology and inflammation. Porphyromonas gingivalis, a major pathogen in periodontitis, is the only prokaryote described to possess PAD. P. gingivalis infection may generate citrullinated peptides, which trigger anti-citrullinated peptide antibodies. In susceptible individuals, host protein citrullination by human PADs in the joint probably perpetuates antibody formation, paving the way for the development of chronic arthritis. Blockades of bacterial and human PADs may act as powerful novel therapies by inhibiting the generation of the antigens that trigger and sustain autoimmunity in rheumatoid arthritis.
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Metadaten
Titel
Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis?
verfasst von
Pamela Mangat
Natalia Wegner
Patrick J Venables
Jan Potempa
Publikationsdatum
01.06.2010
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 3/2010
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3000

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