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01.04.2010 | Review

Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications

verfasst von: Koenraad F van der Sluijs, Tom van der Poll, René Lutter, Nicole P Juffermans, Marcus J Schultz

Erschienen in: Critical Care | Ausgabe 2/2010

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Abstract

Seasonal and pandemic influenza are frequently complicated by bacterial infections, causing additional hospitalization and mortality. Secondary bacterial respiratory infection can be subdivided into combined viral/bacterial pneumonia and post-influenza pneumonia, which differ in their pathogenesis. During combined viral/bacterial infection, the virus, the bacterium and the host interact with each other. Post-influenza pneumonia may, at least in part, be due to resolution of inflammation caused by the primary viral infection. These mechanisms restore tissue homeostasis but greatly impair the host response against unrelated bacterial pathogens. In this review we summarize the underlying mechanisms leading to combined viral/bacterial infection or post-influenza pneumonia and highlight important considerations for effective treatment of bacterial pneumonia during and shortly after influenza.

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Titel: Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications
verfasst von: Koenraad F van der Sluijs
Tom van der Poll
René Lutter
Nicole P Juffermans
Marcus J Schultz
Publikationsdatum: 01.04.2010
Verlag: BioMed Central
Erschienen in: Critical Care / Ausgabe 2/2010
Elektronische ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc8893

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Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications

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