Erschienen in:
01.03.2011 | Original Communication
BG-12 reduces evolution of new enhancing lesions to T1-hypointense lesions in patients with multiple sclerosis
verfasst von:
D. G. MacManus, D. H. Miller, L. Kappos, R. Gold, E. Havrdova, V. Limmroth, C. H. Polman, K. Schmierer, T. A. Yousry, M. Eraksoy, E. Meluzinova, M. Dufek, M. Yang, G. N. O’Neill, K. Dawson
Erschienen in:
Journal of Neurology
|
Ausgabe 3/2011
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Abstract
BG-12, an immunomodulatory agent, reduces frequency of new gadolinium-enhancing (Gd+) lesions in relapsing multiple sclerosis (MS). This study reports the effect of 240 mg BG-12 orally three times daily (tid) for 24 weeks on the evolution of new Gd+ lesions to T1-hypointense lesions. Brain magnetic resonance imaging (MRI) scans from patients in placebo and 240 mg BG-12 tid arms of a phase 2b study were examined retrospectively. Included patients had at least one new Gd+ lesion from weeks 4 to 12. Week 24 scans were analyzed for number and proportion of new Gd+ lesions that evolved to T1-hypointense lesions. Eighteen patients receiving BG-12 and 38 patients receiving placebo were included in the analysis. The analysis tracked 147 new Gd+ lesions in patients from the BG-12 group and 221 Gd+ lesions in patients from the placebo group. The percentage of Gd+ lesions that evolved to T1-hypointense lesions was 34% lower with BG-12 treatment versus placebo (29%, BG-12; 44%, placebo; odds ratio 0.51; 95% confidence interval 0.43, 0.61; p < 0.0001). In addition to reducing frequency of new Gd+ lesions, BG-12 significantly reduced probability of their evolution to T1-hypointense lesions in patients with MS compared with placebo.