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Gynäkologische Endokrinologie

Erschienen in:

02.10.2023 | Biomarker | Leitthema

Modulation mütterlicher Immunzellen durch plazentare extrazelluläre Vesikel und microRNA

verfasst von: Rachel R. Zabel, José M. Murrieta-Coxca, Diana M. Morales-Prieto, Prof. Dr. Udo R. Markert

Erschienen in: Gynäkologische Endokrinologie | Ausgabe 4/2023

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Zusammenfassung

Die fetomaternale Kommunikation spielt eine entscheidende Rolle während der Schwangerschaft. Dazu werden lösliche Faktoren wie Hormone und Neuropeptide, aber auch extrazelluläre Vesikel (EV) von der Plazenta in den mütterlichen Kreislauf abgegeben. EV sind membrangebundene Vesikel, die von Zellen freigesetzt werden und eine wichtige Rolle in der interzellulären Kommunikation spielen. Sie können in verschiedene Klassen eingeteilt werden, darunter Exosomen und Mikrovesikel. EV enthalten eine Vielzahl von Molekülen wie Proteine, Lipide, Nukleinsäuren und microRNAs (miRNAs), die durch verschiedene Mechanismen von Zielzellen aufgenommen werden können. EV tragen zur Kommunikation zwischen Plazenta und mütterlichen Organen und Zellen einschließlich des Immunsystems bei. Plazentare miRNAs spielen eine wichtige Rolle bei der Regulation von Zellfunktionen in der Plazenta, gelangen aber auch mittels EV in Immunzellen. Deren Aufnahme kann die Immunantwort beeinflussen und zur Entwicklung der maternofetalen Immuntoleranz beitragen. Bei Schwangerschaftsstörungen und -erkrankungen kann die Menge und Zusammensetzung plazentarer EV verändert sein. Daher haben sie das Potenzial, zukünftig als diagnostische Marker für Schwangerschaftskomplikationen genutzt zu werden.

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Titel: Modulation mütterlicher Immunzellen durch plazentare extrazelluläre Vesikel und microRNA
verfasst von: Rachel R. Zabel
José M. Murrieta-Coxca
Diana M. Morales-Prieto
Prof. Dr. Udo R. Markert
Publikationsdatum: 02.10.2023
Verlag: Springer Medizin
Schlagwort: Biomarker
Erschienen in: Gynäkologische Endokrinologie / Ausgabe 4/2023
Print ISSN: 1610-2894
Elektronische ISSN: 1610-2908
DOI: https://doi.org/10.1007/s10304-023-00534-1

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