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Erschienen in: Sports Medicine 12/2009

01.12.2009 | Review Article

Bovine Colostrum Supplementation and Exercise Performance

Potential Mechanisms

verfasst von: Cecilia M. Shing, Denise C. Hunter, Lesley M. Stevenson

Erschienen in: Sports Medicine | Ausgabe 12/2009

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Abstract

Bovine colostrum (BC) is rich in immune, growth and antimicrobial factors, which promote tissue growth and the development of the digestive tract and immune function in neonatal calves. Although the value of BC to human adults is not well understood, supplementation with BC is becoming increasingly popular in trained athletes to promote exercise performance. The combined presence of insulin-like growth factors (IGF), transforming growth factors, immunoglobulins, cytokines, lactoferrin and lysozyme, in addition to hormones such as growth hormone, gonadotrophin-releasing hormone, luteinizing hormone-releasing hormone and glucocorticoids, would suggest that BC might improve immune function, gastrointestinal integrity and the neuroendocrine system, parameters that may be compromised as a result of intensive training. A review of studies investigating the influence of BC supplementation on exercise performance suggests that BC supplementation is most effective during periods of high-intensity training and recovery from high-intensity training, possibly as a result of increased plasma IGF-1, improved intramuscular buffering capacity, increases in lean body mass and increases in salivary IgA. However, there are contradicting data for most parameters that have been considered to date, suggesting that small improvements across a range of parameters might contribute to improved performance and recovery, although this cannot be concluded with certainty because the various doses and length of supplementation with BC in different studies prevent direct comparison of results. Future research on the influence of BC on sports performance will only be of value if the dose and length of supplementation of a well-defined BC product is standardized across studies, and the bioavailability of the active constituents in BC is determined.
Literatur
1.
Zurück zum Zitat Uruakpa FO, Ismond MAH, Akobundu ENT. Colostrum and its benefits: a review. Nutr Res 2002; 22: 755–67CrossRef Uruakpa FO, Ismond MAH, Akobundu ENT. Colostrum and its benefits: a review. Nutr Res 2002; 22: 755–67CrossRef
2.
Zurück zum Zitat Korhonen H, Marnila P, Gill HS. Milk immunoglobulins and complement factors. Br J Nutr 2000; 84 Suppl. 1: S75–80 Korhonen H, Marnila P, Gill HS. Milk immunoglobulins and complement factors. Br J Nutr 2000; 84 Suppl. 1: S75–80
3.
Zurück zum Zitat Hagiwara K, Kataoka S, Yamanaka H, et al. Detection of cytokines in bovine colostrum. Vet Immunol Immunopathol 2000; 76: 183–90PubMedCrossRef Hagiwara K, Kataoka S, Yamanaka H, et al. Detection of cytokines in bovine colostrum. Vet Immunol Immunopathol 2000; 76: 183–90PubMedCrossRef
4.
Zurück zum Zitat Mandalapu P, Pabst HF, Paetkau V. A novel immunosuppressive factor in human colostrum. Cell Immunol 1995; 162: 178–84PubMedCrossRef Mandalapu P, Pabst HF, Paetkau V. A novel immunosuppressive factor in human colostrum. Cell Immunol 1995; 162: 178–84PubMedCrossRef
5.
Zurück zum Zitat Ginjala V, Pakkanen R. Determination of transforming growth factor-beta 1 (TGF-beta 1) and insulin-like growth factor (IGF-1) in bovine colostrum samples. J Immunoassay 1998; 19: 195–207PubMedCrossRef Ginjala V, Pakkanen R. Determination of transforming growth factor-beta 1 (TGF-beta 1) and insulin-like growth factor (IGF-1) in bovine colostrum samples. J Immunoassay 1998; 19: 195–207PubMedCrossRef
6.
Zurück zum Zitat Blattler U, Hammon HM, Morel C, et al. Feeding colostrum, its composition and feeding duration variably modify proliferation and morphology of the intestine and digestive enzyme activities of neonatal calves. J Nutr 2001; 131: 1256–63PubMedCrossRef Blattler U, Hammon HM, Morel C, et al. Feeding colostrum, its composition and feeding duration variably modify proliferation and morphology of the intestine and digestive enzyme activities of neonatal calves. J Nutr 2001; 131: 1256–63PubMedCrossRef
7.
Zurück zum Zitat Mach JP, Pahud JJ. Secretory IgA: a major immunoglobulin in most bovine external secretions. J Immunol 1971; 106: 552–63PubMed Mach JP, Pahud JJ. Secretory IgA: a major immunoglobulin in most bovine external secretions. J Immunol 1971; 106: 552–63PubMed
8.
Zurück zum Zitat Suga M, Ando M, Tanaka F, et al. Triggering effects of opsonized-IgG antibody on the superoxide release in the phagosome and phagosome-lysosome fusion by pulmonary alveolar macrophages in rabbits. J Clin Lab Immunol 1990; 33: 55–9PubMed Suga M, Ando M, Tanaka F, et al. Triggering effects of opsonized-IgG antibody on the superoxide release in the phagosome and phagosome-lysosome fusion by pulmonary alveolar macrophages in rabbits. J Clin Lab Immunol 1990; 33: 55–9PubMed
9.
Zurück zum Zitat Togo S, Shimokawa T, Fukuchi Y, et al. Alternative splicing of myeloid IgA Fc receptor (Fc alpha R, CD89) transcripts in inflammatory responses. FEBS Lett 2003; 535: 205–9PubMedCrossRef Togo S, Shimokawa T, Fukuchi Y, et al. Alternative splicing of myeloid IgA Fc receptor (Fc alpha R, CD89) transcripts in inflammatory responses. FEBS Lett 2003; 535: 205–9PubMedCrossRef
10.
Zurück zum Zitat Pakkanen R, Aalto J. Growth factors and antimicrobial factors of bovine colostrum. Int Dairy J 1997; 7: 285–97CrossRef Pakkanen R, Aalto J. Growth factors and antimicrobial factors of bovine colostrum. Int Dairy J 1997; 7: 285–97CrossRef
11.
Zurück zum Zitat Francis GL, Upton FM, Ballard FJ, et al. Insulin-like growth factors 1 and 2 in bovine colostrums: sequences and biological activities compared with those of a potent truncated form. Biochem J 1988; 251: 95–103PubMedPubMedCentralCrossRef Francis GL, Upton FM, Ballard FJ, et al. Insulin-like growth factors 1 and 2 in bovine colostrums: sequences and biological activities compared with those of a potent truncated form. Biochem J 1988; 251: 95–103PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat Fryburg DA, Jahn LA, Hill SA, et al. Insulin and insulinlike growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest 1995; 96: 1722–9PubMedPubMedCentralCrossRef Fryburg DA, Jahn LA, Hill SA, et al. Insulin and insulinlike growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest 1995; 96: 1722–9PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Froesch ER, Hussain MA, Schmid C, et al. Insulin-like growth factor I: physiology, metabolic effects and clinical uses. Diabetes Metab Rev 1996; 12: 195–215PubMedCrossRef Froesch ER, Hussain MA, Schmid C, et al. Insulin-like growth factor I: physiology, metabolic effects and clinical uses. Diabetes Metab Rev 1996; 12: 195–215PubMedCrossRef
14.
Zurück zum Zitat Wong WM, Wright NA. Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation. J Parenter Enteral Nutr 1999; 23 (5 Suppl.): S83–8CrossRef Wong WM, Wright NA. Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation. J Parenter Enteral Nutr 1999; 23 (5 Suppl.): S83–8CrossRef
15.
Zurück zum Zitat Amarant T, Fridkin M, Koch Y. Luteinizing hormonereleasing hormone and thyrotropin-releasing hormone in human and bovine milk. Eur J Biochem 1982; 127: 647–50PubMedCrossRef Amarant T, Fridkin M, Koch Y. Luteinizing hormonereleasing hormone and thyrotropin-releasing hormone in human and bovine milk. Eur J Biochem 1982; 127: 647–50PubMedCrossRef
16.
Zurück zum Zitat Gopal PK, Gill HS. Oligosaccharides and glycoconjugates in bovinemilk and colostrum. Br J Nutr 2000; 84 Suppl. 1: S69–74 Gopal PK, Gill HS. Oligosaccharides and glycoconjugates in bovinemilk and colostrum. Br J Nutr 2000; 84 Suppl. 1: S69–74
17.
Zurück zum Zitat Ceciliani F, Pocacqua V, Provasi E, et al. Identification of the bovine alpha1-acid glycoprotein in colostrum and milk. Vet Res 2005; 36: 735–46PubMedCrossRef Ceciliani F, Pocacqua V, Provasi E, et al. Identification of the bovine alpha1-acid glycoprotein in colostrum and milk. Vet Res 2005; 36: 735–46PubMedCrossRef
18.
Zurück zum Zitat van Hooijdonk AC, Kussendrager KD, Steijns JM. In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence. Br J Nutr 2000; 84 Suppl. 1: S127–34 van Hooijdonk AC, Kussendrager KD, Steijns JM. In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence. Br J Nutr 2000; 84 Suppl. 1: S127–34
19.
Zurück zum Zitat Floren CH, Chinenye S, Elfstrand L, et al. ColoPlus, a new product based on bovine colostrum, alleviates HIVassociated diarrhoea. Scand J Gastroenterol 2006; 41: 682–6PubMedCrossRef Floren CH, Chinenye S, Elfstrand L, et al. ColoPlus, a new product based on bovine colostrum, alleviates HIVassociated diarrhoea. Scand J Gastroenterol 2006; 41: 682–6PubMedCrossRef
20.
Zurück zum Zitat Kim JW, Jeon WK, Yun JW, et al. Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pac J Clin Nutr 2005; 14: 103–7PubMed Kim JW, Jeon WK, Yun JW, et al. Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pac J Clin Nutr 2005; 14: 103–7PubMed
21.
Zurück zum Zitat Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 1999; 44: 653–8PubMedPubMedCentralCrossRef Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 1999; 44: 653–8PubMedPubMedCentralCrossRef
22.
Zurück zum Zitat Playford RJ, MacDonald CE, Calnan DP, et al. Coadministration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci (Lond) 2001; 100: 627–33PubMedCrossRef Playford RJ, MacDonald CE, Calnan DP, et al. Coadministration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci (Lond) 2001; 100: 627–33PubMedCrossRef
23.
Zurück zum Zitat Patel K, Rana R. Pedimune in recurrent respiratory infection and diarrhea: the Indian experience. The PRIDE study. Indian J Pediatr 2006; 73: 585–91 Patel K, Rana R. Pedimune in recurrent respiratory infection and diarrhea: the Indian experience. The PRIDE study. Indian J Pediatr 2006; 73: 585–91
24.
Zurück zum Zitat Brinkworth GD, Buckley JD. Concentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult males. Eur J Nutr 2003; 42: 228–32PubMedCrossRef Brinkworth GD, Buckley JD. Concentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult males. Eur J Nutr 2003; 42: 228–32PubMedCrossRef
25.
Zurück zum Zitat McGuire TC, Pfeiffer NE, Weikel JM, et al. Failure of colostral immunoglobulin transfer in calves dying from infectious disease. J Am Vet Med Assoc 1976; 169: 713–8PubMed McGuire TC, Pfeiffer NE, Weikel JM, et al. Failure of colostral immunoglobulin transfer in calves dying from infectious disease. J Am Vet Med Assoc 1976; 169: 713–8PubMed
26.
Zurück zum Zitat Rea DE, Tyler JW, Hancock DD, et al. Prediction of calf mortality by use of tests for passive transfer of colostral immunoglobulin. J Am Vet Med Assoc 1996; 208: 2047–9PubMed Rea DE, Tyler JW, Hancock DD, et al. Prediction of calf mortality by use of tests for passive transfer of colostral immunoglobulin. J Am Vet Med Assoc 1996; 208: 2047–9PubMed
27.
Zurück zum Zitat Brignole TJ, Stott GH. Effect of suckling followed by bottle feeding colostrum on immunoglobulin absorption and calf survival. J Dairy Sci 1980; 63: 451–6PubMedCrossRef Brignole TJ, Stott GH. Effect of suckling followed by bottle feeding colostrum on immunoglobulin absorption and calf survival. J Dairy Sci 1980; 63: 451–6PubMedCrossRef
28.
Zurück zum Zitat Walker-Smith JA, Phillips AD, Walford N, et al. Intravenous epidermal growth factor/urogastrone increases small-intestinal cell proliferation in congenital microvillous atrophy. Lancet 1985; 2: 1239–40PubMedCrossRef Walker-Smith JA, Phillips AD, Walford N, et al. Intravenous epidermal growth factor/urogastrone increases small-intestinal cell proliferation in congenital microvillous atrophy. Lancet 1985; 2: 1239–40PubMedCrossRef
29.
Zurück zum Zitat Steeb CB, Shoubridge CA, Tivey DR, et al. Systemic infusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats. Am J Physiol 1997; 272: G522–33 Steeb CB, Shoubridge CA, Tivey DR, et al. Systemic infusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats. Am J Physiol 1997; 272: G522–33
30.
Zurück zum Zitat Khan Z, Macdonald C, Wicks AC, et al. Use of the ‘nutriceutical’, bovine colostrum, for the treatment of distal colitis: results from an initial study. Aliment Pharmacol Ther 2002; 16: 1917–22PubMedCrossRef Khan Z, Macdonald C, Wicks AC, et al. Use of the ‘nutriceutical’, bovine colostrum, for the treatment of distal colitis: results from an initial study. Aliment Pharmacol Ther 2002; 16: 1917–22PubMedCrossRef
31.
Zurück zum Zitat Playford RJ, Woodman AC, Clark P, et al. Effect of luminal growth factor preservation on intestinal growth. Lancet 1993; 341: 843–8PubMedCrossRef Playford RJ, Woodman AC, Clark P, et al. Effect of luminal growth factor preservation on intestinal growth. Lancet 1993; 341: 843–8PubMedCrossRef
32.
Zurück zum Zitat Kim JW, Jeon WK, Kim EJ. Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. Clin Nutr 2005; 24: 785–93PubMedCrossRef Kim JW, Jeon WK, Kim EJ. Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. Clin Nutr 2005; 24: 785–93PubMedCrossRef
33.
Zurück zum Zitat Brinkworth GD, Buckley JD. Bovine colostrum supplementation does not affect nutrient absorptive capacity in healthy young men. Nutr Res 2003; 23: 1619–29CrossRef Brinkworth GD, Buckley JD. Bovine colostrum supplementation does not affect nutrient absorptive capacity in healthy young men. Nutr Res 2003; 23: 1619–29CrossRef
34.
Zurück zum Zitat Salmon H. The mammary gland and neonate mucosal immunity. Vet Immunol Immunopathol 1999; 72: 143–55PubMedCrossRef Salmon H. The mammary gland and neonate mucosal immunity. Vet Immunol Immunopathol 1999; 72: 143–55PubMedCrossRef
35.
Zurück zum Zitat Quigley JD, Strohbehn RE, Kost CJ, et al. Formulation of colostrum supplements, colostrum replacers and acquisition of passive immunity in neonatal calves. J Dairy Sci 2001; 84: 2059–65PubMedCrossRef Quigley JD, Strohbehn RE, Kost CJ, et al. Formulation of colostrum supplements, colostrum replacers and acquisition of passive immunity in neonatal calves. J Dairy Sci 2001; 84: 2059–65PubMedCrossRef
36.
Zurück zum Zitat Stott GH, Marx DB, Menefee BE, et al. Colostral immunoglobulin transfer in calves: I. Period of absorption. J Dairy Sci 1979; 62: 1632–8PubMedCrossRef Stott GH, Marx DB, Menefee BE, et al. Colostral immunoglobulin transfer in calves: I. Period of absorption. J Dairy Sci 1979; 62: 1632–8PubMedCrossRef
37.
Zurück zum Zitat Ontsouka CE, Sauter SN, Blum JW, et al. Effects of colostrum feeding and dexamethasone treatment on mRNA levels of insulin-like growth factors (IGF)-I and -II, IGF binding proteins-2 and -3, and on receptors for growth hormone, IGF-I, IGF-II, and insulin in the gastrointestinal tract of neonatal calves. Domest Anim Endocrinol 2004; 26: 155–75PubMedCrossRef Ontsouka CE, Sauter SN, Blum JW, et al. Effects of colostrum feeding and dexamethasone treatment on mRNA levels of insulin-like growth factors (IGF)-I and -II, IGF binding proteins-2 and -3, and on receptors for growth hormone, IGF-I, IGF-II, and insulin in the gastrointestinal tract of neonatal calves. Domest Anim Endocrinol 2004; 26: 155–75PubMedCrossRef
38.
Zurück zum Zitat Yamanaka H, Hagiwara K, Kirisawa R, et al. Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression. Microbiol Immunol 2003; 47: 461–8PubMedCrossRef Yamanaka H, Hagiwara K, Kirisawa R, et al. Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression. Microbiol Immunol 2003; 47: 461–8PubMedCrossRef
39.
Zurück zum Zitat Elfstrand L, Lindmark-Mansson H, Oaulsson M, et al. Immunoglobulins, growth factors and growth hormone in bovine colostrum and the effects of processing. Int Dairy J 2002; 12: 879–87CrossRef Elfstrand L, Lindmark-Mansson H, Oaulsson M, et al. Immunoglobulins, growth factors and growth hormone in bovine colostrum and the effects of processing. Int Dairy J 2002; 12: 879–87CrossRef
40.
Zurück zum Zitat Boudry C, Buldgena A, Portetelleb D, et al. Effect of bovine colostrum supplementation on cytokine mRNA expression in weaned piglets. Livestock Sci 2007; 108: 295–8CrossRef Boudry C, Buldgena A, Portetelleb D, et al. Effect of bovine colostrum supplementation on cytokine mRNA expression in weaned piglets. Livestock Sci 2007; 108: 295–8CrossRef
41.
Zurück zum Zitat Shing CM, Peake J, Suzuki K, et al. Bovine colostrum modulates cytokine production in human peripheral blood mononuclear cells stimulated with lipopolysaccharide and phytohemagglutinin. J Int Cyt Res 2007; 27: 835–9CrossRef Shing CM, Peake J, Suzuki K, et al. Bovine colostrum modulates cytokine production in human peripheral blood mononuclear cells stimulated with lipopolysaccharide and phytohemagglutinin. J Int Cyt Res 2007; 27: 835–9CrossRef
42.
Zurück zum Zitat Jeukendrup AE, Vet-Joop K, Sturk A, et al. Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin Sci (Lond) 2000; 98: 47–55PubMedCrossRef Jeukendrup AE, Vet-Joop K, Sturk A, et al. Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin Sci (Lond) 2000; 98: 47–55PubMedCrossRef
43.
Zurück zum Zitat Gleeson M. Mucosal immune responses and risk of respiratory illness in elite athletes. Exerc Immunol Rev 2000; 6: 5–42PubMed Gleeson M. Mucosal immune responses and risk of respiratory illness in elite athletes. Exerc Immunol Rev 2000; 6: 5–42PubMed
44.
Zurück zum Zitat Shing CM, Peake J, Suzuki K, et al. Effects of bovine colostrum supplementation on immune variables in highly trained cyclists. J Appl Physiol 2007; 102: 1113–22PubMedCrossRef Shing CM, Peake J, Suzuki K, et al. Effects of bovine colostrum supplementation on immune variables in highly trained cyclists. J Appl Physiol 2007; 102: 1113–22PubMedCrossRef
45.
Zurück zum Zitat Talukder MJ, Takeuchi T, Harada E. Receptor-mediated transport of lactoferrin into the cerebrospinal fluid via plasma in young calves. J Vet Med Sci 2003; 65: 957–64PubMedCrossRef Talukder MJ, Takeuchi T, Harada E. Receptor-mediated transport of lactoferrin into the cerebrospinal fluid via plasma in young calves. J Vet Med Sci 2003; 65: 957–64PubMedCrossRef
46.
Zurück zum Zitat Talukder MJ, Takeuchi T, Harada E. Transport of colostral macromolecules into the cerebrospinal fluid via plasma in newborn calves. J Dairy Sci 2002; 85: 514–24PubMedCrossRef Talukder MJ, Takeuchi T, Harada E. Transport of colostral macromolecules into the cerebrospinal fluid via plasma in newborn calves. J Dairy Sci 2002; 85: 514–24PubMedCrossRef
47.
Zurück zum Zitat Watkins LR, Maier SF. The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol 2000; 51: 29–57PubMedCrossRef Watkins LR, Maier SF. The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol 2000; 51: 29–57PubMedCrossRef
48.
Zurück zum Zitat Maso F, Lac G, Filaire E, et al. Salivary testosterone and cortisol in rugby players: correlation with psychological overtraining items. Br J Sports Med 2004; 38: 260–3PubMedPubMedCentralCrossRef Maso F, Lac G, Filaire E, et al. Salivary testosterone and cortisol in rugby players: correlation with psychological overtraining items. Br J Sports Med 2004; 38: 260–3PubMedPubMedCentralCrossRef
49.
Zurück zum Zitat Marshall-Gradisnik SM, Sample R, O’Leary L, et al. Improvements in health and psychological indicators in healthy males after eight-week bovine colostrum powder supplementation [abstract]. Aust J Dairy Technol 2003; 58: 197 Marshall-Gradisnik SM, Sample R, O’Leary L, et al. Improvements in health and psychological indicators in healthy males after eight-week bovine colostrum powder supplementation [abstract]. Aust J Dairy Technol 2003; 58: 197
50.
Zurück zum Zitat Filaire E, Legrand B, Lac G, et al. Training of elite cyclists: effects on mood state and selected hormonal responses. J Sports Sci 2004; 22: 1025–33PubMedCrossRef Filaire E, Legrand B, Lac G, et al. Training of elite cyclists: effects on mood state and selected hormonal responses. J Sports Sci 2004; 22: 1025–33PubMedCrossRef
51.
Zurück zum Zitat Odland L, Wallin S, Walum E. Lipid peroxidation and activities of tyrosine aminotransferase and glutamine synthetase in hepatoma and glioma cells grown in bovine colostrum-supplemented medium. In Vitro Cell Dev Biol 1986; 22: 259–62PubMedCrossRef Odland L, Wallin S, Walum E. Lipid peroxidation and activities of tyrosine aminotransferase and glutamine synthetase in hepatoma and glioma cells grown in bovine colostrum-supplemented medium. In Vitro Cell Dev Biol 1986; 22: 259–62PubMedCrossRef
52.
Zurück zum Zitat Przybylska J, Albera E, Kankofer M. Antioxidants in bovine colostrum. Reprod Domest Anim 2007; 42: 402–9PubMedCrossRef Przybylska J, Albera E, Kankofer M. Antioxidants in bovine colostrum. Reprod Domest Anim 2007; 42: 402–9PubMedCrossRef
53.
Zurück zum Zitat Korhonen BH. Antimicrobial factors in bovine colsotrum. J Sci Agric Soc Finland 1977; 49: 434–47 Korhonen BH. Antimicrobial factors in bovine colsotrum. J Sci Agric Soc Finland 1977; 49: 434–47
54.
Zurück zum Zitat Torre C, Jeusette I, Serra M, et al. Bovine colostrum increases proliferation of canine skin fibroblasts. J Nutr 2006; 136: 2058–60CrossRef Torre C, Jeusette I, Serra M, et al. Bovine colostrum increases proliferation of canine skin fibroblasts. J Nutr 2006; 136: 2058–60CrossRef
55.
Zurück zum Zitat Sporn MB, Roberts AB, Shull JH, et al. Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science 1983; 219: 1329–31PubMedCrossRef Sporn MB, Roberts AB, Shull JH, et al. Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science 1983; 219: 1329–31PubMedCrossRef
56.
Zurück zum Zitat Mero A, Miikkulainen H, Riski J, et al. Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training. J Appl Physiol 1997; 83: 1144–51PubMedCrossRef Mero A, Miikkulainen H, Riski J, et al. Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training. J Appl Physiol 1997; 83: 1144–51PubMedCrossRef
57.
Zurück zum Zitat Hofman Z, Smeets R, Verlaan G, et al. The effect of bovine colostrum supplementation on exercise performance in elite field hockey players. Int J Sport Nutr Exerc Metab 2002; 12: 461–9PubMedCrossRef Hofman Z, Smeets R, Verlaan G, et al. The effect of bovine colostrum supplementation on exercise performance in elite field hockey players. Int J Sport Nutr Exerc Metab 2002; 12: 461–9PubMedCrossRef
58.
Zurück zum Zitat Buckley JD, Brinkworth GD, Abbott MJ. Effect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor I. J Sports Sci 2003; 21: 577–88PubMedCrossRef Buckley JD, Brinkworth GD, Abbott MJ. Effect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor I. J Sports Sci 2003; 21: 577–88PubMedCrossRef
59.
Zurück zum Zitat Leppäluoto J, Rasi S, Martikkala V, et al. Bovine colostrum supplementation enhances physical performance on maximal exercise tests. 2000 Pre-Olympic Congress Sports Medicine and Physical Education International Congress on Sport Science; 2000 Sep 7–13: Brisbane (QLD) Leppäluoto J, Rasi S, Martikkala V, et al. Bovine colostrum supplementation enhances physical performance on maximal exercise tests. 2000 Pre-Olympic Congress Sports Medicine and Physical Education International Congress on Sport Science; 2000 Sep 7–13: Brisbane (QLD)
60.
Zurück zum Zitat Coombes JS, Conacher M, Austen SK, et al. Dose effects of oral bovine colostrum on physical work capacity in cyclists. Med Sci Sports Exerc 2002; 34: 1184–8PubMedCrossRef Coombes JS, Conacher M, Austen SK, et al. Dose effects of oral bovine colostrum on physical work capacity in cyclists. Med Sci Sports Exerc 2002; 34: 1184–8PubMedCrossRef
61.
Zurück zum Zitat Buckley JD, Abbott MJ, Brinkworth GD, et al. Bovine colostrum supplementation during endurance running training improves recovery, but not performance. J Sci Med Sport 2002; 5: 65–79PubMedCrossRef Buckley JD, Abbott MJ, Brinkworth GD, et al. Bovine colostrum supplementation during endurance running training improves recovery, but not performance. J Sci Med Sport 2002; 5: 65–79PubMedCrossRef
62.
Zurück zum Zitat Kerksick C, Kreider R, Rasmussen C, et al. Effects of bovine colostrum supplementation on training adaptations II: performance [abstract]. FASEB J 2001; 15: LB315 Kerksick C, Kreider R, Rasmussen C, et al. Effects of bovine colostrum supplementation on training adaptations II: performance [abstract]. FASEB J 2001; 15: LB315
63.
Zurück zum Zitat Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition 2001; 17: 243–7PubMedCrossRef Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition 2001; 17: 243–7PubMedCrossRef
64.
Zurück zum Zitat Fry A, Schilling B, Chiu L, et al. Muscle fibre and performance adaptations to resistance exercise with MyoVive, colostrum or casein and whey supplementation. Res Sports Med 2003; 11: 109–27CrossRef Fry A, Schilling B, Chiu L, et al. Muscle fibre and performance adaptations to resistance exercise with MyoVive, colostrum or casein and whey supplementation. Res Sports Med 2003; 11: 109–27CrossRef
65.
Zurück zum Zitat Kreider R, Rasmussen C, Kerksick C, et al. Effects of bovine colostrum supplementation on training adaptations: I. Body composition [abstract]. FASEB J 2001; 15: LB316 Kreider R, Rasmussen C, Kerksick C, et al. Effects of bovine colostrum supplementation on training adaptations: I. Body composition [abstract]. FASEB J 2001; 15: LB316
66.
Zurück zum Zitat Hoffman JR, Kang J, Ratamess NA, et al. Biochemical and hormonal responses during an intercollegiate football season. Med Sci Sports Exerc 2005; 37: 1237–41PubMedCrossRef Hoffman JR, Kang J, Ratamess NA, et al. Biochemical and hormonal responses during an intercollegiate football season. Med Sci Sports Exerc 2005; 37: 1237–41PubMedCrossRef
67.
Zurück zum Zitat Brinkworth GD, Buckley JD, Bourdon PC, et al. Oral bovine colostrum supplementation enhances buffer capacity but not rowing performance in elite female rowers. Int J Sport Nutr Exerc Metab 2002; 12: 349–65PubMedCrossRef Brinkworth GD, Buckley JD, Bourdon PC, et al. Oral bovine colostrum supplementation enhances buffer capacity but not rowing performance in elite female rowers. Int J Sport Nutr Exerc Metab 2002; 12: 349–65PubMedCrossRef
68.
Zurück zum Zitat Mero A, Nykänen T, Rasi S, et al. IGF-1, IGFBP-3, growth hormone and testosterone in male and female athletes during bovine colostrum supplementation [abstract]. Med Sci Sports Exerc 2002; 35: s299CrossRef Mero A, Nykänen T, Rasi S, et al. IGF-1, IGFBP-3, growth hormone and testosterone in male and female athletes during bovine colostrum supplementation [abstract]. Med Sci Sports Exerc 2002; 35: s299CrossRef
69.
Zurück zum Zitat O’Leary L. Assessment of anaerobic performance in healthy males after an eight week concentrated bovine colostrum supplementation. Australian Conference of Science and Medicine in Sport; 2003 Oct 25-28: Canberra (ACT) O’Leary L. Assessment of anaerobic performance in healthy males after an eight week concentrated bovine colostrum supplementation. Australian Conference of Science and Medicine in Sport; 2003 Oct 25-28: Canberra (ACT)
70.
Zurück zum Zitat Brinkworth GD, Buckley JD, Slavotinek JP, et al. Effect of bovine colostrum supplementation on the composition of resistance trained and untrained limbs in healthy young men. Eur J Appl Physiol 2004; 91 (1): 53–60PubMedCrossRef Brinkworth GD, Buckley JD, Slavotinek JP, et al. Effect of bovine colostrum supplementation on the composition of resistance trained and untrained limbs in healthy young men. Eur J Appl Physiol 2004; 91 (1): 53–60PubMedCrossRef
71.
Zurück zum Zitat Brinkworth GD, Buckley JD. Bovine colostrum supplementation does not affect plasma buffer capacity or haemoglobin content in elite female rowers. Eur J Appl Physiol 2004; 91: 353–6PubMedCrossRef Brinkworth GD, Buckley JD. Bovine colostrum supplementation does not affect plasma buffer capacity or haemoglobin content in elite female rowers. Eur J Appl Physiol 2004; 91: 353–6PubMedCrossRef
72.
Zurück zum Zitat Sample R, O’Leary L, Myers S, et al. Bovine colostrum supplementation and its effect on muscle histology, strength, performance and body composition in the elderly [abstract]. J Sci Med Sport 2004; 7: S16 Sample R, O’Leary L, Myers S, et al. Bovine colostrum supplementation and its effect on muscle histology, strength, performance and body composition in the elderly [abstract]. J Sci Med Sport 2004; 7: S16
73.
Zurück zum Zitat Mero A, Nykanen T, Keinanen O, et al. Protein metabolism and strength performance after bovine colostrum supplementation. Amino Acids 2005; 28: 327–35PubMedCrossRef Mero A, Nykanen T, Keinanen O, et al. Protein metabolism and strength performance after bovine colostrum supplementation. Amino Acids 2005; 28: 327–35PubMedCrossRef
74.
Zurück zum Zitat Crooks C, Wall C, Cross M, et al. The effect of bovine colostrum supplementation on salivary IgA in distance runners. Int J Sport Nutr Exerc Metab 2006; 16: 47–64PubMedCrossRef Crooks C, Wall C, Cross M, et al. The effect of bovine colostrum supplementation on salivary IgA in distance runners. Int J Sport Nutr Exerc Metab 2006; 16: 47–64PubMedCrossRef
75.
Zurück zum Zitat Shing CM, Jenkins DG, Stevenson L, et al. The influence of bovine colostrum supplementation on exercise performance in highly-trained cyclists. Br J Sports Med 2006; 40: 797–801PubMedPubMedCentralCrossRef Shing CM, Jenkins DG, Stevenson L, et al. The influence of bovine colostrum supplementation on exercise performance in highly-trained cyclists. Br J Sports Med 2006; 40: 797–801PubMedPubMedCentralCrossRef
76.
Zurück zum Zitat Kuhne S, Hammon HM, Bruckmaier RM, et al. Growth performance, metabolic and endocrine traits, and absorptive capacity in neonatal calves fed either colostrum or milk replacer at two levels. J Anim Sci 2000; 78: 609–20PubMedCrossRef Kuhne S, Hammon HM, Bruckmaier RM, et al. Growth performance, metabolic and endocrine traits, and absorptive capacity in neonatal calves fed either colostrum or milk replacer at two levels. J Anim Sci 2000; 78: 609–20PubMedCrossRef
77.
Zurück zum Zitat Hammon H, Blum JW. The somatotropic axis in neonatal calves can be modulated by nutrition, growth hormone, and Long-R3-IGF-I. Am J Physiol 1997; 273: E130–8CrossRef Hammon H, Blum JW. The somatotropic axis in neonatal calves can be modulated by nutrition, growth hormone, and Long-R3-IGF-I. Am J Physiol 1997; 273: E130–8CrossRef
78.
Zurück zum Zitat Sacheck JM, Ohtsuka A, McLary SC, et al. IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab 2004; 287: E591–601CrossRef Sacheck JM, Ohtsuka A, McLary SC, et al. IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab 2004; 287: E591–601CrossRef
79.
Zurück zum Zitat Malisoux L, Francaux M, Nielens H, et al. Calcium sensitivity of human single muscle fibers following plyometric training. Med Sci Sports Exerc 2006; 38: 1901–8PubMedCrossRef Malisoux L, Francaux M, Nielens H, et al. Calcium sensitivity of human single muscle fibers following plyometric training. Med Sci Sports Exerc 2006; 38: 1901–8PubMedCrossRef
80.
Zurück zum Zitat Mero A, Kahkonen J, Nykanen T, et al. IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training. J Appl Physiol 2002; 93: 732–9PubMedCrossRef Mero A, Kahkonen J, Nykanen T, et al. IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training. J Appl Physiol 2002; 93: 732–9PubMedCrossRef
81.
Zurück zum Zitat Kimura T, Murakawa Y, Ohno M, et al. Gastrointestinal absorption of recombinant human insulin-like growth factor-1 in rats. J Pharmacol Exp Ther 1997; 283: 611–8PubMed Kimura T, Murakawa Y, Ohno M, et al. Gastrointestinal absorption of recombinant human insulin-like growth factor-1 in rats. J Pharmacol Exp Ther 1997; 283: 611–8PubMed
82.
Zurück zum Zitat Kuipers H, van Breda E, Verlaan G, et al. Effects of oral bovine colostrum supplementation on serum insulin-like growth factor-I levels. Nutrition 2002; 18: 566–7PubMedCrossRef Kuipers H, van Breda E, Verlaan G, et al. Effects of oral bovine colostrum supplementation on serum insulin-like growth factor-I levels. Nutrition 2002; 18: 566–7PubMedCrossRef
83.
Zurück zum Zitat Nemet D, Pontello AM, Rose-Gottron C, et al. Cytokines and growth factors during and after a wrestling season in adolescent boys. Med Sci Sports Exerc 2004; 36: 794–800PubMedCrossRef Nemet D, Pontello AM, Rose-Gottron C, et al. Cytokines and growth factors during and after a wrestling season in adolescent boys. Med Sci Sports Exerc 2004; 36: 794–800PubMedCrossRef
84.
Zurück zum Zitat Steimer KS, Packard R, Holden D, et al. The serum-free growth of cultured cells in bovine colostrum and in milk obtained later in the lactation period. J Cell Physiol 1981; 109: 223–34PubMedCrossRef Steimer KS, Packard R, Holden D, et al. The serum-free growth of cultured cells in bovine colostrum and in milk obtained later in the lactation period. J Cell Physiol 1981; 109: 223–34PubMedCrossRef
85.
Zurück zum Zitat Donath MY, Jenni R, Brunner HP, et al. Cardiovascular and metabolic effects of insulin-like growth factor I at rest and during exercise in humans. J Clin Endocrinol Metab 1996; 81: 4089–94PubMed Donath MY, Jenni R, Brunner HP, et al. Cardiovascular and metabolic effects of insulin-like growth factor I at rest and during exercise in humans. J Clin Endocrinol Metab 1996; 81: 4089–94PubMed
86.
Zurück zum Zitat Hussain MA, Schmitz O, Mengel A, et al. Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans. J Clin Invest 1994; 94: 1126–33PubMedPubMedCentralCrossRef Hussain MA, Schmitz O, Mengel A, et al. Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans. J Clin Invest 1994; 94: 1126–33PubMedPubMedCentralCrossRef
87.
Zurück zum Zitat Buckley J, Abbott M, Martin S, et al. Effects of an oral bovine colostrum supplement (intact TM) on running performance. Australian Conference of Science and Medicine in Sport; 1998 Oct 13–16; Adelaide (SA) Buckley J, Abbott M, Martin S, et al. Effects of an oral bovine colostrum supplement (intact TM) on running performance. Australian Conference of Science and Medicine in Sport; 1998 Oct 13–16; Adelaide (SA)
88.
Zurück zum Zitat Hammon HM, Sauter SN, Reist M, et al. Dexamethasone and colostrum feeding affect hepatic gluconeogenic enzymes differently in neonatal calves. J Anim Sci 2003; 81: 3095–106PubMedCrossRef Hammon HM, Sauter SN, Reist M, et al. Dexamethasone and colostrum feeding affect hepatic gluconeogenic enzymes differently in neonatal calves. J Anim Sci 2003; 81: 3095–106PubMedCrossRef
89.
Zurück zum Zitat Hawley JA, Palmer GS, Noakes TD. Effects of 3 days of carbohydrate supplementation on muscle glycogen content and utilisation during a 1-h cycling performance. Eur J Appl Physiol Occup Physiol 1997; 75: 407–12PubMedCrossRef Hawley JA, Palmer GS, Noakes TD. Effects of 3 days of carbohydrate supplementation on muscle glycogen content and utilisation during a 1-h cycling performance. Eur J Appl Physiol Occup Physiol 1997; 75: 407–12PubMedCrossRef
90.
Zurück zum Zitat Kavouras SA, Troup JP, Berning JR. The influence of low versus high carbohydrate diet on a 45-min strenuous cycling exercise. Int J Sport Nutr Exerc Metab 2004; 14: 62–72PubMedCrossRef Kavouras SA, Troup JP, Berning JR. The influence of low versus high carbohydrate diet on a 45-min strenuous cycling exercise. Int J Sport Nutr Exerc Metab 2004; 14: 62–72PubMedCrossRef
91.
Zurück zum Zitat McInerney P, Lessard SJ, Burke LM, et al. Failure to repeatedly supercompensate muscle glycogen stores in highly trained men. Med Sci Sports Exerc 2005; 37: 404–11PubMedCrossRef McInerney P, Lessard SJ, Burke LM, et al. Failure to repeatedly supercompensate muscle glycogen stores in highly trained men. Med Sci Sports Exerc 2005; 37: 404–11PubMedCrossRef
92.
Zurück zum Zitat Karlsson J, Saltin B. Diet, muscle glycogen, and endurance performance. J Appl Physiol 1971; 31: 203–6PubMedCrossRef Karlsson J, Saltin B. Diet, muscle glycogen, and endurance performance. J Appl Physiol 1971; 31: 203–6PubMedCrossRef
93.
Zurück zum Zitat Rauprich AB, Hammon HM, Blum JW. Influence of feeding different amounts of first colostrum on metabolic, endocrine, and health status and on growth performance in neonatal calves. J Anim Sci 2000; 78: 896–908PubMedCrossRef Rauprich AB, Hammon HM, Blum JW. Influence of feeding different amounts of first colostrum on metabolic, endocrine, and health status and on growth performance in neonatal calves. J Anim Sci 2000; 78: 896–908PubMedCrossRef
94.
Zurück zum Zitat Nieman DC. Is infection risk linked to exercise workload? Med Sci Sports Exerc 2000; 32: S406–11CrossRef Nieman DC. Is infection risk linked to exercise workload? Med Sci Sports Exerc 2000; 32: S406–11CrossRef
95.
Zurück zum Zitat Atlaoui D, Duclos M, Gouarne C, et al. The 24-h urinary cortisol/cortisone ratio for monitoring training in elite swimmers. Med Sci Sports Exerc 2004; 36: 218–24PubMedCrossRef Atlaoui D, Duclos M, Gouarne C, et al. The 24-h urinary cortisol/cortisone ratio for monitoring training in elite swimmers. Med Sci Sports Exerc 2004; 36: 218–24PubMedCrossRef
96.
Zurück zum Zitat Halson SL, Bridge MW, Meeusen R, et al. Time course of performance changes and fatigue markers during intensified training in trained cyclists. J Appl Physiol 2002; 93: 947–56PubMedCrossRef Halson SL, Bridge MW, Meeusen R, et al. Time course of performance changes and fatigue markers during intensified training in trained cyclists. J Appl Physiol 2002; 93: 947–56PubMedCrossRef
97.
Zurück zum Zitat Halson SL, Lancaster GI, Jeukendrup AE, et al. Immunological responses to overreaching in cyclists. Med Sci Sports Exerc 2003; 35: 854–61PubMedCrossRef Halson SL, Lancaster GI, Jeukendrup AE, et al. Immunological responses to overreaching in cyclists. Med Sci Sports Exerc 2003; 35: 854–61PubMedCrossRef
98.
Zurück zum Zitat Fitzgerald L. Overtraining increases the susceptibility to infection. Int J Sports Med 1991; 12 Suppl. 1: S5–8CrossRef Fitzgerald L. Overtraining increases the susceptibility to infection. Int J Sports Med 1991; 12 Suppl. 1: S5–8CrossRef
99.
Zurück zum Zitat Gleeson M. Assessing immune function changes in exercise and diet intervention studies. Curr Opin Clin Nutr Metab Care 2005; 8: 511–5PubMedCrossRef Gleeson M. Assessing immune function changes in exercise and diet intervention studies. Curr Opin Clin Nutr Metab Care 2005; 8: 511–5PubMedCrossRef
100.
101.
Zurück zum Zitat McKune AJ, Smith LL, Semple SJ, et al. Influence of ultraendurance exercise on immunoglobulin isotypes and subclasses. Br J Sports Med 2005; 39: 665–70PubMedPubMedCentralCrossRef McKune AJ, Smith LL, Semple SJ, et al. Influence of ultraendurance exercise on immunoglobulin isotypes and subclasses. Br J Sports Med 2005; 39: 665–70PubMedPubMedCentralCrossRef
102.
Zurück zum Zitat McKune AJ, Smith LL, Semple SJ, et al. Changes in mucosal and humoral atopic-related markers and immunoglobulins in elite cyclists participating in the Vuelta a Espana. Int J Sports Med 2006; 27: 560–6PubMedCrossRef McKune AJ, Smith LL, Semple SJ, et al. Changes in mucosal and humoral atopic-related markers and immunoglobulins in elite cyclists participating in the Vuelta a Espana. Int J Sports Med 2006; 27: 560–6PubMedCrossRef
103.
Zurück zum Zitat Biron CA. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr Opin Immunol 1994; 6: 530–8PubMedCrossRef Biron CA. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr Opin Immunol 1994; 6: 530–8PubMedCrossRef
104.
Zurück zum Zitat Sethi SK, Bianco A, Allen JT, et al. Interferon-gamma (IFN-gamma) down-regulates the rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) on human airway epithelial cells. Clin Exp Immunol 1997; 110: 362–9PubMedPubMedCentralCrossRef Sethi SK, Bianco A, Allen JT, et al. Interferon-gamma (IFN-gamma) down-regulates the rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) on human airway epithelial cells. Clin Exp Immunol 1997; 110: 362–9PubMedPubMedCentralCrossRef
105.
Zurück zum Zitat Bachert C, van Kempen MJ, Hopken K, et al. Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections. Eur Arch Otorhinolaryngol 2001; 258: 406–12PubMedCrossRef Bachert C, van Kempen MJ, Hopken K, et al. Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections. Eur Arch Otorhinolaryngol 2001; 258: 406–12PubMedCrossRef
106.
Zurück zum Zitat Carmichael MD, Davis JM, Murphy EA, et al. Role of brain IL-beta on fatigue following exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol 2006; 291 (5): R1344–8CrossRef Carmichael MD, Davis JM, Murphy EA, et al. Role of brain IL-beta on fatigue following exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol 2006; 291 (5): R1344–8CrossRef
107.
Zurück zum Zitat Lakier Smith L. Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? Sports Med 2003; 33: 347–64PubMedCrossRef Lakier Smith L. Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? Sports Med 2003; 33: 347–64PubMedCrossRef
108.
Zurück zum Zitat Lambert GP, Broussard LJ, Mason BL, et al. Gastrointestinal permeability during exercise: effects of aspirin and energy-containing beverages. J Appl Physiol 2001; 90: 2075–80PubMedCrossRef Lambert GP, Broussard LJ, Mason BL, et al. Gastrointestinal permeability during exercise: effects of aspirin and energy-containing beverages. J Appl Physiol 2001; 90: 2075–80PubMedCrossRef
109.
Zurück zum Zitat Prosser C, Stelwagen K, Cummins R, et al. Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders. J Appl Physiol 2004; 96: 650–4PubMedCrossRef Prosser C, Stelwagen K, Cummins R, et al. Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders. J Appl Physiol 2004; 96: 650–4PubMedCrossRef
110.
Zurück zum Zitat Lim CL, Wilson G, Brown L, et al. Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress. Am J Physiol Regul Integr Comp Physiol 2007; 292: R186–94CrossRef Lim CL, Wilson G, Brown L, et al. Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress. Am J Physiol Regul Integr Comp Physiol 2007; 292: R186–94CrossRef
111.
Zurück zum Zitat Buckley JD, Brinkworth GD, Southcott E, et al. Bovine colostrum and whey protein supplementation during running training increase intestinal permeability [abstract]. Asia Pac J Clin Nutr 2004; 13: S81 Buckley JD, Brinkworth GD, Southcott E, et al. Bovine colostrum and whey protein supplementation during running training increase intestinal permeability [abstract]. Asia Pac J Clin Nutr 2004; 13: S81
112.
Zurück zum Zitat Caradonna L, Amati L, Magrone T, et al. Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance. J Endotoxin Res 2000; 6: 205–14PubMed Caradonna L, Amati L, Magrone T, et al. Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance. J Endotoxin Res 2000; 6: 205–14PubMed
113.
Zurück zum Zitat Spiekermann GM, Finn PW, Ward ES, et al. Receptormediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med 2002; 196: 303–10PubMedPubMedCentralCrossRef Spiekermann GM, Finn PW, Ward ES, et al. Receptormediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med 2002; 196: 303–10PubMedPubMedCentralCrossRef
114.
Zurück zum Zitat Roos N, Mahe S, Benamouzig R, et al. 15N-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine. J Nutr 1995; 125: 1238–44PubMed Roos N, Mahe S, Benamouzig R, et al. 15N-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine. J Nutr 1995; 125: 1238–44PubMed
115.
Zurück zum Zitat Davis PF, Greenhill NS, Rowan AM, et al. The safety of New Zealand bovine colostrum: nutritional and physiological evaluation in rats. Food Chem Toxicol 2007; 45: 229–36PubMedCrossRef Davis PF, Greenhill NS, Rowan AM, et al. The safety of New Zealand bovine colostrum: nutritional and physiological evaluation in rats. Food Chem Toxicol 2007; 45: 229–36PubMedCrossRef
Metadaten
Titel
Bovine Colostrum Supplementation and Exercise Performance
Potential Mechanisms
verfasst von
Cecilia M. Shing
Denise C. Hunter
Lesley M. Stevenson
Publikationsdatum
01.12.2009
Verlag
Springer International Publishing
Erschienen in
Sports Medicine / Ausgabe 12/2009
Print ISSN: 0112-1642
Elektronische ISSN: 1179-2035
DOI
https://doi.org/10.2165/11317860-000000000-00000

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