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01.10.2010 | Original Paper

Cardiovascular risk factors and noninvasive assessment of arterial structure and function in obese Turkish children

verfasst von: Murat Muhtar Yilmazer, Vedide Tavli, Özgür Umaç Carti, Timur Mese, Barış Güven, Banu Aydın, Ilker Devrim, Talat Tavlı

Erschienen in: European Journal of Pediatrics | Ausgabe 10/2010

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Abstract

Obesity is associated with a number of risk factors, such as hyperlipidemia, hyperinsulinemia, hypertension, and early atherosclerosis. Evidence indicates that atherosclerosis begins in childhood and progresses over decades. In this work, we examined the relationship between cardiovascular risk factors and ultrasonographic signs of subclinical atherosclerosis in 77 obese children and adolescents compared to 40 non-obese healthy peers. Carotis intima media thickness (cIMT), carotid artery compliance (CAC), brachial artery flow-mediated dilatation (FMD), and established cardiovascular risk factors were studied. In the obese patients, cIMT was significantly increased (0.57 mm vs 0.45 mm, p < 0.001) whereas CAC (1.84% vs 3.29%, p < 0.001) and FMD (9.67 % vs 14.81%, p < 0.001) were significantly decreased. In multiple linear regression analysis, a relation was observed between cIMT, CAC, brachial FMD on one hand, and body mass index (BMI) on the other. Among the lipid anomalies, only hypertriglyceridemia was found to be positively correlated with cIMT. Additionally, we found a significant association between waist circumference (WC) and FMD. These findings indicate that obesity in children is associated with arterial wall alterations and endothelial dysfunction. In hyperlipidemic situations, only hypertriglyceridemia was found to be positively correlated with cIMT. This finding has consistently indicated TG to be a risk factor for the development of atherosclerosis. To our knowledge this is the first study to determine the relation between FMD and WC, which is used as a parameter of obesity in childhood.

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Titel: Cardiovascular risk factors and noninvasive assessment of arterial structure and function in obese Turkish children
verfasst von: Murat Muhtar Yilmazer
Vedide Tavli
Özgür Umaç Carti
Timur Mese
Barış Güven
Banu Aydın
Ilker Devrim
Talat Tavlı
Publikationsdatum: 01.10.2010
Verlag: Springer-Verlag
Erschienen in: European Journal of Pediatrics / Ausgabe 10/2010
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-010-1216-5

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