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19.07.2016 | Original Communication

Carotid intima-media thickness and cognitive function in a middle-aged and older adult community: a cross-sectional study

verfasst von: Anxin Wang, Guojuan Chen, Zhaoping Su, Xiaoxue Liu, Xiaodong Yuan, Ruixuan Jiang, Yibin Cao, Shuohua Chen, Yanxia Luo, Xiuhua Guo, Shouling Wu, Xingquan Zhao

Erschienen in: Journal of Neurology | Ausgabe 10/2016

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Abstract

The relationship between atherosclerosis and cognitive function is less well studied in Chinese populations. In addition, the results among middle-aged adults have been mixed. We aimed to investigate the association of atherosclerosis measured by carotid intima-media thickness (CIMT) and cognitive function in middle-aged and older adults from a Chinese community. Participants in the Asymptomatic Polyvascular Abnormalities in Community study (APAC) who had completed the CIMT detection and cognitive function measurements in 2012/2013 were included. Cognitive function was measured using the Mini-Mental State Examination (MMSE). Multivariate linear regression analysis was used to analyze the association between CIMT and MMSE. Then, a stratified analysis was performed separately in middle-aged and older adults. A total of 3227 participants were included in this study (mean age 57.9 years, range 43–93 years); 56.6 % of them were men, 66.0 % were middle-aged adults. After adjusting for potential confounders, larger CIMT was associated with lower MMSE scores, with a 0.75-point decrease in MMSE score for every 1-mm increase in CIMT (β = − 0.75, P = 0.0020). The association remained statistically significant in middle-aged adults (β = − 0.57, P = 0.0390), and was stronger in older adults and adults with low education levels. There is a significant association between CIMT and cognitive function among middle-aged and older adults sampled from a Chinese population. This association was stronger in older adults and adults with low education levels.

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Titel: Carotid intima-media thickness and cognitive function in a middle-aged and older adult community: a cross-sectional study
verfasst von: Anxin Wang
Guojuan Chen
Zhaoping Su
Xiaoxue Liu
Xiaodong Yuan
Ruixuan Jiang
Yibin Cao
Shuohua Chen
Yanxia Luo
Xiuhua Guo
Shouling Wu
Xingquan Zhao
Publikationsdatum: 19.07.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 10/2016
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-016-8234-9

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