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01.12.2004 | Original Article

CD10 expression in diffuse large B-cell lymphomas does not influence survival

verfasst von: Bettina Fabiani, Alain Delmer, Eric Lepage, Catherine Guettier, Tony Petrella, Josette Brière, Anne-Marie Penny, Marie-Christine Copin, Jacques Diebold, Felix Reyes, Philippe Gaulard, Thierry J. Molina, Groupe d’Etudes des Lymphomes de l’Adulte

Erschienen in: Virchows Archiv | Ausgabe 6/2004

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Abstract

CD10 expression is considered as a marker of centrofollicular-derived diffuse large B-cell lymphomas (DLBCL). The aim of our study was to determine retrospectively among 98 patients with DLBCL, enrolled in the LNH93 trial of the Groupe d’Etude des Lymphomes de l’Adulte (GELA) and homogeneously treated with high-dose cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP)-like regimen [doxorubicin, cyclophosphamide, vindesine, bleomycin and prednisone (ACVBP)], the expression of CD10 using immunohistochemistry and its correlation with morphological features and clinical parameters. Of the 98 patients studied, 33 (34%) expressed CD10. There was no correlation among clinical parameters, International Prognostic Index risk groups and CD10 expression, with the exception of lactic dehydrogenase levels, which were lower in CD10-negative cases (P=0.005). There was no significant correlation between CD10 expression and morphological subtyping of DLBCL. Indeed, centrofollicular-derived DLBCL may present with numerous immunoblasts or as an immunoblastic lymphoma. Overall survival rate and event-free survival were not significantly different according to CD10 expression (P=0.44 and P=0.34 respectively). Therefore, it appears that CD10 expression does not influence survival or event-free survival in DLBCL.

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Titel: CD10 expression in diffuse large B-cell lymphomas does not influence survival
verfasst von: Bettina Fabiani
Alain Delmer
Eric Lepage
Catherine Guettier
Tony Petrella
Josette Brière
Anne-Marie Penny
Marie-Christine Copin
Jacques Diebold
Felix Reyes
Philippe Gaulard
Thierry J. Molina
Groupe d’Etudes des Lymphomes de l’Adulte
Publikationsdatum: 01.12.2004
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 6/2004
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-004-1129-7

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

CD10 expression in diffuse large B-cell lymphomas does not influence survival

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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