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Physiologie von Nozizeption und Schmerz

  • Chapter
Schmerzpsychotherapie

Zusammenfassung

Das nozizeptive System ist ein Subsystem der Somatosensorik mit sog. Nozizeptoren, spezifischen Sensoren zur Entdeckung faktisch oder potenziell schädigender Einwirkungen auf das Körpergewebe. Die Eigenschaften und Polymodalität der Nozizeptoren werden funktionell und molekular beschrieben. Die Eigenschaften der Zielneurone, die Besonderheiten der synaptischen Umschaltung im Rückenmark sowie der zum Gehirn aufsteigenden Bahnen werden ebenso erörtert wie die supraspinale Organisation des nozizeptiven Systems und die Rolle von Thalamus, Amygdala und Kortex. Einen besonderen Stellenwert haben die mannigfachen Plastizitätsmechanismen des nozizeptiven Systems: periphere und zentrale Sensibilisierung sowie synaptische Langzeitpotenzierung. Dies leitet über zu einem Exkurs in die Pathophysiologie des nozizeptiven Systems bei peripheren oder zentralen Läsionen (neuropathischer Schmerz).

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Author information

Authors and Affiliations

  1. Zentrum für Biomedizin und Medizintechnik (CBTM) Forschungsbereich Neurobiologie Medizinische Fakultät Mannheim, Ruprecht-Karls-Universität Heidelberg, Mannheim, Ludolf-Krehl-Str. 13, 68167

    PD Dr. Walter Magerl

  2. Zentrum für Biomedizin und Medizintechnik (CBTM) Forschungsbereich Neurobiologie Medizinische Fakultät Mannheim, Ruprecht-Karls-Universität Heidelberg, Mannheim, Ludolf-Krehl-Str. 13, 68167

    Prof. Dr. med. Rolf-Detlef Treede

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  1. PD Dr. Walter Magerl
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  2. Prof. Dr. med. Rolf-Detlef Treede
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Editor information

Editors and Affiliations

  1. Georg-Elias-Müller-Institut für Psychologie, Georg-August-Universität, Göttingen, Goßlerstr. 14, 37073

    Birgit Kröner-Herwig

  2. Abteilung für Schmerztherapie Berufsgenossenschaftliches, Universitätsklinikum Bergmannsheil GmbH, Bochum, Bürkle-de-la-Camp-Platz 1, 44789

    Jule Frettlöh

  3. Fachbereich Psychologie, Psychotherapeutische Hochschulambulanz Verhaltenstherapie, Universität Hamburg, Hamburg, Von-Melle-Park 5, 20146

    Regine Klinger

  4. DRK Schmerz-Zentrum Mainz, Mainz, Steig 16, 55131

    Paul Nilges (Leitender Psychologe) (Leitender Psychologe)

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Magerl, W., Treede, RD. (2011). Physiologie von Nozizeption und Schmerz. In: Kröner-Herwig, B., Frettlöh, J., Klinger, R., Nilges, P. (eds) Schmerzpsychotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12783-0_3

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  • DOI: https://doi.org/10.1007/978-3-642-12783-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12782-3

  • Online ISBN: 978-3-642-12783-0

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